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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

Assessment of Potential Nutrient Release from Phosphate Rock and Dolostone for Application in Acid Soils

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Pedosphere 2018年第1期28卷 44-58页

作者： Rogério Borguete Alves RAFAEL María Luisa FERNáNDEZ-MARCOS Stefania cocco Maria Letizia RUELLO David C.WEINDORF valeria CARDELLI Giuseppe CORTI Department of Rural Engineering University Eduardo Mondlane Department of Agriculture Food and Environmental Sciences Università Politecnica delle Marche Department of Soil Science and Agricultural Chemistry Universidad de Santiago de Compostela Department of Materials Environmental Sciences and Urban Planning Università Politecnica delle Marche Department of Plant and Soil Science Texas Tech University

Finding alternative local sources of plant nutrients is a practical, low-cost, and long-term strategy. In this study, laboratory column experiments were conducted in a completely randomized design to evaluate the feasibility of using phosphate rock and dolostone as fertilizers or acid-neutralizing agents for application in tropical acid soils. The dissolution rates of different particle-size fractions(0.063–0.25, 0.25–0.5, and 0.5–2 mm) of both rocks were studied by citric acid solution at p H 4 and 2 and water, with extraction times of 1, 3, 5, 7, 12, 24, 72, 144, 240, and 360 h. The results showed that the dissolution of both rocks depended on the particle size,leaching solution, and extraction time. The dissolution rate of rock-forming minerals increased as the specific surface area increased,corresponding to a decrease in particle size. In all cases, the release kinetics was characterized by two phases: 1) a first stage of rapid release that lasted 24 h and would ensure short-term nutrient release, and 2) a second stage of slow release after 24 h, representing the long-term nutrient release efficiency. Both rocks were suitable as slow-release fertilizers in strongly acid soils and would ensure the replenishment of P, Ca, and Mg. A combination of fine and medium particle-size fractions should be used to ensure high nutrient-release efficiency. Much work could remain to determine the overall impact of considerable amounts of fresh rocks in soils.

关键词： citric acid dissolution rate leaching solution particle-size fraction release kinetics slow-release fertilizer

Thermal survival limits of young and mature larvae of a cold stenothermal chironomid from the Alps （Diamesinae： Pseudodiamesa branickii [Nowicki, 1873]）

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Insect Science 2017年第2期24卷 314-324页

作者： valeria Lencioni Paola Bernabo Section of Invertebrate Zoology and Hydrobiology MUSE-Museo delle Scienze Corso del Lavoro e della Scienza 3 38123 Trento Italy

The threats posed by climate change make it important to expand knowl- edge concerning cold and heat tolerance in stenothermal species from habitats potentially threatened by temperature changes. Thermal limits and basal metabolism variations were investigated in Pseudodiamesa branickii （Diptera： Chironomidae） under thermal stress between -20 and 37 ℃. Supercooling point （SCP）, lower （LLTs） and upper lethal temper- atures （ULTs）, and oxygen consumption rate were measured in overwintering young （lst and 2nd instar） and mature （3rd and 4th instar） larvae from an Alpine glacier-fed stream. Both young and mature larvae were freezing tolerant （SCPs = -7.1 ℃ and -6.4 ℃, re- spectively; LLT100 〈SCP and 〉 -20 ℃） and thermotolerant （ULTso = 31.7 ± 0.4, 32.5± 0.3, respectively）. However, ontogenetic differences in acute tolerance were observed. The LLT50 calculated for the young larvae （=-7.4 ℃） was almost equal to their SCP （= -7.1 ℃） and the overlapping of the proportion of mortality curve with the CPIF curve highlighted that the young larvae are borderline between freezing tolerance and freezing avoidance. Furthermore, a lower ULT100 in the young larvae （of ca. 1 ℃）, suggests that they are less thermotolerant than mature larvae. Finally, young larvae exhibit a higher oxygen consumption rate （mgO2/gAFDM/h） at any temperature tested and are overall less resistant to oxygen depletion compared to mature larvae at ≥ 10 ℃. These findings sug- gest that mature larvae enter into a dormant state by lowering their basal metabolism until environmental conditions improve in order to save energy for life cycle completion during stressful conditions.

关键词： basal metabolism glacier-fed streams larval development supercooling point thermotolerance

The intricate debate on neurodegeneration and neuroinflammation in Parkinson’s disease:which came first?

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Neural Regeneration Research 2023年第1期18卷 125-126页

作者： Antonella Cardinale valeria Calabrese Experimental Neurophysiology Laboratory IRCCS San Raffaele RomaRomeItaly Department of Medicine Universitàdegli Studi di PerugiaPerugiaItaly

Parkinson’s disease(PD)is a heterogeneous multifactorial disorder and,during the last years,new scientific evidence has supported this *** principal hallmarks of PD are the loss of dopaminergic neurons in the substan... 详细信息

关键词： inflammation aggregation debate

Soil bacterial communities under slash and burn in Mozambique as revealed by a metataxonomic approach

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Pedosphere 2023年第3期33卷 508-520页

作者： Dominique SERRANI Ilario FERROCINO Cristiana GAROFALO Andrea OSIMANI Maria Rita CORVAGLIA Vesna MILANOVIĆ Lucia AQUILANTI Stefania cocco valeria CARDELLI Rogério Borguete Alves RAFAEL Elena FRANCIOSI Kieran TUOHY Francesca CLEMENTI Giuseppe CORTI Department of Agriculture Food and Environmental SciencesPolytechnic University of MarcheAncona 60131(Italy) Department of Agriculture Forest and Food SciencesUniversity of TurinGrugliasco 10095(Italy) Department of Rural Engineering Faculty of Agronomy and Forestry EngineeringUniversidade Eduardo MondlaneMaputo 257(Mozambique) Research and Innovation Center Fondazione Edmund Mach(FEM)San Michele all'Adige 38010(Italy)

The slash-and-burn system is a subsistence agronomical practice widespread in tropical areas *** system has been extensively studied,especially for its impacts on agronomical aspects and soil physicochemical properties;however,knowledge of soil microbial diversity under slash and bum is *** this study,for the first time,soil bacterial diversity of three locations from Central Mozambique,where slash and burn has been practiced for different durations of the forest fallow period(ca.25,35,and 50 years),was elucidated through a metataxonomic *** communities were evaluated in the genetic horizons of soils under charcoal kilns,crop fields,and *** aim of this study was to examine the influence of spatial(location and land use),temporal(forest fallow period),and vertical(horizon)variations on bacterial community structure in relation to soil physicochemical *** analysis detected 25 different phyla whose distribution varied horizontally and vertically in relation to soil properties(i.e.,p H,easily oxidizable organic carbon,total nitrogen,and available phosphorus),as well as particle size distribution and mineralogical *** properties were strongly affected and altered by land-use management;in particular,charcoal kilns exhibited better soil properties and greater differences in bacterial community than crop fields and forests,which were quite *** might suggest the inability of a forest fallow period shorter than 50 years to improve soil fertility and induce changes in bacterial *** uncommon application of the pedological approach for microbial evaluation facilitated the detection of a clear separation in bacterial composition along the soil profile,with eutrophic bacteria mainly located in the A horizon whereas oligotrophic bacteria were found in the Bo *** horizontal and vertical heterogeneities in the same study represent a novelty for bacterial metataxonomic analysis.

关键词： 16S rRNA gene agroforestry land use soil microbiota soil physicochemical property

The interplay of drug therapeutics and immune responses to SARS-CoV-2

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Cellular & Molecular Immunology 2024年第2期21卷 197-200页

作者： valeria Fumagalli Matteo Iannacone Division of Immunology Transplantationand Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly Experimental Imaging Centre IRCCS San Raffaele Scientific InstituteMilanItaly

The SARS-CoV-2 pandemic has necessitated rapid therapeutic and preventative *** vaccines form the frontline of defense,antiviral treatments such as nirmatrelvir have emerged as vital adjunctive measures,particularly for those unable or unwilling to be *** review delves into the potential influence of nirmatrelvir on enduring *** parallel,the potential of drug repurposing is explored,with bisphosphonates being examined for their possible effects against COVID-19 due to their immunomodulatory *** importance of rigorous clinical trials and careful interpretation of preliminary data is emphasized.

关键词： SARS-CoV-2 Nirmatrelvir Bisphosphonates Adaptive immunity Drug repurposing

Expanding through the Emerald Isle:exploration and spatial orientation of non-native bank voles in Ireland

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Current Zoology 2024年第3期70卷 320-331页

作者： valeria Mazza Jana A.Eccard Animal Ecology Institute for Biochemistry and BiologyUniversity of PotsdamMaulbeerallee 114469PotsdamGermany and Department of Ecological and Biological Sciences University of TusciaLargo dell'Università10100 ViterboItaly

Whether introduced into a completely novel habitat or slowly expanding their current range,the degree to which animals can effciently explore and navigate new environments can be key to survival,ultimately determining population establishment and colonization *** tested whether spatial orientation and exploratory behavior are associated with non-native spread in free-living bank voles(Myodes glareolus,N=43)from a population accidentally introduced to Ireland a century *** measured spatial orientation and navigation in a radial arm maze,and behaviors associated to exploratory tendencies and risk-taking in repeated open-feld tests,at the expansion edge and in the source *** voles at the expansion edge re-visited unrewarded arms of the maze more,waited longer before leaving it,took longer to start exploring both the radial arm maze and the open feld,and were more risk-averse compared to conspecifcs in the source *** together,results suggest that for this small mammal under heavy predation pressure,a careful and thorough exploration strategy might be favored when expanding into novel environments.

关键词： animal personality biological invasions exploration behavior Myodes glareolus range expansion spatial orientation.

Probiotics, prebiotics and their role in Alzheimer's disease

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Neural Regeneration Research 2021年第9期16卷 1768-1769页

作者： valeria D’Argenio Daniela Sarnataro Department of Human Sciences and Quality of Life Promotion San Raffaele Open UniversityRomaItaly CEINGE-Biotecnologie Avanzate NaplesItaly Department of Molecular Medicine and Medical Biotechnologies University of Naples Federico IINaplesItaly

Accumulation of amyloid and dysfunctional tau proteins in the brain, along with the development of dementia, characterizes Alzheimer 's disease(AD). Although the cause of AD is currently unknown, it has been shown that the onset of the disease, with amyloid-beta peptide(Aβ) accumulation, occurs 10–20 years before the development of the clinical signs.

关键词： Alzheimer tau Aβ

Activation of β2 adrenergic receptors promotes adult hippocampal neurogenesis

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Neural Regeneration Research 2020年第12期15卷 2258-2259页

作者： valeria Bortolotto Mariagrazia Grilli Laboratory of Neuroplasticity Department of Pharmaceutical SciencesUniversity of Piemonte OrientaleNovaraItaly

The subgranular zone (SGZ) of the hippocampal dentate gyrus is one of the few central nervous system regions where generation of adult born neurons occurs *** process,referred to as adult hippocampal neurogenesis (ahN... 详细信息

关键词： progenitor adult adrenergic