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GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers

International Journal of Ophthalmology(English edition) 2018年第9期11卷 1514-1520页

作者： Miroslav Stamenkovic vesna Lukic Sonja Suvakov Tatjana Simic Ivan Sencanic Marija Pljesa-Ercegovac vesna Jaksic Sinisa Babovic Marija Matic Aleksandra Radosavljevic Ana Savic-Radojevic Tatjana Djukic University Eye Clinic Medical Center ZvezdaraBelgrade 11000Serbia Faculty of Special Education and Rehabilitation University of BelgradeBelgrade 11000Serbia Institute of Medical and Clinical Biochemistry Belgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia Hospital for Eye Diseases Clinical Center of SerbiaBelgrade 11000Serbia

AIM： To evaluate glutathione transferase theta 1 and mu 1（GSTT1 and GSTM1） polymorphisms as determinants of primary open angle glaucoma（POAG） risk, independently or in combination with cigarette smoking, hypertension and diabetes ***： A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or χ~2 test. Logistic regression analysis was used for assessing the risk for disease ***： The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma（P=0.044） which increased up to 4.36 when combined with GSTM1-null carriers（P=0.024）. When glutathione transferase（GST） genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively （OR=3.52, P=0.003; OR=10.02, P〈0.001; OR=4.53, P=0.002）. CONCLUSION： The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.

关键词： GSTM1 GSTT1 primary open angle glaucoma risk smoking hypertension diabetes mellitus

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Febrile cholestatic disease as an initial presentation of nodular lymphocyte-predominant Hodgkin lymphoma

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World Journal of Gastroenterology 2010年第35期16卷 4491-4493页

作者： Anna Mrzljak Slavko Gasparov Ika Kardum-Skelin vesna Colic-Cvrlje Slobodanka Ostojic Kolonic Slobodanka Ostojic-Kolonic University of ZagrebSchool of Medicine Department of Gastroenterology University Hospital Merkur Department of Pathology and Cytology University Hospital Merkur Laboratory for Cytology and Hematology Department of MedicineUniversity Hospital Merkur Department of Hematology University Hospital Merkur

Febrile cholestatic liver disease is an extremely unusual presentation of Hodgkin lymphoma(HL).The liver biopsy of a 40-year-old man with febrile episodes and cholestatic laboratory pattern disclosed an uncommon subtype of HL,a nodular lymphocyte-predominant HL(NLPHL).Liver involvement in the early stage of the usually indolent NLPHL's clinical course suggests an aggressiveness and unfavorable *** a liver biopsy early in the diagnostic algorithm enables accurate diagnosis and appropriate *** rare,HL should be considered in the differential diagnosis of cholestasis.

关键词： Cholestatic disease Hodgkin lymphoma Nodular lymphocyte-predominant Hodgkin lymphoma

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Validation of the Glaucoma Quality of Life-15 Questionnaire in Serbian language

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1674-1684页

作者： Ivan Sencanic Tatjana Gazibara Jelena Dotlic Miroslav Stamenkovic vesna Jaksic Marija Bozic Anita Grgurevic Clinic for Eye Disease "Prof. dr Ivan Stankovic" University Medical Center "Zvezdara" Institute of Epidemiology Faculty of Medicine University of Belgrade Faculty of Medicine University of Belgrade Faculty of Special Education and Rehabilitation University of Belgrade Clinic for Eye Disease "Prof. dr Djordje Nesic" Clinical Center of Serbia

AIM：To translate the Glaucoma Quality of Life-15（GQL-15）to Serbian language and asses its validity and reliability in the population of Serbian ***：The study included 177 glaucoma *** parameters（visual acuity,mean defect and square root of loss variance of visual field）and socio-demographic data were *** were stratified according to the Nelson’s glaucoma staging system as mild,moderate and advanced *** patients filled out the GQL-15 and National Eye Institute Visual Function Questionnaire（NEI-VFQ 25）.The GQL-15 was translated following the internationally-accepted methodology,and its psychometric properties were assessed by using classical test theory and Rasch ***：The mean total score for the GQL-15 was 20.68±*** Cronbach’s alpha coefficient for the whole scale was 0.89（central and near vision,α=0.24;peripheral vision,α=0.85;glare and dark adaptation,α=0.83）.Factor analysis established 4 factors（70.3% of variance）：two corresponding to the original factors and two new factors specific for the Serbian *** GQL-15 score correlated positively with almost all clinical parameters and NEI-VFQ 25 proving good criterion *** of the GQL-15 total score on test-retest confirmed appropriate scale reproducibility（ρ=0.96,P〈0.001）.The GQL-15 discriminated well advanced from mild and moderate *** Rasch analysis we obtained adequate item（0.95）reliability *** all items had infit and outfit mean squares in the accepted ***：Serbian version of the GQL-15 demonstrates adequate reliability and *** version of the GQL-15is a valid instrument for evaluation of quality of life among Serbian speaking patients with glaucoma and can be applied in daily clinical work.

关键词： glaucoma GQL-15 scale validation Serbian

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Dynamic control of high-voltage actuator arrays by light-pattern projection on photoconductive switches

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微系统与纳米工程(英文) 2023年第3期9卷 387-396页

作者： vesna Bacheva Amir Firouzeh Edouard Leroy Aiste Balciunaite Diana Davila Israel Gabay Federico Paratore Moran Bercovici Herbert Shea Govind Kaigala Faculty of Mechanical Engineering Technion-Israel Institute of Technology3200003 HaifaIsrael IBM Research Europe-Zurich Säumerstrasse 48803 RüschlikonSwitzerland Soft Transducers Laboratory(LMTS) Ecole Polytechnique Fédérale de Lausanne(EPFL)2000 NeuchâtelSwitzerland Present address:Laboratory of Soft Materials and Interfaces ETH Zürich8093 ZürichSwitzerland Present address:School of Biomedical Engineering Vancouver Prostate CentreLife Sciences InstituteUniversity of British ColumbiaVancouverCanada

The ability to control high-voltage actuator arrays relies, to date, on expensive microelectronic processes or on individual wiring of each actuator to a single off-chip high-voltage switch. Here we present an alternative approach that uses on-chip photoconductive switches together with a light projection system to individually address high-voltage actuators. Each actuator is connected to one or more switches that are nominally OFF unless turned ON using direct light illumination. We selected hydrogenated amorphous silicon (a-Si:H) as our photoconductive material, and we provide a complete characterization of its light to dark conductance, breakdown field, and spectral response. The resulting switches are very robust, and we provide full details of their fabrication processes. We demonstrate that the switches can be integrated into different architectures to support both AC and DC-driven actuators and provide engineering guidelines for their functional design. To demonstrate the versatility of our approach, we demonstrate the use of the photoconductive switches in two distinctly different applications—control of µm-sized gate electrodes for patterning flow fields in a microfluidic chamber and control of cm-sized electrostatic actuators for creating mechanical deformations for haptic displays.

关键词： projection light sized

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Preparatory training attenuates drastic response of the insulin-like growth factor binding protein 1 at the point of maximal oxygen consumption in handball players

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Journal of Sport and Health Science 2017年第3期6卷 372-377页

作者： Olgica Nedic Milos Sunderic Goran Miljus Zoran Valdevit Vladimir Jakovljevic Marija Glibetic vesna Vucic Institute for the Application of Nuclear Energy University of BelgradeBelgrade 11080Serbia Faculty of Sport and Physical Education University of BelgradeBelgrade 11000Serbia Department of Physiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Centre of Research Excellence in Nutrition and Metabolism Institute for Medical ResearchUniversity of BelgradeBelgrade 11000Serbia

Background:Intensive exercise changes physiological need for glucose and several biochemical pathways responsible for its metabolism *** them are those which involve insulin,insulin-like growth factor(IGF-1),and IGF-binding proteins(IGFBPs).Different types and degrees of exercise,as well as an athlete's fitness,may induce a range of responses regarding concentrations and time needed for the *** idea of the work was to find out whether and how insulin/IGF axis responds to additional physical activity in the already trained subjects and if so,is the adaptation potentially beneficial from the aspect of metabolic ***:The effect of 4-week intensive training on campus(preparatory training) on the levels of insulin,IGF-1,and IGFBPs during maximal progressive exercise test(MPET) on a treadmill was compared to the results obtained during MPET conducted after a regular training season of a female elite handball team(n = 17,age:17 ± 1 years,height:171 ± 8 cm,weight:65 ± 8 kg,body mass index:22 ± 1 kg/m^2 at the beginning of the study;there were no significant changes at the end).Serum samples were obtained from players immediately before the test(basal),at the end of the test after reaching the point of maximal oxygen consumption(VO_(2max)),and after ***:The concentration of insulin decreased at VO_(2max),but remained higher in players after preparatory training(12.2 ± 2.5 m U/L vs.8.9 ± 4.4 m U/L,p = 0.049).The level of IGFBP-1 decreased in players at VO_(2max) in either case of training,but it remained much higher in tests performed after the preparatory regime than before(p = 0.029).Concentrations of IGF-1,IGFBP-2,-3,and-4 did not change ***:The inverse relation between insulin and IGFBP-1 was lost during MPET,as these 2 molecules changed in the same *** results obtained suggest less severe stress-induced depression of insulin and IGFBP-1 after preparatory *** another metabolic mechanism

关键词：女性 IGF 有约束力的蛋白质(IGFBP ) 胰岛素像胰岛素的生长因素我(IGF-1 ) 进步锻练测试 VO 2max

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Architectural quality of the productive facades integrating photovoltaic and vertical farming systems: Survey among experts in Singapore

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Frontiers of Architectural Research 2020年第2期9卷 301-318页

作者： Abel Tablada vesna Kosoric Huajing Huang Stephen S.Y.Lau Veronika Shabunko Department of Architecture School of Design and EnvironmentNational University of SingaporeSingapore Facultad de Arquitectura Technological University of Havana J.A Echeverri´aMarianaoHavana19390Cuba BauLab GmbH 4656 Starrkirch-WilSwitzerland Solar Energy Research Institute of Singapore(SERIS) Singapore

Buildings could play a critical role in energy and food production while making highdensity cities more *** facades(PFs),as flexible and multi-functional systems integrating photovoltaic(PV)and vertical farming(VF)systems,could contribute to transforming buildings and communities from consumers to *** study analyses the architectural quality of the developed PF concept drawing on the findings of a web-survey conducted among experts e building professionals in *** developed design variants are compared with regards to key design aspects such as facade aesthetics,view from the inside,materialisation,ease of operation,functionality and overall architectural *** study also compares and discusses the results of the web-survey with the results of a previously conducted door-to-door survey among the potential users-residents of the Housing&Development Board(HDB)*** findings confirm an overall acceptance of the PF concept and reveal a need for synergetic collaboration between architects/designers and other building *** on the defined PF design framework and the results of the two surveys,a series of recommendations and improved PF prototypes are proposed for further assessment and implementation in order to foster their scalability from buildings into communities and cities.

关键词： Facade systems Building integrated photovoltaic(BIPV) Solar shading devices Vertical farming(VF) Sustainable buildings Survey

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Mercury in an ultraoligotrophic North Patagonian Andean lake (Argentina): Concentration patterns in different components of the water column

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Journal of Environmental Sciences 2010年第8期22卷 1171-1178页

作者： María Arribére María C Diéguez Sergio Ribeiro Guevara Claudia P Queimalios vesna Fajon Mariana Reissig Milena Horvat LAAN-CNEA CAB Av. Bustillo Km 9.5 8400 Bariloche Argentina Laboratorio de Fotobiología INIBIOMA (Universidad Nacional del Comahue-CONICET) Department of Environmental Sciences Jozef Stefan Institute

The deep, ultraoligotrophic piedmont lakes of Northern Patagonia （Argentina） are located in pristine and barely impacted areas, along a wide latitudinal range. Several studies have reported moderate to high total mercury （Hg） concentrations and contrasting methylmercury （CH3Hg＋） production in different lake compartments. Sources of Hg for western Patagonian terrestrial and aquatic ecosystems are still not clear; while point sources can be ruled out and atmospheric deposition is a plausible source, along with contribution from active volcanic areas of the Andes. In this investigation, we reported a noticeably seasonal, spatial （between lake branches）, and vertical （between water column strata） heterogeneity in the total Hg concentrations found in the pelagic zone of Lake Moreno. Sterile water samples taken in a depth profile of the lake showed moderate to high concentrations of CH3Hg＋ in autumn with a decreasing trend with depth. Our results indicated that Hg is largely allocated in the plankton fraction between 10–53 μm; which dominated within the euphotic （epilimnetic） zone of the lake due to the high densities attained by two species of the dinoflagellate Gymnodinium. The 53–200 μm planktonic size fraction （comprising rotifers, ciliates and immature stages of crustaceans） and the 200 μm fraction （calanoid copepods and cladocerans） were found to bear strikingly lower total Hg concentrations, suggesting that the magnification of Hg at the planktonic consumer level is negligible.

关键词： Patagonia deep lakes total mercury plankton

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Toxic Effects of Pirimiphos-methyl Residues on Rats

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Biomedical and Environmental Sciences 1989年第2期2卷 115-130页

作者： NEkO K.NEKOVI VESELA .KARAN vesna SABOVLJEVI SLAVOLJUB LJ.VITOROVI Institute of Pesticides and Environmental Protection INEPBanatska 31 bPO Box 4611080 Zemun Yugoslavia Institute of Plant and Food Protection Faculty of AgricultureUniversity of BelgradeNemanjina 6PO Box 12711081 ZemunYugoslavia

This study analyzes the level of total and bound pirimiphos-methyl residues in treated wheat grain and its toxic effects on *** grain was treated with[(14)~C]pirimiphos-methyl of 16.36 mCi/mmol specific activity to determine the bioavailability of bound residues in *** the same time,grain was treated with nonlabeled pirimiphos-methyl as required to determine any possible toxic effects of bound residues in a subacute feeding study in *** dose levels were used:10 and 100 ppm(the former being the recommended dose level in practical treatment). Estimation of the type of residues was performed at intervals of 0,30,90,120,150,and 180 *** and after the animal feeding study,changes in body weight gain,organ weight, cholinesterase activity,serum enzyme activity,and hematology were *** is an indication that bound residues of the pesticide pirimiphos-methyl provoke toxic effects to some extent.1989 Academic ***.

关键词： In Toxic Effects of Pirimiphos-methyl Residues on Rats

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Fear, Hate, and Competence:Could COVID-19 Be a Turning Point?

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China Today 2020年第9期69卷 14-15页

作者： vesna PUSIC the Croatian Parliament

THE global COVID-19 health crisis has shocked the world,making us all aware of the need for a major rethink of international relations,multilateral organizations,organized healthcare,poverty,sovereignty,and many other aspects of human ***,this crisis did not occur in a healthy,prosperous,and comprehensible *** this been the case,we might have been more prepared,more united,and less rudderless in confronting ***,it comes at the tail end of three major catastrophes in just over a *** have been disastrously disruptive,exacerbating inequality,marginalizing accountability,ridiculing and punishing solidarity,and upending the value systems that different peoples and societies have long upheld—if not exactly living by them,at least using them as a yardstick for their way of *** all these crises have in common is the prominent global resurgence of two instruments of mass mobilization:fear and hate.

关键词： inequality exactly catastrophe

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Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 879-892页

作者： HMC Shantha Kumara Hiromichi Miyagaki Sajith A Herath Erica Pettke Xiaohong Yan vesna Cekic Richard L Whelan Division of Colon and Rectal Surgery Department of SurgeryLenox Hill HospitalNorthwell HealthNew YorkNY 10028United States Department of Gastroenterological Surgery Osaka UniversitySuita 565-0862OsakaJapan Analytic Department NovartisMorris PlainsNJ 07905United States Department of Surgery Swedish Medical CenterSeattleWA 98122United States Department of Surgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNY 11549United States

BACKGROUND MMP-2 also known as gelatinase A and MMP-7(matrilysin)are members of the zinc-dependent family of MMPs(Matrix metalloproteinase).MMP-2 and MMP-7 are remodeling enzymes that digest extracellular matrix;MMP-2 is extensively expressed during development and is upregulated at sites of tissue damage,inflammation,and in stromal cells of metastatic ***-7 is expressed in the epithelial cells and in a variety of cancers including colon *** MMP-2 and MMP-7 levels were assessed before and after minimally invasive colorectal resection for cancer *** To determine plasma MMP-2 and MMP-7 levels before and after minimally invasive colorectal resection for cancer *** Patients enrolled in a plasma bank for whom plasma was available were *** obtained from preoperative(Preop)and postoperative blood samples was *** colorectal cancer(CRC)patients who underwent elective minimally invasive cancer resection with preop,post-operative day(POD)1,3 and at least 1 late postop sample(POD 7-34)were *** samples were bundled into 7 d blocks(POD 7-13,14-20,etc.)and treated as single time *** MMP-2 and MMP-7 levels were determined via enzyme-linked immunosorbent assay in *** Total 88 minimally invasive CRC resection CRC patients were studied(right colectomy,37%;sigmoid,24%;and LAR/AR 18%).Cancer stages were:1,31%;2,30%;3,34%;and 4,5%.Mean Preop MMP-2 plasma level(ng/mL)was 179.3±40.9(n=88).Elevated mean levels were noted on POD1(214.3±51.2,n=87,P<0.001),POD3(258.0±63.9,n=80,P<0.001),POD7-13(229.9±62.3,n=65,P<0.001),POD 14-20(234.9±47.5,n=25,P<0.001),POD 21-27(237.0±63.5,n=17,P<0.001,)and POD 28-34(255.4±59.7,n=15,P<0.001).Mean Preop MMP-7 level was 3.9±1.9(n=88).No significant differences were noted on POD 1 or 3,however,significantly elevated levels were noted on POD 7-13(5.7±2.5,n=65,P<0.001),POD 14-20(5.9±2.5,n=25,P<0.001),POD 21-27(6.1±3.6,n=17,P=0.002)and on POD 28-34(6.8±3.3,n=15 P<0.001,)vs p

关键词： Effects of surgery Colorectal resection Colorectal cancer Plasma MMP-2 and MMP-7 levels Angiogenesis

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