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Asymptomatic Hepadnaviral Persistence and its Consequences in the Woodchuck Model of Occult Hepatitis B Virus infection

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Journal of Clinical and Translational Hepatology 2015年第3期3卷 211-219页

作者： Patricia M.Mulrooney-Cousins Tomasz i.Michalak Molecular Virology and Hepatology Research Group Faculty of Medicine Health Sciences Centre Memorial University St.John's NL Canada

Woodchuck hepatitis virus (WHV) is molecularly and pathogenically closely related to hepatitis B virus (HBV).Both viruses display tropism towards hepatocytes and cells of the immune system and cause similar liver pathology,where acute hepatitis can progress to chronic hepatitis and to hepatocellular carcinoma (HCC).Two forms of occult hepadnaviral persistence were identified in the woodchuck-WHV model:secondary occult infection (SOi) and primary occult infection (POi).SOi occurs after resolution of a serologically apparent infection with hepatitis or after subclinical serologically evident virus *** is caused by small amounts of virus and progresses without serological infection markers,but the virus genome and its replication are detectable in the immune system and with time in the *** can be accompanied by minimal hepatitis,while the hallmark of POi is normal liver ***,HCC develops in about 20% of animals with SOi or POi within 3 to 5 *** virus persists throughout the lifespan in both SOi and POi at serum levels rarely greater than 100 copies/mL,causes hepatitis and HCC when concentrated and administered to virus-na(i)ve *** is accompanied by virusspecific T and B cell immune responses,while only virusspecific T cells are detected in *** coincides with protection against reinfection,while POi does not and hepatitis develops after challenge with liver pathogenic doses >1000 *** SOi and POi are associated with virus DNA integration into the liver and the immune system ***,SOi and POi are two distinct forms of silent hepadnaviral persistence that share common ***,we review findings from the woodchuck model and discuss the relevant observations made in human occult HBV infection (OBi).

关键词： Hepatitis B Occult hepatitis B virus infection Woodchuck model of hepatitis B Woodchuck hepatitis virus Secondary occult infection Primary occult infection Consequences of occult hepadnaviral infection Hepatocellular carcinoma

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influence of anastomoses on intestine ischemia and cefuroxime concentrations:Evaluated in the ileum and colon in a porcine model

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World Journal of Gastrointestinal Pathophysiology 2021年第1期12卷 1-13页

作者： Pelle Hanberg Mats Bue Maja Thomassen Uffe Schou Løve Josephine Olsen Kipp Christina Harlev Elisabeth Petersen Kjeld Søballe Maiken Stilling Department of Orthopaedic Surgery Horsens Regional HospitalHorsens 8700Denmark Aarhus Microdialysis Research Group Orthopaedic Research UnitAarhus University HospitalAarhus N 8200Denmark Department of Clinical Medicine Aarhus UniversityAarhus N 8200Denmark Department of Orthopaedic Surgery Aarhus University HospitalAarhus N 8200Denmark Department of Surgery Viborg Regional HospitalViborg 8800Denmark

BACKGROUND Anastomotic leakage is a serious complication following gastrointestinal surgery and is associated with increased morbidity and *** incidence of anastomotic leakage is determined by anatomy and is reported to be between 4%-33%for colon anastomosis and 1%-3%for small intestine *** etiology of anastomotic leakage of the intestine has been divided into three main factors:healing disturbances,communication between intra-and extra-luminal compartments,and *** three factors interact,and one factor will inevitably lead to the other two factors resulting in tissue ischemia,tissue necrosis,and anastomotic *** To evaluate ischemic metabolites and cefuroxime concentrations in both anastomosis and non-anastomosis ileum and colon in a porcine *** Eight healthy female pigs(Danish Landrace breed,weight 58-62 kg)were included in this *** catheters were placed for sampling of ischemic metabolites(glucose,lactate,glycerol,and pyruvate)and cefuroxime concentrations in both anastomosis and non-anastomosis ileum and *** 1.5 g was administered as an intravenous infusion over 15 ***,dialysates and blood samples were collected over 8 h and the ischemic metabolites and cefuroxime concentrations were quantified in all *** concentrations of glucose,lactate,glycerol and pyruvate were determined using the CMA 600 Microdialysis Analyzer with Reagent Set A(M Dialysis AB,Sweden),and the concentrations of cefuroxime and meropenem were quantified using a validated ultra-high-performance liquid chromatography *** Only the colon anastomosis induced mean ischemic lactate/pyruvate ratios above 25(ischemic cut-off)throughout the entire sampling interval,and simultaneously decreased glucose *** mean time for which cefuroxime concentrations were maintained above the clinical breakpoint minimal inhibitory concentration for Escherichia coli(8μg/mL)ranged between 116-128 min

关键词： Anastomosis Cefuroxime Colon ileum ischemic metabolites Microdialysis

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心脏正常和疾病时心肌功能的调节——变力性药物的影响

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国外医学.心血管疾病分册 1983年第5期 262-266页

作者： Katz AM Smith ve 吴光烈陈尚恭

心肌功能异常可以是心力衰竭发病机制的表现,也可以是代偿机制的表现.在心肌病和缺血性心脏病人,心肌功能改变是心力衰竭的根本原因.心肌收缩性的改变也可以是心脏对慢性负荷过重的反应,如主动脉瓣狭窄时的压力负荷过重或主动脉瓣关闭... 详细信息

心肌功能异常可以是心力衰竭发病机制的表现,也可以是代偿机制的表现.在心肌病和缺血性心脏病人,心肌功能改变是心力衰竭的根本原因.心肌收缩性的改变也可以是心脏对慢性负荷过重的反应,如主动脉瓣狭窄时的压力负荷过重或主动脉瓣关闭不全时的容量负荷过重.这种心肌收缩性的继发性改变,在不同场合可改善或损害心脏应付负荷异常的能力.心肌功能的原发性和继发性改变,能对心肌的收缩期(收缩性)和舒张

关键词：心肌功能 ATP 肌动蛋白肌纤蛋白肌肉蛋白肌凝蛋白心脏心肌收缩蛋白向宁蛋白心肌收缩性疾病

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钢帘线用线材机械去锈的最佳条件

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金属制品 1993年第A11期19卷 24-27,16页

作者： D.Genéve M.Francois 姜岩

线材的机械去锈在拉丝工业中越来越重要,因为这一技术在环保和降低成本方面有许多优点。虽然机械去锈已被生产钢帘线的厂家广泛采用,由于脱落阻力大的料用起来很困难,因此目前大量需要去锈能力更好的线材。

关键词：钢帘线机械去锈线材

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influence of magnetic iron oxide nanoparticles on red blood cells and Caco-2 cells

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Advances in Bioscience and Biotechnology 2010年第5期1卷 439-443页

作者： Daniel Moersdorf Pierre Hugounenq Lai Truonc Phuoc Hind Mamlouk-Chaouachi Delphine Felder-Flesch Sylvie Begin-Colin Geneviève Pourroy ingolf Bernhardt Laboratory of Biophysics Saarland University institut de Physique et Chimie des Matériaux de Strasbourg UMR 7504 CNRS-Université de Strasbourg-ECPM

The interactions of two types of cells (red blood cells, Caco-2 cells) with magnetic iron oxide nanoparticles (non-grafted, citrate-grafted, dendrimer-grafted) of 11 nm in size have been investigated. We focused on two important physiological parameters of the cells, the intracellular pH and the intracellular Ca2+ content. The results show that the nanoparticles do not have a significant influence on the pH and Ca2+ content of Caco-2 cells. The Ca2+ content of red blood cells is also not affected but the intracellular pH is slightly reduced.

关键词： Red Blood Cells Caco-2 Cells Ca2+ Content intracellular PH Magnetic iron Oxide Nanoparticles

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码的重量谱系的充分条件

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科学通报 1997年第2期42卷 223-223页

作者：陈文德 TorleivKlφve 中国科学院系统科学研究所 Deptofinformatics UnivofBergen

令C是[n,k;q]码,即码长为n,维数为k的q元线性码。对C的任意子码D,定义D的支持是D中码字不全为零的分量的位置集,记为χ(D),D的支持重量为,|χ(D)|。对1≤r≤k。

关键词：码重量谱系充分条件线性码

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Does food addiction distinguish a specific subgroup of overweight/obese overeating women?

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Health 2012年第12期4卷 1492-1499页

作者： Catherine Bégin Marie-ève St-Louis Sophie Turmel Béatrice Tousignant Louis-Philippe Marion Francine Ferland Nadine Blanchette-Martin Marie-Pierre Gagnon-Girouard Rehabilitation Center for Dependency Quebec City Canada School of Psychology Laval University Quebec Canada

Neurophysiological and behavioral similarities have been evidenced between excessive food consumption leading to obesity and addiction to other substances. in accordance, food addiction was defined following the DSM-iV diagnostic criteria for substance dependence. The aim of this pilot study was to identify a subgroup of women suffering from food addiction (n = 11), and to compare them to women suffering from substance-use disorder (n = 23), and to women seeking treatment for compulsive overeating but free from food addiction (n = 12) on addiction-related characteristics (reward sensitivity, impulsivity, personality traits, depression, emotion dysregulation). We hypothesized that women with food addiction would be similar to women with substance-use disorders, and different from women with compulsive overeating without food addiction. Participants completed self-reported questionnaires assessing food addiction and other variables related to addiction. Almost half (47.8%) of women with compulsive overeating fulfilled the criteria for food addiction. Although food addiction does not account for every case of compulsive overeating, it characterizes a specific subgroup of overweight/obese women who show more severe overeating. Women with food addiction seem to be more similar to women suffering from substance-use disorders than to other women with overeating difficulties, particularly regarding impulsivity and self-directedness.

关键词： Food addiction Compulsive Overeating Binge Eating Addiction

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Reasons for Delayed Breastfeeding initiation among Newly Delivered Women in Two First-Category Hospitals in Yaoundé, Cameroon

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Open Journal of Pediatrics 2020年第3期10卷 474-485页

作者： Félicitée Nguefack Dany Hermann Ngwanou Georges Pius Kamsu Moyo Louise Ejake Evelyn Mungyeh Mah Guy Wafeu Danny Stève Fodoung Wamba Andreas Chiabi Faculty of Medicine and Biomedicals Sciences University of Yaoundé 1 Yaoundé Cameroon Yaoundé Gynaeco-Obstetric and Pediatric Hospital Yaoundé Cameroon Faculty of Health Sciences University of Bamenda Bamenda Cameroon

introduction: Exclusive breastfeeding is fundamental for the good health and development of the mother and the child. According to the World Health Organization (WHO), breastfeeding after childbirth should be initiated within 30 minutes. For a number of reasons, WHO recommendations on guiding principles for infants and young children feeding are often not followed. Objective: To determine the reasons for the delayed initiation of breastfeeding in newly delivered women. Means and Method: We carried out a mixed cross-sectional study over a period of six months from December 1st 2018 to May 31st 2019, at the Yaoundé Gynaeco-Obstetric and Pediatric Hospital. We included all mothers with full-term or premature babies weighing ≥ 2000 grams and those whom initiated breastfeeding more than one hour after delivery. The mother’s reasons for delaying breastfeeding initiation were recorded using a dictaphone and data were accurately extracted for analysis. Results: We interviewed 153 mothers. Their mean age was 27.9 ± 6.2 years. The main reasons for delaying breastfeeding initiation were caesarean delivery (22%), the belief in “spoiled milk” (21%), lack of knowledge about the time to initiate breastfeeding (21%), baby asleep (18%), and lack of instruction given to the mother by the health staff (2%). Conclusion:verdana;"> Delayed breastfeeding was common in our cont

关键词： Childbirth Breastfeeding Delay Reasons Yaoundé

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Robust Attack Detection Approach for iioT Using Ensemble Classifier

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Computers, Materials & Continua 2021年第3期66卷 2457-2470页

作者： V.Priya i.Sumaiya Thaseen Thippa Reddy Gadekallu Mohamed K.Aboudaif Emad Abouel Nasr School of information Technology and Engineering Vellore Institute of TechnologyVellore632014India Advanced Manufacturing institute King Saud UniversityRiyadh11421Saudi Arabia industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

Generally,the risks associated with malicious threats are increasing for the internet of Things(ioT)and its related applications due to dependency on the internet and the minimal resource availability of ioT ***,anomaly-based intrusion detection models for ioT networks are *** detection methodologies need to be developed for the industrial internet of Things(iioT)network as threat detection is a significant expectation of *** learning approaches are considered to be evolving techniques that learn with experience,and such approaches have resulted in superior performance in various applications,such as pattern recognition,outlier analysis,and speech *** techniques and tools are not adequate to secure iioT networks due to the use of various protocols in industrial systems and restricted possibilities of *** this paper,the objective is to develop a two-phase anomaly detection model to enhance the reliability of an iioT *** the first phase,SVM and Naïve Bayes,are integrated using an ensemble blending technique.K-fold cross-validation is performed while training the data with different training and testing ratios to obtain optimized training and test *** blending uses a random forest technique to predict class *** Artificial Neural Network(ANN)classifier that uses the Adam optimizer to achieve better accuracy is also used for *** the second phase,both the ANN and random forest results are fed to the model’s classification unit,and the highest accuracy value is considered the final *** proposed model is tested on standard ioT attack datasets,such as WUSTL_iiOT-2018,N_BaioT,and Bot_*** highest accuracy obtained is 99%.A comparative analysis of the proposed model using state-of-the-art ensemble techniques is performed to demonstrate the superiority of the *** results also demonstrate that the proposed model outperforms traditional techniques and thus improv

关键词： Blending ensemble intrusion detection industrial internet of Things(iioT)

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MODELLiNG OF ALKALi-SiLiCA REACTiON iN CONCRETE,PART 3:STRUCTURAL EFFECTS iNDUCED BY ASR

MODELLING OF ALKALI-SILICA REACTION IN CONCRETE,PART 3:STRUC...

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第十二届国际混凝土碱集料反应会议

作者： Stéphane POYET Alain SELLiER Bruno CAPRA Geneviève FORAY Jean-Michel TORRENTi Hélène COGNON Eric BOURDAROT Laboratoire de Mécanique-Université de Marne la Vallée Cité Descartes-5 boulevard Descartes-77454 Marne la Vallée Cedex 2 France Laboratoire Matériaux et Durabilité des Constructions-iNSA/UPS Département de Génie Civil-135 avenue de Rangueil 31077 Toulouse cedex 4France Laboratoire de Mécanique-Université de Marne la Vallée Cité Descartes-5 boulevard Descartes-77454 Marne la Vallée Cedex 2 France Laboratoire de Mécanique-Université de Marne la Vallée Cité Descartes-5 boulevard Descartes-77454 Marne la Vallée Cedex 2 France iRSN-BP 17 92262 Fontenay aux Roses CedexFrance Electricité de France/DER-Site des Renardières Route de SensEcuelles-77818 Moret-sur-LoingFrance Direction de l’Equipement Centre d’Ingénierie Hydraulique Savoie-Technolac73373 Le Bourget-du-Lac France

＜正＞ A constitutive viscoelastic damage modelling has been developed in the framework of anisotropic damage theory. This mechanical modelling can be classified in the rotating crack formulation category. it includes orthotropic damage induced by ASR swelling, delayed strains and mechanical loads. Coupling between all sources of orthotropic damage is done by a generalised weakest link approach. Data for the mechanical modelling are macroscopic mechanical characteristics （Young’s modulus, Poisson’s ratio, tensile strength, compressive strength, tensile fracture energy） and parameters defining ASR swelling. This macroscopic coupling damage modelling has been implemented into the finite element code CAST3M. This implementation allows simulating strains, stresses and damages evolutions. A numerical simulation for a simple bending beam loaded by its dead weight and submitted to ASR affected by an external moisture gradient has been carried out. Comparison between experimental observations and numerical predictions are discussed.

关键词： Alkali Silica Reaction modelling structural effects finite elements method damage.

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