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An Unusual Case of Herpes Simplex Meningitis after Inadvertent Puncture of the Subarachnoid Space

Case Reports in Clinical Medicine 2021年第9期10卷 232-239页

作者： Richell Bastos vale Bruno v.tor Martins Santiago José Abel de Almeida Neto Luiz Otávio Ribeiro de Lemos Felgueiras Karine Grillo de Freitas Thiago dos Santos Ferreira Department of Anesthesiology Piedade Municipal Hospital Rio de Janeiro Brazil Department of Anesthesiology Marcílio Dias Naval Hospital Rio de Janeiro Brazil Interleague Association of Anesthesiology of the State of Rio de Janeiro Rio de Janeiro Brazil

The study seeks to report the clinical evolution of a patient who suffered an inadvertent subarachnoid puncture and evolved with a herpetic viral meningitis, confirmed by cerebrospinal fluid (CSF) analysis. Female, 48 years old, submitted to epidural anesthesia, for surgery, with median puncture, between L2-L3 and inadvertently accessed the subarachnoid space, with clear cerebrospinal fluid. The same puncture was used and the solution with 15 mg hyperbaric bupivacaine and 80 mcg morphine was administered. There was no complication during the entire surgical procedure. On the first postoperative day, she started complaining of headache and nausea, being treated with dipyrone, non-steroidal anti-inflammatory drugs (NSAIDs) and ondansetron. On the third day, she presented two episodes of seizure that ceased with the use of diazepam 10 mg. On the fifth day, the patient presented fever and seizures, which did not stop with medication, requiring sedation, orotracheal intubation and transfer to the intensive care unit. Lumbar puncture was performed for CSF analysis, which was positive for Herpes simplex type I. The patient was extubated, on the second day of hospitalization, maintained with a maintenance dose of phenytoin, sumatriptan, dipyrone, metoclopramide and acyclovir 500 mg, remaining intravenous, without presenting new seizures for 45 days, when she was discharged. After 30 days, he returned for a review consultation without making a complaint.

关键词： Headache Opioids Herpes Simplex Dural Puncture

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图文制作系统Inscriber TitleMotion Pro v5.0

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电视字幕．特技与动画 2003年第8期10卷 60-61页

作者： tor Rolf Seemann 美国加州Glendale GTv6套节目广播主管

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Transcriptome analyses of the Dof-like gene family in grapevine reveal its involvement in berry, flower and seed development

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Horticulture Research 2016年第1期3卷 124-133页

作者： Danielle Costenaro da Silva v.tor da Silveira Falavigna Marianna Fasoli vanessa Buffon Diogo Denardi Porto Georgios Joannis Pappas Jr Mario Pezzotti Giancarlo Pasquali Luís Fernando Revers Graduate Program in Cell and Molecular Biology Center for BiotechnologyUniversidade Federal do Rio Grande do SulPorto Alegre91501-970RSBrazil Dipartimento di Biotecnologie Universitàdegli Studi di VeronaVerona37134Italy Embrapa Uva e vinho Bento Gonçalves95701-008RSBrazil Embrapa Semiárido Petrolina56302-970PEBrazil Department of Cell Biology Universidade de BrasíliaBrasília70910-900DFBrazil Syngenta Seeds Ltda UberlândiaMG38407-049Brazil Modesto CA 95354USA

The Dof(DNA-binding with one finger)protein family spans a group of plant transcription factors involved in the regulation of several functions,such as plant responses to stress,hormones and light,phytochrome signaling and seed *** we describe the Dof-like gene family in grapevine(vitis vinifera L.),which consists of 25 genes coding for *** extensive in silico characterization of the vviDofL gene family was ***,the expression of the entire gene family was assessed in 54 grapevine tissues and organs using an integrated approach with microarray(cv Corvina)and real-time PCR(cv Pinot Noir)*** phylogenetic analysis comparing grapevine sequences with those of Arabidopsis,tomato,poplar and already described Dof genes in other species allowed us to identify several duplicated *** diversification of grapevine DofL genes during evolution likely resulted in a broader range of biological ***,distinct expression patterns were identified between samples analyzed,corroborating such *** expression results indicate that several vviDofL genes perform their functional roles mainly during flower,berry and seed development,highlighting their importance for grapevine growth and *** identification of similar expression profiles between both approaches strongly suggests that these genes have important regulatory roles that are evolutionally conserved between grapevine cvs Corvina and Pinot Noir.

关键词： involvement organs assessed

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Application of a long short-term memory for deconvoluting conductance contributions at charged ferroelectric domain walls

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npj Computational Materials 2020年第1期6卷 319-325页

作者： Theodor S.Holstad Trygve M.Ræder Donald M.Evans Didirk R.Småbråten Stephan Krohns Jakob Schaab Zewu Yan Edith Bourret Antonius T.Jvan Helvoort tor Grande Sverre M.Selbach Joshua C.Agar Dennis Meier Department of Materials Science and Engineering Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway Department of Materials Science and Engineering Lehigh UniversityBethlehemPA 18015USA Experimental Physics v Center for Electronic Correlations and MagnetismUniversity of Augsburg86159 AugsburgGermany Department of Materials ETH Zurich8093 ZürichSwitzerland Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Physics ETH Zurich8093 ZürichSwitzerland Department of Physics Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway

Ferroelectric domain walls are promising quasi-2D structures that can be leveraged for miniaturization of electronics components and new mechanisms to control electronic signals at the *** the significant progress in experiment and theory,however,most investigations on ferroelectric domain walls are still on a fundamental level,and reliable characterization of emergent transport phenomena remains a challenging task.

关键词： walls ferroelectric conductance

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Expression of juvenile hormone acid O-methyltransferase and juvenile hormone synthesis in Blattella germanica

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Insect Science 2018年第5期25卷 787-796页

作者： Claudia v. Dominguez Jose L. Maestro Institute of Evolutionary Biology CSIC-Universitat Pompeu Fabra Barcelona Spain

Juvenile hormone （JH）, a sesquiterpenoid synthetized by the insect corpora allata （CA）, plays critical roles in metamorphosis and reproduction. Penultimate or last step of JH synthesis is catalyzed by juvenile hormone acid O-methyltransferase （JHAMT）. Here we report the cloning and expression analysis of the JHAMT orthologue in the cockroach, Blattella germanica （L.）（BgJHAMT）. BgJHAMT is mainly expressed in CA, with only expression traces in ovary. Three different isoforms, differing in the 3＇-UTR sequence, were identified. Isoform A shows between 35 and 65 times higher expression than B and C in CA from penultimate nymphal instar and adult females. RNAi-triggered knock down of BgJHAMT produces a dramatic reduction of JH synthesis, concomitant with a decrease of fat body viteUogenin expression and basal follicle length. BgJHAMT mRNA levels in CA of females along the gonadotrophic cycle parallel, with a slight advancement, JH synthesis profile. BgJHAMT mRNA levels were reduced in starved females and in females in which we reduced nutritional signaling by knocking down insulin receptor and target of rapamycin （tor）. Results show that conditions that modify JH synthesis in adult B. germanica females show parallel changes of BgJHAMT mRNA levels and that the JH-specifie branch of the JH synthesis pathway is regulated in the same way as the mevalonate branch. Furthermore, we demonstrate that nutrition and its signaling through the insulin receptor and tor pathways are essential for activating BgJHAMT expression, which suggests that this enzyme can be a checkpoint for the regulation of JH production in relation to nutritional status.

关键词： Blattella germanica corpora allata JHAMT juvenile hormone nutritionalsignaling

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Targeting of the AKT/m-tor Pathway: Biomarkers of Resistance to Cancer Therapy——AKT/m-tor Pathway and Resistance to Cancer Therapy

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中国肺癌杂志 2018年第1期21卷 63-66页

作者： Liudmila v SPIRINA Irina v KONDAKOvA Natalia v TARASENKO Elena M SLONIMSKAYA Evgeny A USYNIN Alexey K GORBUNOv Zahar A YURMAZOv Svetlana Yu CHIGEvSKAYA Research Institute Tomsk National Research Medical Center of the Russian Academy of Sciences Russia

Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-tor signaling pathway components as markers predicting resistance. The AKT/m-tor signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-tor signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy.

关键词： of

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Neuroprotective role of protein tyrosine phosphatase-1B in rod photoreceptor neurons

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Protein & Cell 2013年第12期4卷 890-892页

作者： Raju v.S.Rajala Ammaji Rajala Department of Ophthalmology University of Oklahoma Health Sciences CenterOklahoma CityOklahoma 73104USA Department of Physiology University of Oklahoma Health Sciences CenterOklahoma CityOklahoma 73104USA Department of Cell Biology University of Oklahoma Health Sciences CenterOklahoma CityOklahoma 73104USA Dean A.McGee Eye Institute Oklahoma CityOklahoma 73104USA

Dear Editor,Protein tyrosine phosphatase-1B(PT-P1B)is an abundant,widely expressed non-receptor tyrosine phosphatase,which is thought to be a key negative regulator of insulin signaling(Tonks,2003).Increased and prolo... 详细信息

关键词： PTP1B insulin of

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Congenital peritoneal encapsulation

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World Journal of Gastrointestinal Surgery 2015年第8期7卷 174-177页

作者： Diana Teixeira v.tor Costa Paula Costa Carlos Alpoim Pinto Correia General Surgery Department Centro Hospitalar do Alto Ave

Peritoneal encapsulation(PE) is a rare congenital malformation, characterized by a thin accessory peritoneal membrane which covers all or part of the small bowel, forming an accessory peritoneal sac. Most cases areasymptomatic and diagnosed incidentally during surgery and/or autopsy. Clinical presentation with intestinal obstruction is extremely rare and we report a case. A 25-year-old male, referred to emergency department with diffuse abdominal pain, crampy, with 8 h evolution, associated with nausea, vomiting and constipation in the last 48 h. The abdominal examination revealed an asymmetric and fixed distension, with hard consistency on palpation of lower abdominal quadrants. The abdominal radiography reveals a small bowel distension and fluid levels. Submitted to laparoscopic surgery that recourse to conversion because there is a total peritoneal encapsulation of the small bowel. After opening the peritoneal sac, we find a rotation of mesentery, at its root, conditioning twisting of small bowel and consequently occlusion. Uneventful postoperative with discharged at the 6th day. The PE is a very rare congenital anomaly characterized by abnormal bowel back into the abdominal cavity in the early stages of development. Your knowledge becomes important because, although rare, it might be diagnosis in patients with intestinal obstruction, in the absence of other etiologic factors.

关键词： Peritoneal encapsulation Surgery Intestinal obstru

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Spectrofluorometric Study of the Inclusion Complexation of Fluorescent Whitening Agents and β-Cyclodextrins

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International Journal of Organic Chemistry 2016年第4期6卷 192-206页

作者： Carlos Alberto Ramírez Barragán Ezequiel Delgado Fornué Jesús Angel Andrade Ortega Guillermo toríz González Héctor Jesús Contreras Quiñones Centro de Investigación en Biomateriales Departamento de Madera Celulosa y Papel Centro Universitario de Ciencias Exactas e Ingenierías Universidad de Guadalajara Guadalajara Jalisco México

The inclusion complexation behavior of 2,5-Bis(5-tert-butyl-benzoxazol-2yl)-thiophene (UvOB) with native β-cyclodextrin (βCD) and βCD-monochlorotriazinyl (βCD-MCT) was evaluated by fluorescence spectroscopy. The association constant (Ks), stoichiometry, , and were evaluated at 25℃ ± 0.1℃ in phosphate buffer solution (pH = 10.5, 0.1 mo•dm–3) in order to find out the complex formation ability and stability. Fluorescence enhancement for UvOB and UvBNB with both CDs has been observed as a result of the complex formation. A stoichiometry 1:1 for UvOB in both CDs was observed;a stoichiometry 3:1 for UvBNB in both CDs has been observed. The Ksvalues for UvOB were 4916 ± 137 M–1 and 655 ± 19 M–1 (acetone: water 90/10, v/v) with βCD and βCD-MCT, respectively. The value obtained indicates a spontaneous and stable complex formation, but the complex βCD-UvOB showed high Ks value as an indicative of a high concentration of complex formed. Additionally, Ks and thermodynamic parameters and were evaluated in a commercial product UvBNB (UvOB, 13%, v/v). In aqueous solution, the values obtained were 2552 ± 115 and 1787 ± 75 M–1 respectively. Complexation of UvOB with CDs is an interesting approach for utilization of UvOB in aqueous systems without the need of solvents and or surfactants used in commercial product (UvBNB).

关键词： Spectrofluorometry β-Cyclodextrin Monochlorotriazinyl Fluorescent Whitening Agents Inclusion Complexation

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Upgraded role of autophagy in colorectal carcinomas

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World Journal of Gastrointestinal Oncology 2018年第11期10卷 367-369页

作者： Evangelos Koustas Panagiotis Sarantis Athanassios G Papavassiliou Michalis v Karamouzis Division of Molecular Oncology Department of Biological Chemistry Medical SchoolNational and Kapodistrian University of Athens

Autophagy is a basic catabolic process closely asso-ciated with degradation of cellular components. The role of autophagy in colorectal cancer(CRC) remains controversial. The mechanism of autophagy has been identified as protecting mechanism against tumorige-nesis by isolation of damaged organelles or as cytopro-tective provides energy in hypoxic regions of CRC tumors. Mutations in proto-oncogenes, such as RAS and BRAF, have been associated with autophagy initiation through signaling pathways of BRAF/MEK/ERK and PI3 K/AKT/m tor. A combination therapy of chemotherapeutic agents and autophagy inhibitors such as hydroxychloroquine or immunotherapy might represent a major step that could be evaluated as a putative novel therapeutic strategy in CRC patients.

关键词： Autophagy Tumorigenesis Clinical trials Autophagy inhibitors Colorectal cancer

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