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Repellent effect of synanthropic house mouse urine odor on small forest mammals

Current Zoology 2023年第3期69卷 315-323页

作者： Igor A.Zhigarev vasiliy v.alpatov Dmitry A.Shitikov Maria v.Nekrasova Olga G.Alekseeva Elena v.Kotenkova Department of Zoology and Ecology Institute of Biology and ChemistryMoscow Pedagogical State University129164 Kibalchicha Str.6/3MoscowRussia Laboratory for Behaviour and Behavioural Ecology of Mammals A.N.Severtsov Institute of Ecology and Evolution of the Russian Academy of Sciences119071 Leninsky prospect33MoscowRussia Department of Zoology Ecology and Nature ConservationK.I.Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology109472 Skrvabin Str.23MoscowRussia

In this study,we examined the effect of synanthropic house mouse(Mus musculus)urine odor on catching probability of small mammals to live *** conducted a series of field experiments in August 2016 and 2017 in a natural forests of the northwestern Moscow Region(Russia).Small mammals were trapped at two 4-ha fields using capture-mark-recapture technique by setting 200 live traps(100 points,2 traps per point)within each *** trap in each pair was odorless(control)with bait only,whereas the other one was odor-baited with 20μL of the urine of a synanthropic house *** analysis was based on the data collected from 2 rodent species(bank vole Myodes glareolus,herb field mouse Apodemus uralensis)and 3 shrew species(common shrew Sorex araneus,Laxmann’s shrew Sorex caecutiens,and Eurasian pygmy shrew Sorex minutus).As a result,only bank voles significantly avoided odor-baited live *** generalized linear mixed models,we showed that the choice of a trap by bank voles depended on their age,whereas the probability of repeated capture to a certain live trap was related to their prior *** discuss the possible role of components of synanthropic house mouse urine in the population management of exoanthropic small mammals.

关键词： field experiment Mus musculus olfactory cues repellent response to traps small mammals

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Concept on the pathogenesis and treatment of primary biliarycirrhosis

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World Journal of Gastroenterology 2006年第45期12卷 7250-7262页

作者： vasiliy Ivanovich Reshetnyak Scientific Research Institute of General Reaniamatology Russia Academy of Medical SciencesMoscowRussia

Primary biliary cirrhosis (PBC) is an organ-specific autoimmune disease that predominantly affects women and is characterized by chronic, progressive destruction of small intrahepatic bile ducts with portal inflammation and ultimately fibrosis, leading to liver failure in the absence of treatment. Little is known about the etiology of PBC. PBC is characterized by anti-mitochondrial antibodies and destruction of intrahepatic bile ducts. The serologic hallmark of PBC is the presence of auto-antibodies to mitochondria, especially to the E2 component of the pyruvate dehydrogenase complex (PDC). Current theories on the pathogenesis of PBC favor the hypothesis that the disease develops as a result of an inappropriate immune response following stimulation by an environmental or infectious agent. Some reports suggest that xenobiotics and viral infections may induce PBC. The pathogenetic mechanism is believed to be caused by a defect in immunologic tolerance, resulting in the activation and expansion of self-antigen specific T and B lymphocyte clones and the production of circulating autoantibodies in addition to a myriad of cytokines and other inflammatory mediators. This leads to ductulopenia and persistent cholestasis, by developing end-stage hepatic-cell failure. In this review are given our own and literary data about mechanisms of development of intrahepatic cholestasis and possible ways of its correction.

关键词： Primary biliary cirrhosis Pathogenesis Treatment

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Physiological and molecular biochemical mechanisms of bile formation

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World Journal of Gastroenterology 2013年第42期19卷 7341-7360页

作者： vasiliy Ivanovich Reshetnyak v.A. Negovsky Scientific Research Institute of General Reanimatology Russian Academy of Medical Sciences107031 MoscowRussia

This review considers the physiological and molecular biochemical mechanisms of bile *** composition of bile and structure of a bile canaliculus,biosynthesis and conjugation of bile acids,bile phospholipids,formation of bile micellar structures,and enterohepatic circulation of bile acids are *** general,the review focuses on the molecular physiology of the transporting systems of the hepatocyte sinusoidal and apical *** of physiological and biochemical basis of bile formation has implications for understanding the mechanisms of development of pathological processes,associated with diseases of the liver and biliary tract.

关键词： Bile acids Bile phospholipids Bile micelle structures Bile salt transporters

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Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis

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World Journal of Gastroenterology 2015年第25期21卷 7683-7708页

作者： vasiliy Ivanovich Reshetnyak v.A. Negovsky Research Institute of General Reanimatology

Primary biliary cirrhosis(PBC) is a chronic progressive cholestatic granulomatous, and destructive inflammatory lesion of small intralobular and septal bile ducts, which is likely to be caused by an autoimmune mechanism with a the presence of serum antimitochondrial antibodies and a potential tendency to progress to cirrhosis. Despite the fact that the etiology of this disease has beenunknown so far, there has been a considerable body of scientific evidence that can reveal the clinical and laboratory signs of PBC and the individual components of its pathogenesis and elaborate diagnostic criteria for the disease and its symptomatic therapy. Deficiencies in autoimmune tolerance are critical factors for the initiation and perpetuation of the disease. The purpose of this review is to summarize the data available in the literature and the author's findings on clinical and laboratory criteria for the diagnosis of PBC. This review describes the major clinical manifestations of the disease and the mechanisms of its development. It presents the immunological, biochemical, and morphological signs of PBC and their significance for its diagnosis. A great deal of novel scientific evidence for the problem of PBC has been accumulated. However, the inadequate efficiency of therapy for the disease lends impetus to the quest for its etiological factors and to further investigations of its pathogenetic mechanisms and, on this basis, to searches for new methods for its early diagnosis.

关键词： Primary biliary cirrhosis Clinical criteria Laboratory criteria Immunological signs Biochemicalsigns Morphological signs

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Peripheral blood lymphocytes DNA in patients with chronic liver diseases

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World Journal of Gastroenterology 2001年第2期7卷 235-237页

作者： vasiliy I Reshetnyak Tatyana I Sharafanova Ludmila U Ilchenko Elena v Golovanova Gennadiy G Poroshenko Central Research Institute of Gastroenterology MoscowRussia

BACKGROUND: viral replication in blood cells with nucleases may lead to the damage of lymphocytes genetic apparatus and the beginning of immunopathological reactions. AIM: Of this investigation is to reveal the damage to peripheral blood lymphocytes (PBL) DNA in the patients with chronic liver diseases. MATERIALS AND METHODS: Sixteen-nine patients with chronic liver diseases (37 patients with chronic viral hepatitis, 2 patients with liver cirrhosis of mixed etiology (alcohol+virus G), 30 women with primary biliary cirrhosis-PBC) were examined. The condition of DNA structure of PBL was measured by the fluorescence analysis of DNA unwinding (FADU) technique with modification. Changes of fluorescence (in %) reflected the DNA distractions degree (the presence of DNA single-stranded breaks and alkalinelabile sights). RESULTS AND CONCLUSION: The quantity of DNA single-stranded breaks and alkalinelabile sights in DNA in all patients with chronic viral hepatitis didn't differ from the control group, excluding the patients with chronic hepatitis (CH) C+G. Patients with HGv and TTv monoinfection had demonstrated the increase of the DNA single-stranded breaks PBL quantity. This fact may be connected with hypothesis about the viruses replication in white blood cells discussed in the literature. Tendency to increase quantity of DNA PBL damages in the patients with primary biliary cirrhosis (PBC) accordingly to the alkaline phosphatase activity increase was revealed. Significant decrease of the DNA single-stranded breaks and alkalinelabile sights in the PBC patients that were treated with prednisone was demonstrated. Probably, the tendency to increase the quantity of DNA single stranded breaks and alkalinelabile sights in lymphocytes of the PBC patients was depended on the surplus of the blood bile acid content.

关键词： DNA Damage Adolescent Adult Aged Alkaline Phosphatase Chronic Disease Female Hepatitis, Chronic Hepatitis, viral, Human Humans Leukocytes, Mononuclear Liver Cirrhosis Liver Cirrhosis, Biliary Liver Diseases Male Middle Aged Research Support, Non-U.S. Gov't

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Torque teno virus in liver diseases: On the way towards unity of view

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World Journal of Gastroenterology 2020年第15期26卷 1691-1707页

作者： vasiliy I Reshetnyak Igor v Maev Alexandr I Burmistrov Igor A Chekmazov Tatiana I Karlovich Department of Propaedeutic of Internal Diseases and Gastroenterology A.I.Yevdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia Central Clinical Hospital with Polyclinic Presidential Administration of the Russian FederationMoscow 121359Russia

The review presents the data accumulated for more than 20 years of research of torque teno virus(TTv).Its molecular genetic structure,immunobiology,epidemiology,diagnostic methods,possible replication sites,and pathogenicity factors are *** is a virus that is frequently detectable in patients with different viral hepatitides,in cases of hepatitis without an obvious viral agent,as well as in a healthy *** is evidence suggesting that biochemical and histological changes occur in liver tissue and bile duct epithelium in TTv *** are sufficient histological signs of liver damage,which confirm that the virus can undergo a replicative cycle in *** with this,cytological hybridization in TTv-infected cells has shown no substantial cytopathic(cell-damaging)effects that are characteristic of pathogenic hepatotropic *** TTv has led to the evolution of views on its role in the development of human *** first ideas about the hepatotropism of the virus were gradually reformed as new data became available on the prevalence of the virus and its co-infection with other viruses,including the viruses of the known types of *** high prevalence of TTv in the human population indicates its persistence in the body as a virome and a nonpathogenic *** has recently been proposed that the level of TTv DNA in the blood of patients undergoing organ transplantation should be used as an endogenous marker of the body’s immune *** available data show the polytropism of the virus and deny the fact that TTv can be assigned exclusively to hepatitis ***,the rare detection of the damaging effect of TTv on hepatic and bile duct epithelial cells may be indirect evidence of its conditionally pathogenic *** ubiquity of the virus and the variability of its existence in humans cannot put an end to its study.

关键词： Torque teno virus Prevalence of torque teno virus Torque teno virus in liver disease virome and torque teno virus Torque teno virus and human immune status

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New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage

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World Journal of Gastroenterology 2023年第37期29卷 5292-5304页

作者： vasiliy Ivanovich Reshetnyak Igor veniaminovich Maev Department of Propaedeutics of Internal Diseases and Gastroenterology A.I.Yevdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia

Primary biliary cholangitis(PBC)is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in *** to cholangiocytes triggers the development of intrahepatic cholestasis,which progresses to cirrhosis in the terminal stage of the *** data indicate that damage to biliary epithelial cells[(BECs),cholangiocytes]is most likely associated with the intracellular accumulation of bile acids,which have potent detergent properties and damaging effects on cell *** mechanisms underlying uncontrolled bile acid intake into BECs in PBC are associated with pH change in the bile duct lumen,which is controlled by the bicarbonate(HCO3-)buffer system“biliary HCO3-umbrella”.The impaired production and entry of HCO3-from BECs into the bile duct lumen is due to epigenetic changes in expression of the X-linked microRNA *** on the growing body of knowledge on the molecular mechanisms of cholangiocyte damage in patients with PBC,we propose a hypothesis explaining the pathogenesis of the first morphologic(ductulopenia),immunologic(antimitochondrial autoantibodies)and clinical(weakness,malaise,rapid fatigue)signs of the disease in the asymptomatic *** review focuses on the consideration of these mechanisms.

关键词： Primary biliary cholangitis Antimitochondrial autoantibodies MicroRNA 506 Inositol-1,4,5-trisphosphate receptor type 3 Chloride/bicarbonate anion exchanger 2 Biliary bicarbonate umbrella Dihydrolipoyl transacetylase(E2 subunit) Pyruvate dehydrogenase complex

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Significance of dormant forms of Helicobacter pylori in ulcerogenesis

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World Journal of Gastroenterology 2017年第27期23卷 4867-4878页

作者： vasiliy Ivanovich Reshetnyak Tatiana Magomedalievna Reshetnyak vA Negovsky Research Institute of General Reanimatology of Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology Department of Systemic Connective Tissue Diseases VA Nasonova Research Institute of Rheumatology

Nearly half of the global population are carriers of Helicobacter pylori(H. pylori),a Gram-negative bacterium that persists in the healthy human stomach. H. pylori can be a pathogen and causes development of peptic ulcer disease in a certain state of the macroorganism. It is well established that H. pylori infection is the main cause of chronic gastritis and peptic ulcer disease(PUD). Decontamination of the gastric mucosa with various antibiotics leads to H. pylori elimination and longer remission in this disease. However,the reasons for repeated detection of H. pylori in recurrent PUD after its successful eradication remain unclear. The reason for the redetection of H. pylori in recurrent PUD can be either reinfection or ineffective anti-Helicobacter therapy. The administration of antibacterial drugs can lead not only to the emergence of resistant strains of microorganisms,but also contribute to the conversion of H. pylori into the resting(dormant) state. The dormant forms of H. pylori have been shown to play a potential role in the development of relapses of PUD. The paper discusses morphological H. pylori forms,such as S-shaped,C-shaped,U-shaped,and coccoid ones. The authors proposes the classification of H. pylori according to its morphological forms and viability.

关键词： Helicobacter pylori Forms of H. pylori Dormant forms of H. pylori viable forms of H. pylori Non-viable forms of H. pylori Physiological states of H. pylori Culturable forms of H. pylori Unculturable forms of H. pylor Resuscitation of dormant H. pylori Ulcerogenesis

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Concept of the pathogenesis and treatment of cholelithiasis

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World Journal of Hepatology 2012年第2期4卷 18-34页

作者： vasiliy Ivanovich Reshetnyak vA Negovsky Scientific Research Institute of General Reanimatology Russia Academy of Medical Sciences

Gallstone disease(GD) is a chronic recurrent hepatobiliary disease,the basis for which is the impaired metabolism of cholesterol,bilirubin and bile acids,which is characterized by the formation of gallstones in the hepatic bile duct,common bile duct,or *** is one of the most prevalent gastrointestinal diseases with a substantial burden to health care *** can result in serious outcomes,such as acute gallstone pancreatitis and gallbladder *** epidemiology,pathogenesis and treatment of GD are discussed in this *** prevalence of GD varies widely by *** prevalence of gallstone disease has increased in recent *** is connected with a change in lifestyle:reduction of motor activity,reduction of the physical load and changes to *** of the important benefits of early screening for gallstone disease is that ultrasonography can detect asymptomatic cases,which results in early treatment and the prevention of serious *** pathogenesis of GD is suggested to be multifactorial and probably develops from complex interactions between many genetic and environmental *** suggests that corticosteroids and oral contraceptives,which contain hormones related to steroid hormones,may be regarded as a model system of cholelithiasis development in *** achievement in the study of the physiology of bile formation and the pathogenesis of GD has allowed expanding indications for therapeutic treatment of GD.

关键词： Gallstone disease:Epidemiology Pathogenesis of cholesterol stones Treatment

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Specific features of Eu^(3+) and Tb^(3+) magnetooptics in gadolinium-gallium garnet (Gd_3Ga_5O_(12))

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Journal of Rare Earths 2011年第8期29卷 776-782页

作者： Uygun v. valiev John B. Gruber 付德君 vasiliy O. Pelenovich Gary W. Burdick Mariya E. Malysheva Faculty of Physics National University of Uzbekistan Department of Physics and Astronomy The University of Texas at San Antonio Department of Physics Wuhan University Department of Physics Andrews University

We reported magnetooptical properties of Eu3＋（4f（6）） and Tb3＋（4f（8）） in single crystals of Gd3Ga5O12 （GGG）, Y3Ga5O12 （YGG）, and Eu3＋（4f（6）） in Eu3Ga5O12 （EuGG） for both ions occupying sites of D2 symmetry in the garnet structure. Absorption, luminescence, and magnetic circular polarization of luminescence （MCPL） spectra of Tb3＋ in GGG and YGG and absorption and magnetic circular dichroism （MCD） of Eu3＋ in EuGG were studied. The data were obtained at 85 K and room temperature （RT）. Magnetic susceptibility of Eu3＋ in EuGG was also measured between 85 K and RT. The magnetooptical and magnetic susceptibility data were modeled using the wavefunctions of the crystal-field split energy （Stark） levels of Eu3＋ and Tb3＋ occupying D2 sites in the same garnets. The results reported gave a precise determination of these Stark level assignments and confirmed the symmetry labels （irreducible representations） of the closely-spaced Stark levels （quasi-doublets） found in the 5D1 （Eu3＋） and 5D4 （Tb3＋） multiplets. Ultraviolet （Uv） excitation （300 nm） of the 6PJ and 6IJ states of Gd3＋ in the doped GGG crystals led to emission from 5D4 （Tb3＋） and 5D1 and 5D0 （Eu3＋） through radiationless energy transfer to the 4f（n–1）5d band of Tb3＋ and to Uv quintet states of Eu3＋. The temperature-dependent emission line shapes and line shifts of the magnetooptical transitions excited by Uv radiation suggested a novel way to explore energy transfer mechanisms in this rare-earth doped garnet system.

关键词： magnetic circular polarization of luminescence magnetic circular dichroism absorption quantum qutting energy transfer magnetic susceptibility rare earths

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