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Long-term durable response to lenalidomide in a patient with hepatic epithelioid hemangioendothelioma

World Journal of Gastroenterology 2014年第22期20卷 7049-7054页

作者： Maria Caterina Pallotti Margherita Nannini Claudio Agostinelli Simona Leoni valerio di scioscio Anna Mandrioli Cristian Lolli Maristella Saponara Stefano Pileri Luigi Bolondi Guido Biasco Maria Abbondanza Pantaleo Department of Specialized Experimentaland Diagnostic MedicineS. Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Hematopathology Section Department of ExperimentalDiagnosticand Specialty MedicineS. Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly division of Internal Medicine Department of Digestive Disease and Internal MedicineS. Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Department of Radiology S. Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly InterdepartmentalCentre for Cancer Research "G. Prodi" University of Bologna40138 BolognaItaly

Epithelioid hemangioendothelioma(EH)is a rare tumor arising from the vascular endothelial cells of soft tissue or visceral *** most common visceral site is the liver,where it is often involved in a multifocal man-ner known as hepatic EH(HEH).Surgical resection with curative intent represents the gold standard *** surgery is not feasible,or in cases of metastatic disease,no standard medical treatment is currently *** small series,drugs with anti-angiogenic activity(such as bevacizumab,sorafenib,thalidomide,and lenalidomide)have been proposed with promising *** describe a 73-year-old man with multifocal non-resectable HEH treated with *** status was evaluated by abdominal ultrasound and magnetic resonance every four *** patient was treated for a total of 39 mo with prolonged disease stabilization and,at the time of writing,is still under treatment with a good tolerance *** a short period of treatment discontinuation,the disease showed slight progression that immediately resolved after the reintroduction of *** may represent a valid treatment option for HEH due to its anti-angiogenic and antineoplastic *** preliminary result merits further study in a large series.

关键词： Hepatic epithelioid hemangioendothelioma Liver Lenalidomide Magnetic resonance Abdominal ultrasound

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