Mixed neuroendocrine-non-neuroendocrine neoplasms of the digestive system:A mini-review

作     者：Deepak Toor Jonathan M Loree Zu-Hua Gao Gang Wang Chen Zhou 

作者机构：Department of Pathology and Laboratory MedicineBC CancerVancouver V5Z 1H5Canada Department of Pathology and Laboratory MedicineUniversity of British ColumbiaVancouver V5Z 1H5Canada Department of MedicineBC CancerVancouver V5Z 4E6Canada 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第19期

页      面：2076-2087页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Amgen Ipsen Biopharmaceuticals 

主　　题：Mixed neuroendocrine non-neuroendocrine neoplasms Mixed adenoneuorendocrine carcinoma Mixed neuroendocrine neoplasms Neuroendocrine Non-neuroendocrine 

摘      要：Mixed neuroendocrine-non-neuroendocrine neoplasms(MiNENs)are rare mixed tumors containing both neuroendocrine(NE)and non-NE *** component must occupy at least 30%of the tumor volume by *** molecular evidence suggests MiNENs are clonal neoplasms and potentially harbor targetable mutations similar to conventional *** have been multiple changes in the nomenclature and classification of MiNENs which has created some confusion among pathologists on how to integrate the contributions of each component in a MiNEN,an issue which in turn has resulted in confusion in communication with front-line treating *** mini review summarizes our current understanding of MiNENs and outline diagnosis,prognosis,and management of these *** authors emphasize the importance of treating the most aggressive component of the tumor regardless of its percentage volume.