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Impact of X-radiation in the management of COVID-19 disease

World Journal of Radiology 2022年第7期14卷 219-228页

作者： Aishwarya T A Divya K Mohan K Nandhini Venkateswarlu Raavi venkatachalam perumal Department of Human Genetics Sri Ramachandra Institute of Higher Education and Research(Deemed to be University)PorurChennai 600116Tamil NaduIndia Department of Cell Biology and Molecular Genetics Sri Devaraj Urs Academy of Higher Education and Research(Deemed to be University)TamakaKolar 563103KarnatakaIndia

Coronaviruses are a diverse group of viruses that infect both animals and *** though the existence of coronavirus and its infection to humans is not new,the 2019-novel coronavirus(nCoV)caused a major burden to individuals and society i.e.,anxiety,fear of infection,extreme competition for hospitalization,and more importantly financial *** nCoV infection/disease diagnosis was based on non-specific signs and symptoms,biochemical parameters,detection of the virus using reverse-transcription polymerase chain reaction(RTPCR),and X-ray-based *** review focuses on the consolidation of potentials of X-ray-based imaging modality[chest-X radiography(CXR)and chest computed tomography(CT)]and low-dose radiation therapy(LDRT)for screening,severity,and management of COVID-19 *** studies suggest that CXR contributed significantly toward initial rapid screening/diagnosis and CT-imaging to monitor the disease *** chest CT has high sensitivity up to 98%and low specificity for diagnosis and severity of COVID-19 disease compared to ***,LDRT compliments drug therapy in the early recovery/Less hospital stays by maintaining the physiological parameters better than the drug therapy *** the results undoubtedly demonstrated the evidence that X-ray-based technology continues to evolve and play a significant role in human health care even during the pandemic.

关键词： Corona virus COVID-19 infection COVID-19 disease X-rays Computed tomography Low dose radiotherapy

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铬解毒机制诱导香根草的生长和抗氧化反应（英文）

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Journal of Central South University 2019年第2期26卷 489-500页

作者： Manikdanan RAJENDRAN 安文慧李伟展 venkatachalam perumal 吴川 Shivendra Vikram SAHI Santosh Kumar SARKAR School of Metallurgy and Environment Central South University Plant Genetic Engineering and Molecular Biology Lab Department of Biotechnology Periyar University Department of Science and Environmental Studies The Education University of Hong Kong Department of Biology Western Kentucky University Department of Marine Science University of Calcutta

本文研究了铬(Cr)对香根草(Chrysopogon zizanioides)生长以及抗氧化防御酶活性的影响,探讨其对Cr的解毒机制。在50 mg/L Cr处理条件下,植物地上部分和地下部分的生长量分别降低了36.8%和45.0%;Cr在植物地下部分的积累量(9807μg/g干重... 详细信息

本文研究了铬(Cr)对香根草(Chrysopogon zizanioides)生长以及抗氧化防御酶活性的影响,探讨其对Cr的解毒机制。在50 mg/L Cr处理条件下,植物地上部分和地下部分的生长量分别降低了36.8%和45.0%;Cr在植物地下部分的积累量(9807μg/g干重)大于地上部分的积累量(8730μg/g干重)。随着Cr添加量的增加,光合色素和丙二醛含量增加,在30 mg/L Cr处理条件下含量达到最高,之后,随着Cr处理浓度的增加略有下降;同时,抗氧化防御酶(超氧化物歧化酶、过氧化氢酶和过氧化物酶)的活性显著提高,在较高浓度Cr处理下略有下降。同工酶结果显示在高浓度Cr处理下,超氧化物歧化酶、过氧化氢酶和过氧化物酶的条带强度降低。目前研究结果表明,高浓度Cr导致活性氧过量产生,从而增加了对香根草的氧化损伤,而光合色素、丙二醛、抗氧化酶含量的增加表明香根草对Cr有潜在的耐性机制。结果表明,香根草具有对Cr的解毒机制,并可以积累高浓度的Cr。本文为更深入地研究根草对Cr的解毒机制提供了依据。

关键词：铬 Chrysopogon zizanioides 解毒机制抗氧化酶植物修复

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Radiation signature on exposed cells: Relevance in dose estimation

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World Journal of Radiology 2015年第9期7卷 266-278页

作者： venkatachalam perumal Tamizh Selvan Gnana Sekaran Venkateswarlu Raavi Safa Abdul Syed Basheerudeen Karthik Kanagaraj Amith Roy Chowdhury Solomon FD Paul Department of Human Genetics College of BiomedicalSciences Technology and Research Sri Ramachandra University

The radiation is considered as a double edged sword, as its beneficial and detrimental effects have been demonstrated. The potential benefits are being exploited to its maximum by adopting safe handling of radionuclide stipulated by the regulatory agencies. While the occupational workers are monitored by personnel monitoring devices, for general publics, it is not a regular practice. However, it can be achieved by using biomarkers with a potential for the radiation triage and medical management. An ideal biomarker to adopt in those situations should be rapid, specific, sensitive, reproducible, and able to categorize the nature of exposure and could provide a reliable dose estimation irrespective of the time of the exposures. Since cytogenetic markers shown to have many advantages relatively than other markers, the origins of various chromosomal abnormalities induced by ionizing radiations along with dose-response curves generated in the laboratory are presented. Current status of the gold standard dicentric chromosome assay, micronucleus assay, translocation measurement by fluorescence insitu hybridization and an emerging protein marker the g-H2 AX assay are discussed with our laboratory data. With the wide choice of methods, an appropriate assay can be employed based on the net.

关键词： Biomarker Dicentric chromosomes Micronucleus Fluor

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