Radiation signature on exposed cells: Relevance in dose estimation
Radiation signature on exposed cells: Relevance in dose estimation作者机构：Department of Human Genetics College of BiomedicalSciences Technology and Research Sri Ramachandra University
出 版 物：《World Journal of Radiology》 (世界放射学杂志（英文版）（电子版）)
年 卷 期：2015年第7卷第9期
页 面：266-278页
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 100602[医学-中西医结合临床] 10[医学]
基 金：Supported by Department of Science and Technology,Government of India,No.SR-SO/HS-127/2012 Defence Research and Development Organisation,Government of India,No.DLS/81/48222/LSRB-261 Atomic Energy Regulatory Board,Government of India(AERB/CSRP/Proj.No.58/04/2014)
主 题：Biomarker Dicentric chromosomes Micronucleus Fluor
摘 要：The radiation is considered as a double edged sword, as its beneficial and detrimental effects have been demonstrated. The potential benefits are being exploited to its maximum by adopting safe handling of radionuclide stipulated by the regulatory agencies. While the occupational workers are monitored by personnel monitoring devices, for general publics, it is not a regular practice. However, it can be achieved by using biomarkers with a potential for the radiation triage and medical management. An ideal biomarker to adopt in those situations should be rapid, specific, sensitive, reproducible, and able to categorize the nature of exposure and could provide a reliable dose estimation irrespective of the time of the exposures. Since cytogenetic markers shown to have many advantages relatively than other markers, the origins of various chromosomal abnormalities induced by ionizing radiations along with dose-response curves generated in the laboratory are presented. Current status of the gold standard dicentric chromosome assay, micronucleus assay, translocation measurement by fluorescence insitu hybridization and an emerging protein marker the g-H2 AX assay are discussed with our laboratory data. With the wide choice of methods, an appropriate assay can be employed based on the net.
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