Small-world networks of neuroblastoma cells cultured in three-dimensional polymeric scaffolds featuring multi-scale roughness

作     者：Valentina Onesto Angelo Accardo Christophe Vieu Francesco Gentile Valentina Onesto;Angelo Accardo;Christophe Vieu;Francesco Gentile

作者机构：Center for Advanced Biomaterials for HealthcareItalian Institute of TechnologyNaplesItaly Laboratoire d’Analyse et d’Architecture des Systemes(LAAS)Centre National de la Recherche ScientifiqueUniversite de ToulouseCNRSToulouseFrance Institut National des Sciences Appliquees–INSAToulouseFrance Department of Electric Engineering and Information TechnologyUniversity Federico IINaplesItaly Department of Precision and Microsystems EngineeringDelft University of TechnologyMekelweg 22628 CD DelftThe Netherlands 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第4期

页      面：759-768页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 100215[医学-康复医学与理疗学] 10[医学] 

主　　题：3D networks biomaterials nano-topography network topology neuro-regeneration small-world networks tissue engineering two-photon lithography 

摘      要：Understanding the mechanisms underlying cell-surface interaction is of fundamental importance for the rational design of scaffolds aiming at tissue engineering,tissue repair and neural regeneration ***,we examined patterns of neuroblastoma cells cultured in three-dimensional polymeric scaffolds obtained by two-photon *** of the intrinsic resolution of the technique,the micrometric cylinders composing the scaffold have a lateral step size of^200 nm,a surface roughness of around 20 nm,and large values of fractal dimension approaching *** found that cells in the scaffold assemble into separate groups with many elements per *** cell wiring,we found that resulting networks exhibit high clustering,small path lengths,and small-world *** values of the topological characteristics of the network can potentially enhance the quality,quantity and density of information transported in the network compared to equivalent random graphs of the same *** is one of the first direct observations of cells developing into 3D small-world networks in an artificial matrix.