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Pistachio genomes provide insights into nut tree domestication and ZW sex chromosome evolution

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Plant Communications 2023年第3期4卷 80-98页

作者： Salih Kafkas Xiaokai Ma Xingtan Zhang Hayat Topc¸u Rafael Navajas-Pérez Ching Man Wai Haibao Tang Xuming Xu Mortaza Khodaeiaminjan Murat Güney Aibibula Paizila Harun Karcı Xiaodan Zhang Jing Lin Han Lin Roberto de la Herrán Carmelo Ruiz Rejón Jerson Alexander García-Zea Francisca Robles Coral del val Muñoz Agnes Hotz-Wagenblatt Xiangjia Jack Min HakanÖzkan Elmira Ziya Motalebipour Hatice Gozel Nergiz C¸oban Nesibe Ebru Kafkas Andrej Kilian HuaXing Huang Xuanrui Lv Kunpeng Liu Qilin Hu Ewelina Jacygrad William Palmer Richard Michelmore Ray Ming Department of Horticulture Faculty of AgricultureUniversity of C¸ukurovaAdana 01330Turkey Center for Genomics and Biotechnology Haixia Institute of Science and TechnologySchool of Future TechnologyFujian Agriculture and Forestry UniversityFuzhouChina Key Laboratory of Orchid Conservation and Utilization of National Forestry and Grassland Administration Fujian Agriculture and Forestry UniversityFuzhouChina Departamento de Genética Facultad de CienciasCampus de Fuentenueva s/n18071 GranadaSpain Department of Plant Biology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems College of the Environment and EcologyXiamen UniversityXiamen 361102China Department of Computer Science University of GranadaGranadaSpain Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI Institute) 18014 GranadaSpain German Cancer Research Center Omics IT and Data Management Core FacilityHeidelbergGermany Department of Biological Sciences Youngstown State UniversityYoungstownOH 44555USA Department of Field Crops Faculty of AgricultureUniversity of C¸ukurovaAdana 01330Turkey Pistachio Research Institute SxahinbeyGaziantep 27060Turkey Diversity Arrays Technology University of CanberraCanberraACTAustralia Genome Center University of California Davis451 Health Sciences DriveDavisCA 95616USA

Pistachio is a nut crop domesticated in the Fertile Crescent and a dioecious species with ZW sex *** sequenced the genomes of Pistacia vera cultivar(cv.)Siirt,the female parent,and *** ***,the male *** chromosome-level reference genomes of pistachio were generated,and Z and W chromosomes were *** ZW chromosomes originated from an autosome following the first inversion,which occurred approximately 8.18 *** inversion events in the W chromosome led to the formation of a 12.7-Mb(22.8%of the W chromosome)non-recombining *** W-specific sequences contain several genes of interest that may have played a pivotal role in sex determination and contributed to the initiation and evolution of a ZW sex chromosome system in *** W-specific genes,including defA,defA-like,DYT1,two PTEN1,and two tandem duplications of six VPS13A paralogs,are strong candidates for sex determination or *** history analysis of resequenced genomes suggest that cultivated pistachio underwent severe domestication bottlenecks approximately 7640 years ago,dating the domestication event close to the archeological record of pistachio domestication in *** identified 390,211,and 290 potential selective sweeps in 3 cultivar subgroups that underlie agronomic traits such as nut development and quality,grafting success,flowering time shift,and drought *** findings have improved our understanding of the genomic basis of sex determination/differentiation and horticulturally important traits and will accelerate the improvement of pistachio cultivars and rootstocks.

关键词： Pistacia vera pistachio sequencing reference genome sex chromosome domestication

低地国家的高风险危机管理:政府应对新冠肺炎疫情的比较研究

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国际行政科学评论（中文版） 2021年第3期 192-210页

作者：瓦莱里·帕廷乔尔·马蒂斯史蒂文·范·赫克陆传英(译) 王秋蕾(审校) 荷兰莱顿大学公共管理学院安全与全球事物学院荷兰莱顿大学危机研究中心比利时鲁汶大学公共治理研究所中国人事科学研究院公共管理与人事制度研究室不详

与许多西欧国家一样,比利时和荷兰也受到了新冠肺炎的严重打击。病毒在两国几乎同时传播,感染人数相对较多,两国也都采取了严厉的封锁措施。然而,与此同时,两国的危机应对管理却大相径庭,需要进行系统的比较分析。本文基于这样的前提假... 详细信息

与许多西欧国家一样,比利时和荷兰也受到了新冠肺炎的严重打击。病毒在两国几乎同时传播,感染人数相对较多,两国也都采取了严厉的封锁措施。然而,与此同时,两国的危机应对管理却大相径庭,需要进行系统的比较分析。本文基于这样的前提假设,即依据不完整信息作出的决策,显示了政府应对危机的真实性质,这取决于过去的历史遗产和组织文化、现有和新的治理结构以及特定行动者使用的策略所产生的影响。本研究表明,危机管理的差异反映了各国不同类型的联合制,尽管比利时联邦制和荷兰分权制都阻碍了真正连贯的反应。协调各级政府的成本也使得运用统一方法更为困难。试图利用危机的行动者策略似乎对危机应对的影响最小,但确实对危机应对如何被察觉产生了影响。

关键词：比利时新冠肺炎危机利用危机管理流行病荷兰

UPLC-MS/MS法鉴定苏格木勒-10中的成分

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华西药学杂志 2022年第5期37卷 527-530页

作者：张哈旦宝力高良良鲍布日额王秀兰陈香梅吉日木巴图内蒙古民族大学附属医院内蒙古通辽028007 内蒙古民族大学内蒙古通辽028005 内蒙古医科大学民族医药创新中心内蒙古呼和浩特010110

目的采用XEVO G2-XS Q-TOF质谱仪快速鉴定苏格木勒-10的化学成分。方法采用Acquity UPLC BEH C色谱柱(100 mm×2.1 mm, 1.7μm),流速0.3 mL·min^(-1),柱温40℃,进样量3μL,流动相为乙腈-0.1%甲酸,梯度洗脱,质谱扫描范围为m/z150~1500... 详细信息

目的采用XEVO G2-XS Q-TOF质谱仪快速鉴定苏格木勒-10的化学成分。方法采用Acquity UPLC BEH C色谱柱(100 mm×2.1 mm, 1.7μm),流速0.3 mL·min^(-1),柱温40℃,进样量3μL,流动相为乙腈-0.1%甲酸,梯度洗脱,质谱扫描范围为m/z150~1500;通过保留时间及质谱数据信息对比,并结合精确相对分子质量、质谱裂解规律对苏格木勒-10的化学成分进行快速鉴定。结果共鉴定了59个化学成分,并解析了其中4个成分的裂解规律。结论苏格木勒-10含有丰富的化学成分且来源于多个组方药,可为其质量研究及药物体内代谢分析提供基础。

关键词：蒙药苏格木勒-10 超高效液相色谱-电喷雾/四极杆飞行时间串联质谱法裂解规律成分鉴定质量标准

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土壤中的生物多样性与生态系统功能

人类环境杂志 1997年第8期26卷 555-562页

作者： Lijbert Brussaard val M.Behan-Pelletier David E.Bignell valerie K.Brown Wim Didden Patrica Folgarait Carlos Fragoso Diana Wall Freckman Vadakattu V.S.R.Gupta Tsutomu Hattori's David L.Hawkworth Carole Klopatek Patric Lavelle David W.Malloch Josef Rusek Bengt Sderstrom James M.Tiedje Ross A.Virginia 闵庆文瓦赫宁根农业大学渥太华加拿大农业马来西亚沙巴大学国际昆虫研究所 IFEVA Facultad de Agronomia 墨西哥Xalapa的生态研究所科罗拉多州立大学澳大利亚Adelaide土壤与土地管理合作研究中心 Attic 英国CAB国际真菌学研究所森林服务中心中全国地下可持续性研究项目组巴黎第四大学多伦多大学植物学系维采的捷克共和国科学院土壤生物学研究所 Lund大学微生物生态学系密歇根州立大学微生物生态学研究中心达特茅斯学院环境学

我们回顾了目前关于土壤生物多样性及其在生态系统过程中的作用、对于人类目标的重要性及对胁迫和扰动的恢复能力等的研究进展。现存物种的数量远远大于人们已经描述的数量,即使是对于肉眼可见的分类群也是如此。而且也普遍缺乏在生物... 详细信息

我们回顾了目前关于土壤生物多样性及其在生态系统过程中的作用、对于人类目标的重要性及对胁迫和扰动的恢复能力等的研究进展。现存物种的数量远远大于人们已经描述的数量,即使是对于肉眼可见的分类群也是如此。而且也普遍缺乏在生物地理学上的综合描述。迫切需要在分类学和对新一代系统科学家培训上做更大努力。尤其是应当集中致力于就我们所知。对生态系统功能起关键作用的土壤生物类群方面。为了确定这种类群,需要对土壤生物区系的影响圈(sphere of Influence,SOI),如根的生物区系、有机物质破碎者(shredder)和土壤生物扰动者(bioturbator)加以识别,这些影响圈比如可能通过与植物的相互作用而控制着生态系统的过程。在这些SOI中,我们分析出了土壤有机体的功能类群。最迫切需要研究的问题是将物种按功能类群进行区分,并确定功能类群中的物种冗余。这种迫切性是根据为阐述与集约化农业、森林扰动、环境污染和全球环境变化有关的土壤功能丧失程度的需要而确定的。目前认为最处于危险的土壤生物区系是那些大型动物群的有机物破碎者、土壤生物扰动者、某些专门的细菌(如硝化细菌和固氮菌)以及形成真菌的菌根中贫乏物种的功能类群。在开展这些优先性研究时,需要使用长期的和大尺度的田间试验,以及地理统计学和地理信息系统等现代方法进行试验研究。

关键词：土壤生物多样性生态系统功能

Recent progress and limitations of chemotherapy for pancreatic and biliary tract cancers

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World Journal of Clinical Oncology 2011年第3期2卷 158-163页

作者： Minoru Tada Yousuke Nakai Takashi Sasaki Tsuyoshi Hamada rie Nagano Dai Mohri Koji Miyabayashi Keisuke Yamamoto Hirofumi Kogure Kazumichi Kawakubo Yukiko Ito Natsuyo Yamamoto Naoki Sasahira Kenji Hirano Hideaki Ijichi Keishuke Tateishi Hiroyuki Isayama Masao Omata Kazuhiko Koike Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Yamanashi Prefectural Hospital Organization 400-8506 YamanashiJapan

Gemcitabine chemotherapy has been the standard for advanced pancreatic cancer for more than a *** oral fluoropyrimidines such as S-1 and capecitabine are other key *** plus erlotinib was the only combination therapy that significantly prolonged survival,although the effect was *** or no improvement in survival with recent moleculartargeted drugs might be attributed to the very high incidence of K-ras gene mutation in pancreatic ***,the non-gemcitabine-based-regimen of FOLFIRINOX showed significantly greater overall survival compared with gemcitabine for the first *** biliary tract cancer,gemcitabine plus cisplatin combination chemotherapy has been proved to significantly prolong survival and will become the standard *** improvement in survival is expected by the addition of cetuximab.

关键词： Cisplatin Epidermal growth factor receptor Gemcitabine K-ras S-1

急性心肌梗塞患者应激性ST段抬高的放射性核素研究

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现代临床医学生物工程学杂志 1996年第2期2卷 159-159页

作者：陈广原 Isabel Coma-canella Maria del val G’omez Ignacio Terol Francisco Rodrgo Jose Manuel Castro Madrid Spain

急性心肌梗塞后应激性sT段拾高(△ST)的意义仍有争议．一些研究显示其与左室运动不协调有关．另一些则认为与缺血有关．目前尚无将同组病人的应激性缺血和不协调与△sT加以比较的报道．为此．对88例急性心肌梗塞16±4天后的病人进行了... 详细信息

急性心肌梗塞后应激性sT段拾高(△ST)的意义仍有争议．一些研究显示其与左室运动不协调有关．另一些则认为与缺血有关．目前尚无将同组病人的应激性缺血和不协调与△sT加以比较的报道．为此．对88例急性心肌梗塞16±4天后的病人进行了研究．在间歇1-2天的不同时间，分别对其进行多巴酚丁胺激发实验．

关键词：急性心肌梗塞患者 ST段抬高应激性左室不同时间 sT段缺血激发

单纯硬化性神经纤维瘤:一种类似硬化纤维瘤的神经纤维瘤

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 56-56页

作者： González-Vela M.C. val-Bernal J.F. González-López M.A. 党倩丽 Departamento de Anatoma Patoló gica Hospital Universitario Marqué s de Valdecilla Avda. Valdecilla 1 ES-39008 Santander Spain Dr.

Background: Neurofibroma (NF) is a benign tumor of the nerve sheath. Several variants of NF have been described. Purpose: We report a case of NF with sclerotic changes resembling sclerotic fibroma (SF). Methods and Results: The patient was a 61-year-old man who had an asymptomatic cutaneous lesion on the right scapular region. Physical examination revealed a pedunculated, white-to-pinkish nodule that had a firm consistency, spherical morphology, and smooth surface. Microscopically, the nodule showed a well-circumscribed, nonencapsulated dermal umor composed of scant cells and thick collagen bundles with prominent cleft. The tumor cells were immunoreactive for vimentin and S100 protein. The patient was diagnosed as having pure sclerotic NF. To our knowledge, only five cases of NF with SF-like pattern have been previously published, and in two this pattern was pure. Conclusion: It is important to recognize this exceptional type of NF because it may be easily confused with SF, as well as with a wide variety of neoplasms or hamartomatous conditions containing similar sclerotic pattern.

关键词：神经纤维瘤硬化性肩胛区神经鞘错构瘤免疫反应性弹性蛋白无症状新生物

既往深部静脉血栓形成部位出现局限性移植后Kaposi肉瘤:停用西罗莫司后的突发皮损

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世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 48-48页

作者： Gonzlez-Ló pezM.A. Rodrigo E. Gonzlez-VelaM.C. J.F. val-Bernal 吴佳纹 Departamento de Anatoma Patoló gica Hospital Universitario Marqué s de Valdecilla Avda. Valdecilla 1 ES- 39008 Santander Spain Dr.

Kaposi’s sarcoma (KS) is an angio proliferative neoplasia associated with human herpesvirus 8 (HHV-8) infection. HHV-8 generates KS by means of the secretion of vascular endothelial growth factor (VEGF) and up-regulation of VEGF receptor, KDR, in endothelial cells. We report a case of KS in a 72-year-old male with a renal transplant who had received immunosuppressant drugs including sirolimus, mycophenolatemofetil, tacrolimus and steroids. KS developed 11 months after transplantation, in relation to deep venous thrombosis and withdrawal of sirolimus due to toxicity. Multiple purple papules and nodules were observed exclusively in the limb affected by thrombosis. Diagnosis of KS was confirmed by biopsy. Progressive withdrawal of prednisone was accompanied by full remission of the tumour. The thrombosis and withdrawal of sirolimus may have acted as cofactors in the development of KS, favouring the activation of the VEGF/KDR autocrine loop. Our experience contributes to further evidence that sirolimus may protect against KS.

关键词： Kaposi肉瘤深部静脉血栓西罗莫司分泌血管内皮生长因子形成部位移植后 VEGF受体皮损

Dengue-specific serotype related to clinical severity during the 2012/2013 epidemic in centre of Brazil

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Infectious Diseases of Poverty 2017年第1期6卷 1043-1053页

作者： Benigno A.M.Rocha Adriana O.Guilarde Angela F.L.T.Argolo Marianna Peres Tassara Lucimeire Ada Silveira Isabela C.Junqueira Marilia D.Turchi valeria C.R.Feres Celina M.T.Martelli Institute of Tropical Pathology and Public Health Federal University of GoiasGoianiaBrazil Faculty of Pharmacy Federal University of GoiasGoianiaBrazil School of Nursing State University of GoiasCeresBrazil

Multilingual abstracts:Please see Additional file 1 for translations of the abstract into the five official working languages of the United ***:Currently,in Brazil,there is a co-circulation of the four dengue(DENV-1 to DENV-4)*** study aimed to assess whether different serotypes and antibody response patterns were associated with the severity of the disease during a dengue outbreak,which occurred in 2012/2013 in centre of ***:We conducted a prospective study with 452 patients with laboratory confirmed dengue in central Brazil,from January 2012 to July *** clinical outcome was the severity of cases:dengue,dengue with warning signs,and severe *** patients were evaluated at three different *** sampling for laboratory testing and confirmatory tests for dengue infection were *** performed a multinomial analysis considering the three categories of the dependent variable,as outlined *** odds ratios(ORs)were calculated.A multinomial logistic regression model was applied for variables with a P-value<*** analysis was performed with STATA 12.0 ***:Four hundred fifty-two patients(452/632,71.5%)were diagnosed with *** dengue virus(DENV)serotypes were identified in 243 ***-4 was detected in 135 patients(55.6%),DENV-1 in 91(37.4%),DENV-3 in 13(5.3%),and DENV-2 in 4(1.6%).Patients with the DENV-1 serotype were more prone to present with several clinical and laboratory features as compared with DENV-4 patients,including spontaneous bleeding(P=0.03),intense abdominal pain(P=0.004),neurological symptoms(P=0.09),and thrombocytopenia(P=0.01).Secondary infection was more predominant among DENV-4 cases(80.0%)compared with DENV-1 cases(62.3%)(P=0.03).The univariate analysis showed that females(OR=2.12;95%CI:1.44-3.13;P<0.01)had a higher risk of having dengue with warning *** multinomial analysis showed that severe dengue cases with secondary infection had an adjusted OR o

关键词： Dengue Secondary infection Severe dengue Dengue type 4 Brazil