检索结果-南通市图书馆

Endogenous fungal endophthalmitis:risk factors,clinical course,and visual outcome in 13 patients

International Journal of Ophthalmology(English edition) 2021年第1期14卷 97-105页

作者： Jamel Corredores Itzhak Hemo Tareq Jaouni Zohar Habot-Wilner Michal kramer Shiri Shulman Haneen Jabaly-Habib Ala'a Al-Talbishi Michael Halpert Edward Averbukh Jaime Levy Iris Deitch-Harel Radgonde Amer Department of Ophthalmology Hadassah Medical CenterJerusalem 91240Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Avi 6997801Israel Division of Ophthalmology Tel Aviv Sourasky Medical CenterTel Aviv 64239Israel Division of Ophthalmology Rabin Medical CenterPetah Tikva 49100Israel Department of Ophthalmology Poriya Medical CenterTiberias 1528001Israel St John Eye Hospital Jerusalem 91198Israel Faculty of Medicine Hebrew University of JerusalemJerusalem 9112102Israel

AIM:To analyze the risk factors,ophthalmological features,treatment modalities and their effect on the visual outcome in patients with endogenous fungal endophthalmitis(EFE).METHODS:Data retrieved from the medical files included age at presentation to the uveitis clinic,gender,ocular symptoms and their duration before presentation,history of fever,eye affected,anatomical diagnosis and laboratory evidence of fungal *** therapy recorded included systemic antifungal therapy and its duration,use of intravitreal antifungal agents and use of oral/intravitreal *** procedures and the data of ophthalmologic examination at presentation and at last follow-up were also ***:Included were 13 patients(20 eyes,mean age 58 y).Ten patients presented after gastrointestinal or urological interventions and two presented after organ *** one patient,there was no history of previous *** vitrectomy was performed in 16 eyes(80%)and vitreous cultures were positive in 10 of the vitrectomized eyes(62.5%).In only 4 patients(31%),blood cultures were *** patients received systemic antifungal *** eyes(80%)received intravitreal antifungal agent with voriconazole being the most commonly *** acuity(VA)improved from 0.9±0.9 at initial exam to 0.5±0.8 logMAR at last followup(P=0.03).A trend of greater visual improvement was noted in favor of eyes treated with oral steroids(±intravitreal dexamethasone)than eyes that were not treated with *** most common complication was *** eyes(60%)showed no ocular ***:High index of suspicion in patients with inciting risk factors is essential because of the low yield of blood cultures and the good general condition of patients at *** prognosis is improved with the prompt institution of systemic and intravitreal pharmacotherapy and the immediate surgical ***±local steroids could be considered

关键词： endophthalmitis endogenous fungal endophthalmitis endogenous endophthalmitis fungal endophthalmitis candida endophthalmitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肿瘤物理学——探索癌症的新思路

引用

物理 2014年第11期43卷 749-750页

作者：韩伟静刘雳宇 David kramer 中国科学院物理研究所美国亚利桑那州立大学研究中心

目前全球每年约有700万人死于癌症，而到2030年将可能超过1310万。在过去的几十年里，尽管癌症研究不断出现新进展，但研究成果不甚显著，最直接的证明便是死亡率无明显下降。癌症研究进展迟缓，可以说处于探索时期。这让越来越多的研... 详细信息

目前全球每年约有700万人死于癌症，而到2030年将可能超过1310万。在过去的几十年里，尽管癌症研究不断出现新进展，但研究成果不甚显著，最直接的证明便是死亡率无明显下降。癌症研究进展迟缓，可以说处于探索时期。这让越来越多的研究人员开始怀疑，用经典的生物学或医学思路研究癌症是否存在策略上的缺陷？

关键词：癌症物理学肿瘤研究成果研究人员死亡率生物学医学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

只需要一个微笑（英文）

引用

英语画刊(高级版) 2013年第1期 3-6页

作者： Katie kramer

'一个19岁的女孩远离自己的国家来到菲律宾,帮助那些面部有缺陷的儿童,这需要多大的勇气和毅力!让我们聆听微笑行动的志愿者凯蒂的故事。'Katie,19,always felt there had to be something more to life than just partying,buying clot... 详细信息

'一个19岁的女孩远离自己的国家来到菲律宾,帮助那些面部有缺陷的儿童,这需要多大的勇气和毅力!让我们聆听微笑行动的志愿者凯蒂的故事。'Katie,19,always felt there had to be something more to life than just partying,buying clothes and driving a cool *** finally discovered what she was missing out on when she traveled halfway around the world to help underprivileged(贫困的)kids.I am really lucky.I grew up with my parents and two brothers in a really nice house in Malibu,*** was an amazing place to have a ***,I had the same problems other

关键词：微笑英文

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections

引用

World Journal of Gastroenterology 2021年第14期27卷 1465-1482页

作者： Sarah A Malik Chencan Zhu Jinyu Li Joseph F LaComb Paula I Denoya Igor Kravets Joshua D Miller Jie Yang Melissa kramer W Richard McCombie Charles E Robertson Daniel N Frank Ellen Li Department of Medicine Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of Applied Mathematics and Statistics Stony Brook UniversityStony BrookNY 11794United States Stony Brook Cancer Center Biostatistics and Bioinformatics Shared Resource Stony Brook UniversityStony BrookNY 11794United States Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of Surgery Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of Family Population and Preventive MedicineStony Brook UniversityStony BrookNY 11794United States Cold Spring Harbor Laboratory Cancer Center Sequencing Technologies and Analysis Shared Resource Cold Spring HarborNY 11724United States Department of Medicine University of Colorado Anschutz Medical CampusAuroraCO 80045United States

BACKGROUND Integrative multi-omic approaches have been increasingly applied to discovery and functional studies of complex human ***-term preoperative antibiotics have been adopted to reduce site infections in colorectal cancer(CRC)*** hypothesize that the antibiotics will impact analysis of multi-omic datasets generated from resection samples to investigate biological CRC risk *** To assess the impact of preoperative antibiotics and other variables on integrated microbiome and human transcriptomic data generated from archived CRC resection *** Genomic DNA(gDNA)and RNA were extracted from prospectively collected 51 pairs of frozen sporadic CRC tumor and adjacent non-tumor mucosal samples from 50 CRC patients archived at a single medical center from *** 16S rRNA gene sequencing(V3V4 region,paired end,300 bp)and confirmatory quantitative polymerase chain reaction(qPCR)assays were conducted on *** sequencing(IPE,125 bp)was performed on parallel tumor and non-tumor RNA samples with RNA Integrity Numbers scores≥*** PERMANOVA detected significant effects of tumor vs nontumor histology(P=0.002)and antibiotics(P=0.001)on microbialβ-diversity,but CRC tumor location(left vs right),diabetes mellitus vs not diabetic and Black/African Ancestry(AA)vs not Black/AA,did not reach *** mixed models detected significant tumor vs nontumor histology*antibiotics interaction terms for 14 genus level *** confirmed increased Fusobacterium abundance in tumor vs nontumor groups,and detected significantly reduced bacterial load in the(+)antibiotics *** coordinate analysis of the transcriptomic data showed a clear separation between tumor and nontumor *** expressed genes obtained from separate analyses of tumor and nontumor samples,are presented for the antibiotics,CRC location,diabetes and Black/AA race *** Recent adoption of additional preoperative antibiotics as sta

关键词： Colorectal cancer Antibiotics African Continental Ancestry Group Diabetes mellitus 16S rRNA gene RNA-sequencing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Meeting 24-h Movement Guidelines is Related to Better Academic Achievement:Findings from the YRBS 2019 Cycle

引用

International Journal of Mental Health Promotion 2022年第1期24卷 13-24页

作者： Shaoying Liu Qian Yu Md Mahbub Hossain Scott Doig Ran Bao Yaping Zhao Jin Yan Xun Luo Jiaxuan Yang Arthur F.kramer Liye Zou College of Sports Science Haikou University of EconomicsHaikouChina College of Sports Science Jishou UniversityJishouChina Exercise Psychophysiology Laboratory Institute of KEEP Collaborative InnovationSchool of PsychologyShenzhen UniversityShenzhenChina Department of Health Promotion and Community Health Sciences School of Public HealthTexas A&M UniversityCollege StationUSA College of Education and Health Professions Limestone UniversitySouth CarolinaUSA School of Physical Education and Sport Training Shanghai University of SportShanghaiChina The Library of Shandong University of Sport ShandongChina Priority Research Centre in Physical Activity and Nutrition School of EducationUniversity of NewcastleCallaghanAustralia Beckman Institute University of IllinoisUrbanaIllinoisUSA Canter for Cognitive&Brain Health Northeastern UniversityBostonUSA

This research is designed to investigate the relationship between the 24-h movement guidelines(24-HMG)and self-reported academic achievement(AA)using nationally representative data derived from the 2019 *** Youth Risk Behaviour Survey.A multiple-stage cluster sampling procedure has been adopted to ensure a representative sample(N=9127 adolescents;mean age=15.7 years old;male%=49.8%).Logistic regression has been adopted to obtain the odds ratio(OR)regarding the associations between adherence to 24-HMG and AA while controlling for ethnicity,body mass index,sex and *** prevalence of meeting the 24-h movement guidelines in isolation and combination varied greatly(physical activity=23.3%,screen time=32.5%,sleep=22.3%,and 24-HMG=2.8%),while the percentage of highest-class AA was 42.5%.Compared with the situation when none of 24-HMG is met,the achievement of any of the combined guidelines(except for meeting the physical activity guidelines)was significantly associated with higher odds of achieving first-class *** the sleep guideline had 1.42 times increased likelihood to achieve highest-class AA as compared with not meeting the sleep *** screen time guidelines and physical activity guidelines,respectively,were 1.32 and 1.13 times more likely to report first-class AA;but meeting the guidelines of physical activity was not significantly related to *** the 24-HMG had the highest odds of achieving first-class AA(OR=2.01,95%CI:1.47-2.73).In both sexes,adolescents who met 24-HMG self-reported better AA(boys OR=2.05,95%CI:1.34-3.15;girls OR=2.26,95%CI:1.36-3.76).Significant relationships were observed in adolescents from 9-10th grade,but not higher *** research findings suggest that optimal movement behaviours can be seen as an important element to better academic achievement among *** studies can adopt our discoveries to promote adolescents’academic achievement through implementing optimal 24-h movement behaviour

关键词： Sedentary behaviour physical activity sleep academic performance high school students U.S.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Look into my eyes:What can eye-based measures tell us about the relationship between physical activity and cognitive performance?

引用

Journal of Sport and Health Science 2023年第5期12卷 568-591页

作者： Liye Zou Fabian Herold Sebastian Ludyga Keita Kamijo Notger G.Muller Matthew B.Pontifex Matthew Heath Ryuta Kuwamizu Hideaki Soya Charles H.Hillman Soichi Ando Brandon L.Alderman Boris Cheval Arthur F.kramer Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen 518060China Research Group Degenerative and Chronic Diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdam 14476Germany Department of Sport Exerciseand HealthUniversity of BaselBasel 4052Switzerland Faculty of Liberal Arts and Sciences Chukyo UniversityNagoya 466-8666Japan Department of Kinesiology Michigan State UniversityEast LansingMI 48824USA School of Kinesiology Faculty of Health SciencesUniversity of Western OntarioLondon ON N6A 3K7Canada Canadian Centre for Activity and Aging University of Western OntarioLondon ONN6A 3K7Canada Graduate Program in Neuroscience University of Western OntarioLondon ONN6A 3K7Canada Laboratory of Exercise Biochemistry and Neuroendocrinology Faculty of Health and Sport SciencesUniversity of TsukubaTsukuba 305-0006Japan Sport Neuroscience Division Advanced Research Initiative for Human High Performance(ARIHHP)Faculty of Health and Sport SciencesUniversity of TsukubaTsukuba 305-0006Japan Center for Cognitive and Brain Health Department of PsychologyDepartment of Physical TherapyMovementand Rehabilitation SciencesNortheastern UniversityBostonMA 02115USA Graduate School of Informatics and Engineering The University of Electro-CommunicationsTokyo 182-8585Japan Department of Kinesiology and Health Rutgers UniversityNew BrunswickNew BrunswickNJ 08854USA Swiss Center for Affective Sciences University of GenevaGeneva 1205Switzerland Laboratory for the Study of Emotion Elicitation and Expression(E3Lab) Department of PsychologyUniversity of GenevaGeneva 1205Switzerland Department of Psychology Center for Cognitive and Brain HealthNortheastern UniversityBostonMA 02115USA Beckman Institute University of Illinois at Urbana-ChampaignChampaignIL 61820USA

Background:There is a growing interest to understand the neurobiological mechanisms that drive the positive associations of physical activity and fitness with measures of cognitive *** better understand those mechanisms,several studies have employed eye-based measures(e.g., eye movement measures such as saccades,pupillary measures such as pupil dilation,and vascular measures such as retinal vessel diameter)deemed to be proxies for specific neurobiological ***,there is currently no systematic review providing a comprehensive overview of these studies in the field of exercise-cognition ***,this review aimed to address that gap in the ***:To identify eligible studies,we searched 5 electronic databases on October 23,*** researchers independently extracted data and assessed the risk of bias using a modified version of the Tool for the assEssment of Study qualiTy and reporting in EXercise(TESTEX scale,for interventional studies) and the critical appraisal tool from the Joanna Briggs Institute(for cross-sectional studies).Results:Our systematic review(n=35 studies) offers the following main findings:(a) there is insufficient evidence available to draw solid conclusions concerning gaze-fixation-based measures;(b) the evidence that pupillometric measures,which are a proxy for the noradrenergic system,can explain the positive effect of acute exercise and cardiorespiratory fitness on cognitive performance is mixed;(c) physical training-or fitness-related changes of the cerebrovascular system(operationalized via changes in retinal vasculature) are,in general,positively associated with cognitive performance improvements;(d) acute and chronic physical exercises show a positive effect based on an oculomotor-based measure function(operationalized via antisaccade tasks);and(e) the positive association between cardiorespiratory fitness and cognitive performance is partly mediated by the dopaminergic system(operationalized via spo

关键词： Cognition Exercise Fitness Pupil size RetinaTagedAPTARAEnd

来源：

维普期刊数据库

同方期刊数据库评论