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Ground-based and additional science support for SMIlE

Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： J.A.carter M.Dunlop c.Forsyth K.Oksavik E.Donovon A.Kavanagh S.E.Milan T.Sergienko R.c.Fear D.G.Sibeck M.connors T.Yeoman X.Tan M.G.G.T.Taylor K.McWilliams J.Gjerloev R.Barnes D.D.Billet G.chisham A.Dimmock M.P.Freeman D.-S.Han M.D.Hartinger S.-Y.W.Hsieh Z.-J.Hu M.K.James l.Juusola K.Kauristie E.A.Kronberg M.lester J.Manuel J.Matzka I.Mccrea Y.Miyoshi J.Rae l.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun M.-T.Walach B.Walsh c.Wang J.Weygand J.Wild J.Yan J.Zhang Q.-H.Zhang Planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Environment Beihang UniversityBeijing 100191China Key laboratory of Space Environment Monitoring and Information Processing Ministry of Industry and Information TechnologyBeijing 100017China Department of Space and climate Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland centre for Space Science Department of Physics and Technology.University of BergenBergenNorway Department of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of Space Physics KirunaSweden West Highfield campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space Flight center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada ESTEc European Space AgencyNetherlands University of Saskatchewan SaskatoonCanada The Johns Hopkins University Applied Physics laboratory LaurelMarylandUSA Swedish Institude of Space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China center for Space Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of china Shanghai 200136China Finnish Meteorological Institute(FMI) Finland Department of Earth and Environmental Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany canadian Space Agency MontrealCanada GFZ German Research centre for Geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and chinese Academy of Sciences Solar wind Magnetosphere Ionosphere link Explorer(SMIlE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMIlE ***,we describe current community efforts to prepare for SMIlE,and the benefits and context various experiments that have explicitly expressed support for SMIlE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online SMIlE Data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the SMIlE mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SMIlE conjunctions missions

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Sodium-glucose cotransporter-2 inhibitors protect tissues via cellular and mitochondrial pathways:Experimental and clinical evidence

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World Journal of Experimental Medicine 2024年第2期14卷 46-52页

作者： Raúl lelio Sanz Sebastián García Menéndez Felipe Inserra leon Ferder Walter Manucha Department of Pathology Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendoza 5500Argentina Department of Pharmacology Instituto de Medicina y Biología Experimental de CuyoCentro Científico TecnológicoMendoza 5500Argentina Department of Nephrology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina Department of cardiology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina

Mitochondrial dysfunction is a key driver of cardiovascular disease(cVD)in metabolic syndrome and *** dysfunction promotes the production of reactive oxygen species(ROS),which cause oxidative stress and *** II,the main mediator of the renin-angiotensin-aldosterone system,also contributes to cVD by promoting ROS *** activity of sirtuins(SIRTs),a family of proteins that regulate cellular metabolism,also worsens oxidative *** of energy production by mitochondria is a common feature of all metabolic *** SIRT levels and 5’adenosine monophosphate-activated protein kinase signaling stimulate hypoxia-inducible factor 1 beta,which promotes ***,in turn,increases autophagy and mitophagy,processes that clear cells of debris and protect against *** cotransporter-2 inhibitors(SGlT2i),a class of drugs used to treat type 2 diabetes,have a beneficial effect on these *** clinical trials have shown that SGlT2i improves cardiac function and reduces the rate of cardiovascular and renal ***2i also increase mitochondrial efficiency,reduce oxidative stress and inflammation,and strengthen *** findings suggest that SGlT2i hold great potential for the treatment of ***,they are proposed as anti-aging drugs;however,rigorous research is needed to validate these preliminary findings.

关键词： Sodium-glucose cotransporter-2 inhibitors cardiovascular diseases Sirtuins Oxidative stress Inflammation Mitochondrial dysfunction

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Resilience, the 6th Vital Sign: conceptualizing, contextualizing, and Operationalizing All Six Vital Signs

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Health 2024年第7期16卷 657-673页

作者： Rose E. constantino Betty J. Braxter chi ching Vivian Hui larissa c. Allen lillian J. Wolfe Katherine H. Endres Jezyl cempron cutamora laurence l. Garcia Daisy R. Palompon Kathleen Thimsen Brayden N. Kameg Margarete l. Zalon Department of Health and community Systems School of Nursing University of Pittsburgh Pittsburgh PA USA Undergraduate Affairs School of Nursing University of Pittsburgh Pittsburgh PA USA The Hong Kong Polytechnic University Hong Kong China School of Nursing Adjunct Faculty at the University of Pittsburgh Pittsburgh PA USA School of Nursing University of Pittsburgh Pittsburgh PA USA Department of Health Promotion and Development School of Nursing University of Pittsburgh Pittsburgh PA USA college of Nursing Cebu Normal University Cebu City Philippines School of Nursing University of Nevada Las Vegas USA Department of Health and community Systems University of Pittsburgh PA USA Department of Nursing University of Scranton Scranton PA USA

There are five vital signs that healthcare providers assess: temperature, pulse, respiration, blood pressure, and pain. Normal levels for the five vital signs are published by the American Heart Association, and other specialty organizations, however, the sixth vital sign (resilience) which adopts the measure of immune resilience is suggested in this paper. Resilience is the ability of the immune system to respond to attacks and defend effectively against infections and inflammatory stressors, and psychological resilience is the capacity to resist, adapt, recover, thrive, and grow from a challenge or a stressor. Individuals with better optimal immune resilience had better health outcomes than those with minimal immune resilience. The purpose of this paper is to conceptualize, contextualize, and operationalize all six vital signs. We suggest measuring resilience subjectively and objectively. Subjectively, use a 5-item guided interview revised from the connor-Davidson Resilience Scale (cDRc), a scale of 10 items. The revised cDRc scale is a 5-item scale. The scale is rated on a 5-point likert scale from 0 (not true) to 4 (true all the time). The total score ranges from 0 to 20, with higher total scores indicating greater resilience. The scale demonstrated good construct validity and internal consistency (α = 0.85) during the development of the scale. The cD-RISc had a good cronbach’s alpha level of 0.85. The Revised cD-RISc can be completed in 2 - 4 minutes. To measure resilience objectively, we suggest using Immune Resilience (IR) levels, the level of resilience to preserve and/or rapidly restore immune resilience functions that promote disease resistance and control inflammation and other inflammatory stress. IR levels are gauged with two peripheral blood metrics that quantify the balance between cD8 and cD4 T-cell levels and gene expression signatures tracking longevity-associated immunocompetence and mortality- or entropy-associated inflammation. IR deregulation i

关键词： conceptualization contextualization Operationalization Body Temperature Pulse Respiration Blood Pressure Pain Resilience

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A comparative study of machine learning in predicting the mechanical properties of the deposited AA6061 alloys via additive friction stir deposition

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Materials Genome Engineering Advances 2024年第1期2卷 134-147页

作者： Qian Qiao Quan liu Jiong Pu Haixia Shi Wenxiao li Zhixiong Zhu Dawei Guo Hongchang Qian Dawei Zhang Xiaogang li c.T.Kwok l.M.Tam Department of Electromechanical Engineering University of MacaoMacaoChina Institute for the Development and Quality MacaoChina IDQ Science and Technology Development(Hengqin Guangdong)Co.LtdHengqinGuangdongChina Aerospace Engineering Equipment(Suzhou)co.ltd SuzhouChina National Materials corrosion and Protection Data center Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijingChina

Additive friction stir deposition(AFSD)provides strong flexibility and better performance in component design,which is controlled by the process *** is an essential and difficult task to tune those *** recent exploration of machine learning(Ml)exhibits great potential to obtain a suitable balance between productivity and set *** this study,Ml techniques,including support vector machine(SVM),random forest(RF)and artificial neural network(ANN),are applied to predict the mechanical properties of the AFSD-based AA6061 *** for the stable parameters(temperature,force and torque)in situ monitored by the self-developed process-aware kit during the AFSD process and the other factors(rotation speed,traverse speed,feed rate and layer thickness)are also set as input *** output variables are microhardness and ultimate tensile strength(UTS).Prediction results show that the ANN model performs the best prediction accuracy with the highest R2(0.9998)and the lowest mean absolute error(MAE,0.0050)and root mean square error(RMSE,0.0063).Furthermore,analysis suggests that the feed rate(24.8%/24.1%)and layer thickness(25.6%/26.6%)indicate a higher contribution that affects the mechanical properties.

关键词： additive friction stir deposition in-situ monitored machine learning mechanical properties prediction

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The first record of dermochelyid turtles in the Eocene of Tierra del Fuego:new insights on the evolution of the Weddellian faunas

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Advances in Polar Science 2024年第1期35卷 63-77页

作者： Paula BONA Juliana STERlI Marcelo Saúl de la FUENTE Eduardo OlIVERO Marta S.FERNÁNDEZ Marcelo REGUERO División Paleontología Vertebrados Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina consejo Nacional de Investigaciones científicas y Técnicas(cONIcET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina Museo Paleontológico Egidio Feruglio Trelew U9100Argentina Instituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina centro Austral de Investigaciones científicas-cONIcET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina División Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Antarctic Paleogene marine fossil record has been the key to reconstructing the evolution of the Weddellian Sea and final dismemberment of Southern *** this context,Eocene marine vertebrates from Seymour(Marambio)Island have provided valuable *** present the first Eocene record of marine reptiles from the southern Atlantic coast of South *** corresponds to several postcranial turtle remains represented by a proximal end of the right humerus,three caudal and one thoracic vertebrae,a fragment of the left pubis,and ten ossicles of the dorsal carapace,coming from the leticia Formation(late-mid Eocene)at cabo Tiburones,Tierra del Fuego,*** materials show severalfeatures such as the size and general morphology of the humerus and vertebrae,and the presence of relatively small,irregular,smooth,and unkeeled ossicles,which allow us to assign them to Dermochelyidae *** are a cosmopolitan group ofcryptodiran turtles,registered from the late cretaceous up to the recent,with some physiological-biological peculiarities(e.g.,endothermy and an exclusive jellyfish-based diet)and characterized by the presence of an osseous carapace formed by *** new finding from the leticia Formation is an addition to the scarce and extremely fragmentary record of Eocene dermochelyids from the southern seas like those from the la Meseta and Submeseta formations(Antarctica)and the Waihao and Burnside formations(New Zealand).This new information allows us to discuss the presence of these turtles in such high latitudes in the past and its implication in the evolution of the Weddellian fauna.

关键词： marine reptiles sea turtles Dermochelyidae Paleogene la Meseta Formation Submeseta Formation leticia Formation

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Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler Stuart lanham Andrew Rawlings Marta Roldo Gianluca Tozzi Jonathan I.Dawson Gianluca cidonio Richard O.c.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK center for life Nano-and Neuro-Science(clN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-EcM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMScs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(lAB)by blending human bone-EcM(B)with nanoclay(l,laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMScs viability upon *** composite of human bone-EcM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(cAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMScs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-EcM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

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Hepatology communications|质子泵抑制剂治疗是失代偿期肝硬化患者发生慢加急性肝衰竭的危险因素

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临床肝胆病杂志 2024年第5期40卷 1002-1002页

作者：周靖媛高沿航吉林大学第一医院感染病中心肝病科

慢加急性肝衰竭(AclF)是肝硬化的一种严重并发症,其发病率和死亡率较高。先前研究已证明质子泵抑制剂(PPI)的应用与肝硬化的并发症[如肝性脑病(HE)和自发性细菌性腹膜炎(SBP)]有关。关于PPI治疗与肝硬化并发症相关的病理机制还有待进一... 详细信息

慢加急性肝衰竭(AclF)是肝硬化的一种严重并发症,其发病率和死亡率较高。先前研究已证明质子泵抑制剂(PPI)的应用与肝硬化的并发症[如肝性脑病(HE)和自发性细菌性腹膜炎(SBP)]有关。关于PPI治疗与肝硬化并发症相关的病理机制还有待进一步研究。然而,许多研究表明,PPI治疗,特别是长期使用,会导致肠道生态失调,这可能加重肠道细菌的易位,增强失代偿期肝硬化的慢性炎症状态。值得注意的是,炎症状态是发生AclF的患者的典型特征。在此背景下,本研究假设PPI治疗可能是AclF发生的一个易感因素,研究的目的是调查在倾向评分匹配的肝硬化患者群体中,PPI治疗是否是失代偿期肝硬化患者发生AclF的危险因素。

关键词：失代偿期肝硬化慢加急性肝衰竭炎症状态易感因素肝硬化并发症生态失调危险因素肠道细菌

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Pleistocene glaciation advances the cryptic speciation of Stellera chamaejasme *** a major biodiversity hotspot

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Journal of Integrative Plant Biology 2024年第6期66卷 1192-1205页

作者： Santosh Kumar Rana Hum Kala Rana Jacob Blandis Tianhui Kuang Juntong chen Hengchang Wang Tao Deng charles c.Davis Hang Sun cAS Key laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Arkansas Biosciences Institute Arkansas State UniversityJonesboroArkansas 72401USA School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey HortoriumCornell UniversityIthacaNew York 14853USA BTI computational Biology center Boyce Thompson InstituteIthacaNew York 14853USA cAS Key laboratory of Plant Germplasm Enhancement and Specialty Agriculture Chinese Academy of SciencesWuhan Botanical GardenWuhan 430074China Department of Organismic and Evolutionary Biology HerbariaHarvard UniversityCambridgeMassachusetts 02138USA

The mountains of Southwest china comprise a significant large mountain range and biodiversity hotspot imperiled by global climate *** high species diversity in this mountain system has long been attributed to a complex set of factors,and recent large-scale macroevolutionary investigations have placed a broad timeline on plant diversification that stretches from 10 million years ago(Mya)to the *** our increasing understanding of the temporal mode of speciation,finer-scale populationlevel investigations are lacking to better refine these temporal trends and illuminate the abiotic and biotic influences of cryptic *** is largely due to the dearth of organismal sampling among closely related species and populations,spanning the incredible size and topological heterogeneity of this *** study dives into these evolutionary dynamics of speciation using genomic and ecomorphological data of Stellera chamaejasme *** identified four previously unrecognized cryptic species having indistinct morphological traits and large metapopulation of evolving lineages,suggesting a more recent diversification(~2.67-0.90 Mya),largely influenced by Pleistocene glaciation and biotic *** factors likely influenced allopatric speciation and advocated cyclical warming–cooling episodes along elevational gradients during the *** study refines the evolutionary timeline to be much younger than previously implicated and raises the concern that projected future warming may influence the alpine species diversity,necessitating increased conservation efforts.

关键词： cryptic speciation glacial-interglacial Hengduan Mountains north-south migration Stellera chamaejasme

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How will biomining be applied in future?

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中国有色金属学会会刊：英文版 2008年第6期18卷 1302-1310页

作者： c.l.BRIERlEY Brierley consultancy llc P.O.Box 630012Highlands Ranch

这篇论文在全世界考察商业 biomining 操作的当前的地位，识别作为一种处理技术驾驶 biomining 的选择的因素，描述挑战到利用这些革新，并且与 biomining 的未来的讨论得出结论。Biomining 商业地用设计垃圾场，堆和搅动的坦克被使用... 详细信息

这篇论文在全世界考察商业 biomining 操作的当前的地位，识别作为一种处理技术驾驶 biomining 的选择的因素，描述挑战到利用这些革新，并且与 biomining 的未来的讨论得出结论。Biomining 商业地用设计垃圾场，堆和搅动的坦克被使用。克服阴沉的费用的技术挑战，处理在矿的低档，低质量、复杂的矿石和利用存在大写的投资要求微生物引起的活动和创新工程的更好的理解。克服 biomining 广告挑战必要改进采矿 company/biomining 改革者合作和知识产权控制。

关键词：生物采矿生物浸取应用技术研究

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Enantioselective Synthesis,(chir)optical Properties,and Postsynthetic Functionalization of Furan-containing Oxa[5]-,Oxa[6]-,and Dioxa[6]helicenes

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ccS chemistry 2024年第10期6卷 2439-2451页

作者： Wei Fu Valentina Pelliccioli Raquel casares-lópez Juan M.cuerva Martin Simon christopher Golz Manuel Alcarazo Institut für Organische und Biomolekulare chemie Georg-August-Universität Göttingen37077 Göttingen Departamento de Química Orgánica Universidad de GranadaUnidad de Excelencia Química Aplicada a Biomedicina y MedioambienteE-18071 Granada

An expedient synthesis of a series of configurationally stable oxa[5]helicenes,oxa[6]helicenes,and dioxa[6]helicenes has been developed using an intramolecular,highly enantioselective,Au-catalyzed,alkyne hydroarylation *** absolute configuration of the newly prepared structures has been established by crystallography,their inversion barriers have been determined theoretically and experimentally,and their chiroptical properties have been *** of these data with those reported for thia-or carbohelicenes sharing an otherwise identical helical framework enables the establishment of comprehensive correlations between the nature of the embedded(hetero)atom(s)and the magnitude of these *** studies on the postsynthetic functionalization of the oxahelicenes obtained are also ***,siteselective bromination at the 15-position in oxa[5]helicene 5d allows its subsequent manipulation into pyridine-containing aza-oxa[7]helicene 13d;while the two termini of oxa[6]helicene 7d have been intramolecularly cyclised into the pleiadeno[1,12,11-bcde]benzofuran derivative 15d by acidic *** transformations take place without erosion of the enantiopurity.

关键词： Au-catalysis enantioselective synthesis oxa[n]helicenes racemization dynamics postsynthetic functionalization

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