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Some Results of Direct FR Technology Applied to Study Methane Seepage Areas in the Arctic Region

Advances in Geological and Geotechnical Engineering Research 2023年第3期5卷 25-38页

作者： Mykola Yakymchuk Ignat Korchagin valery Soloviev Institute of Applied Problems of Ecology Geophysics and GeochemistryKyiv03126Ukraine Institute of Geophysics NAS of UkraineKyiv03680Ukraine

The experimental study of the seepage processes’sources formation in structures of the Arctic Region was carried out using modified methods of frequency-resonance(FR)processing and decoding of satellite images and photographs with the vertical scanning of the *** newly obtained results show that the intensity and dynamics of the methane seeps and pockmarks fields’formation depend on active deep degassing processes in the continental margin *** use of direct FR-sounding technologies allows for determining the probable origin and depth of geological sources of gas migration at marginal migration centers in Greenland,and Norwegian and Barents *** results confirm the crust-mantle gas fluids’influence on the nature and degassing processes features in the scan points of polar marginal *** data are important arguments in favor of the“volcanic model”of various structural elements formation in this and other *** FR technologies data also showed a possibility of seeps use as shallow and deep hydrocarbon field indicators in gas emission *** independent data can be used in compiling models of the deep lithosphere structure and possible mechanisms of abiogenetic hydrocarbon formation in Arctic margin *** authors suppose that hydrocarbons through deep channels migrate(from 57 km deep)to the upper crustal horizons where their fields can *** this migration,gas seeps and pockmarks are formed on the sea bottom and part of the gas can migrate into the *** show that basaltic volcanoes in Greenland scan points can be the real channels through which hydrogen migrates to the upper crustal horizons and further into the *** gas migration in Arctic seepage areas can be an important factor in the global climate change processes.

关键词： FR mobile technologies Active hydrocarbon seepage Greenland Spitsbergen Polar Arctic

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Challenges in the Detection and Attribution of Northern Hemisphere Surface Temperature Trends Since 1850

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Research in Astronomy and Astrophysics 2023年第10期23卷 367-386页

作者： Ronan Connolly Willie Soon Michael Connolly Sallie Baliunas Johan Berglund C.J.Butler Rodolfo Gustavo Cionco Ana G.Elias valery M.Fedorov Hermann Harde Gregory W.Henry Douglas v.Hoyt Ole Humlum David R.Legates Nicola Scafetta Jan-Erik Solheim LászlóSzarka víctor M.velasco Herrera Hong Yan Weijia Zhang Center for Environmental Research and Earth Science(CERES) SalemMA 01970USA Independent scientists DublinIreland Institute of Earth Physics and Space Science(EPSS) SopronHungary Retired formerly Harvard-Smithsonian Center for AstrophysicsCambridgeMA 02138USA Independent researcher MalmöSweden Retired formerly Armagh ObservatoryCollege HillArmagh BT619DGNorthern IrelandUK Comisión de Investigaciones Científicas de la Provincia de Buenos Aires Argentina Grupo de Estudios Ambientales Universidad Tecnológica NacionalColón 332San Nicolás(2900)Buenos AiresArgentina Laboratorio de Ionosfera Atmosfera Neutra y Magnetosfera(LIANM)Facultad de Ciencias Exactas y TecnologíaUniversidad Nacional de TucumánAv.Independencia 18004000 TucumánArgentina Instituto de Física del Noroeste Argentino(Consejo Nacional de Investigaciones Científicas y Técnicas—Universidad Nacional de Tucumán) 4000 TucumánArgentina Faculty of Geography Lomonosov Moscow State UniversityLeninskie Gory St.1Moscow 119991Russia Helmut-Schmidt-University HamburgGermany Center of Excellence in Information Systems Tennessee State UniversityNashvilleTN 37209 USA Independent scientist Berkeley SpringsWVUSA Emeritus Professor in Physical Geography Department of GeosciencesUniversity of OsloNorway Professor Emeritus College of EarthOceanand the EnvironmentUniversity of DelawareNewark DE 19716-2541USA Department of Earth Sciences Environment and GeoresourcesUniversity of Naples Federico IIComplesso Universitario di Monte S.Angelovia Cinthia21I-80126 NaplesItaly Retired formerly Department of Physics and TechnologyUiT The Arctic University of Norway9037 TromsøNorway Instituto de Geofisica Universidad Nacional Autónoma de MéxicoCiudad UniversitariaCoyoacán04510México D.F.México State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Department of Mathematics and Physics Shaoxing UniversityShaoxing 312000China

Since 2007,the Intergovernmental Panel on Climate Change(IPCC)has heavily relied on the comparison between global climate model hindcasts and global surface temperature(ST)estimates for concluding that post-1950s global warming is mostly *** Connolly et al.,we cautioned that this approach to the detection and attribution of climate change was highly dependent on the choice of Total Solar Irradiance(TSI)and ST data *** compiled 16 TSI and five ST data sets and found by altering the choice of TSI or ST,one could(prematurely)conclude anything from the warming being“mostly human-caused”to“mostly natural.”Richardson and Benestad suggested our analysis was“erroneous”and“flawed”because we did not use a multilinear *** argued that applying a multilinear regression to one of the five ST series re-affirmed the IPCC's attribution *** also objected that many of the published TSI data sets were ***,here we show that when applying multilinear regression analysis to an expanded and updated data set of 27 TSI series,the original conclusions of Connolly et *** confirmed for all five ST data ***,it is still unclear whether the observed warming is mostly human-caused,mostly natural or some combination of both.

关键词： Sun:activity (Sun:)solar-terrestrial relations Earth

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ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasis

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Genes & Diseases 2021年第4期8卷 493-508页

作者： valery Adorno-Cruz Andrew D.Hoffmann Xia Liu Nurmaa K.Dashzeveg Rokana Taftaf Brian Wray Ruth A.Keri Huiping Liu Department of Pharmacology Case Western Reserve UniversityClevelandOH 11318USA Department of Pharmacology Northwestern University Feinberg School of MedicineChicagoIL 60611USA University of Kentucky College of MedicineLexingtonKY 40536USA Bioinformatic Core Northwestern University Feinberg School of MedicineChicagoIL 60611USA Department of Genetics and Genome Sciences The Division of General Medical Sciences-OncologyCase Western Reserve UniversityClevelandOH 11318USA Department of Medicine The Division of Hematology and OncologyNorthwestern University Feinberg School of MedicineChicagoIL 60611USA Lurie Comprehensive Cancer Center Northwestern University Feinberg School of MedicineChicagoIL 60611USA Department of Pathology and Case Comprehensive Cancer Center Case Western Reserve UniversityClevelandOH 11318USA

Cancer metastasis is largely incurable and accounts for 90%of breast cancer deaths,especially for the aggressive basal-like or triple negative breast cancer(TNBC).Combining patient database analyses and functional studies,we examined the association of integrin family members with clinical outcomes as well as their connection with previously identified microRNA regulators of metastasis,such as miR-206 that inhibits stemness and metastasis of *** we report that the integrin receptor CD49b-encoding ITGA2,a direct target of miR-206,promotes breast cancer stemness and ***2 knockdown sup-pressed self-renewal related mammosphere formation and pluripotency marker expression,in-hibited cell cycling,compromised migration and invasion,and therefore decreased lung metastasis of breast ***2 overexpression reversed miR-206-caused cell cycle arrest in *** sequencing analyses revealed that ITGA2 knockdown inhibits genes related to cell cycle regulation and lipid metabolism,including CCND1 and ACLY as representative targets,*** of CCND1 or ACLY inhibits mammosphere formation of breast cancer *** of CCND1 rescues the phenotype of ITGA2 knockdown-induced cell cycle ***-encoded ATP citrate lyase is essential to maintain cellular acetyl-CoA ***1 knockdown further mimics 1TGA2 knodkdown in abolishing lung colonization of breast cancer *** identified that the low levels of miR-206 as well as high expression levels of 1TGA2,ACLY and CCND1 are associated with an unf avor able relapse-free survival of the pa-tients with estrogen receptor-negative or high grade breast cancer,especially basal-like or TNBC,possibly serving as potential biomarkers of cancer stemness and thera peutic targets of breast cancer metastasis.

关键词： ACLY Breast cancer CCND1 CD49b Integrins ITGA2 Metastasis Stemness

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A special issue on Biophotonics in Europe

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Frontiers of Optoelectronics 2017年第3期10卷 203-210页

作者： valery v. TUCHIN Ekaterina BORISOvA Malgorzata JEDRZEJEWSKA-SZCZERSKA Martin J. LEAHY Francesco S. PAvONE Jurgen POPP Jose POZO Research-Educational Institute of Optics and Biophotonics Samtov State University (National Research University of Russia) 410012 Saratov Russia Interdisciplinary Laboratory of Biophotonics Tomsk State University (National Research University of Russia) 634050 Tomsk Russia Laboratory of-Laser Diagnostics of Technical and Living Systems Instituteof Precision Mechanics and Control of RAS 410028 Saratov Russia 4 Institute of Electronics Bulgarian Academy of Sciences Sofia Bulgaria Institute of Electronics Bulgarian Academy of Sciences Sofia Bulgaria Faculty of Electronics Telecommunicationand Informatics Gdafisk University of Technology Poland National Biophotonics and Imaging Platform Ireland Chair of Applied Physics School of Physics National University of Ireland Galway Ireland European Laboratory for Non Linear Spectroscopy (LENS) and University of Florence Sesto Fiorentino Italy Leibniz Institute of Photonic Tectmology Jena Institute of Physical chemistry & AbbeCenter of Photonics Friedrich Schiller University Jena Germany Technology and Innovation EPIC - European Photonics Industry Consortium Netherlands

Biophotonics is an emerging multidisciplinary research area, embracing all light-based technologies applied to the life sciences and medicine [1-6]. The expression itself is the combination of the Greek syllables ＂bios＂ standing for life and ＂phos＂ standing for light. Photonics is the technical term for all methodologies and technologies utilizing photons over the whole spectrum from X-ray over the ultraviolet, visible and the infrared to the terahertz region, and its interaction with any matter. Beyond this definition, biophotonics is a scientific discipline of remarkable societal importance. As a part of photonics, it has proved to be an important enabling technology for accelerated progress in medicine and biotechnology. It can do so, because it originated at the interface of the most innovative academic disciplines of the last century, i.e., photonics, biotechnology and nanotechnologies. This field of research brings together scientists from different professions, such as physicists, biologists, pharmacists, medical doctors, etc. To work on common projects, they need to understand the ideas and the techniques of their counterparts.

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先进光学流式细胞测量术

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国外科技新书评介 2011年第10期 16-17页

作者： valery v．Tuchin 聂树真不详中国科学院光电研究院

流式细胞术从上世纪60年代发展至今，已经成为现代科学研究和临床实验中不可或缺的工具。流式细胞术（Flow Cytometry，FCM）是一种在功能水平上对单细胞或其他生物粒子进行定量分析和分选的检测手段，它可以高速分析上万个细胞，并能... 详细信息

流式细胞术从上世纪60年代发展至今，已经成为现代科学研究和临床实验中不可或缺的工具。流式细胞术（Flow Cytometry，FCM）是一种在功能水平上对单细胞或其他生物粒子进行定量分析和分选的检测手段，它可以高速分析上万个细胞，并能同时从一个细胞中测得多个参数，与传统的荧光镜检测相比，具有速度快、精度高、准确性好等优点，成为当代最先进的细胞定量分析技术。

关键词：细胞测量定量分析技术流式细胞术光学临床实验科学研究生物粒子单细胞

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3-Phenyl/Pyridinyl Derivatives of <i>Trans</i>-2-(aryl/heteryl)vinyl-3<i>H</i>-quinazolin-4-ones: Synthesis and Fluorescent Properties

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International Journal of Organic Chemistry 2012年第1期2卷 56-63页

作者： Emiliya v. Nosova Tatyana v. Stupina Galina N. Lipunova Marina S. valova Pavel A. Slepukhin valery N. Charushin Department of Organic Chemistry Chemical Technology Institute Urals Federal University Ekaterinburg Russia Postovsky Institute of Organic Synthesis Ural Branch of the Russian Academy of Sciences Ekaterinburg Russia

Novel 3-phenyl/pyridinyl-trans-2-(aryl/heteryl)vinyl-3H-quinazolin-4-ones 3a,b, 4a, 5a, 7a and their 6,7-difluoro de- rivatives 3c,d, 4b, 5b, 7b have been obtained by condensation of the correspondent 2-methylquinazolin-4-ones 1, 6 with aromatic (heterocyclic) aldehydes in the presence of ZnCl2 (AcONa) or by the reaction of 2-methyl-3,1-benzoxazin-4- ones 2 with the Shiff bases. Effects of aryl(heteryl) substituents on photophysical properties of (aryl/heteryl) quinazolinylethenes have been studied.

关键词： Styryl Benzazines Fluorinated Quinazolin-4-Ones Uv and FL Spectra X-Ray Trans-cis-Isomerisation 2-Methylquinazolinones 2-Methyl-3 1-benzoxazinones

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Clinical outcomes in patients with native valve infective endocarditis and diabetes mellitus

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World Journal of Cardiology 2021年第1期13卷 11-20页

作者： Temidayo Abe Harry Onoriode Eyituoyo Gabrielle De Allie Titilope Olanipekun valery Sammah Effoe Kikelomo Olaosebikan Paul Mather Department of Internal Medicine Morehouse School of MedicineAtlantaGA 30310United States Department of Internal Medicine Mercer University School of MedicineMaconGA 31207United States Department of Cardiovascular Disease Morehouse School of MedicineAtlantaGA 30310United States Department of Medicine University of Debrecen Medical and Health Science CenterDebrecen 4032Hungary Department of Cardiovascular Disease University of PennsylvaniaPennsylvaniaPA 19104United States

BACKGROUND There is a lack of data on the clinical outcomes in patients with native valve infective endocarditis(NvIE)and diabetes mellitus(DM).AIM To investigate(1)trends in the prevalence of DM among patients with NvIE;and(2)the impact of DM on NvIE *** We identified 76385 with NvIE from the 2004 to 2014 National Inpatient Sample,of which 22284(28%)had *** assessed trends in DM from 2004 to 2014 using the Cochrane Armitage *** compared baseline comorbidities,microorganisms,and in-patients procedures between those with vs without *** match analysis and multivariate logistic regression were used to investigate study outcomes in in-hospital mortality,stroke,acute heart failure,cardiogenic shock,septic shock,and atrioventricular *** Crude rates of DM increased from in 22%in 2004 to 30%in *** were significant differences in demographics,comorbidities and NvIE risk factors between the two *** aureus was the most common organism identified with higher rates in patients with DM(33.1%vs 35.6%;Pvs 11.9%;Pvs 3.0%;Pvs 6.5%;P=0.001),cardiogenic shock(1.5%vs 1.9%;Pvs 9.6%;Pventricular block(1.5%vs 2.4%;PvIE patients with DM include hemodialysis,congestive heart failure,atrial fibrillation,staphylococcus aureus,and older *** There is an increasing prevalence of DM in NvIE and it is associated with poorer *** studies are crucial to identify the clinical,and sociodemographic contributors to this trend and develop strategies to mitigate its attendant risk.

关键词： Infective endocarditis Native valve infective endocarditis Diabetes mellitus valvular heart disease Cardiovascular disease National Inpatient Sample

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Stability of heterogeneous single-atom catalysts:a scaling law mapping thermodynamics to kinetics

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npj Computational Materials 2020年第1期6卷 460-466页

作者： Ya-Qiong Su Long Zhang Yifan Wang Jin-Xun Liu valery Muravev Konstantinos Alexopoulos Ivo A.W.Filot Dionisios G.vlachos Emiel J.M.Hensen Laboratory of Inorganic Materials and Catalysis Department of Chemical Engineering and ChemistryEindhoven University of TechnologyP.O.Box 5135600 MB EindhovenThe Netherlands Department of Chemical and Biomolecular Engineering The Delaware Energy InstituteUniversity of Delaware221 Academy St.NewarkDE 19716USA Department of Chemical Engineering University of MichiganAnn ArborMI 48109-2136USA

Heterogeneous single-atom catalysts(SACs)hold the promise of combining high catalytic performance with maximum utilization of often precious *** extend the current thermodynamic view of SAC stability in terms of the binding energy(E_(bind))of singlemetal atoms on a support to a kinetic(transport)one by considering the activation barrier for metal atom diffusion.A rapid computational screening approach allows predicting diffusion barriers for metal-support pairs based on Ebind of a metal atom to the support and the cohesive energy of the bulk metal(E_(c)).

关键词： kinetics thermodynamics scaling

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Numerical Modeling of the Initial Formation of Cyclonic vortices at Tropical Latitudes

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Atmospheric and Climate Sciences 2014年第5期4卷 899-906页

作者： Igor v. Mingalev Natalia M. Astafieva Konstantin G. Orlov victor S. Mingalev Oleg v. Mingalev valery M. Chechetkin Polar Geophysical Institute Kola Scientific Center of the Russian Academy of Sciences Apatity Russia Space Research Institute of the Russian Academy of Sciences Moscow Russia Keldysh Institute of Applied Mathematics of the Russian Academy of Sciences Moscow Russia

To investigate the initial formation of large-scale vortices at tropical latitudes a regional non-hydrostatic mathematical model of the wind system of the lower atmosphere, developed earlier in the Polar Geophysical Institute, is utilized. Three-dimensional distributions of the atmospheric parameters in the height range from 0 to 15 km over a limited region of the Earth’s surface are produced by the utilized model. Simulations are performed for the case when the limited three-dimensional simulation domain is intersected by an intertropical convergence zone in the west-east direction. Simulation results indicated that the origin of two convexities in the north direction in the configuration of the intertropical convergence zone can lead to the formation of three distinct tropical cyclones during the period of about four days.

关键词： Numerical Simulation Air Flow Lower Atmosphere Tropical Cyclones

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Numerical Study of the Dynamic, Thermodynamic and Microstructural Parameters of Convective Clouds

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Natural Science 2018年第2期10卷 63-69页

作者： vitaly A. Shapovalov Alexander v. Shapovalov Boris P. Koloskov Ruslan Kh. Kalov valery N. Stasenko Department of Cloud Physics High-Mountain Geophysical Institute Nalchik Russia Autonomous Nonprofit Organization “Agency of Atmospheric Technologies” Moscow Russia State research center on Space Hydrometeorology PLANETA Moscow Russia

On the basis of a three-dimensional non stationary model of a convective cloud with detailed description of dynamic, thermodynamic and microphysical processes, numerical experiments were conducted to study the formation of parameters of convective clouds under unstable stratification of the atmosphere. Numerical experiments have been carried out to study the formation of convective processes in the atmosphere. The thermo hydrodynamic parameters in the zone of a thunderstorm cloud are determined, and regions with a vortex motion of air are identified. The main flows feeding the convective cloud in the mature stage are determined. Due to the means of visualization, the areas of formation and growth of precipitation particles are identified. In a three-dimensional form, the interaction of dynamic and thermodynamic processes is analyzed. The interaction of fields is manifested in the form of deformation of fields of thermodynamic parameters under the influence of dynamic processes. Trajectories of air streams around a cloud and the trajectories of drops in a cloud are determined. The results of numerical experiments confirm that dynamic processes significantly influence the formation of fields of thermodynamic parameters in the cloud, which also determine the course of microphysical processes and the nature of the growth of precipitation particles.

关键词： Numerical 3D Modeling Convective Processes in the Atmosphere Thermodynamic Parameters Microstructural Parameters velocity Field of Air Flow Particles Trajectories

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