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Neural Regeneration Research 2020年第4期15卷 759-768页

作者： valentina Onesto Angelo Accardo Christophe Vieu Francesco Gentile Center for Advanced Biomaterials for Healthcare Italian Institute of TechnologyNaplesItaly Laboratoire d’Analyse et d’Architecture des Systemes(LAAS) Centre National de la Recherche ScientifiqueUniversite de ToulouseCNRSToulouseFrance Institut National des Sciences Appliquees–INSA ToulouseFrance Department of Electric Engineering and Information Technology University Federico IINaplesItaly Department of Precision and Microsystems Engineering Delft University of TechnologyMekelweg 22628 CD DelftThe Netherlands

Understanding the mechanisms underlying cell-surface interaction is of fundamental importance for the rational design of scaffolds aiming at tissue engineering,tissue repair and neural regeneration ***,we examined patterns of neuroblastoma cells cultured in three-dimensional polymeric scaffolds obtained by two-photon *** of the intrinsic resolution of the technique,the micrometric cylinders composing the scaffold have a lateral step size of^200 nm,a surface roughness of around 20 nm,and large values of fractal dimension approaching *** found that cells in the scaffold assemble into separate groups with many elements per *** cell wiring,we found that resulting networks exhibit high clustering,small path lengths,and small-world *** values of the topological characteristics of the network can potentially enhance the quality,quantity and density of information transported in the network compared to equivalent random graphs of the same *** is one of the first direct observations of cells developing into 3D small-world networks in an artificial matrix.

关键词： 3D networks biomaterials nano-topography network topology neuro-regeneration small-world networks tissue engineering two-photon lithography

Non-exposed endoscopic wall-inversion surgery with one-step nucleic acid amplification for early gastrointestinal tumors:Personal experience and literature review

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World Journal of Gastroenterology 2023年第24期29卷 3883-3898页

作者： Francesco Crafa Serafino Vanella Aristide Morante Onofrio A Catalano Kelsey L Pomykala Mario Baiamonte Maria Godas Alexandra Antunes Joaquim Costa Pereira valentina Giaccaglia Division of General and Surgical Oncology St.Giuseppe Moscati HospitalCenter of National Excellence and High SpecialtyAvellino 83100Italy Division of Gastorenterology and Endoscopy St.Giuseppe Moscati HospitalCenter of National Excellence and High SpecialtyAvellino 83100Italy Department of Radiology Athinoula A Martinos Center for Biomedical ImagingMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Department of Nuclear Medicine Department of Radiological SciencesUniversity Hospital EssenUniversity of Duisburg-EssenEssen 45141Germany Department of General Surgery Braga HospitalBraga 4710-243Portugal Department of Surgery Medclinic City HospitalDubai 505004United Arab Emirates

BACKGROUND Laparoscopic and endoscopic cooperative surgery is a safe,organ-sparing surgery that achieves full-thickness resection with adequate *** studies have demonstrated the safety and efficacy of these ***,these techniques are limited by the exposure of the tumor and mucosa to the peritoneal cavity,which could lead to viable cancer cell seeding and the spillage of gastric juice or enteric liquids into the peritoneal ***-exposed endoscopic wallinversion surgery(NEWS)is highly accurate in determining the resection margins to prevent intraperitoneal contamination because the tumor is inverted into the visceral lumen instead of the peritoneal *** intraoperative assessment of the nodal status could allow stratification of the extent of ***-step nucleic acid amplification(OSNA)can provide a rapid method of evaluating nodal tissue,whilst nearinfrared laparoscopy together with indocyanine green can identify relevant nodal tissue *** To determine the safety and feasibility of NEWS in early gastric and colon cancers and of adding rapid intraoperative lymph node(LN)assessment with *** The patient-based experiential portion of our investigations was conducted at the General and Oncological Surgery Unit of the *** Moscati Hospital(Avellino,Italy).Patients with early-stage gastric or colon cancer(diagnosed via endoscopy,endoscopic ultrasound,and computed tomography)were *** lesions were treated by NEWS procedure with intraoperative OSNA assay between January 2022 and October *** were examined intraoperatively with OSNA and postoperatively with conventional *** analyzed patient demographics,lesion features,histopathological diagnoses,R0 resection(negative margins)status,adverse events,and follow-up *** were collected prospectively and analyzed *** A total of 10 patients(5 males and 5 females)with an average age of 70.4±4.5 years(range:62

关键词： Laparoscopic and endoscopic cooperative surgery Non-exposed endoscopic wall inversion surgery Early gastric cancer Early colorectal cancer Sentinel lymph node One-step nucleic acid amplification Endoscopic full-thickness resection

Spontaneous passage of common bile duct stones in jaundiced patients

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Hepatobiliary & Pancreatic Diseases International 2011年第2期10卷 209-213页

作者： valentina Lefemine Richard John Morgan Department of General Surgery Glan Clwyd Hospital

BACKGROUND:Common bile duct(CBD)stones are known to pass spontaneously in a significant number of patients. This study investigated the rate of spontaneous CBD stones passage in a series of patients presenting with jaundice due to *** patients were managed surgically,allowing CBD intervention to be avoided in the event of spontaneous passage of CBD stones. METHOD:Retrospective analysis of patients presenting with jaundice due to CBD stones,and managed surgically with laparoscopic cholecystectomy and intra-operative cholangiogram with or without CBD exploration. RESULTS:The jaundice settled pre-operatively in 76/108 patients, and in 60/108 the CBD stones had passed spontaneously by the time of *** 60 patients avoided any intervention to their CBD. CONCLUSIONS:CBD stones pass spontaneously in more than half of jaundiced *** management(laparoscopic cholecystectomy and intra-operative cholangiogram,with willingness to perform CBD exploration if positive)allows the avoidance of CBD intervention in these patients.

关键词： cholecystectomy cholangiogram common bile duct stones

Radioguided surgery with 68Ga-DOTATATE for patients with neuroendocrine tumors

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Hepatobiliary Surgery and Nutrition 2020年第1期9卷 67-69页

作者： valentina Ambrosini Stefano Fanti Nuclear Medicine DIMESUniversity of BolognaS.Orsola-Malpighi HospitalBolognaItaly

Targeted precision neuroendocrine neoplasms (NEN) surgery may represent an innovative, yet promising, development of surgical procedures to achieve a radical resection of the primary tumour (by intra-operative confirmation of tumour-free margins) and to improve the identification of small sized lesions (that might otherwise be missed by either pre-operative functional imaging, ultrasound or manual palpation during surgery). From a practical point of view, radioguided surgery (RGS) requires a close collaboration between the nuclear medicine and the surgical teams, so that a small amount of radiopharmaceutical is intravenously injected in the patient right before surgery. The tumour lesions’ emitted radiation is then detected by a hand-held probe by the surgeon intra-operatively.

关键词： surgery operative neoplasms

Seasonal Dynamics of Male and Female Reproductive Systems in the Siberian Salamander, Salamandrella keyserlingii (Caudata, Hynobiidae)

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Asian Herpetological Research 2015年第3期6卷 169-183页

作者： Vadim V.YARTSEV valentina N.KURANOVA Department of Vertebrate Zoology and Ecology Institute of BiologyTomsk State University

It is not well known how low temperatures, like a subarctic steppe–tundra climate, influence reproductive traits of ectothermic vertebrates. To begin answering this question, we studied male and female reproductive systems of Salamandrella keyserlingii inhabiting a Tomsk population（southeast of Western Siberia）, Russia, in ecological and physiological terms. In males, before spermiation, the testicular size and weight in late April–early May were greatest of all. Spermiation occurred during breeding immigration in spring when mean air temperature was above 10°С, and at the same time rain fell. After spermiation, the testicular size and weight decreased sharply, and the diameter of the vasa deferentia increased. ＂Spawning＂（i.e., simultaneous extrusion of sperm and oviposition） occurred from late April to late May, and this duration fluctuated in temperature and humidity. The testicular size and weight increased in summer. Sperm mass was detected in the testes by the smear method in April–September, except in June when single fragmented unrealized sperm was detected and in July when spermatids were detected. In females, ovarian weight was greatest in spring before ovulation. From late June, vitellogenesis began in ovarian follicles, in which mint green yolks accumulated. Melanin deposited in the surface of the ovary from July when oviducts were hypertrophying. In contrast, some large-sized females did not show any sexual maturity shortly before hibernation（although these females may be subadults）. These results suggest that low temperatures in Siberia induce early timing of gamete maturation in females, but the females＇ reproductive cycle might also be biennial. A reproductive cycle in males was annual with the completion of the gamete maturation process in August.

关键词： annual reproductive cycle biennial reproductive cycle breeding immigration gamete maturation subarctic climate

Evaluating the best treatment for multifocal hepatocellular carcinoma:A propensity score-matched analysis

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World Journal of Gastroenterology 2022年第29期28卷 3981-3993页

作者： Matteo Risaliti Ilenia Bartolini Claudia Campani Umberto Arena Carlotta Xodo valentina Adotti Martina Rosi Antonio Taddei Paolo Muiesan Amedeo Amedei Giacomo Batignani Fabio Marra Department of Experimental and Clinical Medicine AOU CareggiFlorence 50134Italy

BACKGROUND Hepatocellular carcinoma(HCC)is a common tumour often diagnosed with a multifocal *** with multifocal HCC represent a heterogeneous *** Trans-Arterial ChemoEmbolization(TACE)is the most frequently employed treatment for these patients,previous data suggested that liver resection(LR)could be a safe and effective *** To compare LR and TACE in patients with multifocal HCC in terms of procedurerelated morbidity and oncologic *** All patients with multifocal HCC who underwent LR or TACE as the first procedure between May 2011 and March 2021 were *** decision to perform surgery or TACE was made after a multidisciplinary team *** patients in Child-Pugh class A or B7 and stage B(according to the Barcelona Clinic Liver Cancer staging system,without severe portal hypertension,vascular invasion,or extrahepatic spread)were included in the final *** score matching was used to adjust the baseline differences between patients undergoing LR and the TACE group[number and diameter of lesions,presence of cirrhosis,alpha-fetoprotein(AFP)levels,and Model for End-Stage Liver Disease score].The Kaplan-Meier method was used to estimate overall survival(OS)and disease-free survival(DFS).The outcomes of LR and TACE were compared using the log-rank *** After matching,30 patients were eligible for the final analysis,15 in each *** rates were 42.9% and 40% for LR and TACE,respectively(P=0.876).Median OS was not different in the LR and TACE groups(53 mo vs 18 mo,P=0.312),while DFS was significantly longer with LR(19 mo vs 0 mo,P=0.0001).Subgroup analysis showed that patients in the Italian Liver Cancer(***)B2 stage,with AFP levels lower than 400 ng/mL,less than 3 lesions,and lesions bigger than 41 mm,benefited more from LR in terms of *** classified as *** B3,with AFP levels higher than 400 ng/mL and with more than 3 lesions,appeared to receive more benefi

关键词： Hepatocellular carcinoma Multifocal hepatocellular carcinoma Liver resection Trans-arterial chemoembolization Guidelines Liver tumour management

Emergency Management in Critical Infrastructures: A Complex-Event-Processing Paradigm

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Journal of Systems Science and Systems Engineering 2019年第1期28卷 37-62页

作者： Vuk Mijovic Nikola Tomasevic valentina Janev Mladen Stanojevic Sanja Vranes The Mihajlo Pupin Institute University of Belgrade Volgina 1511060 Belgrade Serbia

Critical infrastructures (CI) are difficult to handle due to their complexity, size and the number of stakeholders involved. During emergency situations (e.g. fire or terrorist attack), a CI operator in the control room is faced with a flood of information coming from different sensors and legacy monitoring systems. Since in these situations, time is critical and the operators are under a great deal of pressure, a holistic management of all the technical systems and actors involved is needed, reinforced by the Recommendation and Decision Support System (RDSS) that helps emergency managers to take correct and timely decisions. One way to provide an adequate RDSS support to the operator is proposed in this paper which is based on an intelligent, event driven layer that sits on top of the legacy CI monitoring system. Powered by the complex event processing capabilities and facility data model implemented in the form of CI ontology, this layer processes events originating from different sources, conducts the situation and risk assessment, and reacts accordingly, either automatically or via recommendations proposed to emergency personnel. To validate the proposed approach, an event-driven RDSS was deployed on an airport use case (Nikola Tesla airport in Belgrade), as one of the most complex CIs.

关键词： Emergency management event-driven decision support complex event processing emergency personnel training

Gene therapy in Parkinson's disease: targeting the endplasmic reticulum proteostasis network

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Neural Regeneration Research 2015年第7期10卷 1053-1054页

作者： valentina Castillo Gabriela Mercado Claudio Hetz Biomedical Neuroscience Institute Faculty of MedicineUniversity of Chile Program of Cellular and Molecular Biology Center for Molecular Studies of the Cell Institute of Biomedical SciencesUniversity of Chile Department of Immunology and Infectious Diseases Harvard School of Public Health

Parkinson’s disease（PD）is the second most common neurodegenerative disease affecting 1%of the population over 60 years of *** progressive degeneration of dopaminergic neurons at the substantia nigra pars compacta（SNpc）results in a severe and gradual depletion of dopamine content in the striatum,a phenomena that is responsible for the characteristic motor symptoms of this disease.

关键词： gene Gene therapy in Parkinson’s disease targeting the endplasmic reticulum proteostasis network

Higher production of tumor necrosis factor alpha in hemozoin-fed human adherent monocytes is dependent on lipidic component of malarial pigment:new evidences on cytokine regulation in Plasmodium falciparum malaria

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 85-89页

作者： Prato Mauro Gallo valentina Arese Paolo Department of Genetics Biology and BiochemistryUniversity of Torino Medical School

Objective:To investigate whether the increase of tumor necrosis factor alpha is dependent on lipidic component of malarial ***:Adherent human monocytes were fed for 3 hours with different meals(native hemozoin;lipid free hemozoin;and control latex particles),then tumor necrosis factor alpha was monitored in cell supernatants up to 48 hours through western blotting or specific enzyme-linked immunoadsorbent *** selected experiments,unfed monocytes were treated with different doses of 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid or 4-hydroxynonenal instead of ***:Hemozoin-fed monocytes produced higher levels of tumor necrosis factor alpha than unstimulated and latex-fed cells, while lipid-free hemozoin did not reproduce these ***,hemozoin effects were mimicked dose-dependently by 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid,but not by ***:Present data suggest an essential role for lipids in hemozoindependent enhanced release of tumor necrosis factor alpha from monocytes,and 15(S,R)hydroxy -6,8,11,13-eicosatetraenoic acid could be one possible specific mediator.

关键词： Hemozoin Plasmodium falciparum Malaria Monocyte Phagocytosis Tumor necrosis factor alpha(TNFalpha) 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid(15-HETE) Matrix metalloproteinase-9(MMP-9)

The promise of liquid biopsy in cancer:a clinical perspective

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Chinese Journal of Cancer Research 2015年第5期27卷 488-490页

作者： Enrico Cortesi Michela Palleschi valentina Magri Giuseppe Naso Medical Oncology Unit Department of Radiological Oncological and Pathological SciencesSapienzaUniversity of Rome

The clinical utility of liquid biopsy in cancer treatment will increase as circulating tumor cells （CTCs） analysis move from the enumeration to the real-time measurement of tumor characteristics. Intratumor heterogeneity is becoming increasingly recognized as a major drawback to the shift to personalized medicine. Spatial and temporal heterogeneity might be reflected by the serial assessment of CTCs. Indeed, the developing technologies for CTCs analysis now allow digital genomic and next- generation sequencing approaches, able to differentiate molecular subtypes of the disease and to monitor genetic variation over time. The liquid biopsy of cancer might offer a real-time assessment of tumor biology, providing the opportunity to serially evaluate patients most likely to benefit from targeted drugs based on a dynamic characterization of the disease at the molecular level. Mthough hurdles remain before liquid biopsy is seen in routine clinical practice, the information derived from CTCs may facilitate the real-time identification of actionable mutations in cancer leading the way toward personalized medicine.

关键词： Circulating tumor cells (CTCs) breast liquid biopsy cancer