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Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

Oncology Research 2024年第1期32卷 73-94页

作者： v.gnesh balaji e DIvYA RAMeSH MANISHA CHUNGAN SHAJU AKSHARA KUMAR SAMYAK PANDeY RAKSHA NAYAK v.ALKA SRISHTI MUNJAL AMIR SALIMI K.SReeDHARA RANGANATH PAI SHANKAR M.BAKKANNAvAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human *** is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological ***,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome ***,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological *** are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor *** the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological *** though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic ***,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： exosomes Physiology Cancer Therapeutics Challenges

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Gray-Hole Attack Minimization in IoMT with 5G Based D2D Networks

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Computer Systems Science & engineering 2022年第9期42卷 1289-1303页

作者： v.balaji P.Selvaraj Department of Computing Technologies College of Engineering and TechnologyFaculty of Engineering and TechnologySRM Institute of Science and TechnologyKattankulathur603203TamilnaduIndia

Reliable transmission is vital to the success of the next generation ofcommunications technologies and Fifth Generation (5G) networks. Many sensitive applications, such as eHealth and medical services, can benefit from a 5G network. The Internet of Medical Things (IoMT) is a new field that fosters themaintenance of trust among various IoMT Device to Device (D2D) modern technologies. In IoMT the medical devices have to be connected through a wirelessnetwork and constantly needs to be self-configured to provide consistent and effi-cient data transmission. The medical devices need to be connected with sophisticated protocols and architecture to handle the synergy of the monitoring ***, one of the commonly used algorithms in D2D communication is the Optimized Link State Routing protocol (OLSR). The OLSR is considerably good ateffectively utilizing the bandwidth and reserving the paths. One of the majorattack against the OLSR is the Node isolation attack, also known as the Gray holedenial of service attack. The Gray hole attack exploits the vulnerabilities presentwith sharing the topological information of the network. The attackers may usethis topological information to maliciously disconnect the target nodes from theexisting network and stops rendering the communication services to the victimnode. Hence, considering the sensitivity and security concerns of the data usedin e-Health applications, these types of attacks must be detected and disabledproactively. In this work, a novel Node Authentication (NA) with OLSR is proposed. The simulation experiments illustrated that the proposed protocol has anexcellent Packet Delivery Ratio, minimal end-end delay, and minimal Packet losswhen compared to the Ad-hoc On-Demand Distance victor (AODv) protocol andthe proposed authentication scheme was able to protect the OLSR protocol from anode isolation attack.

关键词： 5G AODv D2D IoMT OLSR security issues

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Intravenous immunoglobulin-mediated expansion of regulatory T cells in autoimmune patients is associated with increased prostaglandin e2 levels in the circulation

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Cellular & Molecular Immunology 2015年第5期12卷 650-652页

作者： Mohan S Maddur Jamma Trinath Magalie Rabin Francis Bolgert Moneger Guy Jean-Michel vallat Laurent Magy Kithiganahalli N balaji Srini v Kaveri Jagadeesh Bayry Institut National de la Sante et de la Recherche Medicale Paris France Centre de Recherche des Cordeliers Equipe - Immunopathology and Therapeutic Immunointervention Paris France Sorbonne Universites - UPMC Univ Paris 6 Paris France Universite Paris Descartes Paris France Department of Microbiology and Cell Biology Indian Institute of Science Bangalore India Centre de Reference 'Neuropathies Peripheriques Rares' et Service de Neurologie Hopital Universitaire Limoges Limoges France Reanimation Neurologique Neurologie 1 Hopital de la Pitie-Salpetriere Paris France International Associated Laboratory IMPACT (Institut National de la Sante et de la Recherche Medicale France -Indian Council of Medical Research India) National Institute of Immunohaematology Mumbai India

CD4＋FoxP3＋ regulatory T cells （Tregs） are immunosuppressive cells that are critical for immune tolerance. Several studies have demonstrated that one of the anti-inflammatory mechanisms of action of intravenous immunoglobulin （Wig） involves the expansion of Tregs. Recently, we demonstrated that IvIgmediated Treg expansion involves the cyclooxygenase-2 （COX-2）-dependent induction of prostaglandin e2 （PGe2） in human dendritic cells （DCs）. However, the validity of these findings in autoimmune patients is lacking.

关键词： associated increased prostaglandin

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Nasopharyngeal colonization of otopathogens in South Indian children with acuteotitis media -- A case control pilot study

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Journal of Otology 2021年第4期16卷 220-224页

作者： M.Napolean v.Rosemol M.John A.M.varghese J.Periyasamy v.balaji P.Naina Department of eNT Christian Medical CollegeVelloreTamil NaduIndia Department of Clinical Microbiology Christian Medical CollegeVelloreIndia

Background: Acute otitis media (AOM) is an inflammatory disease of the middle ear causing significantmorbidity in early childhood. A pilot study was undertaken to identify the role of various risk factorsSouth Indian children with AOM, especially the role of nasopharyngeal ***: A prospective case control pilot study was conducted in children aged below six years,presenting to a single tertiary care from 2018 to 2019. Fifty cases with AOM and 45 age and gendermatched controls were recruited. Two nasopharyngeal swabs were collected, one was processed forbacterial culture. The other swab was processed according to the CDC recommended broth enrichmentmethod to identify carriage of S. pneumoniae. Subsequent serotyping was done by Quellung method andconventional sequential multiplex ***: Otalgia was the major presentation seen in 92% of the children with AOM. None of the clinical anddemographic characteristics were found to be statistically significant between the cases and controls. Themost common otopathogen was S. pneumoniae (55%) followed by H. influenza (29%). The commonS. pneumoniae serotypes encountered were 11A and *** colonization with S. pneumoniae[OR 6.57, p enzae [OR14.18, p ere significant risk factors for AOM inchildren. The risk increased with co-colonization (OR 13.89,p engthens the significant association between nasopharyngeal colonization ofotopathogens and AOM as a risk factor that is enhanced by co-colonization.S. pneumoniae was the mainotopathogen in this population, serotypes 11A and 19F being the most common.

关键词： Acute otitis media Nasopharyngeal Otopathogens Case control study Streptococcus pneumoniae Haemophilus influenzae Moraxella catarrhalis Staphylococcus aureus

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A Critical Comparison of Mildly Acidic versus Alkaline Zinc Batteries

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Accounts of Materials Research 2023年第4期4卷 299-306页

作者： vinod Mathew Noah B.Schorr balaji Sambandam Timothy N.Lambert Jaekook Kim Chonnam National University Gwangju 61186South Korea Sandia National Laboratories AlbuquerqueNew Mexico 87185United States

Aqueous rechargeable batteries are cost-effective,easy to fabricate,and safe,deliver high energy output,and employ stable water-based electrolytes compared to organicbased lithium-ion batteries(LIBs).Aqueous Zn electrochemistry,specifically,has attracted researchers since the *** Zn is a nearly ideal anode owing to its low cost(ca.2 USD kg^(−1)),existing supply chain,environmental benignity,relative safety,and high stability in water[−0.76 v vs standard hydrogen electrode(SHe)],as compared to Li.^(1−3) The high theoretical capacity(2e−@820 mAh g^(−1))and low polarizability(6×10^(−8)Ωm)further motivate Zn-based battery development,especially for stationary storage.2,4 Alkaline Zn batteries(AZBs)and neutral/mildly acidic Znion batteries(MZIBs)are proposed as rivals to the established Pb-acid and LIBs owing to their competitive theoretical energy densities(∼200−400 Wh L^(−1)).The efficiency of these inexpensive and safe battery technologies is dependent on the cathode type,Zn anode formulation,separator materials,and the electrolyte type(liquid,gel,solid state)and *** AZBs and MZIBs have commonalities,including Zn dendrite formation at high capacity utilization and inherent low voltage(Zn batteryve materials chemistry challenges and operating principles distinguish *** example,in AZBs,the preference is to prevent the crossover of the soluble anode oxidation product[zincate,Zn(OH)_(4)^(2−) anion]through the separator to the cathode,while MZIBs necessitate aversion to intermediate multiphase formation with active cathode material and removal of ambiguity in the reaction route of water-solvated Zn^(2+) cation with the cathode.

关键词： battery Zinc electrolyte

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