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Storylines of family medicine Ⅱ:foundational building blocks—context,community and health

Family Medicine and community Health 2024年第S3期12卷 12-22页

作者： William B Ventres leslie A Stone Rupal Shah Tamala carter Geoffrey M Gusoff Winston liaw Bich-May Nguyen Joanna V Rachelson Mary Alice Scott Teresa l Schiff-Elfalan Seiji Yamada Robert c like Kathleen Zoppi A Peter catinella Richard M Frankel Shailendra Prasad Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Bridge lane Group Practice LondonUK Penn center for community Health Workers University of PennsylvaniaPhiladelphiaPennsylvaniaUSA National clinician Scholars Program UCLA David Geffen School of MedicineLos AngelesCaliforniaUSA Health Systems and Population Health Sciences University of Houston Tilman J Fertitta Family College of MedicineHoustonTexasUSA Southern New Mexico Family Medicine Residency Program Las CrucesNew MexicoUSA New Mexico Primary care Training Program Silver CityNew MexicoUSA Anthropology New Mexico State UniversityLas CrucesNew MexicoUSA Family Medicine and community Health University of Hawai'i at Manoa John A Burns School of MedicineHonoluluHawaiiUSA Family Medicine and community Health Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNew JerseyUSA Family Medicine Indiana University School of MedicineIndianapolisIndianaUSA Family Medicine–Transmountain Texas Tech University Health Sciences CenterEl PasoTexasUSA Medicine Indiana University School of MedicineIndianapolisIndianaUSA Family Medicine and community Health University of Minnesota Medical School-Twin Cities CampusMinneapolisMinnesotaUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅱ:foundational building blocks—context,community and health’,authors address the following themes:‘context—grounding family medicine in time,place and being’,‘Recentring community’,‘community-oriented primary care’,‘Embeddedness in practice’,‘The meaning of health’,‘Disease,illness and sickness—core concepts’,‘The biopsychosocial model’,‘The biopsychosocial approach’and‘Family medicine as social medicine.’May readers grasp new implications for medical education and practice in these essays.

关键词： thematic illustration dimensions

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Phase composition,conductivity,and sensor properties of cerium-doped indium oxide

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Nano Materials Science 2024年第2期6卷 193-200页

作者： M.I.Ikim G.N.Gerasimov V.F.Gromov O.J.Ilegbusi l.I.Trakhtenberg N.N.Semenov Federal Research center for chemical Physics of RAS MoscowRussia University of central Florida OrlandoFLUSA Moscow Institute of Physics and Technology(State University) DolgoprudnyMoscow RegionRussia lomonosov Moscow State University MoscowRussia

The hydrothermal synthesis of In_(2)O_(3)and ceO_(2)–In_(2)O_(3)is investigated as well as the properties of sensor layers based on these *** the synthesis of In_(2)O_(3),intermediate products In(OH)_(3)and InOOH are formed,which are the precursors of stable cubic(c-In_(2)O_(3))and metastable rhombohedral(rh-In_(2)O_(3))phases,respectively.A transition from c-In_(2)O_(3)to rh-In_(2)O_(3)is observed with the addition of ceO_(2).The introduction of cerium into rh-In_(2)O_(3)results in a decrease in the sensor response to hydrogen,while it increases in composites based on c-In_(2)O_(3).The data on the sensor activity of the composites correlate with XPS results in which ceO_(2)causes a decrease in the concentrations of chemisorbed oxygen and oxygen vacancies in rh-In_(2)O_(3).The reverse situation is observed in composites based on c-In_(2)O_(3).compared to In_(2)O_(3)and ceO_(2)–In_(2)O_(3)obtained by other methods,the synthesized composites demonstrate maximum response to H_(2)at low temperatures by 70–100℃,and have short response time(0.2–0.5 s),short recovery time(6–7 s),and long-term stability.A model is proposed for the dependence of sensitivity on the direction of electron transfer between In_(2)O_(3)and ceO_(2).

关键词： cerium oxide Indium oxide Nanocomposite Hydrothermal method cubic phase Rhombohedral phase Sensor response conductivity Hydrogen Response/recovery time

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Satellite-enabled enviromics to enhance crop improvement

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Molecular Plant 2024年第6期17卷 848-866页

作者： Rafael T.Resende lee Hickey cibele H.Amaral lucas l.Peixoto Gustavo E.Marcatti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil ThecROP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLDAustralia Earth lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Environmental Data Science Innovation&Inclusion lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de Sa˜o Joa˜o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Peking University Institute of Advanced Agricultural Sciences WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

Enviromics refers to the characterization of micro-and macroenvironments based on large-scale environmental *** providing genotypic recommendations with predictive extrapolation at a site-specific level,enviromics could inform plant breeding decisions across varying conditions and anticipate productivity in a changing ***-based integration of statistics,envirotyping(i.e.,determining environmental factors),and remote sensing could help unravel the complex interplay of genetics,environment,and *** support this goal,exhaustive envirotyping to generate precise environmental profiles would significantly improve predictions of genotype performance and genetic gain in ***,informatics management platforms aggregate diverse environmental datasets obtained using optical,thermal,radar,and light detection and ranging(liDAR)sensors that capture detailed information about vegetation,surface structure,and *** wealth of information,coupled with freely available climate data,fuels innovative enviromics *** enviromics holds immense potential for breeding,a few obstacles remain,such as the need for(1)integrative methodologies to systematically collect field data to scale and expand observations across the landscape with satellite data;(2)state-of-the-art AI models for data integration,simulation,and prediction;(3)cyberinfrastructure for processing big data across scales and providing seamless interfaces to deliver forecasts to stakeholders;and(4)collaboration and data sharing among farmers,breeders,physiologists,geoinformatics experts,and programmers across research *** these challenges is essential for leveraging the full potential of big data captured by satellites to transform 21st century agriculture and crop improvement through enviromics.

关键词： envirotyping precision breeding genotype-environment interactions remote sensing predictive models enviromic information

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Budd-chiari like syndrome in decompensated alcoholic steatohepatitis and liver cirrhosis

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World Journal of Gastroenterology 2006年第40期12卷 6564-6566页

作者： carlos Robles-Medranda Hannah lukashok Beatriz Biccas vera l Pannain Homero S Fogaa Gastroenterology Division Hospital Universitario Clementino Fraga Filho Federal University of Rio de Janeiro Rio de Janeiro Brazil Pathology Division Hospital Universitario Clementino Fraga Filho Federal University of Rio de Janeiro Rio de Janeiro Brazil Gastroenterology Division Universitario Clementino Fraga Filho Federal University of Rio de Janeiro Rio de Janeiro Brazil

A rare case of pseudo-Budd-chiari Syndrome in a patientwith decompensated alcoholic liver disease is *** clinical and radiological findings suggestedBudd-chiari Syndrome, the liver biopsy revealedmicronodular cirrhosi... 详细信息

关键词： Pseudo Budd-chiari Budd-chiari syndrome liver cirrhosis Alcoholic steatohepatitis

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Allophane as a Nanotechnological Additive in Masonry Materials to Increase Resistance and Waterproofing

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Advances in Materials Physics and chemistry 2024年第8期14卷 196-212页

作者： Edward H. Jiménez Joao Rivera Juan H. Villalba Paola E. vera Marlon cuenca Belén Granja Javier Fuentes Sandra Gavilanes Daniel Hidalgo Fernando Garcia Jose Bermudez Washington Ruiz Alexis Martial Debut Facultad de Ingeniera Qumica Universidad Central del Ecuador Quito Ecuador Facultad de Arquitectura y Urbanismo Universidad Central del Ecuador Quito Ecuador Nanomaterials characterization laboratory Universidad de las Fuerzas Armadas ESPE Sangolqu Ecuador

The constant need for high-strength materials in the construction industry promotes the research of additives that improve the properties of masonry materials. The use of allophane as an additive in concrete and mortar mixtures was implemented to improve their strength and waterproofing, respectively, using compression and water absorption tests according to their corresponding standards (ASTM c1231, ASTM D2938, and ASTM c1585). The samples were evaluated at different concentrations and curing ages. In addition, different sand/cement ratios were considered for the mortar. The results revealed that there was a 9.4% increase in compressive strength in concrete and a 23.7% reduction in water absorption in mortar for the 5:1 ratio. These changes would be the result of the interaction of the nanoporous additive in the atomic crystal structure of the material demonstrating the nanotechnological nature of allophane.

关键词： Allophane Nano Additive Strength Impermeability concrete Mortar

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Semiotics and political discourse in the post-truth era

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language and Semiotic Studies 2024年第1期10卷 65-82页

作者： BetülÇanakpınar Murat Kalelioğlu V.Doğan Günay Istinye University IstanbulTürkiye School of Foreign languages T C Mardin Artuklu UniversityMardinTürkiye Faculty of literature Department of LinguisticsDokuz Eylül UniversityIzmirTürkiye

The concept of post-truth has been on the world’s agenda since *** this concept,which is frequently encountered in political life,provides the speaker with a freer speaking ***,instead of presenting the reality to their constituents as it is,want to reshape this reality according to their own ideology and present it to the *** have certain objectives in creating such a virtual *** aims can be listed as keeping the voters,increasing the voting potential,and attracting undecided voters to their *** common result of all these aims is to gain political power or to remain in the existing ***-truth reality is constructed relatively more easily in social media *** construction of reality can be through beliefs or *** such ways,the recipient is tried to be persuaded,and thus behavioral change is *** of the most necessary subjects for this artificial reality atmosphere is the *** idea that the anti-subject does not know the truth that we(you and I)know and believe and is trying to destroy it is the main theme of post-truth *** try to persuade the voters to believe in their own truth by expressing this idea to *** are many examples of this around the *** this study,firstly,the concept of post-truth is examined and its various definitions are *** distinctions between the concepts of real and truth are analyzed and then it is explained how and for what purposes the concept of post-truth is used in *** the comparison of post-truth and fake news,the concept is discussed within the framework of sender-receiver interaction in terms of *** concept is tried to be elucidated with the modalities such as/convincing/,/believing/,/being/,/appearing/.Besides,using the semiotic square,the study also tries to reveal the different purposes and forms of use of the concept of *** a result,it has been observed

关键词： semiotics discourse politics post-truth fake news

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Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions

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World Journal of Gastroenterology 2006年第21期12卷 3425-3429页

作者： Mateja legan Bo(s|ˇ)tjan luzar vera Ferlan Marolt Andrej c(o|¨)r Institute for Histology and Embryology Medical Faculty University of ljubljana Korytkova 21000 LjubljanaSlovenia Institute of Pathology Medical Faculty University of ljubljana Korytkova 21000 LjubljanaSlovenia

AIM： To examine the relationship between cyclooxygenase-2 （cOX-2） overexpression and p53 accumulation in gallbladder carcinoma and its precursor ***： Sixty-eight gallbladder tissue samples comprising 14 cases of normal gallblader epithelium, 27 cases of dysplasia （11 low-grade dyplasia and 16 high-grade dysplasia） and 27 adenocarcinomas were evaluated by immunohistochemistry for cOX-2 expression and p53 accumulation. The relationship among cOX-2 expression, p53 accumulation and clinicopathological characteristics was ***： cOX-2 was expressed in 14.3% of normal gallbladder epithelium, 70.3% of dysplastic epite hlium, and 59.2% of adenocarcinomas. When divided into low- and high-grade dysplasia, cOX-2 was positive in 5 （45.4%） cases of low-grade and 2d （87.5%） of high- grade dysplasia （P = 0.019）. Accumulation of p53 was detected in 5 （32.2%） cases of high-grade dysplasia and in 23 （48.2%） of carcinomas. No p53 accumulation was found in normal epithelium or low-grade dysplasia. cOX-2 overexpression was observed in 27 of 28 （94.4%） cases with p53-accumulation in comparison with 20 （40.0%） out of 50 cases without p53 accumulation （P 〈 0.001）.cONclUSION： The significant differences in cOX-2 expression among normal epithelium, low-grade dysplasia and high-grade dysplasia suggest that overexpression of cOX-2 enzyme is an early event in gallbladder carcinogenensis. Furthermore, since accumulation of p53 correlates with cOX-2 expression, cOX-2 overexpression observed in gallbladder high-grade dysplasia and carcinoma might be partly due to the dysfunction of p53.

关键词： Gallbladder carcinogenesis cyclooxygenase-2 p53 Immunohystochemistry

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clinical-based phenotypes in children with pediatric post-cOVID-19 condition

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World Journal of Pediatrics 2024年第7期20卷 682-691页

作者： lieke c.E.Noij Jelle M.Blankestijn coen R.lap Marlies A.van Houten Giske Biesbroek Anke-Hilse Maitland-van der Zee Mahmoud I.Abdel-Aziz Johannes B.van Goudoever Mattijs W.Alsem caroline l.H.Brackel Kim J.Oostrom Simone Hashimoto Suzanne W.J.Terheggen-lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary Medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation Medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of child and Adolescent Psychiatry and Psychosocial care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(cOVID-19)condition(PPcc)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPcc,to better characterize and treat this *** Participants were children with physician-diagnosed PPcc,referred to the academic hospital Amsterdam UMc in the Netherlands between November 2021 and March *** factors and information on post-cOVID symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPcc phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-cOVID symptoms in children.

关键词： Adolescents clusters long cOVID Pediatric Phenotypes Post-cOVID syndrome

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Endoscopic ultrasound-guided portal pressure gradient identifies patients with previously undiagnosed clinically significant portal hypertension

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Portal Hypertension & cirrhosis 2024年第2期3卷 67-74页

作者： Jerome c.Edelson Scott F.D.Edelson John G.Quiles cyrus V.Edelson Eric M.Montminy christian l.Horn John P.Magulick Don c.Rockey Department of Gastroenterology and Hepatology Brooke Army Medical CenterFort Sam HoustonTexasUSA Department of Medicine Uniformed Services University of the Health SciencesBethesdaMarylandUSA Department of Medicine Brooke Army Medical CenterFort Sam HoustonTexasUSA John H.Stroger Jr.Hospital of cook county ChicagoIllinoisUSA Digestive Disease Research center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension(PH)is a complication of cirrhosis that leads to hepatic *** the portal pressure gradient(PPG)provides valuable information for disease assessment,staging,and *** this study,we aimed to report the utilization of endoscopic ultrasound(EUS)-guided PPG(EUS-PPG)measurements in a real-world ***:This retrospective analysis included patients at a tertiary care center who underwent EUS-PPG between February 2021 and May *** most common indication was to establish or exclude the diagnosis of cirrhosis,followed by an assessment of surgical risk in the setting of suspected *** demographic and clinical data were collected,and statistical analysis was performed using the Student's t ***:Eighteen patients underwent *** success was achieved in 17 of the 18 *** complications were *** mean scores of child-Pugh,Model for End-Stage liver Disease-Sodium,and Fibrosis-4 scores were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** the 18 patients,two presented with esophageal varices and six with portal hypertensive *** mean PPG was 5.8±4.5 mmHg,and five patients exhibited clinically significant PH(cSPH).Of the 18 patients,15 underwent concurrent EUS-liver biopsy,which was 100%successful and provided diagnostic histology for all *** PPG data led to changes in the clinical management of 17 ***:EUS-PPG is safe and technically *** child-Pugh score did not correlate well with the presence of cSPH;however,PPG measurements resulted in changes in the management of almost all *** studies correlating EUS-PPG with other assessments of liver diseases are required.

关键词： EUS portal hypertension portal pressure gradient

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chitin-glucan improves important pathophysiological features of irritable bowel syndrome

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World Journal of Gastroenterology 2024年第16期30卷 2258-2271页

作者： caroline Valibouze caroline Dubuquoy Philippe chavatte Michaël Genin Veronique Maquet Salvatore Modica Pierre Desreumaux christel Rousseaux Department of Digestive Surgery and Transplantation Lille UniversityLille 59037France Intestinal Biotech Development Facultéde MédicineLille 59045France U1286-INFINITE-Institute for Translational Research in Inflammation Universitéde LilleLille 59000France UlR 2694-METRIcS Évaluation des Technologies de santéet des Pratiques MédicalesUniversity of LilleLille 59000France KitoZyme SA Institution SociétéAnonymeZone 2Parc des Hauts SartsRue de MilmortHerstal 4040Belgium Hepato-Gastroenterology Department Lille University HospitalLille 59037France

BAcKGROUND Irritable bowel syndrome(IBS)is one of the most frequent and debilitating conditions leading to gastroenterological ***,recommended treatments remain limited,yielding only limited therapeutic ***-glucan(cG)is a novel dietary prebiotic classically used in humans at a dosage of 1.5-3.0 g/d and is considered a safe food ingredient by the European Food Safety *** provide an alternative approach to managing patients with IBS,we performed preclinical molecular,cellular,and animal studies to evaluate the role of chitin-glucan in the main pathophysiological mechanisms involved in *** To evaluate the roles of cG in visceral analgesia,intestinal inflammation,barrier function,and to develop computational molecular *** Visceral pain was recorded through colorectal distension(cRD)in a model of long-lasting colon hypersensitivity induced by an intra-rectal administration of TNBS[15 milligrams(mg)/kilogram(kg)]in 33 Sprague-Dawley *** pressure was regularly assessed during the 9 wk-experiment(weeks 0,3,5,and 7)in animals receiving cG(n=14)at a human equivalent dose(HED)of 1.5 g/d or 3.0 g/d and compared to negative control(tap water,n=11)and positive control(phloroglucinol at 1.5 g/d HED,n=8)*** anti-inflammatory effect of cG was evaluated using clinical and histological scores in 30 c57bl6 male mice with colitis induced by dextran sodium sulfate(DSS)administered in their drinking water during 14 ***-29 cells under basal conditions and after stimulation with lipopolysaccharide(lPS)were treated with cG to evaluate changes in pathways related to analgesia μ-opioid receptor(MOR),cannabinoid receptor 2(cB2),peroxisome proliferator-activated receptor alpha,inflammation[interleukin(Il)-10,Il-1b,and Il-8]and barrier function[mucin 2-5Ac,claudin-2,zonula occludens(ZO)-1,ZO-2]using the real-time PcR *** modelling of cG,lPS,lipoteichoic acid(lTA),and phospholipomannan(PlM)was developed,and the abili

关键词： chitin-glucan Irritable bowel syndrome Abdominal pain Inflammation Intestinal barrier Molecular modelling Microbial cell walls chelation

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