Neuroprotective role of protein tyrosine phosphatase-1B in rod photoreceptor neurons

作     者：Raju V.S.Rajala Ammaji Rajala 

作者机构：Department of OphthalmologyUniversity of Oklahoma Health Sciences CenterOklahoma CityOklahoma 73104USA Department of PhysiologyUniversity of Oklahoma Health Sciences CenterOklahoma CityOklahoma 73104USA Department of Cell BiologyUniversity of Oklahoma Health Sciences CenterOklahoma CityOklahoma 73104USA Dean A.McGee Eye InstituteOklahoma CityOklahoma 73104USA 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2013年第4卷第12期

页      面：890-892页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This work was supported by grants from the NIH(Nos.EY016507,EY00871,and EY021725) by an unrestricted depart-mental grant from Research to Prevent Blind-ness,Inc 

主　　题：PTP1B insulin of 

摘      要：Dear Editor,Protein tyrosine phosphatase-1B(PT-P1B)is an abundant,widely expressed non-receptor tyrosine phosphatase,which is thought to be a key negative regulator of insulin signaling(Tonks,2003).Increased and prolonged tyrosine phosphorylation of the insulin recep-tor(IR)was observed in mice lacking PTP1B(Elchebly et al.,1999).