检索结果-南通市图书馆

Proteome alterations in aqueous humour of primary open angle glaucoma patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2020年第1期13卷 176-179页

作者： Hanhan Liu Fabian Anders Sebastian funke Karl Mercieca Franz Grus Verena Prokosch Department of Ophthalmology University Medical Center of the Johannes Gutenberg University MainzMainz 55131Germany Experimental and Translational Ophthalmology Department of OphthalmologyUniversity Medical Center of the Johannes Gutenberg University MainzMainz 55131Germany Royal Eye Hospital School of MedicineUniversity of ManchesterManchester M202ULUnited Kingdom

AIM: To unravel the primary open angle glaucoma(POAG) related proteomic changes in aqueous humour(AH).METHODS: Totally 35 patients listed for cataract surgery(controls: n=12, age: 67.4±13.6 y) or trabeculectomy for POAG(n=23, age: 72.5±8.3 y) were included. AH samples of those patients were obtained during cataract surgery or trabeculectomy. AH samples were subsequently pooled into the experimental groups under equal contribution in terms of protein amount of each individual patient. Protein samples were analyzed by a linear trap quadrupol Orbitrap Mass Spectrometry device with an upstream liquid chromatography system. The obtained raw data were analyzed using the Maxquant proteome software and compared. Proteins with a fold-change ratio higher than a cut-off of 2 were considered as noticeably ***: A total number of 175 proteins could be identified out of the AH from POAG and cataract by means of quantitative mass spectrometric analysis. Apolipoprotein D(fold change, 3.16 times), complement C3(2.96), pigment epithelium-derived factor(2.86), dickkopf-related protein 3(2.18) and wingless-related integration(Wnt) inhibitory factor 1(2.35) were significantly upregulated within the AH of glaucoma compared to cataract serving as ***: AH provides a tool to analyze changes in glaucoma and shows striking changes in Wnt signaling inhibitory molecules and other proteins.

关键词： primary open angle glaucoma aqueous humor proteomics Wnt signaling pathway

A co-interaction model of HIV and syphilis infection among gay,bisexual and other men who have sex with men

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2020年第1期5卷 855-870页

作者： Jummy funke David Viviane Dias Lima Jielin Zhu Fred Brauer Department of Mathematics University of British ColumbiaVancouverBCV6T 1Z2Canada British Columbia Centre for Excellence in HIV/AIDS St.Paul’s HospitalVancouverBCV6Z 1Y6Canada Department of Interdisciplinary Studies University of British ColumbiaVancouverBCV6T 1Z4Canada Department of Medicine Faculty of MedicineUniversity of British ColumbiaVancouverBCV6T 1Z3Canada

We developed a mathematical model to study the co-interaction of HIV and syphilis infection among gay,bisexual and other men who have sex with men(gbMSM).We qualitatively analysed the model and established necessary conditions under which disease-free and endemic equilibria are asymptotically *** gave analytical expressions for the reproduction number,and showed that whenever the reproduction numbers of sub-models and co-interaction model are less than unity,the epidemics die out,while epidemics persist when they are greater than *** presented numerical simulations of the full model and showed qualitative changes of the dynamics of the full model to changes in the transmission *** numerical simulations using a set of reasonable parameter values showed that:(a)both diseases die out or co-exist whenever their reproduction number is less than or exceed unity.(b)HIV infection impacts syphilis prevalence negatively and vice versa.(c)one possibility of lowering the co-infection of HIV and syphilis among gbMSM is to increase both testing and treatment rates for syphilis and HIV infection,and decrease the rate at which HIV infected individuals go off treatment.

关键词： HIV Syphilis Mathematical model gbMSM Reproduction number Testing and treatment Stability

Evaluation of Nutrient Contents of Amaranth Leaves Prepared Using Different Cooking Methods

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2011年第4期2卷 249-252页

作者： Olumakaiye M. funke 不详

Amaranth is a commonly consumed vegetable in households in Southwestern Nigeria. Raw amaranth is known to be rich in micronutrients particularly Iron and Vitamin C, which are lost during cooking due to the method of preparation. Hence, this study was conducted to determine the method of preparation that best retains nutrients. Three common methods of preparing amaranth were identified;method 1 in which no heat was applied but amaranth leaves were finely chopped (samples A), method 2 which was steaming before chopping the leaves (sample B) and method 3 involved chopping of leaves before blanching (sample C). These three samples were subjected to proximate analysis and micronutrient determinations. Results were mean of three determinations. Result of proximate analysis showed that sample B method of preparation has highest percentage of crude fat per gram of sample (2.31 ± 0.45), protein (4.35 ± 0.15) and fibre (1.09 ± 0.06). Sample A has highest percentage of moisture (90.35 ± 0.27) and ash content (1.36 ± 0.28) while sample C has highest percentage per gram of sample in carbohydrate (4.89 ± 1.21) only. Micronutrient determination results showed that sample A was highest in Vitamin C (1.57 mg ± 0.06) and Iron (535.84 ppm ± 123.42), followed by sample C (1.21 ± 0.07) and (501.88 ± 215.19) respectively while sample B had the least vitamin C (0.79 ± 0.06) and Iron (354.18 ± 121.84). The study showed that samples A best retained the nutrient contents of Amaranth leaves after preparation.

关键词： Amaranth Cooking Micronutrient Preparation Proximate

An Alkali Activated Binder for High Chemical Resistant Self-Leveling Mortar

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Composite Materials 2016年第4期6卷 132-142页

作者： Henrik L. funke Sandra Gelbrich Lothar Kroll Institute of Lightweight Structures Technische Universitat Chemnitz Chemnitz Germany

This paper reports the development of an Alkali Activated Binder (AAB) with an emphasis on the performance and the durability of the AAB-matrix. For the development of the matrix, the reactive components granulated slag and coal fly ash were used, which were alkali activated with a mixture of sodium hydroxide (2 - 10 mol/l) and aqueous sodium silicate solution (SiO2/Na2O molar ratio: 2.1) at ambient temperature. A sodium hydroxide concentration of 5.5 mol/l revealed the best compromise between setting time and mechanical strengths of the AAB. With this sodium hydroxide concentration, the compressive and the 3-point bending tensile strength of the hardened AAB were 53.4 and 5.5 MPa respectively after 14 days. As a result of the investigation of the acid resistance, the AAB-matrix showed a very high acid resistance in comparison to ordinary Portland cement concrete. In addition, the AAB had a high frost resistance, which had been validated by the capillary suction, internal damage and freeze thaw test with a relative dynamic E-Modulus of 93% and a total amount of scaled material of 30 g/m2 after 28 freeze-thaw cycles (exposure class: XF3).

关键词： Alkali Activated Binder Geopolymer Durability Chemical Resistance

Function-Integrative Textile Reinforced Concrete Shells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Composite Materials 2018年第4期8卷 161-174页

作者： Sandra Gelbrich Henrik L. funke Lothar Kroll Institute of Lightweight Structures Technische Universit&auml t Chemnitz Chemnitz Germany

This paper presents the development and technological implementation of textile reinforced concrete (TRC) shells with integrated functions, such as illumination and light control. In that regard the establishment of material, structural and technological foundations along the entire value chain are of central importance: From the light-weight design idea to the demonstrator and reference object, to the technological implementation for the transfer of the research results into practice. The development of the material included the requirement-oriented composition of a high-strength fine grained concrete with an integrated textile reinforcement, such as carbon knitted fabrics. Innovations in formwork solutions provide new possibilities for concrete constructions. So, a bionic optimized shape of the pavilion was developed, realized by four connected TRC-lightweight-shells. The thin-walled TRC-shells were manufactured with a formwork made of glass-fibre reinforced polymer (GFRP). An advantage of the GFRP-formwork is the freedom of design concerning the formwork shape. Moreover, an excellent concrete quality can be achieved, while the production of the precast concrete components is simple and efficient simultaneously. After the production the new TRC-shells were installed and assembled on the campus of TU-Chemnitz. A special feature of the research pavilions are the LED light strips integrated in the shell elements, providing homogeneous illumination.

关键词： Textile Reinforced Concrete Carbon Reinforced Concrete Textile Reinforced Composites Function-Integrated Lightweight Structures Glass-Fibre Reinforced Polymer Formwork Thin-Walled Shells

CFD based exploration of the dry-low-NO_(x) hydrogen micromix combustion technology at increased energy densities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Propulsion and Power Research 2017年第1期6卷 15-24页

作者： A.Haj Ayed K.Kusterer H.H.-W.funke J.Keinz D.Bohn B&B-AGEMA GmbH.Jiilicher Str.338 Aachen 52070Germany FH Aachen University of Applied Sciences Hohenstaufenallee 6Aachen 52064Germany RWTH Aachen University Templergraben 55Aachen 52062Germany

Combined with the use of renewable energy sources for its production,hydrogen represents a possible alternative gas tuibine fuel within future low emission power *** to the large difference in the physical properties of hydrogen compared to other fuels such as natural gas,well established gas tuibine combustion systems cannot be directly applied for dry-low-NO_(x)(DLN)hydrogen ***,the development of DLN combustion technologies is an essential and challenging task for the future of hydrogen fuelled gas *** DLN micromix combustion principle for hydrogen fuel has been developed to significantly reduce NO_(x)-*** combustion principle is based on cross-flow mixing of air and gaseous hydrogen which reacts in multiple miniaturized diffusion-type *** major advantages of this combustion principle are the inherent safety against flash-back and the low NO_(x)-emlssions due to a very short residence time of reactants in the flame region of the *** micromix combustion technology has been already proven experimentally and numerically for pure hydrogen fuel operation at different energy density *** aim of the present study is to analyze the influence of different geometry parameter variations on the flame structure and the NO_(x)emission and to identify the most relevant design parameters,aiming to provide a physical understanding of the micromix flame sensitivity to the burner design and identify further optimization potential of this innovative combustion technology while increasing its energy density and making it mature enough for real gas turbine *** study reveals great optimization potential of the micromix combustion technology with respect to the DLN characteristics and gives insight into the impact of geometry modifications on flame structure and NO_(x)*** allows to further increase the energy density of the micromix burners and to integrate this technology in industrial gas turbin

关键词： Micromix combustion Hydrogen gas turbine Dry-low-NO_(x)(DLN)combustion Hydrogen combustion High hydrogen combustion

ESL pre-service teachers＇ views of Teaching Practice supervision and assessment in Nigeria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sino-US English Teaching 2010年第4期7卷 15-28页

作者： funke Lawal Anthonia Maduekwe Nonye Ikonta Oyenike Adeosun Department of Arts ＆ Social Sciences Education Faculty of Education University of Lagos Lagos 10000 Nigeria

This paper suggests that English as a Second Language （ESL） pre-service teachers＇ views and opinions about Teaching Practices be used by faculty to make TP more effective and interesting for the professional development of teachers. The main objective was to study the motivational dimensions of Teaching Practice （TP）, analyze trainees perception of the strength of their content courses （knowledge base） and pedagogy programme （psychology, teaching methods）, and investigate the quality of TP orientation program supervision and assessment by faculty （teacher trainers）. A survey was carried out to determine procedures and processes for minimizing anxieties and fears concerning TP and the relationship between faculty and trainees, mentoring and monitoring procedures, the giving of feedback and utilization of the views of students. Questionnaires were used to obtain information on the content courses or subjects which students found difficult, irrelevant or not adequately taught, what faculty should do to make TP experience better and rewarding to make them become professional teachers. Participants in the study found pedagogy courses relevant to their training and quite enjoyable. They also acknowledge that the courses help them to develop learner centered instructional skills and competence in classroom management. On the contrary, participants confessed they were weak in grammar and spoken English because these were not adequately taught, they also limited exposure to reading and writing. Focused group discussion with students revealed that TP Orientation Programs were too crowded and ill-organized to meet their needs and reduce their anxiety. The points of focus of the orientation-dress code, comportment in schools-were not as crucial as some issues-mentoring, relationship between faculty and students-which were left out. Respondents rated TP supervision and assessment very low because of inadequacies in the number of visits, lack of feedback and low level inte

关键词： pre-service teachers Teaching Practice supervision assessment Nigeria

Microbiology An Introduction Gerard J. Tortora, Berdell R. funke, Christine L. Case 7th ed.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microbiology An Introduction Gerard J. Tortora, Berdell R. F...

Microbiology : an introduction / Gerard J. Tortora, Berdell R. funke, Christine L. Case. 6th ed.

2001年

作者： Gerard J. Tortora Berdell R. funke Christine L. Case

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论