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Multi-modality imaging in transthyretin amyloid cardiomyopathy

World Journal of Cardiology 2019年第11期11卷 266-276页

作者： Bryan Paul Traynor Aamir Shamsi victor voon Department of Cardiology Connolly Hospital BlanchardstownAbbottstownDublin D15X40DIreland Department of Cardiology St George’s University Hospital NHS Foundation TrustLondon SW170QTUnited Kingdom

Transthyretin amyloid(TTR)cardiomyopathy is a disease of insidious onset,which is often accompanied by debilitating neurological and/or cardiac *** true prevalence is not fully known due to its elusive presentation,being often under-recognized and usually diagnosed only late in its natural history and in older *** of this,effective treatment options are usually precluded by multiple comorbidities and frailty associated with such ***,high clinical suspicion with earlier and better detection of this disease is *** this review,the novel applications of multimodality imaging in the diagnostic pathway of TTR cardiomyopathy are *** include the complimentary roles of transthoracic echocardiography,cardiac magnetic resonance,nuclear scintigraphy and positron emission tomography in quantifying cardiac dysfunction,diagnosis and risk *** advances in novel therapeutic options for TTR have further enhanced the importance of a timely and accurate diagnosis of this disease.

关键词： Multimodality imaging Cardiac amyloidosis Transthyretin Echocardiography Cardiac magnetic resonance Nuclear imaging

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Randomized study comparing incidence of radial artery occlusion post-percutaneous coronary intervention between two conventional compression devices using a novel airinflation technique

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World Journal of Cardiology 2017年第11期9卷 807-812页

作者： victor voon Muhammad Ayyaz Ul Haq Ciara Cahill Kirsten Mannix Catriona Ahern Terence Hennessy Samer Arnous Thomas Kiernan Cardiology Department University Hospital LimerickDooradoyleLimerickIreland

AIM To compare post-percutaneous coronary intervention(PCI) radial artery occlusion(RAO) incidence between two conventional radial artery compression devices using a novel air-inflation *** One hundred consecutive patients post-PCI were randomized 1:1 to Safeguard or TR band compression devices. Post-radial sheath removal, each compression device was inflated with additional 2 m L of air above index bleeding point during air-filled device application and gradually down-titrated accordingly. RAO was defined as absence of Doppler flow signal performed at 24 h and at 6 wk post-PCI. Patients with missing data were excluded. Statistical significance was defined as P < *** All patients had 6 F radial sheath inserted. No significant differences were observed between Safeguard Radial(n = 42) vs TR band(n = 42) in terms of age(63 ± 11 years vs 67 ± 11 years), clinical presentation(electives, n = 18 vs n = 16; acute coronary syndrome, n = 24 vs n = 26) and total procedural heparin(7778 ± 2704 IU vs 7825 ± 2450 IU). RAO incidence was not significantly different between groups at 24 h(2% vs 0%, P = 0.32) and 6 wk(0%, both).CONCLUSION Safeguard Radial and TR band did not demonstrate significant between-group differences in short-term RAO incidence. Lack of evidence of RAO in all postPCI patients at 6 wk follow-up, regardless of radial compression device indicate advantage of using the novel and pragmatic air-inflation technique. Further work is required to more accurately confirm these findings.

关键词： Radial artery Arterial occlusive disease Cardiac catheterization

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儿童眼结节病1例(英文)

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国际眼科杂志 2010年第4期10卷 627-629页

作者： Terrence Soong TKJ Chan Hardeep Mudhar IG Rennie victor Soong Angela Loo voon Pei 马来亚大学眼科马来西亚吉隆坡英国谢菲尔德皇家Hallamshire医院眼科英国谢菲尔德皇家Hallamshire医院组织病理学科谢菲尔德大学眼科和视觉矫正学术机构英国谢菲尔德英国Salford皇家医院NHS耳鼻喉科

结节病是一种罕见的和潜在的致残儿科疾病。此病临床治疗困难,需要长期监测。我们报告了1例9岁的白人女孩的情况,就诊最初表现为双侧慢性前葡萄膜炎、白内障和继发于结节病的青光眼。在过去的2a,患者接受左布诺洛尔滴剂,局部和全身类固... 详细信息

结节病是一种罕见的和潜在的致残儿科疾病。此病临床治疗困难,需要长期监测。我们报告了1例9岁的白人女孩的情况,就诊最初表现为双侧慢性前葡萄膜炎、白内障和继发于结节病的青光眼。在过去的2a,患者接受左布诺洛尔滴剂,局部和全身类固醇治疗,随后要求折叠式人工晶状体植入。在白内障手术后的2mo,患者葡萄膜炎以局部类固醇和低剂量甲氨蝶呤一直控制良好。她全血计数和肾功能定期监测,没有甲氨蝶呤不良影响的报告。结节病是一多系统疾病,需要眼科学家,神经学家和儿科医师多学科的投入。内科和外科治疗本病富于挑战。本例强调了低剂量甲氨蝶呤在儿童慢性葡萄膜炎治疗中的安全性和对此病及时治疗以防止显著发病的需要。

关键词：结节病白内障葡萄膜炎

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