Changes in Timing and kinematics of goal directed eye-hand movements in early-stage Parkinson’s disease

作     者：Danya Muilwijk Simone Verheij Johan JM Pel Agnita JW Boon Johannes van der Steen 

作者机构：Department of NeuroscienceErasmus MCPO Box 20403000CA RotterdamThe Netherlands Department of NeurologyErasmus MCPO Box 20403000CA RotterdamThe Netherlands 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2013年第2卷第1期

页      面：1-8页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Erasmus MC  department of Neuroscience 

主　　题：impaired movement directed 

摘      要：Objective:Many daily activities involve intrinsic or extrinsic goal-directed eye and hand *** extensive visuomotor coordination network including nigro-striatal pathways is required for efficient timing and positioning of eyes and *** aim of this study was to investigate how Parkinsons disease(PD)affects eye-hand coordination in tasks with different cognitive ***:We used a touch screen,an eye-tracking device and a motion capturing system to quantify changes in eye-hand coordination in early-stage PD patients(H&Y2.5)and age-matched *** and kinematics of eye and hand were quantified in four eye-hand coordination tasks(pro-tapping,dual planning,anti-tapping and spatial memory task).Results:In the pro-tapping task,saccade initiation towards extrinsic goals was not ***,in the dual planning and anti-tapping task initiation of saccades towards intrinsic goals was faster in PD *** movements were differently affected:initiation of the hand movement was only delayed in the pro-tapping and dual planning ***,hand movements in PD patients were slower executed compared to ***:Whereas initiation of saccades in an extrinsic goal-directed task(pro-tapping task)is not affected,early stage PD patients have difficulty in suppressing reflexive saccades towards extrinsic goals in tasks where the endpoint is an intrinsic goal(*** planning and anti-tapping task).This is specific for eye movements,as hand movements have delayed responses in the pro-tapping and dual planning *** suggests that reported impairment of the dorsolateral prefrontal cortex in early-stage PD patients affects only inhibition of eye *** conclude that timing and kinematics of eye and hand movements in visuomotor tasks are affected in PD *** result may have clinical significance by providing a behavioral marker for the early diagnosis of PD.