Clinical outcomes in patients with native valve infective endocarditis and diabetes mellitus

作     者：Temidayo Abe Harry Onoriode Eyituoyo Gabrielle De Allie Titilope Olanipekun Valery Sammah Effoe Kikelomo Olaosebikan Paul Mather 

作者机构：Department of Internal MedicineMorehouse School of MedicineAtlantaGA 30310United States Department of Internal MedicineMercer University School of MedicineMaconGA 31207United States Department of Cardiovascular DiseaseMorehouse School of MedicineAtlantaGA 30310United States Department of MedicineUniversity of Debrecen Medical and Health Science CenterDebrecen 4032Hungary Department of Cardiovascular DiseaseUniversity of PennsylvaniaPennsylvaniaPA 19104United States 

出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)

年 卷 期：2021年第13卷第1期

页      面：11-20页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Infective endocarditis Native valve infective endocarditis Diabetes mellitus Valvular heart disease Cardiovascular disease National Inpatient Sample 

摘      要：BACKGROUND There is a lack of data on the clinical outcomes in patients with native valve infective endocarditis(NVIE)and diabetes mellitus(DM).AIM To investigate(1)trends in the prevalence of DM among patients with NVIE;and(2)the impact of DM on NVIE *** We identified 76385 with NVIE from the 2004 to 2014 National Inpatient Sample,of which 22284(28%)had *** assessed trends in DM from 2004 to 2014 using the Cochrane Armitage *** compared baseline comorbidities,microorganisms,and in-patients procedures between those with vs without *** match analysis and multivariate logistic regression were used to investigate study outcomes in in-hospital mortality,stroke,acute heart failure,cardiogenic shock,septic shock,and atrioventricular *** Crude rates of DM increased from in 22%in 2004 to 30%in *** were significant differences in demographics,comorbidities and NVIE risk factors between the two *** aureus was the most common organism identified with higher rates in patients with DM(33.1%vs 35.6%;P0.0001).After propensity matching,in-hospital mortality(11.1%vs 11.9%;P0.0001),stroke(2.3%vs 3.0%;P0.0001),acute heart failure(4.6%vs 6.5%;P=0.001),cardiogenic shock(1.5%vs 1.9%;P0.0001),septic shock(7.2%vs 9.6%;P0.0001),and atrioventricular block(1.5%vs 2.4%;P0.0001),were significantly higher in patients with *** predictors of mortality in NVIE patients with DM include hemodialysis,congestive heart failure,atrial fibrillation,staphylococcus aureus,and older *** There is an increasing prevalence of DM in NVIE and it is associated with poorer *** studies are crucial to identify the clinical,and sociodemographic contributors to this trend and develop strategies to mitigate its attendant risk.