Impact of gut microbiome in the development and treatment of pancreatic cancer:Newer insights

作     者：Ayrton I Bangolo Chinmay Trivedi Ishan Jani Silvanna Pender Hirra Khalid Budoor Alqinai Alina Intisar Karamvir Randhawa Joseph Moore Nicoleta De Deugd Shaji Faisal SuchithBoodgere Suresh Parva Gopani Vignesh K Nagesh Tracy Proverbs-Singh Simcha Weissman 

作者机构：Department of Internal MedicinePalisades Medical CenterNorth BergenNJ 07047United States Department of Gastrointestinal MalignanciesJohn Theurer Cancer CenterHackensackNJ 07601United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2023年第29卷第25期

页      面：3984-3998页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Pancreatic cancer Gut microbiome Chemotherapy Dysbiosis Intratumoral microbiome Gut flora 

摘      要：The gut microbiome plays an important role in the variation of pharmacologic *** aspect is especially important in the era of precision medicine,where understanding how and to what extent the gut microbiome interacts with drugs and their actions will be key to individualizing *** impact of the composition of the gut microbiome on the efficacy of newer cancer therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell treatment has become an active area of *** adenocarcinoma(PAC)has a poor prognosis even in those with potentially resectable disease,and treatment options are very *** studies have concluded that there is a synergistic effect for immunotherapy in combination with cytotoxic drugs,in the treatment of PAC.A variety of commensal microbiota can affect the efficacy of conventional chemotherapy and immunotherapy by modulating the tumor microenvironment in the treatment of *** review will provide newer insights on the impact that alterations made in the gut microbial system have in the development and treatment of PAC.