Long-term durable response to lenalidomide in a patient with hepatic epithelioid hemangioendothelioma

作     者：Maria Caterina Pallotti Margherita Nannini Claudio Agostinelli Simona Leoni Valerio Di Scioscio Anna Mandrioli Cristian Lolli Maristella Saponara Stefano Pileri Luigi Bolondi Guido Biasco Maria Abbondanza Pantaleo 

作者机构：Department of SpecializedExperimentaland Diagnostic MedicineS. Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Hematopathology SectionDepartment of ExperimentalDiagnosticand Specialty MedicineS. Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Division of Internal MedicineDepartment of Digestive Disease and Internal MedicineS. Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Department of RadiologyS. Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly InterdepartmentalCentre for Cancer Research "G. Prodi"University of Bologna40138 BolognaItaly 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第22期

页      面：7049-7054页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Hepatic epithelioid hemangioendothelioma Liver Lenalidomide Magnetic resonance Abdominal ultrasound 

摘      要：Epithelioid hemangioendothelioma(EH)is a rare tumor arising from the vascular endothelial cells of soft tissue or visceral *** most common visceral site is the liver,where it is often involved in a multifocal man-ner known as hepatic EH(HEH).Surgical resection with curative intent represents the gold standard *** surgery is not feasible,or in cases of metastatic disease,no standard medical treatment is currently *** small series,drugs with anti-angiogenic activity(such as bevacizumab,sorafenib,thalidomide,and lenalidomide)have been proposed with promising *** describe a 73-year-old man with multifocal non-resectable HEH treated with *** status was evaluated by abdominal ultrasound and magnetic resonance every four *** patient was treated for a total of 39 mo with prolonged disease stabilization and,at the time of writing,is still under treatment with a good tolerance *** a short period of treatment discontinuation,the disease showed slight progression that immediately resolved after the reintroduction of *** may represent a valid treatment option for HEH due to its anti-angiogenic and antineoplastic *** preliminary result merits further study in a large series.