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Apoptosis-inducing effects of extracts from desert plants in HepG2 human hepatocarcinoma cells

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Asian Pacific Journal of Tropical Biomedicine 2015年第2期5卷 87-92页

作者： deepak Bhatia Animesh Mandal Eviatar Nevo Anupam Bishayee Department of Pharmacogenomics Bernard J Dunn School of PharmacyShenandoah University Department of Pharmaceutical Sciences College of PharmacyNortheast Ohio Medical University Institute of Evolution and International Graduate Center of Evolution University of Haifa Department of Pharmaceutical and Biomedical Sciences College of PharmacyCalifornia Northstate University

Objective:To investigat the mechanism of antitumor efficacy of Origanum clayi(***) and Ochradenus baccatus(***) extracts by exploring apoptosis-inducing ***:The aqueous extracts of aerial parts of aforementioned plants were prepared and used for this ***2 cells were treated with varying concentrations(0,2 and 5 mg/mL)of each plant extract for 24 or 48 *** apoptosis was measured by annexin v-fluorescein isothiocyanate binding assay and flow *** expression levels of various apoptosisrelated genes were determined by semi-quantitative reverse transcription-polymerase chain ***:*** and *** extracts exerted apoptotic effects on HepG2 cells for 48 h following *** extract was found to be a better apoptosis-inducing agent than *** extract as the former delivered greater efficacy at a lower *** extracts manifested upregulation of Bax,*** ***-3,***-9 and poly(adenosine diphosphate-ribose) ***:The aqueous extracts of *** and *** are capable of inducing apoptosis in HepG2 cells through modulation of mitochondrial pathway which explains their antitumor *** desert plants may serve as useful resources to develop effective remedies for hepatocellular carcinoma and other human malignancies.

关键词： Ochradenus baccatus Origanum dayi HepG2 cells,Apoptosis Gene expression

Traumatic subcutaneous emphysema of the hand/forearm: A case report

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Chinese Journal of Traumatology 2022年第6期25卷 395-399页

作者： Stephen Saela Alexander Decilveo Roman Isaac deepak v.Patel Department of Orthopaedic Surgery St Josephs University Medical CenterPatersonNJ 07503USA Department of Orthopaedic Surgery Seton Hall UniversitySouth OrangeNJ 07079US

Subcutaneous emphysema is commonly associated with infection caused by gas-producing *** this case report,we describe a rare instance of traumatic subcutaneous emphysema of the hand and forearm caused by a puncture injury to the first web space of the *** objective is to increase awareness of the potential for seemingly minor trauma to cause entrapment of significant air in subcutaneous tissues,thereby decreasing the likelihood that a clinically benign-appearing patient will be started down an unnecessarily aggressive treatment pathway.A 16-year-old,otherwise healthy white female,presented to the pediatric emergency room with an impressive amount of subcutaneous emphysema that developed over a 12-h period after sustaining an accidental laceration to the first web space of her right *** appeared nontoxic and had a clinically benign presentation.A comprehensive work-up was *** was splinted by the orthopedic surgery resident on call,and was admitted to the Pediatric Intensive Care Unit for overnight *** received tetanus vaccination and broad-spectrum *** patient was discharged 2 days after admittance,with a splint applied to her right hand and *** undertook home-based physical and occupational *** had a pain-free range-of-motion in the right wrist,elbow and *** swelling in the right hand subsided *** initially alarming,traumatic subcutaneous emphysema in an otherwise healthy patient from minor wounds(as featured in this case)does not necessarily mean one ought to proceed down an aggressive treatment *** evaluation of the patient's history,clinical examination findings,and determination of the Laboratory Risk Indicator for Necrotizing Fasciitis score can help guide physicians in the management of traumatic subcutaneous emphysema and potentially avoid unnecessary and costly interventions.

关键词： Upper extremity Traumatic subcutaneous emphysema Sucking-wounds Penetrating Necrotizing fasciitis Case reports Laboratory Risk Indicator for Necrotizing Fasciitis(LRINEC)

Response of Photonic Hydrogels of Homogeneous Particles to Uranyl Ions in Aqueous Solutions

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Photonic Sensors 2023年第4期13卷 50-61页

作者： R.G.JOSHI deepak K.GUPTA P.AMESH P.K.PARIDA T.R.RAvINDRAN Materials Science Group Indira Gandhi Centre for Atomic ResearchA CI of Homi Bhabha National InstituteKalpakkam 603102India Materials Chemistry and Metal Fuel Cycle Group Indira Gandhi Centre for Atomic ResearchA CI of Homi Bhabha National InstituteKalpakkam 603102India Metallurgy and Materials Group Indira Gandhi Centre for Atomic ResearchA CI of Homi Bhabha National Institute(HBNI)Kalpakkam 603102India

We study here the response of photonic hydrogels(PHs),made of photonic crystals of homogeneous silica particles in polyacrylamide hydrogels(SPHs),to the uranyl ions 22 UO_(2)^(2+) in aqueous *** is found that the reflection spectra of the SPH show a peak due to the Bragg diffraction,which exhibits a blue shift in the presence of 22 UO_(2)^(2+).Upon exposure to the SPH,22 UO_(2)^(2+)gets adsorbed on the SPH and forms complex coordinate bonds with multiple ligands on the SPH,which causes shrinking of hydrogel and leads to the blue shift in the diffraction *** amount of the blue shift in the diffraction peak increases monotonically up to 22 UO_(2)^(2+)concentrations as high as 2300μ*** equilibration time for the shift in the Bragg peak upon exposure to 22 UO_(2)^(2+)is found to be~30 *** results are in contrast to the earlier reports on photonic hydrogels of inhomogeneous microgel particles hydrogel(MPH),which shows the threshold 22 UO_(2)^(2+)concentration of~600μM,below which the diffraction peak exhibits a blue shift and a change to a red shift above *** equilibration time for MPH is~300 *** observed monotonic blue shift and the faster time response of the SPH to 22 UO_(2)^(2+)as compared to the MPH are explained in terms of homogeneous nature of silica particles in the SPH,against the porous and polymeric nature of microgels in the *** also study the extraction of 22 UO_(2)^(2+)from aqueous solutions using the *** extraction capacity estimated by the arsenazo-III analysis is found to be 112 mM/kg.

关键词： Photonic hydrogels uranium extraction and monitoring arsenazo-Ⅲ-uranium complex polyacrylamide hydrogel Uv-visible spectroscopy

Treatment Initiation among Patients with Multidrug Resistant Tuberculosis in Bhopal District, India

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Journal of Tuberculosis Research 2017年第4期5卷 237-242页

作者： Hemant deepak Shewade Arun M. Kokane Akash Ranjan Singh Manoj verma Malik Parmar Sanjay Singh Chahar Manoj Tiwari Sheeba Naz Khan Mukesh Nagar Sanjai kumar Singh Pradeep kumar Mehra Ajay M. v. kumar International Union against Tuberculosis and Lung Disease (The Union) South-East Asia Office New Delhi India Department of Community Medicine and Family Medicine All India Institute of Medical Sciences (AIIMS) Bhopal India State TB cell Department of Health and Family Welfare Bhopal India World Health Organization Country Office in India New Delhi India International Union against Tuberculosis and Lung Disease (The Union) Paris France

Revised national tuberculosis control programme in India has limited co-hort-wise information about what happens to patients diagnosed with multidrug resistant TB (MDR-TB). We determined the pre-treatment loss to follow-up (non-initiation of treatment by programme within 6 months of diagnosis) and time from diagnosis to treatment initiation in Bhopal district, central India (2014). Pre-treatment loss to follow-up was 13% (0.95 CI: 7%, 23%), not significantly different from the national estimates (18%) and median time to initiate treatment was seven days, lower than that reported elsewhere in the country. Bhopal was performing well with reference to time to treatment initiation in programmatic settings.

关键词： Multidrug-Resistant Tuberculosis Operational Research Pre-Treatment Attrition Diagnosis and Treatment Pathway Initial Loss to Follow-Up

Yield Estimation for a Single Purpose Multi-Reservoir System Using LP Based Yield Model

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Journal of Water Resource and Protection 2013年第7期5卷 28-34页

作者： deepak v. Pattewar Kalpeshkumar M. Sharma P. D. Dahe Civil Engineering Department M. G. M’s College of Engineering Nanded India Civil Water Management S. G. G. S College of Engineering and Technology Nanded India

Application of optimization techniques for determining the optimal operation policy for reservoir is a major area in water resources planning and management. Linear programming, ruled by evolution techniques, has become popular for solving optimization problems in diversified fields of science. An LP-based yield model (YM) has been used to reevaluate the annual yield available from the reservoirs for irrigation. This paper extends the basic yield model and presents a yield model for a multiple-reservoir system consisting of single-purpose reservoirs. Optimum yield of reservoirs system is calculated by yield model. The objective is to achieve prespecified reliability for irrigation and to incorporate an allowable deficit in the annual irrigation target. The yield model is applied to a system of two reservoirs in theManarRiverinIndia. This model can act as a better screening tool in planning by providing outputs that can be very useful in improving the efficiency and accuracy of detailed analysis methods such as simulation.

关键词： Yield Model Reservoir Operation Irrigation Releases Manar River

Identification of Failure Years by Modification of Yield Model in Isapur Reservoir, India

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Journal of Water Resource and Protection 2014年第16期6卷 1509-1516页

作者： Kalpeshkumar M. Sharma deepak v. Pattewar P. D. Dahe Civil Engineering Department MGM’s College of Engineering Nanded India Civil-Water Management Department S.G.G.S’s College of Engineering and Technology Nanded India

The failure years for a desired annual reliability of a water use were prespecified in the yield model. These failure years were identified prior to the solution of the model by observing the critical period in the given annual flow record. Some initial trials of the yield model were usually sufficient to identify the failure years. Simulation can be employed for exact identification of these failure years. A method for determination of failure years through the yield model is presented in this paper, as an alternative to simulation. The yield model employing this method is useful when the reliability of water use is to be considered as a decision variable. The method for determination of failure years by yield model is adopted for further analysis and compare with the simulation model, one of the failure year is not matching with the common set of failure years in the simulation model.

关键词： Yield Model Simulation Model Isapur Reservoir

High energy superstable hybrid capacitor with a self-regulated Zn/electrolyte interface and 3D graphene-like carbon cathode

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InfoMat 2022年第10期4卷 62-77页

作者： Nilesh R.Chodankar Swati J.Patil Sangjin Lee Jaeho Lee Seung-Kyu Hwang Pragati A.Shinde Indrajit v.Bagal Smita v.Karekar Ganji Seeta Rama Raju Kugalur Shanmugam Ranjith deepak P.Dubal Yun-Suk Huh Young-Kyu Han Department of Energy and Material Engineering Dongguk University-SeoulSeoulRepublic of Korea Department of Biological Engineering NanoBio High-Tech Materials Research CenterInha UniversityIncheonRepublic of Korea Department of Biological Sciences and Bioengineering Inha UniversityIncheonRepublic of Korea Research Institute of Sciences and Engineering University of SharjahSharjahUnited Arab Emirates Department of Physics Chonnam National UniversityGwangjuRepublic of Korea School of Chemistry and Physics Centre for Materials ScienceQueensland University of Technology(QUT)BrisbaneQueenslandAustralia

Rechargeable aqueous zinc ion hybrid capacitors(ZIHCs),as an up-and-comer aqueous electrochemical energy storage system,endure in their infancy because of the substandard reversibility of Zn anodes,structural deterioration of cathode materials,and narrow electrochemical stability ***,a scalable approach is described that addresses Zn-anode/electrolyte interface and cathode materials associated deficiencies and boosts the electrochemical properties of *** Zn-anode/electrolyte interface is self-regulated by alteration of the traditional Zn2+electrolyte with Na-based supporting salt without surrendering the cost,safety,and green features of the Zn-based system which further validates the excellent reversibility over 1100 h with suppressed hydrogen *** deficits of cathode materials were overcome by using a high-mass loaded,oxygen-rich,3D,multiscaled graphene-like carbon(3D MGC)*** to the multiscaled texture,high electronic conductivity,and oxygen-rich functional groups of 3D MGC,reversible redox capacitance was obtained with a traditional adsorption/desorption *** ZIHCs containing the modified electrolyte and an oxygen-rich 3D MGC cathode resulted in battery-like specific energy(203 Wh kg1 at 1.6 A g^(-1))and supercapacitor-type power capability(4.9 kW kg1 at 8 A g^(-1))with outstanding cycling durability(96.75%retention over 30000 cycles at 10 A g^(-1)).These findings pave the way toward the utilization of highly efficient ZIHCs for practical applications.

关键词： electrolyte additive graphene-like carbon interface multivalent ion capacitor zinc

Crystal and Molecular Structure Analysis in Knoevenagel Condensation Product of Substituted Napthofuran-2-Carbaldehydes

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Crystal Structure Theory and Applications 2020年第3期9卷 49-62页

作者： Avantika Hasija v. Prakash M. Shet Prakash vasu G. Krishnasamy deepak Chopra Crystallography and Crystal Chemistry Laboratory Department of Chemistry Indian Institute of Science Education and Research Bhopal Bhopal Madhya Pradesh India Sri Sairam College of Engineering Karnataka India Department of Studies and Research in Chemistry University College of Science Tumkur University Tumakuru Karnataka India vivekananda Degree College Malleshwaram Karnataka India Department of Studies and Research in Organic Chemistry Tumkur University Tumakuru Karnataka India

In the current study, two novel Knoevenagel condensation products of substituted napthofuran-2-carbaldehydes were designed, synthesized and characterized. In order to study the intermolecular interactions of title compounds, single crystals were grown by slow evaporation solution growth technique at room temperature and crystal structure has been determined by single crystal X-ray diffraction technique. Both the molecules crystallize in the monoclinic centrosymmetric space group P21/c with one molecule in the asymmetric unit. In compound [4] the molecules are connected via bifurcated C-H···O=C and C-H···N=C H-bonds and van der Waals interactions forming a layered structure, whereas in compound [5a] the molecular conformation is stabilized via intramolecular C-H···O H-bond and molecule interacts with other molecule generated via 21-screw via bifurcated C-H···O=verdana;">C alo

关键词： Napthofuran-2-Carbaldehyde 8-Nitro Napthafura-2-Carbaldehyde Knoevenagel Condensation Single Crystal and Hirshfeld Surface Analysis

Synergetic influence of ex-situ camphoric carbon nano-grafting on lithium titanates for lithium ion capacitors

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Journal of Energy Chemistry 2015年第3期24卷 337-345页

作者： Amruthalakshmi vijayakumar Ranjusha Rajagopalan Anoop S.Sushamakumariamma Jickson Joseph Amrutha Ajay Shantikumar v Nair deepak Krishna M.S Avinash Balakrishnan Nanosolar Division Amrita Center for Nanosciences Institute for Superconducting & Electronic Materials (ISEM) University of Wollongong

The present study provides detailed experimental results on the synthesis and characterization of carbonized lithium titanate spinel（LTO） composites as electrode materials for lithium ion *** LTO particles were grafted with a porous carbon layer obtained from the pyrolysis of *** graphitic nature of the carbon was confirmed through Raman *** relative contributions from the capacitive and diffusion controlled processes underlying these electrodes were mathematically *** transport mechanism underlying these electrodes was determined by measuring the work functions（φ） of LTO and carbon grafted LTO using ultraviolet photoelectron *** carbon grafted LTO composites exhibited an energy density of 330 m Wh L-1and a peak power density of 2.8 k W L-1,when employed as electrodes in coin cells with excellent cycling stability at the end of 4000 cycles.

关键词： functional composites capacitors electrical properties lithium ion energy storage