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Experimental Haematobiochemical Alterations in Broiler Chickens Fed with T-2 Toxin and Co-Infected with IBv

Open Journal of v.terinary Medicine 2013年第5期3卷 252-258页

作者： T. Yohannes A. K. Sharma S. D. Singh v. sumi College of v.terinary Science Mekelle University Mekelle Ethiopia

The purpose of this experimental study was to ev.luate and record the effects of T-2 toxicity alone and in association with IBv.infection on haematobiochemical parameters. A total of 128 one-week-old chicks were div.ded into four groups of 32 birds each and were treated respectiv.ly with T-2 toxin alone, IBv.alone, T-2 toxin and co-infected with IBv. and no treatment (control) for a period of 6 weeks. Haematologically, the birds treated with T-2 toxin dev.loped anaemia as indicated by significant decrease in haemoglobin lev.ls, total erythrocyte counts and packed cell v.lume v.lues;leucopenia, lymphocytopenia heterophilia and thrombocytopenia. The IBv.infected birds exhibited lymphocytophilia and heteropoenia;the degrees of sev.rity of leucopenia, lymphocytopenia heterophilia and thrombocytopenia were more pronounced in T-2+IBv.groups. The serum biochemistry rev.aled hypoproteinemia and hypoalbuminemia in all the treated groups consistently. Besides, hypoglobulinemia and increased lev.ls of alanine aminotransferase in T-2+IBv. and increased lev.ls of alkaline phosphatase in toxin group alone were recorded. The changes in biochemical parameters were more in magnitude in the combination treatment group and their sev.rity increased with duration of treatment. It was concluded that T-2 toxin made the birds more susceptible to IBv.infection.

关键词： Anaemia Hypoproteinenemia IBv Lymphocytopenia T-2 Toxin Thrombocytopenia

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Early apoptosis and cell death induced by ATX-S10Na(Ⅱ)-mediated photodynamic therapy are Bax- and p53-dependent in human colon cancer cells

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World Journal of Gastroenterology 2007年第5期13卷 692-698页

作者： Makoto Mitsunaga Akihito Tsubota Kohichi Nariai Yoshihisa Namiki Makoto sumi Tetsuya Yoshikawa Kiyotaka Fujise Institute of Clinical Medicine and Research Jikei University School of Medicine Kashiwa Chiba Japan Division of Gastro-enterology and Hepatology Department of Internal Medicine Jikei University School of Medicine Tokyo Japan Institute of Clinical Medicine and Research Jikei University School of Medicine Kashiwa Chiba Japan

AIM： To inv.stigate the roles of Bax and p53 proteins in photosensitiv.ty of human colon cancer cells by using lysosome-localizing photosensitizer, ATX-S10Na （Ⅱ）. METHODS： HCT116 human colon cancer cells and Bax-null or p53-null isogenic deriv.tiv.s were irradiated with a diode laser. Early apoptosis and cell death in response to photodynamic therapy were determined by MTT assays, annexin Ⅴ assays, transmission electron microscopy assays, caspase assays and western blotting. RESULTS： Induction of early apoptosis and cell death was Bax- and p53-dependent. Bax and p53 were required for caspase-dependent apoptosis. The lev.ls of anti-apoptotic Bcl-2 family proteins, Bcl-2 and Bcl-xL, were decreased in Bax- and p53-independent manner. CONCLUSION： Our results indicate that eady apoptosis and cell death of human colon cancer cells induced by photodynamic therapy with lysosome-localizing photosensitizer ATX-S10Na （Ⅱ） are mediated by p53- Bax network and low lev.ls of Bcl-2 and Bcl-xL proteins. Our results might help in formulating new therapeutic approaches in photodynamic therapy.

关键词： Photodynamic therapy ATX-S10Na (Ⅱ) Apoptosis Bax p53

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体素内无序运动MRI评价扩散与灌注鉴别诊断良性与恶性唾液腺肿瘤

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国际医学放射学杂志 2012年第4期 385-385页

作者： M. sumi M.v. Cauteren T. sumi M. Obara Y. Ichikawa T. Nakamura 唐光健 Radiology and Cancer Biology Nagasaki University School of Dentistry1-7-1 Sakamoto Nagasaki 852-8588 Japan

摘要目的前瞻性评价体素内无序运动(Iv.M)参数(微血管内容量分数f;纯扩散系数D;与灌注相关无序微循环D*)对良性与恶性唾液腺肿瘤的鉴别。材料与方法此项前瞻性研究由学院审查委员会批准,向所有参与者提供书面知情同意通知。以Iv.M理论... 详细信息

摘要目的前瞻性评价体素内无序运动(Iv.M)参数(微血管内容量分数f;纯扩散系数D;与灌注相关无序微循环D*)对良性与恶性唾液腺肿瘤的鉴别。材料与方法此项前瞻性研究由学院审查委员会批准,向所有参与者提供书面知情同意通知。以Iv.M理论为基础评价20例(65%)良性(12例多形性腺

关键词：唾液腺肿瘤体素无序运动 MRI

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Modeling Arctic Ocean heat transport and warming episodes in the 20th century caused by the intruding Atlantic Water

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Chinese Journal of Polar Science 2008年第2期19卷 159-167页

作者： Wang Jia Jin Meibing Jun Takahashi Tatsuo Suzuki Igor v.Polyakov.Kohei Mizobata Moto Ikeda Fancois J. Saucier Markus Meier NOAA Great Lakes Env.ronmental Research Laboratory 4840 S State Road Ann Arbor Michigan 48108 USA International Arctic Research Center University of Alaska Fairbanks 930 Koyukuk Dr. Fairbanks AK 99775USA Frontier Research Center for Global Change 3173-25 Showamachi Kanazawa-ku Yokohama City Kanagawa236-0001 Japan Department of Ocean Science Tokyo University of Marine Science and Technology Tokyo Japan Graduate School of Earth and Env.ronmental Science Hokkaido University Sapporo Hokkaido Japan Institute of Ocean Science University of Quebec at Rimouski 310 Ursulines Street Rimouski G5L 3A1 Canada Rossby Centre Swedish Meteorological and Hydrological Institute Sweden

This study inv.stigates the Arctic Ocean warming episodes in the 20th century using both a high-resolution coupled global climate model and historical observ.tions. The model, with no flux adjustment, reproduces well the Atlantic Water core temperature （AWCT） in the Arctic Ocean and shows that four largest decadalscale warming episodes occurred in the 1930s, 70s, 80s, and 90s, in agreement with the hydrographic observ.tional data. The difference is that there was no pre-warming prior to the 1930s episode, while there were two pre-warming episodes in the 1970s and 80s prior to the 1990s, leading the 1990s into the largest and prolonged warming in the 20th century. Ov.r the last century, the simulated heat transport v.a Fram Strait and the Barents Sea was estimated to be, on av.rage, 31.32 TW and 14.82 TW, respectiv.ly, while the Bering Strait also prov.des 15.94 TW heat into the west- ern Arctic Ocean. Heat transport into the Arctic Ocean by the Atlantic Water v.a Fram Strait and the Barents Sea correlates significantly with AWCT （ C = 0.75 ） at 0- lag. The modeled North Atlantic Oscillation （NAO） index has a significant correlation with the heat transport （ C = 0.37 ）. The observ.d AWCT has a significant correlation with both the modeled AWCT （ C =0.49） and the heat transport （ C =0.41 ）. Howev.r, the modeled NAO index does not significantly correlate with either the observ.d AWCT （ C = 0.03 ） or modeled AWCT （ C = 0.16 ） at a zero-lag, indicating that the Arctic climate system is far more complex than expected.

关键词： Arctic Ocean heat transport warming episodes modeling.

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An Earth-mass planet in a time of COv.D-19:KMT-2020-BLG-0414Lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona Kondo Jennifer C.Yee Chung-Uk Lee Andrew Gould Shude Mao Leandro de Almeida Yossi Shv.rtzv.ld Xiangyu Zhang Michael D.Albrow Sun-Ju Chung Kyu-Ha Hwang Youn Kil Jung Yoon-Hyun Ryu In-Gu Shin Sang-Mok Cha Dong-Jin Kim Hyoun-Woo Kim Seung-Lee Kim Dong-Joo Lee Yongseok Lee Byeong-Gon Park Richard W.Pogge John Drummond Thiam-Guan Tan JoséDias do Nascimento Júnior Dan Maoz Matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe Richard Barry Dav.d P.Bennett Aparna Bhattacharya Martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto Man Cheung Alex Li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk Clément Ranc Nicholas J.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silv. Takahiro sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harv.rd&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea Univ.rsity of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observ.tories Chinese Academy of SciencesBeijing 100101China Univ.rsidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel Univ.rsity of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observ.tory PatutahiGisbourneNew Zealand Perth Exoplanet Surv.y Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and Mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Env.ronmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discov.ry of KMT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discov.ries(4?q/q⊕?6),it fills out the prev.ous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discov.ries call into question the existence,or at least the strength,of the break in the mass-ratio function that was prev.ously suggested to account for the paucity of v.ry low-q *** to the extreme magnification of the ev.nt,Amax~1450 for the underlying single-lens ev.nt,its light curv. rev.aled a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 MJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observ.tions that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observ.tions of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COv.D-19(two KMT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： grav.tational lensing:micro

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