Butein imparts free radical scavenging, anti-oxidative and proapoptotic properties in the flower extracts of Butea monosperma
作者机构：Virology GroupInternational Centre for Genetic Engineering and BiotechnologyAruna Asaf Ali MargNew Delhi 110067India
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2012年第36卷第2期
页 面：63-71页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by grant no.90(0039)/04/EMR-II of Council of Scientific and Industrial Research Government of India New Delhi.Anuradha Sehrawat has been a Research Associate of Department of Biotechnology Government of India during the period of this study
主 题：butrin cytotoxicity hepatoprotection methanol extract free radical scavenging
摘 要：The flower of Butea monosperma(Lam.)(Fabaceae)has been used in traditional Indian medicine in the treatment of many ailments including liver *** understand the pharmacological basis of its beneficial effects,the extracts of dried flowers in water,methanol,butanol,ethyl acetate and acetone were evaluated for free radical scavenging and pro-apoptotic activities in cell cultures(human hepatoma Huh-7 cell line and immortalized AML-12 mouse hepatocytes).Butrin and butein-the active constituents of flower extracts-were used as reference *** levels of cell injury markers like lactate dehydrogenase,glutathione and lipid peroxidation and primary antioxidant enzymes glutathione S-transferase and catalase were also *** aqueous and butanolic extracts exhibited better 2,2-diphenyl-1-picrylhydrazyl scavenging and cytotoxic activities in hepatoma cells than in immortalized ***,butein inhibited 2,2-diphenyl-1-picrylhydrazyl radical better than *** aqueous and butanolic extracts were further investigated for hepatoprotection against carbon tertrachloride-induced biochemical changes and cell *** extracts,just as butrin and butein,significantly reversed the cellular glutathione levels and lipid peroxidation,and glutathione–S-transferase *** dehydrogenase leakage and cell death were also ***,only butein revived the catalase ***,the butein content of Butea monosperma flower extracts is important for free radical scavenging activity,apoptotic cell death and protection against oxidative injury in hepatic cells.
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