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New developments in small molecular compounds for anti-hepatitis C virus(HCV) therapy

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 56-82页

作者： Jing TONG1,2,You-wei WANG2,Yuan-an LU1,2(1Department of Public Health Sciences,university of hawaii,Honolulu,hawaii 96822,USA)(2Key Laboratory of Combinatorial Biosynthesis and Drug Discovery,Ministry of Education,Institute of Traditional Chinese Medicine & Natural Products,School of Pharmaceutical Sciences,Wuhan university,Wuhan 430071,China) Department of Public Health Sciences University of Hawaii Honolulu Hawaii 96822 USA

Infection with hepatitis C virus （HCV） affects approximately 170 million people worldwide. However, no vaccine or immunoglobulin is currently available for the prevention of HCV infection. The standard of care （SOC） involving pegylated interferon-（] （PEG-IFN a） plus ribavirin （RBV） for 48 weeks results in a sustained virologic re- sponse in less than 50% of patients with chronic hepatitis C genotype 1, the most prevalent type of HCV in North America and Europe. Recently, reliable in vitro culture systems have been developed for accelerating antiviral therapy research, and many new specifically targeted antiviral therapies for hepatitis C （STAT-C） and treatment strategies are being evaluated in clinical trials. These new antiviral agents are expected to improve present treatment significantly and may potentially shorten treatment duration. The aim of this review is to summarize the current developments in new anti-HCV drugs.

关键词： Hepatitis C virus (HCV) Clinical trial Small molecular compounds Review

Moral Reflection on Global Crisis:Learning Harmony and Ethics as a Solution

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Moral Reflection on Global Crisis:Learning Harmony and Ethic...

EFFECT OF HYDROGEN BONDING ON DIRECTION OF PHOTOISOMERIZATION OF RETINOIDS:THE ORIGIN OF THE SOLVENT POLARITY EFFECT.

文明的和谐与共同繁荣：危机的挑战、反思与和谐发展——北京论坛（2009）

作者： Chung-ying Cheng Professor,university of hawaii at Manoa

Two Qualities of Civilizations Civilization has been developed to achieve human ends of human well being as well as fulfillment of human potential as human *** is therefore a form of human existence which substantiates and enriches human life by way of creating ways of survival,tools,economies,human relations,communities,powers,wealth,values,knowledge and wisdom. One can see that in order to warrant human well-being,civilizational creativities must conduce to good results which refresh and yet sustain,

关键词： Moral Reflection on Global Crisis:Learning Harmony and Ethics as a Solution

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Chinese Chemical Letters 1991年第1期2卷 9-12页

作者： Bao-wen ZHANG Robert S.H.LIU Department of Chemistry,2545 The Mall university of hawaii,Honolulu,HI 96822 U.S.A.

Studies of direction of photoisomerization of retinal,retinonitrile,a- retinonitrile and a trienenitrile analog in different solvents with varying wave- lengths of excitation and reaction temperature led to the conclusion that the well known solvent dependent photochemistry of retinoids is due to selective excitation of the hydrogen bonded species.

关键词： EFFECT OF HYDROGEN BONDING ON DIRECTION OF PHOTOISOMERIZATION OF RETINOIDS

Seasonal Predictability of the ensemble seasonal prediction by tier-1 and tier-1.5 models of ECMWF-UH

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Seasonal Predictability of the ensemble seasonal prediction ...

HYDRODYNAMICS OF FRACTAL FLOCS DURING SETTLING

中国气象学会2006年年会“气候变化及其机理和模拟”分会场

作者： Li Tao, Bing Wang*, Xiou-Hua Fu* (Nanjing university of Information Science and Technology, Nanjing, 210044)*IPRC, university of hawaii at Manoa, hawaii, USA

By using a hybrid model tier-1 that is coupled in the Indo-Pacific tropical ocean, we perform a set of 10 ensemble runs with different initial condition for two-season period that starts from November

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Journal of Hydrodynamics 2009年第3期21卷 347-351页

作者： ZHANG Jin-feng ZHANG Qing-he School of Civil Engineering Key Laboratory of Harbour and Ocean Engineering Ministry of Education Tianjin University Tianjin 300072 China Department of Ocean and Resources Engineering University of Hawaii at Manoa HI 96822 USA

The settling and hydrodynamic properties of 3-D fractal flocs in quiescent water are investigated with a numerical model based on the Lattice Boltzmann Method （LBM）, with considering the settling velocity, hydrodynamic drag force and infra-floc flow. The comparisons of floc settling velocities and effective densities indicate that the numerical results present good agreements with observations in field and at laboratory. The results show that the drag force Fo increases with the floc size dr according to the relationship FD ∝ df^3. Moreover, the intra-floc flow field and movement of the pore water provide a better understanding of the intra-floc flow from the microscopic viewpoint. The results also indicate that the lattice Boltzmann method is a promising approach to reveal the mechanisms of the flocculation in aquatic environments.

关键词： Lattice Boltzmann Method (LBM) fractal floc hydrodynamic properties drag force infra-floc flow

Causation Analysis on Urban Transportation Problems in Shanghai

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China City Planning Review 2009年第4期18卷 58-62页

作者： YU Xin, MSCE Candidate, Department of Civil and Environmental Engineering, university of hawaii, Honolulu, HI, USA.

1. Introduction Shanghai, a major commercial and industrial center of China, is located on the Yangtze River Delta in East China (see Fig. 1). It is one of the

关键词： traffic Yangtze transportation facilities congesti

Limitations of absolute current densities derived from the Semel & Skumanich method

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Science China(Physics,Mechanics & Astronomy) 2009年第11期52卷 1678-1685页

作者： LI Jing1 & FAN YuHong2 1 Institute for Astronomy, university of hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822, USA 2 High Altitude Observatory, Earth and Sun Systems Laboratory, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307, USA Institute for Astronomy University of Hawaii 2680 Woodlawn Drive Honolulu HI 96822 USA High Altitude Observatory Earth and Sun Systems Laboratory National Center for Atmospheric Research P.O. Box 3000 Boulder CO 80307 USA Present address: UCLA Institute of Geophysics and Planetary Physics 2713 Geology Building MG 951567 Los Angeles CA 90095-1567 USA

Semel and Skumanich proposed a method to obtain the absolute electric current density, |Jz|, without disambiguation of 180° in the transverse field directions. The advantage of the method is that the uncertainty in the determination of the ambiguity in the magnetic azimuth is removed. Here, we investigate the limits of the calculation when applied to a numerical MHD model. We have found that the combination of changes in the magnetic azimuth with vanishing horizontal field component leads to errors, where electric current densities are often strong. Where errors occur, the calculation gives |Jz| too small by factors typically 1.2 - 2.0.

关键词： numerical MHD model magnetic field electric current density

Mozi: No Aggression,But Universal Love

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China Today 2011年第7期60卷 74-75页

作者： WEN HAIMING is an associate professor at the School of Philosophy of Renmin university of China. He has a doctorate from the university of hawaii and specializes in Chinese and Comparative Philosophy Associate professor at the School of Philosophy of Renmin university of China. university of hawaii

MOZI (ca.475-395 BC) was one of many philosophers in the volatile Pre-Qin Period (before BC 221 when the State of Qin annexed other six kingdoms and unified China) who were committed to restoring and overhauling the social *** was a commoner born in the State of Lü (in today’s Shandong Province),but spent most of his life in the State of Song (in present day Henan Province).He studied Confucian theory in his early years,and later established his own school of thought Mohism,which challenges Confucianism on many *** traveled around the states to sell his political ideas to the rulers,who gave him the cold shoulder *** great thinker never held any high official position in his lifetime.

关键词：墨子通用先秦时期社会秩序哲学家

一个等温状态方程(Ⅴ)——不同温度的高压状态方程

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高压物理学报 1988年第3期2卷 211-217页

作者：徐济安 hawaii Institute of Geophysics university of hawaii

本文以NaCl为例,证实了在我们的状态方程体系中,不同温度的状态方程可以认为是在p_x坐标系中不同起点开始的同一状态方程。于是,可由室温状态方程和常压热膨胀的测量数据估计高温状态方程。

关键词：氯化钠状态方程温度