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Coping with drought?Effects of extended drought conditions on soil invertebrate prey and diet selection by a fossorial amphisbaenian reptile

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Current Zoology 2023年第4期69卷 367-376页

作者： José martín Jesús Ortega Roberto García-Roa Gonzalo Rodríguez-Ruiz Ana Pérez-Cembranos valentín Pérez-Mellado Departamento de Ecología Evolutiva Museo Nacional de Ciencias NaturalesCSICMadridSpain Institute of Evolutionary Biology CSIC-Universitat Pompeu FabraBarcelonaSpain Ethology Lab Cavanilles Institute of Biodiversity and Evolutionary BiologyUniversity of ValenciaValenciaSpain Departamento de Biología Animal Universidad de SalamancaSalamancaSpain

Arid climates are characterized by a summer drought period to which animals seem ***,in some years,the drought can extend for unusually longer *** the effects of these current extreme weather events on biodiversity can help to understand the effects of climate change,as models predict an increase in drought ***,we examined the effects of“unusual”extended drought on soil invertebrate prey availability and on diet composition(based on fecal contents)and diet selection of a fossorial amphisbaenian,the checkerboard worm lizard Trogonophis *** data show interannual variations in summer drought *** abundance and diversity of soil invertebrates in spring were high,and similar to those found in a“normal”early autumn,after some rain had ended with the summer *** contrast,in years with“unusual”extended drought,abundance,and diversity of soil invertebrates in early autumn were very ***,there were seasonal changes in amphisbaenians’diet;in autumn with drought,prey diversity,and niche breadth decreased with respect to spring and autumns after some rain had *** did not eat prey at random in any season,but made some changes in prey selection that may result from drought-related restrictions in prey ***,in spite that amphisbaenians showed some feeding flexibility,their body condition was lower in autumn than in spring,and much lower in autumn with *** extended drought became the norm in the future,amphisbaenians might suffer important negative effects for their health state.

关键词： amphisbaenians drought feeding ecology soil invertebrates Trogonophis wiegmanni weather conditions

Conservative management of perforated duodenal diverticulum: A case report and review of the literature

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World Journal of Gastroenterology 2008年第12期14卷 1949-1951页

作者： David martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor valentí Azcárate Javier Briceo Delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea Hospital Universitario Reina Sofia Av. Menendez Pidal sn. 14005. Córdoba Spain. Clínica Universitaria de navarra Avenida de Pio XII 36 Pamplona 31008 Spain.

Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs.

关键词： Duodenal diverticula Perforation Conservativemanagement

The protein-protein interaction landscape of transcription factors during gynoecium development in Arabidopsis

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Molecular Plant 2023年第1期16卷 260-278页

作者： Humberto Herrera-Ubaldo Sergio E.Campos Pablo López-Gómez valentín Luna-García Víctor M.Zúñiga-Mayo Gerardo E.Armas-Caballero Karla L.González-Aguilera Alexander DeLuna nayelli Marsch-martínez Carlos Espinosa-Soto Stefan de Folter Unidad de Genómica Avanzada(UGA-LAnGEBIO) Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV-IPN)IrapuatoGuanajuato 36824México Departamento de Biotecnología y Bioquímica Unidad IrapuatoCINVESTAV-IPNIrapuatoGuanajuato 36824México Instituto de Física Universidad de San Luis PotosíSan Luis PotosíSLP 78290México Present address:Department of Plant Sciences University of CambridgeCambridgeUK Present address:Department of Molecular and Cellular Biology University of California DavisDavisCAUSA Present address:COnACYT Instituto de FitosanidadColegio de PostgraduadosCampus MontecilloTexcocoMéxico

Flowers are composed of organs whose identity is defined by the combinatorial activity of transcription factors(TFs).The interactions between MADS-box TFs and protein complex formation have been schematized in the floral quartet model of flower *** gynoecium is the flower’s female reproductive part,crucial for fruit and seed production and,hence,for reproductive *** the establishment of carpel identity,many tissues arise to form a mature *** have been described as regulators of gynoecium development,and some interactions and complexes have been ***,broad knowledge about the interactions among these TFs and their participation during development remains *** this study,we used a systems biology approach to understand the formation of a complex reproductive unit—as the gynoecium—by mapping binary interactions between well-characterized *** analyzed almost 4500 combinations and detected more than 250 protein-protein interactions(PPIs),resulting in a process-specific interaction *** analyses suggest hidden functions and novel roles for many *** addition,we observed a close relationship between TFs involved in auxin and cytokinin-signaling pathways and other ***,we analyzed the network by combining PPI data,expression,and genetic data,which helped us to dissect it into several dynamic spatio-temporal subnetworks related to gynoecium development ***,we generated an extended PPI network that predicts new players in gynoecium *** together,all these results serve as a valuable resource for the plant community.

关键词： interactome networks transcription factors gynoecium development

Open versus laparoscopic cholecystectomies in patients with or without type 2 diabetes mellitus in Spain from 2003 to 2013

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Hepatobiliary & Pancreatic Diseases International 2016年第5期15卷 525-532页

作者： JoséM de Miguel-Yanes Manuel Méndez-Bailón Rodrigo Jiménez-García valentín Hernández-Barrera napoleón Pérez-Farinós Fernando Turégano nuria Munoz-Rivas Ana López-de-Andrés Internal Medicine Department Hospital General Universitario“Gregorio Maranón”46Doctor Esquerdo28007MadridSpain Internal Medicine Department Hospital Clínico San CarlosCalle Profesor Martín Lagos28040MadridSpain Preventive Medicine and Public Health Department Health Sciences FacultyRey Juan Carlos UniversityAvenida de AtenasAlcorcón28292MadridSpain Spanish Agency of Alimentary Safety and nutrition Ministry of HealthSocial Policy and Equality56Alcalá28071MadridSpain Internal Medicine Department Hospital Infanta Leonor80Avenida Gran Vía del Este28031MadridSpain Surgery Department Hospital General Universitario“Gregorio Maranón”46Doctor Esquerdo28007MadridSpain

BACKGROUnD: This study aimed to compare the rates of open and laparoscopic cholecystectomies and outcomes in patients with or without type 2 diabetes mellitus (T2DM) in Spain from 2003 to 2013. METHODS: We collected all cases of open and laparoscopic cholecystectomies using national hospital discharge data and evaluated the annual cholecystectomy rates stratiifed by T2DM status. We analyzed tendency for in-hospital mortality (IHM). We also analyzed the impact of T2DM on IHM in patients who underwent cholecystectomies. RESULTS: We identiifed 611 533 cholecystectomies (71.3%laparoscopic) in the patients, in whom 78 227 (12.8%) patients had T2DM. The rates of open cholecystectomies were 3-fold higher (130.0/105 vs 41.1/105) in patients with T2DM than in those without T2DM, and the rate of laparoscopic cholecys-tectomies was almost 2-fold higher (195.2/105 vs 111.8/105) in patients with T2DM. The annual rate of laparoscopic pro-cedures showed an 11-year relative increase of 88.3% (from 117.0/105 to 220.3/105) in T2DM and 49.2% (from 79.2/105 to 118.2/105) in patients without T2DM (Pn procedures showed an 11-year relative decrease of 27.6% in patients with T2DM and 37.9% in those without T2DM (Pncy laparoscopic cho-lecystectomy was increased in the 11 years, whereas the rate of emergency open cholecystectomies was decreased (both Pnalysis revealed that older age, higher comorbidity and emergency cholecystectomy were associated with a higher IHM. Compared with patients without T2DM, patients with T2DM demonstrated a lower IHM after open cholecystectomy [OR=0.82 (0.78-0.87)], but a higher IHM after laparoscopic cholecystectomy (OR=1.18 (1.03-1.35))Time-trend analyses showed a signiifcant reduction in IHM in patients with or without T2DM after the two procedures. COnCLUSIOn: The rate of cholecystectomy was higher in patients with T2DM, and laparoscopic cholecystectomy was p

关键词： diabetes mellitus cholecystectomy mortality in-hospital mortality

Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 295-318页

作者： Ramón Cantero-Cid Karla Marina Montalbán-Hernández Jenny Guevara Alejandro Pascual-Iglesias Elisa Pulido JoséCarlos Casalvilla Cristóbal Marcano Cristina Barragán Serrano Jaime valentín Gloria Cristina Bonel-Pérez JoséAvendaño-Ortiz Verónica Terrón Roberto Lozano-Rodríguez Alejandro martín-Quirós Elvira Marín Eva Pena Laura Guerra-Pastrián Eduardo López-Collazo Luis Augusto Aguirre Tumor Immunology Laboratory The Innate Immune Response GroupHospital La Paz Institute for Health Research(IdiPAZ)Madrid 28046Spain Digestive Surgery Service La Paz University HospitalMadrid 28046Spain Emergency Department and Emergent Pathology Research Group Hospital La Paz Institute for Health Research(IdiPAZ)Madrid 28046Spain Pathologic Anatomy Service Hospital La PazMadrid 28046Spain

BACKGROUnD Colorectal cancer(CRC)accounts for 9.4%of overall cancer deaths,ranking second after lung *** the large number of factors tested to predict their outcome,most patients with similar variables show big differences in ***,right-sided CRC(RCRC)and left-sided CRC(LCRC)patients exhibit large differences in outcome after surgical intervention as assessed by preoperative blood leukocyte *** hypothesised that stronger indexes than circulating(blood)leukocyte ratios to predict RCRC and LCRC patient outcomes will result from combining both circulating and infiltrated(tumour/peritumour fixed tissues)concentrations of *** To seek variables involving leukocyte balances in peripheral blood and tumour tissues and to predict the outcome of CRC *** Sixty-five patients diagnosed with colon adenocarcinoma by the Digestive Surgery Service of the La Paz University Hospital(Madrid,Spain)were enrolled in this study:43 with RCRC and 22 with *** were followed-up from January 2017 to March 2021 to record overall survival(OS)and recurrence-free survival(RFS)after surgical *** concentrations in peripheral blood were determined by routine laboratory ***-fixed samples of tumour and peritumoural tissues were assessed for leukocyte concentrations by immunohistochemical detection of CD4,CD8,and CD14 marker *** of leukocyte concentration in blood and tissues were calculated and evaluated for their predictor values for OS and RFS with Spearman correlations and Cox univariate and multivariate proportional hazards regression,followed by the calculation of the receiver-operating characteristic and area under the curve(AUC)and the determination of Youden’s optimal cutoff values for those variables that significantly correlated with either RCRC or LCRC patient *** patients from the cohort were randomly assigned to modelling and validation sets,and clinician-friendly nomogra

关键词： Left colorectal cancer Leukocyte ratios Prognostic variables Recurrence-free survival Right colorectal cancer Overall survival

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普通用户电子设备使用距离的特征分析

国际眼科杂志 2021年第9期21卷 1508-1514页

作者： Fernando Soler Alicia Sánchez-García Ainhoa Molina-martín Dolores de Fez valentín Díaz David P Piñero Innova Ocular Clinica Dr Soler 西班牙埃尔切03202 Dr Soler Foundation of the Valencian Community 西班牙埃尔03202 阿里坎特大学药理学、解剖学与光学系西班牙阿里坎特03690

目的:分析普通用户使用电子设备/电脑的工作距离(WD)及移动电话使用距离(MPUD)的特征。方法:横向描述性研究。经过筛选后,纳入每天使用电子设备/电脑超过2h的专业人员100例,年龄20-62(平均41.2)岁,测量每位受试者工作环境中使用电子设备... 详细信息

目的:分析普通用户使用电子设备/电脑的工作距离(WD)及移动电话使用距离(MPUD)的特征。方法:横向描述性研究。经过筛选后,纳入每天使用电子设备/电脑超过2h的专业人员100例,年龄20-62(平均41.2)岁,测量每位受试者工作环境中使用电子设备/电脑的工作距离(WD)、手臂长度和MPUD。结果:纳入受检者WD明显长于MPUD(61.22±12.35 vs 32.22±6.35 cm;P<0.001),MPUD明显短于臂长(74.44±4.65 cm;P<0.001)。4%和91%的受检者WD和MPUD分别小于或等于40 cm。WD与MPUD、手臂长度均呈弱相关性(r=0.387,P<0.001;r=0.260,P<0.001)。不同职业受试者WD有显著差异(P=0.021),军队人员相比大学研究人员和讲师的WD更长(P=0.025)。结论:普通用户使用电子设备/电脑的工作距离与移动电话使用距离差别较大,移动电话使用距离较近,这对于矫正老视具有一定的参考意义。

关键词：老视工作距离移动电话使用距离电子设备

SARS-CoV-2 infection in children requiring hospitalization: the experience of navarra, Spain

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World Journal of Pediatrics 2020年第6期16卷 614-622页

作者： Laura Moreno-Galarraga Maria Urretavizcaya-martinez Josune Alegria Echauri Marcos Garcia Howard Eva Ruperez Garcia Sergio Aguilera-Albesa valentin Alzina de Aguilar Mercedes Herranz Aguirre Pediatric Pulmonology Department of PediatricsCHNComplejo Hospitalario de NavarraServicio Navarro de SaludC/Irunlarrea 331080 PamplonaSpain IdiSnA.navarra Institute for Health Research PamplonaSpain Department of Preventive Medicine and Public Health.School of Medicine.University of navarra Pamplona.wSpain Department of Pediatrics CHNComplejo Hospitalario de NavarraServicio Navarro de Salud.Pamplona.Spain Pediatric Cardiology Department of PediatricsCHN.Complejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain Pediatric neurology Department of PediatricsCHN.Complejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain Department of Pediatrics CUN.Clfnica Universidad de NavarraPamplona.Spain Department of Pediatrics School of MedicineUniversity of NavarraPamplona.Spain

Background Coronavirus disease 2019 in children,or pediatric COVID-19,initially was described as an acute respiratory syndrome similar to the adult presentation but with less severe *** We describe the clinical characteristics,disease presentation,treatments and outcomes of all pediatric cases with COVID-19 admitted to the reference hospitals in navarra,Spain during the first wave of the COVID-19 outbreak(February-May 2020).Results We found a low number of hospitalized cases in infants and children compared to adults with a hospitalization ratio of 1:*** of these hospitalized cases did not suffer from severe *** 80%of infections reported household contacts,and the mother was the known-contact in 83%of these cases.72%of hospitalized cases were previously healthy *** describe how symptoms in pediatric cases are nonspecific and how COVID-19 can be presented with a wide range and variety of *** symptoms are not always present,and severe neurological and cardiac features can occur in previously healthy *** Epidemiological description and case reports will be key to a better recognition and to adequate treatment of pediatric patients with COVID-19.

关键词： Coronavirus disease 2019 Hospitalization Severe acute respiratory syndrome coronavirus 2