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Global geoepidemiology of gastrointestinal surgery rates in Crohn’s disease

World Journal of Gastrointestinal Surgery 2024年第6期16卷 1835-1844页

作者： Simcha Weissman Muhammad Aziz Ayrton Bangolo vignesh k nagesh Htat Aung Midhun Mathew Lino Garcia Shiva A Chandar Praveena karamthoti Harinder Bawa Aseel Alshimari Yabets kejela Nazish Mehdi Chrishanti A Joseph Athri kodali Rohan kumar Priya Goyal Sanya Satheesha Fnu Nivedita Nicole Tesoro Tanni Sethi Gurpreet Singh Areej Belal Alina Intisar Hirra khalid Samuel Cornwell Suchith B Suresh kareem Ahmed karabo k Marole Om P Anand Rahat B Reshi Tej I Mehta Sameh Elias Joseph D Feuerstein Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJ 07047United States Division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOH 43614United States Department of Medicine University of WashingtonSeattleWA 98195United States Department of Radiology Johns Hopkins University HospitalBaltimoreMD 21218United States Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States

BACkGROUND Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn’s disease(CD)remains *** To systematically review the global variation in the rates of surgery in *** A comprehensive search analysis was performed using multiple electronic databases from inception through July 1,2020,to identify all full text,randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with *** included continent based demographic data,CD surgery rates over time,as well as the geoepidemiologic variation in CD surgery *** analyses were conducted using *** Twenty-three studies spanning four continents were *** median proportion of persons with CD who underwent gastrointestinal surgery in studies from North America,Europe,Asia,and Oceania were 30%(range:1.7%-62.0%),40%(range:0.6%-74.0%),17%(range:16.0%-43.0%),and 38%*** clear association was found regarding the proportion of patients undergoing gastrointestinal surgery over time in North America(R^(2)=0.035)and Europe(R^(2)=0.100).A moderate,negative association was seen regarding the proportion of patients undergoing gastrointestinal surgery over time(R^(2)=0.520)in *** There appears to be significant inter-continental variation regarding surgery rates in *** evidencebased guidelines accounting for the geographic differences in managing patients with CD is ***,as a paucity of data on surgery rates in CD exists outside the North American and European continents,future studies,particularly in less studied locales,are warranted.

关键词： Gastrointestinal surgery Crohn’s disease Geoepidemiology Inflammatory bowel disease Prevalence

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Impact of artificial intelligence in the management of esophageal,gastric and colorectal malignancies

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Artificial Intelligence in Gastrointestinal Endoscopy 2024年第2期5卷 1-14页

作者： Ayrton Bangolo Nikita Wadhwani vignesh k nagesh Shraboni Dey Hadrian Hoang-Vu Tran Izage kianifar Aguilar Auda Auda Aman Sidiqui Aiswarya Menon Deborah Daoud James Liu Sai Priyanka Pulipaka Blessy George Flor Furman Nareeman khan Adewale Plumptre Imranjot Sekhon Abraham Lo Simcha Weissman Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States

The incidence of gastrointestinal malignancies has increased over the past decade at an alarming *** and gastric cancers are the third and fifth most commonly diagnosed cancers worldwide but are cited as the second and third leading causes of *** institution of appropriate therapy from timely diagnosis can optimize patient *** intelligence(AI)-assisted diagnostic,prognostic,and therapeutic tools can assist in expeditious diagnosis,treatment planning/response prediction,and post-surgical *** can intercept neoplastic lesions in their primordial stages,accurately flag suspicious and/or inconspicuous lesions with greater accuracy on radiologic,histopathological,and/or endoscopic analyses,and eliminate over-dependence on ***-based models have shown to be on par,and sometimes even outperformed experienced gastroenterologists and *** neural networks(state-of-the-art deep learning models)are powerful computational models,invaluable to the field of precision *** models not only reliably classify images,but also accurately predict response to chemotherapy,tumor recurrence,metastasis,and survival rates *** this systematic review,we analyze the available evidence about the diagnostic,prognostic,and therapeutic utility of artificial intelligence in gastrointestinal oncology.

关键词： Artificial intelligence Gastrointestinal malignancies Machine learning Helicobacter pylori State-of-the-art deep learning models

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Therapeutics involved in managing initial and recurrent Clostridium difficile infection:An updated literature review

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第5期15卷 1-14页

作者： vignesh k nagesh Hadrian Hoang-Vu Tran Daniel Elias Izage kianifar Aguilar Tanni Sethi AiswaryaMenon Charlene Mansour Florchi Furman kylie Tsotsos Talia Subar Auda Auda Aman Sidiqui JevonLamar Nikita Wadhwani Shraboni Dey Abraham Lo Adam Atoot Simcha Weissman Humberto Sifuentes Ayrton I Bangolo Department of Internal Medicine Hackensack Palisades Medical CenterNorth BergenNJ 07047United States Department of Gastroenterology Augusta UniversityAugustaGA 30912United States

Clostridium difficile infection(CDI)has been increasing due to the effect of recurrent *** use of antibiotics has been shown to alter the gut microbiome and lead to *** treatment is limited to three major antibiotics;however,the incidence of recurrent CDIs has been increasing and drug resistance is a major *** aspect is a growing concern in modern medicine especially in the elderly population,critical care patients,and immunocompromised individuals who are at high risk of developing *** difficile can lead to various complications including septic shock and fulminant colitis that could prove to be lethal in these *** modalities of treatment have been developed including bezlotoxumab,a monoclonal antibody and fecal microbiota *** have been studies showing asymptomatic carriers and drug resistance posing a major threat to the healthcare *** treatment options are being studied to treat and prevent *** review will provide an insight into the current treatment modalities,prevention and newer modalities of treatment and challenges faced in the treatment of CDIs.

关键词： Clostridium difficile Antibiotics Vancomycin Fidaxomicin Prevention Bezlotoxumab Fecal microbiota transplant

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Characteristics and distinct prognostic determinants of individuals with hepatosplenic T-cell lymphoma over the past two decades

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World Journal of Clinical Oncology 2024年第6期15卷 745-754页

作者： Ayrton Bangolo Pierre Fwelo Shraboni Dey Tanni Sethi Sowmya Sagireddy Jawaria Chatta Ashish Goel Sneha Nagpaul Eric Pin-Shiuan Chen Chiranjeeve Saravanan Sheeja Gangan Joel Thomas Sarah Potiguara vignesh k nagesh Daniel Elias Charlene Mansour Prajakta H Ratnaparkhi Priyanshu Jain Midhun Mathew Taylor Porter Shadiya Sultan Shailaja Abbisetty Linh Tran Megha Chawla Abraham Lo Simcha Weissman Christina Cho Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Epidemiology Human Geneticsand Environmental SciencesUTHealth School of Public HealthHoustonTX 77030United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States Stem Cell Transplantation and Cellular Therapy John Theurer Cancer CenterHackensackNJ 07601United States

BACkGROUND Hepatosplenic T-cell lymphoma(HSTCL)is a rare and aggressive peripheral T-cell lymphoma with historically dismal outcomes,representing less than one percent of non-Hodgkin *** its rarity,the true incidence of HSTCL is unknown and most data have been extrapolated through case *** the best of our knowledge,the largest and most up to date study addressing the epidemiology and outcomes of patients with HSTCL in the United States covered a period from 1996 to 2014,with a sample size of 122 *** To paint the most updated epidemiological picture of *** A total of 186 patients diagnosed with HSTCL,between 2000 and 2017,were ultimately enrolled in our study by retrieving data from the Surveillance,Epidemiology,and End Results *** analyzed demographics,clinical characteristics,and overall mortality(OM)as well as cancer-specific mortality(CSM)of *** with a P valuek for this rare malignancy is very *** this retrospective cohort study of the United States population,non-Hispanic blacks and the elderly had a higher *** data highlights the need for larger prospective studies to investigate factors associated with worse prognosis in one ethnic group,such as treatment delays,which have been shown to increase mortality in this racial/ethnic group for other cancers.

关键词： Extra nodal lymphoma Mortality Survival Racial disparity Age

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Impact of gut microbiome in the development and treatment of pancreatic cancer:Newer insights

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World Journal of Gastroenterology 2023年第25期29卷 3984-3998页

作者： Ayrton I Bangolo Chinmay Trivedi Ishan Jani Silvanna Pender Hirra khalid Budoor Alqinai Alina Intisar karamvir Randhawa Joseph Moore Nicoleta De Deugd Shaji Faisal SuchithBoodgere Suresh Parva Gopani vignesh k nagesh Tracy Proverbs-Singh Simcha Weissman Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Gastrointestinal Malignancies John Theurer Cancer CenterHackensackNJ 07601United States

The gut microbiome plays an important role in the variation of pharmacologic *** aspect is especially important in the era of precision medicine,where understanding how and to what extent the gut microbiome interacts with drugs and their actions will be key to individualizing *** impact of the composition of the gut microbiome on the efficacy of newer cancer therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell treatment has become an active area of *** adenocarcinoma(PAC)has a poor prognosis even in those with potentially resectable disease,and treatment options are very *** studies have concluded that there is a synergistic effect for immunotherapy in combination with cytotoxic drugs,in the treatment of PAC.A variety of commensal microbiota can affect the efficacy of conventional chemotherapy and immunotherapy by modulating the tumor microenvironment in the treatment of *** review will provide newer insights on the impact that alterations made in the gut microbial system have in the development and treatment of PAC.

关键词： Pancreatic cancer Gut microbiome Chemotherapy Dysbiosis Intratumoral microbiome Gut flora

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Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

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Oncology Research 2024年第1期32卷 73-94页

作者： vignesh BALAJI E DIVYA RAMESH MANISHA CHUNGAN SHAJU AkSHARA kUMAR SAMYAk PANDEY RAkSHA NAYAk V.ALkA SRISHTI MUNJAL AMIR SALIMI k.SREEDHARA RANGANATH PAI SHANkAR M.BAkkANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human *** is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological ***,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome ***,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological *** are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor *** the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological *** though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic ***,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges

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Optimized Deep Learning Methods for Crop Yield Prediction

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Computer Systems Science & Engineering 2023年第2期44卷 1051-1067页

作者： k.vignesh A.Askarunisa A.M.Abirami kLN College of Information Technology Pottapalaiyam630612India Sethu Institute of Technology Kariyapatti626115India Thiagarajar College of Engineering Madurai625015India

Crop yield has been predicted using environmental,land,water,and crop characteristics in a prospective research *** it comes to predicting crop production,there are a number of factors to consider,including weather con-ditions,soil qualities,water levels and the location of the farm.A broad variety of algorithms based on deep learning are used to extract useful crops for *** combination of data mining and deep learning creates a whole crop yield pre-diction system that is able to connect raw data to predicted crop *** sug-gested study uses a Discrete Deep belief network with Visual Geometry Group(VGG)Net classiﬁcation method over the tweak chick swarm optimization approach to estimate agricultural *** Network’s successively stacked layers were fed the data *** on the input parameters,a crop produc-tion prediction environment is constructed using the network *** the tweak chick swarm optimization technique,the best characteristics of input data are preprocessed,and the optimal output is used as input for the classiﬁcation *** Deep belief network with the Visual Geometry Group Net clas-siﬁer is used to classify the data and forecast agricultural *** sug-gested model correctly predicts crop output with 97 percent accuracy,exceeding existing models by maintaining the baseline data distribution.

关键词： Data mining deep learning crop production tweak chick swarm optimization algorithm discrete deep belief network with VGG Net classiﬁer

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Identifying the optimal HVOF spray parameters to attain minimum porosity and maximum hardness in iron based amorphous metallic coatings

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Defence Technology（防务技术） 2017年第2期13卷 101-110页

作者： S.vignesh k.Shanmugam V.Balasubramanian k.Sridhar Centre for Materials Joining and Research (CEMAJOR) Department of Manufacturing Engineering Annamalai University Annamalai Nagar 608 002 Tamil Nadu India Protective Technologies Department Naval Materials Research Laboratory (NMRL) Ambernath Thane (Dist) Maharashtra India

Flow based Erosion e corrosion problems are very common in fluid handling equipments such as propellers, impellers, pumps in warships, submarine. Though there are many coating materials available to combat erosionecorrosion damage in the above components, iron based amorphous coatings are considered to be more effective to combat erosionecorrosion problems. High velocity oxy-fuel(HVOF)spray process is considered to be a better process to coat the iron based amorphous powders. In this investigation, iron based amorphous metallic coating was developed on 316 stainless steel substrate using HVOF spray technique. Empirical relationships were developed to predict the porosity and micro hardness of iron based amorphous coating incorporating HVOF spray parameters such as oxygen flow rate, fuel flow rate, powder feed rate, carrier gas flow rate, and spray distance. Response surface methodology(RSM) was used to identify the optimal HVOF spray parameters to attain coating with minimum porosity and maximum hardness.

关键词： High velocity oxy fuel spray Iron based amorphous metallic coating Micro-hardness Porosity

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Graph-theoretic algorithms for cyber-physical vulnerability analysis of power grid with incomplete information

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Journal of Modern Power Systems and Clean Energy 2018年第5期6卷 887-899页

作者： Anurag k.SRIVASTAVA Timothy A.ERNSTER Ren LIU vignesh G.kRISHNAN Department of Electrical Engineering and Computer Science Washington State University U.S. Army Corps of Engineers Dominion Power

A key focus recently has been on assessing therisk of a coordinated cyber-physical attack and minimizing the impact of a successful attack. Most of the cyberattackers will have limited system information and conventional power grid N-1 security analysis cannot be extended to assess the risk. Centrality measures are widely used in the network science and an attacker with incomplete information can use it to identify power system vulnerabilities by defining the system as a complex network but without real-time system measurements. This paper presents a graph theory based centrality indices for vulnerability assessment of the power system due to various bus and branch contingencies using limited system information and provides a preliminary defense mechanism to prevent such an attack. Proposed work answers the fundamental question of possible attack scenarios by balancing risk(limited information with low risk to get caught orhigh risk attack to access more system information) and impact(identifying contingencies with maximal impact on system operation). Statistical comparisons are made between the graph theory measures compared to the corresponding DC power flow based N-X linear sensitivity measures. A unified N-X centrality based performance index is proposed and validated against the AC power flow based performance index by doing the real-time simulations of an N-3 attack scenario. Defensive mechanisms using topology-based performance indices are also presented.

关键词： Cyber-physical security Graph theory Transmission system Contingency Defense mechanism Incomplete information

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A review of conventional and renewable biodiesel production

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Chinese Journal of Chemical Engineering 2021年第12期34卷 1-17页

作者： P.vignesh A.R.Pradeep kumar N.Shankar Ganesh V.Jayaseelan k.Sudhakar Department of Mechanical Engineering Indira Institute of Engineering and TechnologyTiruvallurIndia Department of Mechanical Engineering Dhanalakshmi College of EngineeringChennaiIndia Department of Mechanical Engineering Kingston College of EngineeringVelloreIndia Department of Mechanical Engineering Prathyusha Engineering CollegeChennaiIndia Faculty of Mechanical and Automotive Engineering Technology Universiti Malaysia Pahang26600 PekanPahangMalaysia Automotive Engineering Centre Universiti Malaysia Pahang26600 PekanPahangMalaysia

The need for sustainable fuels has resulted in the production of renewables from a wide range of sources,in particular organic fats and *** use of biofuel is becoming more widespread as a result of environmental and economic *** efforts have been made to substitute fossil fuels with green *** molecules extracted from processed animal fats and organic plant materials are considered alternatives for the use in modern engine *** different methods have been adopted for converting esters in vegetable oils/animal fats into compounds consistent with petroleum products,namely the transesterification and the hydro-processing of ester bonds for the production of *** review paper primarily focuses on conventional and renewable biodiesel feedstocks,the catalyst used and reaction kinetics of the production process.

关键词： Biofuel Methy esters from fatly acids Renewable diesel kinetics Catalyst Transesterification

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