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Mechanism-driven strategies for prevention of rheumatoid arthritis

Rheumatology & Autoimmunity 2022年第3期2卷 109-119页

作者： v.michael holers Kristine A.Kuhn M.Kristen Demoruelle Jill M.Norris Gary S.Firestein Eddie A.James William H.Robinson Jane H.Buckner Kevin D.Deane Division of Rheumatology University of Colorado School of MedicineAuroraColoradoUSA Department of Epidemiology Colorado School of Public HealthAuroraColoradoUSA Division of Rheumatology Allergy and ImmunologyUniversity of California San DiegoLa JollaCaliforniaUSA Benaroya Research Institute SeattleWashingtonUSA Division of Immunology and Rheumatology Stanford UniversityStanfordCaliforniaUSA Department of Medicine Division of RheumatologyVA Palo Alto Health Care SystemPalo AltoCaliforniaUSA

In seropositive rheumatoid arthritis(RA),the onset of clinically apparent inflammatory arthritis(IA)is typically preceded by a prolonged period of autoimmunity manifest by the presence of circulating autoantibodies that can include antibodies to citrullinated protein antigens(ACPA)and rheumatoid *** period before clinical IA can be designated preclinical RA in those individuals who have progressed to a clinical diagnosis of RA,and an“at‐risk”status in those who have not developed IA but exhibit predictive biomarkers of future clinical *** the goal of developing RA prevention strategies,studies have characterized immune phenotypes of preclinical RA/at-risk *** these studies,a model has emerged wherein mucosal inflammation and dysbiosis may lead first to local autoantibody production,which should normally be transient,but instead is followed by a systemic spread of the autoimmunity as manifested by serum autoantibody elevations,ultimately driving the development of clinically identified joint *** model can be envisioned as the progression of disease development through serial“checkpoints”that in principle should constrain or resolve autoimmunity;however,instead,the checkpoints“fail”and clinical RA *** we review the immune processes that are likely to be present at each step and the potential therapeutic strategies that could be envisioned to delay,diminish,halt,or even reverse the progression to clinical ***,these prevention strategies could utilize existing therapies approved for clinical RA,therapies approved for other diseases that target relevant pathways in the preclinical/at-risk state,or approaches that target novel pathways.

关键词： autoimmune disease inflammation mucosa prevention rheumatoid arthritis

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Geometric Programming for Nonlinear Satellite Buffer Networks With Time Delays under L_(1)-Gain Performance

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 554-556页

作者： Yukang Cui Yihui Huang michael v.Basin Zongze Wu College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060China Shenzhen University Shenzhen 518060China Peng Cheng Laboratory Shenzhen 518060China Robotics Institute Ningbo University of TechnologyNingbo 315211China Autonomous University of Nuevo Leon Nuevo Leon 66455Mexico

Dear Editor,This letter concerns the parameter tuning problem for nonlinear satellite buffer networks with communication delays, aiming to optimize their stability properties under L_(1)-gain. We first model the satellite buffer networks by a nonlinear time-delay positive system and propose a novel characterization under which the nonlinear system is asymptotically stable with a prescribed L_(1)-induced performance.

关键词： nonlinear system prescribed

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超顺磁铁纳米材料与血清蛋白结合模式

超顺磁铁纳米材料与血清蛋白结合模式

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作者：陈芳芳王冠奎 James I.Griffin Barbara Brenneman Nirmal K.Banda v.michael holers Donald S.Backos 吴林平 Seyed Moein Monghimi Dmitri Simberg 吉林大学

成果内容研究属于纳米医学转化领域成果,应用医学免疫学及化学、材料学的技术揭示纳米材料与补体、免疫细胞等固有免疫应答系统相互作用的结果及客观规律。纳米材料造影剂和药物载体静脉注射后吸附血液蛋白质形成蛋白冠,蛋白冠的组成取...

成果内容研究属于纳米医学转化领域成果,应用医学免疫学及化学、材料学的技术揭示纳米材料与补体、免疫细胞等固有免疫应答系统相互作用的结果及客观规律。纳米材料造影剂和药物载体静脉注射后吸附血液蛋白质形成蛋白冠,蛋白冠的组成取决于纳米材料固有的物理化学性质,其在纳米材料药代动力学和生物学性能中发挥调节作用,对其靶向、免疫识别和毒性均有影响。本研究尝试通过工程学超顺磁氧化

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Use of an immunocapture device to detect cytokine release in discrete brain regions

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Neural Regeneration Research 2024年第4期19卷 703-704页

作者： Matthew G.Frank michael v.Baratta Department of Integrative Physiology University of Colorado BoulderBoulderCOUSA(Frank MG)Department of Psychology and NeuroscienceUniversity of Colorado BoulderBoulderCOUSA(Baratta MV)

Production of proinflammatory cytokines in the central nervous system is a key process in the neuroinflammatory response to trauma,infection,and neurodegenerative diseases(Kumar,2019).These intercellular signaling molecules play multiple roles in the immune response in the central nervous system including the orchestration of the sickness response to innate immune perturbations in the brain(Dantzer et al.,2008).

关键词： system release innate

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Ion-conducting Membranes Based on Bacterial Cellulose Nanofibers Modified by Poly(sodium acrylate-co-2-acrylamido-2-methylpropanesulfonic acid)

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Chinese Journal of Polymer Science 2024年第3期42卷 333-343,I0007页

作者： Elizaveta v.Batishcheva Nikolay N.Smirnov Natalya v.Bobrova Maria P.Sokolova michael A.Smirnov Institute of Macromolecular Compounds Russian Academy of SciencesBolshoy pr.31Saint Petersburg 199004Russia

Green method for preparation of ion-conducting membranes(ICM) based on bacterial cellulose nanofibers(CNF) modified by a copolymer of sodium acrylate and 2-acrylamido-2-methylpropanesulfonic acid was elaborated. FTIR and NMR data confirmed grafting of polyacrylate onto cellulose surface. Formation of porous structure of the ICM was controlled by SEM and AFM. The maximal ionic conductivity of the membranes reaches 1.5 and 3.1 mS·cm^(-1)(60 ℃ and 98% relative humidity) when they are saturated with water or H_2SO_4(1 mol·L^(-1)) electrolyte,respectively. Prepared ICM was tested as a separator in a symmetrical supercapacitor with electrodes based on polyaniline hydrogel. The assembled cell demonstrate ability to operate at high current density up to 100 A·g^(-1) maintaining specific capacitance 165 F·g^(-1). Maximal specific capacitance of 289 F·g^(-1) was achieved at current density 1 A·g^(-1). Retaining of 90% of initial capacitance after 10000 of charge-discharge cycles proves high electrochemical stability of prepared ICM.

关键词： Bacterial cellulose Ion conductivity Porous membrane Supercapacitor

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An examination of thematic research,development,and trends in remote sensing applied to conservation agriculture

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International Soil and Water Conservation Research 2024年第1期12卷 77-95页

作者： Zobaer Ahmed Aaron Shew Lawton Nalley michael Popp v.Steven Green Kristofor Brye Center for Advanced Spatial Technologies University of ArkansasFayettevilleARUSA Environmental Dynamics Program University of ArkansasFayettevilleARUSA Department of Agricultural Economics and Agribusiness University of ArkansasFayettevilleARUSA College of Agriculture Arkansas State UniversityJonesboroARUSA University of Arkansas System Division of Agriculture Little RockARUSA Department of Crop Soiland Environmental SciencesUniversity of ArkansasFayettevilleARUSA

Conservation agriculture seeks to reduce environmental degradation through sustainable management of agricultural *** the 1990s,agricultural research has been conducted using remote sensing technologies;however,few previous reviews have been conducted focused on different conservation management *** of the previous literature has focused on the application of remote sensing in agriculture without focusing exclusively on conservation practices,with some only providing a narrative review,others using biophysical remote sensing for quantitative estimates of the bio-geo-chemical-physical properties of soils and crops,and few others focused on single agricultural management *** paper used the preferred reporting items for systematic review(PRISMA)methodology to examine the last 30 years of thematic research,development,and trends associated with remote sensing technologies and methods applied to conservation agriculture research at various spatial and temporal scales.A set of predefined key concepts and keywords were applied in three databases:Scopus,Web of Science,and Google Scholar.A total of 188 articles were compiled for initial examination,where 68 articles were selected for final analysis and grouped into cover crops,crop residue,crop rotation,mulching,and tillage *** on conservation agriculture research using remote sensing have been increasing since 1991 and peaked at 10 publications in *** the 68 articles,94%used a pixel-based,while only 6%used an object-based classification *** to 2005,tillage practices were abundantly studied,then crop residue was a focused theme between 2004 and *** 2012 to 2020,the focus shifted again to cover *** spectral indices were used in 76%of the 68 *** examination offered a summary of the new potential and identifies crucial future research needs and directions that could improve the contribution of remote sensing to the provision of long-term operat

关键词： Remote sensing Conservation agriculture Classification algorithm Spatial resolution Satellite Spectral indices PRISMA

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Self-healable and Robust Film Based on Electroactive Polymer Brush as Electrode for Flexible Supercapacitor

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Chinese Journal of Polymer Science 2024年第8期42卷 1049-1059页

作者： Maria P.Sokolova vitaly K.vorobiov Nikolay N.Smirnov Ivan S.Kuryndin Natalya v.Bobrova michael A.Smirnov Institute of Macromolecular Compounds Russian Academy of SciencesBolshoy pr.31Saint Petersburg 199004Russia

The aim of this study was to develop self-healable and robust elect roconductive film based on polyaniline copolymer for application as electrode in flexible *** this purpose,the electroconductive polymer brushes(EPB)was *** synthesis of EPB is based on graft polymerizations of acrylamide(AAm)on poly(vinyl alcohol)(PvA)with formation of PvA-PAAm polymer brush and subsequent graft copolymerization of aniline and p-phenylenediamine on PvA-PAAm resulting in formation of EPB with electroconducting copoly(aniline-co-pphenylenediamine)(PAPh DA).It was found that the ratio between PvA and PAAm at the first stage greatly influence the electrochemical performance of the *** films were prepared by casting of EPB solution with subsequent *** of electrical current distribution through the film with AFM reveal more uniform distribution of PAPhDA in EPB in comparison with reference PvA-PAPhDA and PAAm-PAPhDA *** was demonstrated that mechanical cha racteristics and electrical conductivity values of films restore at large extent after curring and self-healing under optimal relative humidity level(58%).The flexile supercapacitor cell with EPB film electrodes demon strate specific capacitance 602 mF·cm^(-2)at the current density of 1 mA·cm^(-2)and retention 94%of initial capacitance after 5000 charge/discharge cycles.

关键词： Polymer brush Polyaniline Flexible supercapacitor Self-healing Electroconducting film

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Diabetes and pulmonary infection:how hyperglycaemia shapes the immune system

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1245-1246页

作者： Christian Herder michael Roden Nicolas venteclef Institute for Clinical Diabetology German Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf40225DüsseldorfGermany German Center for Diabetes Research(DZD) Partner Düsseldorf85764München-NeuherbergGermany Department of Endocrinology and Diabetology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University Düsseldorf40225DüsseldorfGermany Institut Necker-Enfants Malades(INEM) UniversitéParis CitéINSERM UMR-S1151CNRS UMR-S8253ParisFrance

In a recent study published in Nature,Nobs and colleagues aimed to identify novel mechanisms that may explain why diabetes is associated with an increased susceptibility to viral respiratory *** analyses revealed a central role of lung dendritic cells(DC)which exhibited several functional defects induced by hyperglycaemia and consequently result in impaired antiviral immune responses.

关键词： impaired lung respiratory

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Bacteria colonization and gene expression related to immune function in colon mucosa is associated with growth in neonatal calves regardless of live yeast supplementation

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1980-1995页

作者： Koki Nishihara Clothilde villot Lautaro Cangiano Le Luo Guan michael Steele Department of Animal Biosciences Animal Science and NutritionUniversity of GuelphGuelphON N1G 1Y2Canada Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmonton T6G 2P5Canada Lallemand SAS Blagnac F‑31702France Department of Animal and Dairy Sciences University of Wisconsin-MadisonMadisonWIUSA Faculty of Land and Food Systems The University of British ColumbiaVancouverBC V6T 1Z4Canada Present Address:Department of Animal Biosciences University of GuelphGuelphON N1G 2W1Canada

Background As Holstein calves are susceptible to gastrointestinal disorders during the first week of life,understanding how intestinal immune function develops in neonatal calves is important to promote better intestinal *** probiotics in early life may contribute to host intestinal health by facilitating beneficial bacteria colonization and developing intestinal immune *** objective of this study was to characterize the impact of early life yeast supplementation and growth on colon mucosa-attached bacteria and host immune *** Twenty Holstein bull calves received no supplementation(CON)or Saccharomyces cerevisiae boulardii(SCB)from birth to 5 d of *** tissue biopsies were taken within 2 h of life(D0)before the first colostrum feeding and 3 h after the morning feeding at d 5 of age(D5)to analyze mucosa-attached bacteria and colon *** sequencing showed that there was no difference inαandβdiversity of mucosa-attached bacteria between day and treatment,but bacteria related to diarrhea were more abundant in the colon mucosa on D0 compared to *** addition,q PCR indicated that the absolute abundance of Escherichia coli(***)decreased in the colon mucosa on D5 compared to D0;however,that of Bifidobacterium,Lactobacillus,and Faecalibacterium prausnitzii,which could competitively exclude ***,increased in the colon mucosa on D5 compared to ***-sequencing showed that there were no differentially expressed genes between CON and SCB,but suggested that pathways related to viral infection such as“Interferon Signaling”were activated in the colon mucosa of D5 compared to *** Growth affected mucosa-attached bacteria and host immune function in the colon mucosa during the first 5 d of life in dairy calves independently of SCB *** early life,opportunistic pathogens may decrease due to intestinal environmental changes by beneficial bacteria and/or host immune *** activation

关键词： Colon biopsy Dairy calves RNA-sequencing Saccharomyces cerevisiae boulardii 16S rRNA amplicon-sequencing

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RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

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Bone Research 2024年第1期12卷 165-179页

作者： Luis F.de Castro Jarred M.Whitlock Zachary Michel Kristen Pan Jocelyn Taylor vivian Szymczuk Brendan Boyce Daniel Martin vardit Kram Rebeca Galisteo Kamran Melikov Leonid v.Chernomordik michael T.Collins Alison M.Boyce Skeletal Disorders and Mineral Homeostasis Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Section on Membrane Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA Metabolic Bone Disorders Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Department of Plastic and Reconstructive Surgery The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA NIDCR Genomics and Computational Biology Core National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

Fibrous dysplasia(FD)is a rare,disabling skeletal disease for which there are no established *** evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear kappa-B ligand(RANKL)as a potential treatment *** this study,we investigated the mechanisms underlying RANKL inhibition in FD tissue and its likely indirect effects on osteoprogenitors by evaluating human FD tissue pre-and post-treatment in a phase 2 clinical trial of denosumab(NCT03571191)and in murine in vivo and ex vivo preclinical *** analysis of human and mouse tissue demonstrated increased osteogenic maturation,reduced cellularity,and reduced expression of the pathogenic Gαs variant in FD lesions after RANKL *** sequencing of human and mouse tissue supported these *** interaction between osteoclasts and mutant osteoprogenitors was further assessed in an ex vivo lesion model,which indicated that the proliferation of abnormal FD osteoprogenitors was dependent on *** results from this study demonstrated that,in addition to its expected antiosteoclastic effect,denosumab reduces FD lesion activity by decreasing FD cell proliferation and increasing osteogenic maturation,leading to increased bone formation within *** findings highlight the unappreciated role of cellular crosstalk between osteoclasts and preosteoblasts/osteoblasts as a driver of FD pathology and demonstrate a novel mechanism of action of denosumab in the treatment of bone disease.

关键词： dysplasia treatment finding

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