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Changes in Timing and kinematics of goal directed eye-hand movements in early-stage Parkinson’s disease

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Translational Neurodegeneration 2013年第1期2卷 1-8页

作者： Danya Muilwijk Simone Verheij Johan JM Pel Agnita JW Boon johannes van der Steen Department of Neuroscience Erasmus MCPO Box 20403000CA RotterdamThe Netherlands Department of Neurology Erasmus MCPO Box 20403000CA RotterdamThe Netherlands

Objective:Many daily activities involve intrinsic or extrinsic goal-directed eye and hand *** extensive visuomotor coordination network including nigro-striatal pathways is required for efficient timing and positioning of eyes and *** aim of this study was to investigate how Parkinsons disease(PD)affects eye-hand coordination in tasks with different cognitive ***:We used a touch screen,an eye-tracking device and a motion capturing system to quantify changes in eye-hand coordination in early-stage PD patients(H&Y<2.5)and age-matched *** and kinematics of eye and hand were quantified in four eye-hand coordination tasks(pro-tapping,dual planning,anti-tapping and spatial memory task).Results:In the pro-tapping task,saccade initiation towards extrinsic goals was not ***,in the dual planning and anti-tapping task initiation of saccades towards intrinsic goals was faster in PD *** movements were differently affected:initiation of the hand movement was only delayed in the pro-tapping and dual planning ***,hand movements in PD patients were slower executed compared to ***:Whereas initiation of saccades in an extrinsic goal-directed task(pro-tapping task)is not affected,early stage PD patients have difficulty in suppressing reflexive saccades towards extrinsic goals in tasks where the endpoint is an intrinsic goal(*** planning and anti-tapping task).This is specific for eye movements,as hand movements have delayed responses in the pro-tapping and dual planning *** suggests that reported impairment of the dorsolateral prefrontal cortex in early-stage PD patients affects only inhibition of eye *** conclude that timing and kinematics of eye and hand movements in visuomotor tasks are affected in PD *** result may have clinical significance by providing a behavioral marker for the early diagnosis of PD.

关键词： impaired movement directed

Towards a multiscale model of colorectal cancer

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World Journal of Gastroenterology 2007年第9期13卷 1399-1407页

作者： Ingeborg MM van leeuwen Carina M Edwards Mohammad Ilyas Helen M Byrne Centre for Mathematical Medicine and Biology School of Mathematical Sciences University of Nottingham Nottingham NG7 2RD United Kingdom Centre for Mathematical Biology Oxford Centre for Industrial and Applied Mathematics Mathematical Institute University of Oxford Oxford OX1 3LB United Kingdom Division of Pathology School of Molecular Medical SciencesQueen’s Medical Centre University of Nottingham Nottingham NG7 2UHUnited Kingdom

Colorectal cancer (CRC) is one of the best characterised cancers, with extensive data documenting the sequential gene mutations that underlie its development. Complementary datasets are also being generated describing changes in protein and RNA expression, tumour biology and clinical outcome. Both the quantity and the variety of information are inexorably increasing and there is now an accompanying need to integrate these highly disparate datasets. In this article we aim to explain why we believe that mathematical modelling represents a natural tool or language with which to integrate these data and, in so doing, to provide insight into CRC.

关键词：结肠直肠癌多尺度模型小肠上皮干细胞 Wnt信号转导

心磁图测量心脏复极时间对冠心病患者心功能预后的评估(英文)

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中国临床康复 2005年第31期9卷 216-218页

作者：陈利平王轶 Peter van leeuwen Silke Lange Anita Klein 解放军总医院中医科北京市100853 德国鲁尔医院心肺功能室 germany45031 德国微创治疗中心生物磁研究所德国波鸿44799

背景:有近50%的冠心病患者在第1次发生心肌梗死前没有心脏病的征兆,因此尽早可靠地检测到冠心病、心肌缺血尤为重要。目的:采用心磁图对冠心病患者心脏复极时间变异进行测量,探讨无创的心磁图检查对冠心病患者心功能的评估作用。设计:病... 详细信息

背景:有近50%的冠心病患者在第1次发生心肌梗死前没有心脏病的征兆,因此尽早可靠地检测到冠心病、心肌缺血尤为重要。目的:采用心磁图对冠心病患者心脏复极时间变异进行测量,探讨无创的心磁图检查对冠心病患者心功能的评估作用。设计:病例-对照观察。单位:德国埃森Philippustift医院心内科。对象:选择1998-03/2002-12在德国埃森Philippustift医院心内科住院,怀疑为冠心病的患者52例,另选择10例确诊为陈旧性心肌梗死的患者作为心肌梗死组,以上患者均知情同意。对照组为32例年龄大于40岁的自愿参与观察的健康人。方法:所有患者均进行普通12导联的心电图、负荷心电图、超声心动图、冠状动脉造影检查、血生化检查及心磁图检查;对照组只行普通12导联心电图及心磁图检查,比较患者与对照组间心磁图、心电图QT离散度的变异程度。冠心病的诊断标准为冠状动脉造影检查发现冠状动脉有1支狭窄≥75%。对于心脏复极时间变异的指标,采用心磁图QT离散度及离散度均一性指数(每个心磁图探头信号与周围探头QT离散度的平均数)进行测量。主要观察指标:各组观察对象的心电图QT离散度、心磁图QT离散度及QT离散度均一性指数。结果:怀疑为冠心病的患者52例、陈旧性心肌梗死组10例及对照组32例全部进入结果分析。怀疑为冠心病的患者分为2组,冠心病组27例,无冠心病组25例。①心电图QT离散度的比较:各组差异无显著性意义(P>0.05)。②心磁图QT离散度的比较:心肌梗死组显著高于对照组犤81.3±21.5,52.4±13.6(f=13.113,P<0.05)犦。③QT离散度均一性指数的比较:心肌梗死组与冠心病组均显著高于对照组犤15.6±4.2,14.9±4.1,10.2±2.7(f=2.403,3.332,P<0.01)犦。结论:心磁图能更好地反映冠心病患者心脏复极时间均一性的变异,优于普通心电图,而离散度均一性指数优于QT离散度。因为心磁图对心切线电流更为敏感,而当心肌缺血、梗死时心肌电流在心前区表现为切线电流。

关键词：磁力学冠状动脉疾病预后

Altitudinal analysis of carbon stocks in the Antisana páramo,Ecuadorian Andes

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Journal of Plant Ecology 2016年第5期9卷 553-563页

作者： Verónica Minaya Gerald Corzo Hugo Romero-Saltos johannes van der Kwast Egbert Lantinga Remigio Galárraga-Sánchez Arthur Mynett UNESCO-IHE Institute for Water Education Westvest 72611 AX DelftThe Netherlands Technological University of Delft-TU-Delft Stevinweg 12628 CN DelftThe Netherlands Escuela Politécnica Nacional EPNWater Science UnitLadrón de Guevara E11-253Quito 170517Ecuador Yachay Tech Ciudad del Conocimiento YachayHacienda San JoséS/NSan Miguel de Urcuquí100119Ecuador Farming Systems Ecology Wageningen UniversityPO Box 5636700 AN WageningenThe Netherlands

Aims The importance of quantifying carbon stocks in terrestrial ecosystems is crucial for determining climate change ***,the present regional assessments of carbon stocks in tropical grasslands are extrapolated to unsampled areas with a high degree of uncertainty and without considering the carbon and nitrogen composition of vegetation and soil along altitudinal *** study aims to assess carbon and nitrogen concentrations in soil and vegetation,aboveground carbon stocks distribution and soil organic carbon stocks along an altitudinal range in the páramo region in the Ecuadorian *** The vegetation inventory was conducted using 15×15 m sampling plots distributed in three altitudinal *** on the patterns exhibited by the dominant vegetation growth forms,biomass and soil were sampled to quantify the corresponding carbon and nitrogen ***,the aboveground live biomass along the páramo altitudinal range was estimated using allometric ***,soil and vegetation carbon stocks were estimated for the entire *** Findings Altitudinal analysis supported a potential distribution of carbon and nitrogen concentrations in soil,litter and live tissues,where higher concentrations were found in the low altitudinal range mainly for tussocks and acaulescent *** in litter showed higher concentrations at low altitudinal ranges for acaulescent rosettes and cushions *** the same growth forms,lignin patterns in litter were higher in high altitudinal *** texture provided complementary information:high percentage of silt was highly correlated to high soil nitrogen and carbon *** were found to be responsive to altitude with their,highest aboveground carbon stocks occurring at the low altitudinal range,but cushions and acaulescent rosettes responded *** established relationships among soil,vegetation and altitude shown in this study must be taken into accou

关键词： Andes carbon growth forms nitrogen páramo grassland

CONTINUOUS GALvanIZED REINFORCING(CGR) STEEL IN CONCRETE STRUCTURES

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CONTINUOUS GALVANIZED REINFORCING(CGR) STEEL IN CONCRETE STR...

Sensitive capacitive pressure sensors based on graphene membrane arrays

2021第八届海洋材料与腐蚀防护大会暨2021第二届钢筋混凝土耐久性与设施服役安全大会

作者： Delin Lai M.C.van leeuwen Gang Kong International Zinc Association School of Material Science and Engineering South China University of Technology

Corrosion of steel reinforcing bar(rebar) is the most significant cause of concrete failure,resulting in expensive repairs,reduced load carrying capacity and premature replacement of concrete *** paper will discuss continuous galvanized rebar now available for concrete *** properties of this zinc coated rebar and its contribution to improvement of concrete performance will be presented together with the status of related national and international standards and applications in *** Continuous Galvanized Rebar(CGR) coating process improves product consistency,increases throughput and reduces *** zinc coating is durable and resistant to abrasion that is routine during transport and construction,but is also highly ductile and can be formed after galvanizing to further reduce cost and speeding construction *** in the concrete,the zinc coating protects the rebar both as a barrier coating and with the well-known sacrificial properties of a galvanized coating.

关键词： Corrosion Galvanizing Rebar Reinforcing steel Zinc

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Microsystems & Nanoengineering 2020年第1期6卷 176-184页

作者： Makars Siskins Martin Lee Dominique Wehenkel Richard van Rijn Tijmen W.de Jong johannes R.Renshof Berend C.Hopman Willemijn S.J.M.Peters Dejan Davidovikj Herre S.J.van der Zant Peter G.Steeneken Kavli Institute of Nanoscience Delft University of TechnologyLorentzweg 12628 CJ DelftThe Netherlands Applied Nanolayers B.V. Feldmannweg 172628 CT DelftThe Netherlands Department of Precision and Microsystems Engineering Delft University of TechnologyMekelweg 22628 CD DelftThe Netherlands

The high flexibility,impermeability and strength of graphene membranes are key properties that can enable the next generation of nanomechanical ***,for capacitive pressure sensors,the sensitivity offered by a single suspended graphene membrane is too small to compete with commercial ***,we realize highly sensitive capacitive pressure sensors consisting of arrays of nearly ten thousand small,freestanding double-layer graphene *** fabricate large arrays of small-diameter membranes using a procedure that maintains the superior material and mechanical properties of graphene,even after high-temperature *** sensors are readout using a low-cost battery-powered circuit board,with a responsivity of up to 47:8aF Pa^(−1) mm^(−2),thereby outperforming the commercial sensors.

关键词： graphene arrays thereby

中文版灵性照护能力量表在护理实践中的心理测量学特性

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中文版灵性照护能力量表在护理实践中的心理测量学特性

Growth and Yield of Guar (Cyamopsis tetragonoloba L.) Genotypes under Different Planting Dates in the Semi-Arid Southern High Plains

第二十一届全国心理学学术会议

作者：胡艳丽刘晓虹 René van leeuwen 李凡吉林大学护理学院海军军医大学护理学院中国教育部人畜共患病重点实验室吉林大学基础医学院

背景:灵性照护已被视为整体护理的基本要素,并已整合到护理教育和实践中。对于护士而言,灵性照护能力是能够获得最佳护理实践的主要专业技能之一。因此,使用可靠和有效的工具测量这些能力是很重要的。灵性照护能力量表(SCCS)的英文版本... 详细信息

背景:灵性照护已被视为整体护理的基本要素,并已整合到护理教育和实践中。对于护士而言,灵性照护能力是能够获得最佳护理实践的主要专业技能之一。因此,使用可靠和有效的工具测量这些能力是很重要的。灵性照护能力量表(SCCS)的英文版本是一个用于评估护生或护士的灵性照护能力水平的有效工具。然而,目前尚不清楚此量表在中国护士人群中的适用性。目的:评价SCCS在中国护士中的适用性。方法:将SCCS的英文版本译为中文并进行文化调适。采用方便抽样法抽取400名中国护士进行SCCS中文版的信度和效度评价。400名护士来自于3所大学附属综合医院、两所肿瘤医院、一所精神卫生服务中心,两所中医院,一所妇幼保健服务中心,一个社区卫生服务中心。采用方差分析的主成分分析法确定C-SCCS的结构效度。采用中文版的灵性关怀量表(C-SCGS)和姑息治疗灵性照护能力量表(PCSCCS)与C-SCCS的的皮尔森相关系数来评估C-SCC的同时效度和结构效度。为了验证量表的结构质量,基于另外351名护士的数据进行了验证性因素分析(CFA)。使用克朗巴哈系数和Guttman分半信度系数分别测试了量表的内部一致性和稳定性。结果:共有356名受试者完成问卷调查(有效应答率:89%),所提供的数据均是有效的。从EFA中提取三个因子,解释了总方差变异的64.507%。三个维度的Guttma系数分别为0.947、0.922和0.898,总量表的Guttman分半信度系数为0.855。虽然CFA未显示拟合良好的模型,但C-SCCS与C-SCGS(r=0.590,P<0.01)和C-SCCS与PCSCCS之间的显著相关性(r=0.602,P<0.01)表明量表具有足够的同时效度。结论:目前的研究表明,C-SCCS是一种可用于评估中国护士的灵性照护能力的有效心理测量工具。

关键词：灵性照护能力护士心理测量学信效度

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American Journal of Plant Sciences 2016年第8期7卷 1246-1258页

作者： Sudhir Singla Kulbhushan Grover Sangamesh V. Angadi Sultan H. Begna Brian Schutte Dawn van leeuwen Department of Plant and Environmental Sciences New Mexico State University Las Cruces NM USA Agricultural Science Center New Mexico State University Clovis NM USA Department of Entomology Plant Pathology and Weed Science New Mexico State University Las Cruces NM USA Department of Economics Applied Statistics and International Business New Mexico State University Las Cruces NM USA

Guar is a drought and salt tolerant summer annual legume, which could be a potential alternative crop in the semi-arid Southern High Plains. Increased use of guar gum in oil industries has increased the demand of guar globally. Planting date effects on stand establishment, physiological parameters, and yield formation of guar genotypes were investigated at the New Mexico State University’s Agricultural Science Center at Clovis, NM for two seasons (2014 and 2015). Four guar genotypes (HES 1123, Kinman, Lewis, and Matador) were tested under three planting dates (June 18, July 7, and July 22 in 2014;and June 18, July 6, and July 20 in 2015). Higher temperature and rainfall were recorded under mid-June planting than early-July and late-July plantings. Guar planted under mid-June had better stand establishment as shown by the higher number of plants m-2, better physiology as revealed by higher photosynthetic rate (Pn), transpiration rate (Tr), leaf area index (LAI), and SPAD values than early-July and late-July plantings. Guar planted under mid-June resulted in taller plants, and therefore, produced higher plant biomass than both of the July plantings. Yield attributing characteristics including clusters plant-1, pods plant-1, seeds plant-1, seed spod-1, 1000 seed weight, and harvest index (HI) were highest under mid-June planting followed by the early-July and late-July plantings, respectively. The mid-June planting increased seed yield by 26% and 55% over early-July and late-July (1399 vs. 1111 and 903 kg·ha-1) plantings, respectively in 2014;while the same increase in 2015 was 51% and 243% (1308 vs. 868 and 381 kg·ha-1), respectively. These results indicate that delaying planting beyond mid-June is detrimental to guar productivity. However, genotypes did not show any significant variation in their performance. Overall, warmer growing conditions and more pre

关键词： Guar Planting Date Genotype Yield Southern High Plains

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机械泵驱动两相回路的储液器控温策略研究

工程热物理学报 2012年第1期33卷 91-93页

作者：莫冬传黄臻成何振辉 van Es johannes 吕树申 Zwartbol Teun Pauw Aswin 中山大学化学与化学工程学院广东广州510275 中山大学空间技术中心广东珠海519082 中山大学物理科学与工程技术学院广州510275 National Aerospace Laboratory NLR 8316 PR MarknesseThe Netherlands

本文阐述了一种机械泵驱动两相回路的储液器的控温原理,并对待选的两种控温策略进行了解释:一种是基于电压的PI控制,另一种是基于功率的PI控制。文中将它们作了近似等效转换,并用SINDA/FLUINT软件进行模拟。结果显示:当控温点上升时,两... 详细信息

本文阐述了一种机械泵驱动两相回路的储液器的控温原理,并对待选的两种控温策略进行了解释:一种是基于电压的PI控制,另一种是基于功率的PI控制。文中将它们作了近似等效转换,并用SINDA/FLUINT软件进行模拟。结果显示:当控温点上升时,两种不同控制策略的控温效果大体一致;但当控温点下降时,由于基于功率的PI控制策略包含有Peltier的制冷功能,可以比基于电压的PI控制策略更快到达控温点。另外,基于功率的PI控制策略在死区内的跳跃更少,其应当为优先选择的控制策略。

关键词：机械泵驱动两相回路储液器控温策略