Influence of magnetic iron oxide nanoparticles on red blood cells and Caco-2 cells

作     者：Daniel Moersdorf Pierre Hugounenq Lai Truonc Phuoc Hind Mamlouk-Chaouachi Delphine Felder-Flesch Sylvie Begin-Colin Geneviève Pourroy Ingolf Bernhardt 

作者机构：不详 

出 版 物：《Advances in Bioscience and Biotechnology》 (生命科学与技术进展（英文）)

年 卷 期：2010年第1卷第5期

页      面：439-443页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Red Blood Cells Caco-2 Cells Ca2+ Content Intracellular PH Magnetic Iron Oxide Nanoparticles 

摘      要：The interactions of two types of cells (red blood cells, Caco-2 cells) with magnetic iron oxide nanoparticles (non-grafted, citrate-grafted, dendrimer-grafted) of 11 nm in size have been investigated. We focused on two important physiological parameters of the cells, the intracellular pH and the intracellular Ca2+ content. The results show that the nanoparticles do not have a significant influence on the pH and Ca2+ content of Caco-2 cells. The Ca2+ content of red blood cells is also not affected but the intracellular pH is slightly reduced.