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Effect of minocycline and its nano-formulation on central auditory system in blast-induced hearing loss rat model

Journal of Otology 2023年第1期18卷 38-48页

作者： venkatesan perumal Arun Reddy Ravula Ningning Shao Namas Chandra Center for Injury Biomechanics Materialsand MedicineDepartment of Biomedical EngineeringNew Jersey Institute of TechnologyNewarkNJ07102USA

Blast injuries are common among the military service members and *** of the devastating effects of blast wave induced TBI is either temporary or permanent hearing *** hearing loss using minocycline is restricted by optimal drug concentration,route of administration,and its ***,therapeutic approach using novel therapeutic delivery method is in great *** the different delivery methods,nanotechnology-based drug delivery is desirable,which can achieve longer systemic circulation,pass through some biological barriers and specifically targets desired *** current study aimed to examine therapeutic effect of minocycline and its nanoparticle formulation in moderate blast induced hearing loss rat model through central auditory *** *** nanoparticle at reduced dose and frequency than regularly administered toxic *** moderate blast exposure,rats had hearing impairment as determined by ABR at 7-and 30-days post *** chronic condition,free minocycline also showed the significant reduction in ABR *** central auditory system,it is found in this study that minocycline nanoparticles ameliorate excitation in inferior colliculus;and astrocytes and microglia activation after the blast exposure is reduced by minocycline nanoparticles *** study demonstrated that in moderate blast induced hearing loss,minocycline and its nanoparticle formulation exhibited the optimal therapeutic effect on the recovery of the ABR impairment and a protective effect through central auditory *** conclusion,targeted and non-targeted nanoparticle formulation have therapeutic effect on blast induced hearing loss.

关键词： Minocycline Nanoparticle Hearing loss Blast injury and targeted drug delivery

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Genetically modified mouse models for the study of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2012年第11期18卷 1141-1153页

作者： perumal Nagarajan M Jerald Mahesh Kuma Ramasamy venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma Small Animal Facility National Institute of Immunology NewDelhi 110067 India Animal House Centre for Cellularand Molecular Biology Hyderabad 500007 India Animal House JNU New Delhi110067 India

Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 *** represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) *** animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of *** study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely *** different mouse models can be classified in two large *** first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological *** the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of *** animal models for NASH should closely resemble the pathological characteristics observed in *** date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human ***,it is important that the researchers choose the appropriate animal *** review discusses various genetically modified animal models developed and used in research on NAFLD.

关键词： Nonalcoholic fatty liver disease Steatosis Steatohepatitis Knockout Animal models

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