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Role of bacterial and genetic factors in gastric cancer in Costa Rica

World Journal of gastroenterology 2009年第2期15卷 211-218页

作者： Sergio A con Hiroaki Takeuchi gil R con-chin vicky g con-chin Nobufumi Yasuda Reinaldo con-Wong Centro Digestivo Doctores con-Mediplaza Pavas 245-1200 San José Costa Rica Department of Clinical Laboratory Medicine Kochi Medical School Kochi University Nankoku-city Kochi 783-8505 Japan Department of Public Health Kochi Medical School Kochi University Nankoku-city Kochi 783-8505 Japan

AIM: To evaluate several risk factors for gastric cancer (gC) in Costa Rican regions with contrasting gC incidence rate (gCIR). METHODS: According to gCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high gCIR, n = 101) and B (low gCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 gC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with gCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high gCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with gC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). conCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing gC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in gCIR variability in Costa Rica.

关键词：胃癌遗传因子风险因子治疗方法

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Prospect Theory Based Individual Irrationality Modelling and Behavior Inducement in Pandemic control

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 139-170页

作者： Wenxiang Dong H.vicky Zhao Department of Automation BNRistTsinghua UniversityBeijing100084China

Understanding and modeling individuals’behaviors during epidemics is crucial for effective epidemic ***,existing research ignores the impact of users’irrationality on decision-making in the ***,existing disease control methods often assume users’full compliance with measures like mandatory isolation,which does not align with the actual *** address these issues,this paper proposes a prospect theorybased framework to model users’decision-making process in epidemics and analyzes how irrationality affects individuals’behaviors and epidemic *** to the analysis results,irrationality tends to prompt conservative behaviors when the infection risk is low but encourages risk-seeking behaviors when the risk is ***,this paper proposes a behavior inducement algorithm to guide individuals’behaviors and control the spread of *** and real user tests validate our analysis,and simulation results show that the proposed behavior inducement algorithm can effectively guide individuals’behavior.

关键词： Disease spread behavior model irrationality prospect theory

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Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium

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genes & Diseases 2024年第5期11卷 335-349页

作者： Jinxuan Zheng Rongcheng Yu Yiqi Tang Sihui Su Sainan Wang Chenxi Liao Xuecong Li Jiabin Liao Dongsheng Yu Tingting Ai Wei Zhao vicky Yau Chufeng Liu Liping Wu Yang Cao Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong 510055China guangdong Provincial Key Laboratory of Oral Diseases GuangzhouGuangdong 510055China Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Oral and Maxillofacial Surgery University at BuffaloBuffaloNY 14214USA Department of Orthodontics Stomatological HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China

Developmental defects of enamel are common due to genetic and environmental factors before and after ***42,a Rho family small gTPase,regulates prenatal tooth development in ***,its role in postnatal tooth development,especially enamel formation,remains ***,we investigated Cdc42 functions in mouse enamel development and tooth repair after ***42 showed highly dynamic temporospatial patterns in the developing incisors,with robust expression in ameloblast and odontoblast ***,epithelium-specific Cdc42 deletion resulted in enamel defects in *** differentiation was inhibited,and hypomineralization of enamel was observed upon epithelial Cdc42 *** analysis showed that abnormal mitochondrial components,phosphotransferase activity,and ion channel regulator activity occurred in the Cdc42 mutant dental *** oxygen species accumulation was detected in the mutant mice,suggesting that abnormal oxidative stress occurred after Cdc42 ***,Cdc42 mutant mice showed delayed tooth repair and generated less calcified *** dysfunction and abnormal oxygen consumption were evidenced by reduced Apool and Timm8a1 expression,increased Atp5j2 levels,and reactive oxygen species overproduction in the mutant repair ***-specific Cdc42 deletion attenuated ERK1/2 signaling in the labial cervical *** Sox2 expression in the mutant labial cervical loop after clipping might lead to delayed tooth *** findings suggested that mitochondrial dysfunction,up-regulated oxidative stress,and abnormal ion channel activity may be among multiple factors responsible for the observed enamel defects in Cdc42 mutant ***,Cdc42 exerts multidimensional and pivotal roles in enamel development and is particularly required for ameloblast differentiation and enamel matrix formation.

关键词： Cdc42 Enamel defects Mitochondrial dysfunction Rho gTPase Tooth repair

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一句话和一条法则——一句话帮你培养同理心,一条法则帮你取得成功

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空中英语教室（高级版．彭蒙惠英语） 2024年第2期 18-19,42,43页

作者： vicky TSUNg 不详

理解他人的一句话“我不知道。”为什么这句话如此有效?原因在于这句话背后的含义及其情商基础也就是理解和管理情绪的能力。下面是其内在原理:有人说了不体谅你的话。你自己默默地想:“他们不知道。”这句话的目的并不是看轻对方。这... 详细信息

理解他人的一句话“我不知道。”为什么这句话如此有效?原因在于这句话背后的含义及其情商基础也就是理解和管理情绪的能力。下面是其内在原理:有人说了不体谅你的话。你自己默默地想:“他们不知道。”这句话的目的并不是看轻对方。这句话只是在说他们不可能对你感同身受。认识到这一点,你就不会对对方所说的话投注过多的情绪。

关键词：同理心理解他人内在原理情绪感同身受法则

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居家或外出享受家庭乐趣

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空中英语教室（高级版．彭蒙惠英语） 2024年第4期 20-22,44,45页

作者： vicky TSUNg 不详

请教儿科医生:健康的儿童成长可以充满乐趣吗?大多数父母都希望为孩子提供比自己的父母曾提供的更多的东西。但是你可曾注意到,孩子们往往用像纸箱这样简单的东西就能玩得很开心?游戏对孩子的健康成长至关重要,说到玩,像积木、球、跳绳... 详细信息

请教儿科医生:健康的儿童成长可以充满乐趣吗?大多数父母都希望为孩子提供比自己的父母曾提供的更多的东西。但是你可曾注意到,孩子们往往用像纸箱这样简单的东西就能玩得很开心?游戏对孩子的健康成长至关重要,说到玩,像积木、球、跳绳和水桶等简单的玩具,往往对孩子们最有益。事实上,这些东西比昂贵的玩具更能让孩子们发挥想象力和创造力,而那些昂贵的玩具可能是许多家长负担不起的。

关键词：儿童成长儿科医生想象力和创造力玩具健康成长乐趣

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非凡与平凡现代科技可救人一命,也可料理餐食

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空中英语教室（高级版．彭蒙惠英语） 2024年第7期 14-16,40-42页

作者： PAgE DESIgN BY vicky TSUNg 不详

开创性的新生儿部分心脏移植手术2022年,杜克健康的外科医生们成功地为一名新生儿实施了全世界首例部分心脏移植手术,创造了历史。医生认为,这台历时8小时的开创性手术——将捐赠者心脏的活体动脉与瓣膜缝合于一名新生儿的心脏中——可... 详细信息

开创性的新生儿部分心脏移植手术2022年,杜克健康的外科医生们成功地为一名新生儿实施了全世界首例部分心脏移植手术,创造了历史。医生认为,这台历时8小时的开创性手术——将捐赠者心脏的活体动脉与瓣膜缝合于一名新生儿的心脏中——可以开创心脏外科手术的新领域,使年轻患者在日后的人生当中免于接受多次高风险的手术。

关键词：心脏移植手术心脏外科手术捐赠者年轻患者新生儿外科医生现代科技

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乐高如何培养客户忠诚度

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空中英语教室（高级版．彭蒙惠英语） 2024年第4期 32-33,48页

作者： Jason Aten vicky TSUNg(PAgE DESIgN) 不详

乐高出现在我们身边已经91年了,而其中的大部分时间,它都是全世界最热门的玩具之一。它也是目前营收额最高的玩具制造商,并且建立了堪称全世界忠诚度最高的粉丝群。顺带一提,那些粉丝可不只有儿童,数以百万计充满热情的成年人仍旧喜爱... 详细信息

乐高出现在我们身边已经91年了,而其中的大部分时间,它都是全世界最热门的玩具之一。它也是目前营收额最高的玩具制造商,并且建立了堪称全世界忠诚度最高的粉丝群。顺带一提,那些粉丝可不只有儿童,数以百万计充满热情的成年人仍旧喜爱用乐高积木建造作品。在你可能接触到的所有品牌当中,乐高也许拥有最忠诚的粉丝。

关键词：客户忠诚度粉丝玩具制造商成年人

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geochemical and Petrological Insights into the Neoproterozoic Moumba Metabasites: Implications for Crustal Processes in the West congo Belt (Republic of congo)

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Journal of geoscience and Environment Protection 2024年第2期12卷 1-29页

作者： Ulrich Verne Matiaba-Bazika Nelson Lekeba Makamba vicky Tendresse Télange Bouénitéla Nicy Carmelle Bazebizonza Tchiguina Timothée Miyouna Florent Boudzoumou Laboratory of geosciences Faculty of Sciences and Technics Marien NGOUABI University Brazzaville Republic of Congo National Institute for Research in Exact and Natural Sciences (IRSEN) Brazzaville Republic of Congo geographid Research and Cartographic Production Center (CERgEC) Brazzaville Republic of Congo

The West congo Belt contains in its rocks of Neoproterozoic age from Nemba complex outcropping in the Moumba River. This West congo belt is made up of a crustal segment of the Arcuaï-West congo orogen which extends from southwest gabon to the northeast of Angola. This study aims to constrain the geochemical signature Nemba complex of West congo belt from the petrograhic and geochemical study on the whole rock. The petrographic data from this study show the Moumba metabasites are made up of amphibolites, metagabbros, epidotites and greenschists interstratified in the Eburnean metasediments and affected by mesozonal to epizonal metamorphism characterized by the retromorphosis of intermediate amphibolite facies minerals into greenschist facies. Whole-rock geochemical data indicate that these metabasites are continental flood basalts (CFB) of basic nature and transitional affinity emplaced in intraplate context. These continental flood basalts are generated from magma originating from a significantly enriched shallow mantle plume and this magma then contaminated by the continental crust during their ascent. The reconstruction of tectonic signature suggests that West congo belt would result from closure of an ocean basin with subduction phenomena. This collision would be marked by the establishment of ophiolite complex. We show that this model is incompatible with the CFB nature of metabasites and the orogenic evolution of Neoproterozoic. It does not seem that we can evoke a genetic link with a subduction of oceanic crust, because the paleogeography of Neoproterozoic (Rodinia) is marked by intracontinental rifts linked to opening of Rodinia. We therefore suggest the non-existence of ophiolitic complex in western congo belt and reject the collisional model published by certain authors. We confirm the currently available intracontinental orogen model.

关键词： Mayombe Metabasites Moumba Mantle Plume continental Rifting Basalts Flood continental

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Simply Fine-Tuned Deep Learning-Based Classification for Breast Cancer with Mammograms

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Computers, Materials & continua 2022年第12期73卷 4677-4693页

作者： vicky Mudeng Jin-woo Jeong Se-woon Choe Department of Medical IT convergence Engineering Kumoh National Institute of TechnologyGumi39253Korea Department of Electrical Engineering Institut Teknologi KalimantanBalikpapan76127Indonesia Department of Data Science Seoul National University of Science and TechnologySeoul01811Korea Department of IT convergence Engineering Kumoh National Institute of TechnologyGumi39253Korea

A lump growing in the breast may be referred to as a breast mass related to the ***,not all tumors are cancerous or *** masses can cause discomfort and pain,depending on the size and texture of the *** an appropriate diagnosis,non-cancerous breast masses can be diagnosed earlier to prevent their cultivation from being *** the development of the artificial neural network,the deep discriminative model,such as a convolutional neural network,may evaluate the breast lesion to distinguish benign and malignant cancers frommammogram breast masses *** work accomplished breastmasses classification relative to benign and malignant cancers using a digital database for screening mammography image datasets.A residual neural network 50(ResNet50)model along with an adaptive gradient algorithm,adaptive moment estimation,and stochastic gradient descent optimizers,as well as data augmentations and fine-tuning methods,were *** addition,a learning rate scheduler and 5-fold cross-validation were applied with 60 training procedures to determine the best *** results of training accuracy,p-value,test accuracy,area under the curve,sensitivity,precision,F1-score,specificity,and kappa for adaptive gradient algorithm 25%,75%,100%,and stochastic gradient descent 100%fine-tunings indicate that the classifier is feasible for categorizing breast cancer into benign and malignant from the mammographic breast masses images.

关键词： Medical image analysis convolutional neural network mammogram breast masses breast cancer

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Towards a Large-Scale Hydrogen Industry for Australia

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Engineering 2020年第12期6卷 1346-1348页

作者： Patrick gHartley vicky Au CSIRO Energy Clayton SouthVIC 3169Australia

*** As nations around the world seek to reduce carbon dioxide emissions in order to mitigate climate change risks,there has been a resurgence of interest in the use of hydrogen as a zero-emissions energy *** can be produced from diverse feedstocks via a range of low-emissions pathways and has broad potential in the process of decarbonization across the energy,transport,and industrial *** an abundance of both renewable and fossil fuel energy resources,a comparatively low national energy demand and excellent existing regional resource trading links,Australia is well positioned to pursue industrial-scale hydrogen production for both domestic and export purposes[1,2].In this paper,we present an overview of the progress at the government,industry,and research levels currently undertaken to enable a large-scale hydrogen industry for Australia.

关键词： trading Australia enable

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