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Acta Pharmaceutica Sinica B 2016年第6期6卷 600-613页

作者： vijay Sharma Kamla Pathak Department of Pharmaceutics Rajiv Academy for Pharmacy

The present research aimed to improve the dissolution rate and bioavailability of curcumin using the potential of liquisolid technology. Twelve drug-loaded liquisolid systems (LS-1 to LS-12) were prepared using different vehicles (PEG 200, PEG 400 and Tween 80) and curcumin concentrations in vehicle (40%, 50%, 60% and 70%, w/w). The carrier [microcrystalline cellulose (MCC) PH102] to coat (Aerosil®) ratio was 20 in all formulations. The systems were screened for pre-compression properties before being compressed to liquisolid tablets (LT-1 to LT-12). Post compression tests and in vitro dissolution of LTs were conducted and the results compared with those obtained for a directly compressed tablet (DCT) made of curcumin, MCC PH102 and Aerosil®. LTs exhibited higher cumulative drug release (CDR) than the DCT and the optimum formulation, LT-9 (made using Tween 80), was studied by powder XRD, DSC, SEM and FTIR. Ex-vivo permeation of curcumin from LT-9 through goat gastrointestinal mucosa was significantly (P50) of LT-9 towards NCL 87 cancer cells was 40.2 µmol/L substantiating its anticancer efficacy. Accelerated stability studies revealed insignificant effects of temperature and humidity on LT-9. In summary, solubility enhancement of curcumin in LTs produced significant improvements in its permeation and bioavailability.

关键词： Liquisolid tablet Powder solution technology Curcumin Hydrogen bond formation Cytotoxicity Gastric permeation Bioavailability Pharmacokinetics

SAR interferometric coherence analysis for snow cover mapping in the western Himalayan region

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International Journal of Digital Earth 2011年第1期4卷 78-90页

作者： vijay Kumar Gopalan Venkataraman Centre of Studies in Resources Engineering Indian Institute of Technology BombayPowaiMumbai 400076India

Information of snow cover(SC)over Himalayan regions is very important for regional climatological and hydrological *** monitoring of SC in the Himalayan region is essential for water supply to hydropower stations,irrigation requirements,and flood *** remote sensing has all weather,day and night earth observation capability unlike optical remote *** this study,spaceborne synthetic aperture radar interferometric(InSAR)coherence analysis is used to monitor SC over Himalayan rugged *** feasibility of monitoring SC using synthetic aperture radar(SAR)interferometry depends on the ability to maintain coherence over InSAR pair acquisition time ***-1/2 InSAR coherence and ENVISAT ASAR InSAR coherence images are analyzed for SC *** sets of winter and of snow free months of the Himalayan region are taken for interferogram *** images of the available data sets show maximum decorrelation in most of the area which indicates massive snowfall in the region in the winter season and melting in the *** showing coherence loss due to decorrelation is mapped as a snowcovered *** result is validated with field observations of snow depth and it is found that standing snow is inversely related to coherence in the Himalayan region.

关键词： SAR InSAR coherence snow cover digital earth microwave remote sensing

Anticancer and cytotoxic properties of the latex of Calotropis procera in a transgenic mouse model of hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第16期12卷 2517-2522页

作者： Tenzin Choedon Ganeshan Mathan Soneera Arya vijay L Kumar vijay Kumar Virology Group International Centre for Genetic Engineering and BiotechnologyAruna Asaf Ali MargNew Delhi-110067India Department of Pharmacology All India Institute of Medical SciencesAnsari NagarNew Delhi-110029India

AIM： To evaluate the anticancer property of the dried latex （DL） of Calotropis procera, a tropical medicinal plant, in the X15-myc transgenic mouse model of hepatocellular carcinoma and to elucidate its mechanism of action in cell culture. METHODS： The young transgenic mice were orally fed with the aqueous suspension of DL （400 mg/kg for 5 d/wk） for 15 wk and their liver was examined for histopathological changes at 20 wk. Serum levels of vascu- lar endothelial growth factor （VEGF） were also measured in these animals. To characterize the active fraction, DL was extracted with petroleum ether followed by methanol. The methanolic extract was sub-fractionated on a silica gel G column using a combination of non-polar and polar solvents and eleven fractions were obtained. Each fraction was analysed for cytotoxic effect on hepatoma （Huh7） and non-hepatoma （COS-1） cell lines and nontransformed hepatocytes （AML12） using tetrazolium （MTT） assay. Finally, the mechanism of cell death was investigated by measuring the levels of Bcl2, caspase 3 and DNA fragmentation. RESULTS： DL treatment of mice showed a complete protection against hepatocarcinogenesis. No adverse effect was observed in these animals. The serum VEGF level was significantly lowered in the treated mice as compared to control animals. Cell culture studies revealed that the methanolic extract of DL as well as its fraction 8 induced extensive cell death in both Huh-7 and COS-1 cells while AML12 cells were spared. This was accompanied by extensive fragmentation of DNA in Huh-7 and COS-1 cells. No change in the levels of canonical markers of apoptosis such as Bcl2 and caspase 3 was observed. CONCLUSION： DL of C. procera has the potential for anti-cancer therapy due to its differentJable targets and non-interference with regular pathway of apoptosis.

关键词： Calotropis procera Transgenic mice Hepatocellular carcinoma Cytotoxicity Anticancer agent Differential killing

维杰·普拉沙德:新的社会主义发展理论须注重“五个控制”

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政治经济学研究 2024年第1期 182-183页

作者：维杰·普拉沙德不详

南南合作机构一带一路倡议的出现提供了新的机会社会主义运动和社会主义政府可以合作提出新的社会主义发展理论。这一理论必须应对持续束缚发展议程的五个控制,寻找一个改变这些领域控制权的机制。一是自然资源控制。工业生产所需初级... 详细信息

南南合作机构一带一路倡议的出现提供了新的机会社会主义运动和社会主义政府可以合作提出新的社会主义发展理论。这一理论必须应对持续束缚发展议程的五个控制,寻找一个改变这些领域控制权的机制。一是自然资源控制。工业生产所需初级资源大部分来自亚非拉地区,但主要位于西方国家的跨国企业通过直接拥有或控制商品链掌握了大部分资源。

关键词：跨国企业南南合作发展议程控制权工业生产商品链自然资源普拉沙德

Single image defogging by gain gradient image filter

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Science China(Information Sciences) 2019年第7期62卷 225-227页

作者： Dilbag SINGH vijay KUMAR Computer Science and Engineering Department Apex Institute of Technology Chandigarh University Computer Science and Engineering Department Thapar Institute of Engineering and Technology

Dear editor,With the advancements in computer vision applications, the image defogging methods have received a lot of consideration. Defogging methods are extensively utilized in civil and military areas such as target detection, traffic surveillance,remote sensing. Therefore, the development of visibility restoration models has become a task of great interest and *** and Kumar [1] have proved that the dark

关键词： image Single image defogging by gain gradient image filter

VLSI scaling methods and low power CMOS buffer circuit

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Journal of Semiconductors 2013年第9期34卷 92-99页

作者： vijay Kumar Sharma Manisha Pattanaik Department of Information Technology ABV-Indian Institute of Information Technology & Management

Device scaling is an important part of the very large scale integration （VLSI） design to boost up the success path of VLSI industry, which results in denser and faster integration of the devices. As technology node moves towards the very deep submicron region, leakage current and circuit reliability become the key issues. Both are increasing with the new technology generation and affecting the performance of the overall logic circuit. The VLSI designers must keep the balance in power dissipation and the circuit＇s performance with scaling of the devices. In this paper, different scaling methods are studied first. These scaling methods are used to identify the effects of those scaling methods on the power dissipation and propagation delay of the CMOS buffer circuit. For mitigating the power dissipation in scaled devices, we have proposed a reliable leakage reduction low power transmission gate （LPTG） approach and tested it on complementary metal oxide semiconductor （CMOS） buffer circuit. All simulation results are taken on HSPICE tool with Berkeley predictive technology model （BPTM） BSIM4 bulk CMOS files. The LPTG CMOS buffer reduces 95.16% power dissipation with 84.20% improvement in figure of merit at 32 nm technology node. Various process, voltage and temperature variations are analyzed for proving the robustness of the proposed approach. Leakage current uncertainty decreases from 0.91 to 0.43 in the CMOS buffer circuit that causes large circuit reliability.

关键词： LPTG buffer power dissipation propagation delay scaling nanoscale CMOS figure of merit

Synthesis of ethyl acetate by esterification of acetic acid with ethanol over a heteropolyacid on montmorillonite K10

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Journal of Natural Gas Chemistry 2010年第2期19卷 161-164页

作者： Hanumant Gurav vijay V.Bokade Catalysis Division National Chemical LaboratoryPune-411008India

In present work,liquid phase esterification of acetic acid with ethanol over dodecatungestophosphoric acid （DTPA） supported on K10 montmorillonite was systematically studied and optimization of process parameters was carried *** 20% m/m DTPA/K10 was found to be the optimum catalyst with 90% acetic acid conversion and 100% ethyl acetate *** study was also explored to see the feasibility of 20% m/m DTPA/K10 as a catalyst for the alkylation of acetic acid with other alcohols like methanol,iso-propanol and *** 20% m/m DTPA/K10 has shown increased activity with the increase in carbon number,at the same alcohol *** results are novel.

关键词： acetic acid ethanol heteropolyacid montmorillonite K10 ethyl acetate

Response of thermal source in a transversely isotropic thermoelastic half-space with mass diffusion by using a finite element method

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Chinese Physics B 2012年第8期21卷 307-313页

作者： Ibrahim A.Abbas Rajneesh Kumar vijay Chawla Department of Mathematics Faculty of Science and Arts-KhulaisKing Abdulaziz UniversityJeddahSaudi Arabia Department of Mathematics Faculty of ScienceSohag UniversitySohagEgypt Department of Mathematics Kurukshetra UniversityKurukshetra-136119HaryanaIndia

The two-dimensional problem of generalized thermoelastic diffusion material with thermal and diffusion relaxation times is investigated in the context of the Lord-Shulman theory. As an application of the problem, a particular type of thermal source is considered and the problem is solved numerically by using a finite element method. The components of displacement, stress, temperature distribution chemical potential and mass concentration are obtained. The resulting quantities are depicted graphically for a special model. An appreciable effect of relaxation times is observed on various resulting quantities.

关键词： thermoelastic diffusion thermal source finite element method relaxation time

Butein imparts free radical scavenging, anti-oxidative and proapoptotic properties in the flower extracts of Butea monosperma

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BIOCELL 2012年第2期36卷 63-71页

作者： ANURADHA SEHRAWAT vijay KUMAR Virology Group International Centre for Genetic Engineering and BiotechnologyAruna Asaf Ali MargNew Delhi 110067India

The flower of Butea monosperma(Lam.)(Fabaceae)has been used in traditional Indian medicine in the treatment of many ailments including liver *** understand the pharmacological basis of its beneficial effects,the extracts of dried flowers in water,methanol,butanol,ethyl acetate and acetone were evaluated for free radical scavenging and pro-apoptotic activities in cell cultures(human hepatoma Huh-7 cell line and immortalized AML-12 mouse hepatocytes).Butrin and butein-the active constituents of flower extracts-were used as reference *** levels of cell injury markers like lactate dehydrogenase,glutathione and lipid peroxidation and primary antioxidant enzymes glutathione S-transferase and catalase were also *** aqueous and butanolic extracts exhibited better 2,2-diphenyl-1-picrylhydrazyl scavenging and cytotoxic activities in hepatoma cells than in immortalized ***,butein inhibited 2,2-diphenyl-1-picrylhydrazyl radical better than *** aqueous and butanolic extracts were further investigated for hepatoprotection against carbon tertrachloride-induced biochemical changes and cell *** extracts,just as butrin and butein,significantly reversed the cellular glutathione levels and lipid peroxidation,and glutathione–S-transferase *** dehydrogenase leakage and cell death were also ***,only butein revived the catalase ***,the butein content of Butea monosperma flower extracts is important for free radical scavenging activity,apoptotic cell death and protection against oxidative injury in hepatic cells.

关键词： butrin cytotoxicity hepatoprotection methanol extract free radical scavenging

Phasor Measurement Unit Incorporated Adaptive Out-of-step Protection of Synchronous Generator

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Journal of Modern Power Systems and Clean Energy 2021年第5期9卷 1032-1042页

作者： Jigneshkumar P.Desai vijay H.Makwana Department of Electrical Engineering Sarvajanik College of Engineering and TechnologySurat-395001India Gujarat Technological University Ahmedabad-382424India Department of Electrical Engineering G.H.Patel College of Engineering and TechnologyAnand-388120India

The existing out-of-step(OOS)protection schemes have proven to be deficient in the prevention of significant *** protection schemes must not operate in stable power swing,and rapidly isolate an asynchronous generator or group of generators from the rest of the power system in case of unstable power *** paper proposes a novel phasor measurement unit(PMU)incorporating a polygon-shaped graphical algorithm for OOS protection of the synchronous *** unique PMU-based logic works further to classify the type of swing once the graphical scheme detects it,which can identify the complex power swing produced in the modern power *** proposed algorithm can take the correct relaying decision in the event of power swing due to renewable energy integration,load encroachment,and transient *** this paper,the original and modified Kundur two-area system with a power system stabilizer(PSS)is used to test the proposed *** the end,it provides assessment results of the proposed relay on the Indian power system during the blackout in July *** results demonstrate that the proposed algorithm is fast,accurate,and adaptive in the modern power system and shows better performance than the existing OOS protection schemes.

关键词： Out-of-step protection phasor measurement unit(PMU) power swing detection renewable energy integration