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Colorectal can.er cell growth in.ibition.by lin.leic acid is related to fatty acid composition.chan.es

Journ.l of Zhejian. Un.versity-Scien.e B(Biomedicin. & Biotechn.logy) 2010年第12期11卷 923-930页

作者： Xiao-fen. LU Guo-qin. HE Hai-n.n. YU Qi MA Shen.-ron. SHEn.undurti n. das Departmen. of Food Scien.e an. n.trition College of Biosystems Engineering and Food Science Zhejiang University Hangzhou 310029 China College of Pharmaceutical Scien.es Zhejiang University of Technology Hangzhou 310032 China Un. Life Scien.es Shaker Heights OH 44120 USA College of Medicin. Bharati Vidyapeeth University Pune 411030 India

Polyun.aturated fatty acids （PUFAs） possess an.i-can.er action.both in.vitro an. in.vivo. In.the presen. study, we detected cell viability with methyl thiazolyl tetrazolium （MTT） assay an. cell membran. permeability with propidium iodide （PI） fluorescen.e dyein., an. calculated cell membran. fluidity chan.e as fluorescen.e an.sotropy. Fatty acid con.en. in.cells was measured by gas chromatography/mass spectroscopy （GC/MS）, an. the relation.hip between.fatty acid composition.an. cell viability was studied. We observed that n.6 PUFA lin.leic acid （LA） in.ibited tumor cell growth at high con.en.ration. （〉300 μmol/L）, while low con.en.ration. （100-200 μmol/L） seemed to promote cell proliferation. An.lyses of cell membran. permeability, cell membran. fluidity, an. cell fatty acid composition.suggested that the an.i-can.er action.of LA could be related to chan.es in.the ratio of n.6 to n.3 PUFAs. We observed that pre-in.ubation.of can.er cells with 100 μmol/L LA for 24 h en.an.ed cell sen.itivity to the cytotoxic action.of LA, whereas un.ifferen.iated cell lin. LoVo seemed to have a distin.t path in.LA-in.uced death. These results showed that on. of the mechan.sms by which supplemen.ation.of LA in.uces can.er cell death could be alterin. the ratio of n.6/n.3 PUFAs, an. this may be related to celt differen.iation.status.

关键词： An.i-can.er Fatty acids composition Lin.leic acid In.vitro

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Epigallocatechin.3-gallate affects the growth of Ln.aP cells via membran. fluidity an. distribution.of cellular zin.

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Journ.l of Zhejian. Un.versity-Scien.e B(Biomedicin. & Biotechn.logy) 2009年第6期10卷 411-421页

作者： Jun.guo YAn. Hai-n.n. YU Shi-li SUn.Lan.cui ZHAn. Guo-qin. HE undurti n. das Hui RUAn.Shen.-ron. SHEn Departmen. of Food Scien.e an. n.trition Zhejiang University Hangzhou 310029 China College of Pharmaceutical Scien.es Zhejiang University of Technology Hangzhou 310032 China Tea Research In.titute Guangdong Academy of Agricultural Sciences Guangzhou 510640 China Un. Life Scien.es 13800 Fairhill Road #321 Shaker Heights OH 44120 USA

Objective:To evaluate effects of epigallocatechin.3-gallate (EGCG) on.the viability, membran. properties, an. zin. distribution. with an. without the presen.e of Zn.+, in.human.prostate carcin.ma Ln.aP cells. Methods: We examin.d chan.es in.cellular morphology an. membran. fluidity of Ln.aP cells, distribution.of cellular zin., an. the in.orporated portion.of EGCG after treatmen.s with EGCG, Zn.+, an. EGCG+Zn.+. Results: We observed an.alteration.in.cellular morphology an. a decrease in.membran. fluidity of Ln.aP cells after treatmen. with EGCG or Zn.+. The proportion.of EGCG in.orporated in.o liposomes treated with the mixture of EGCG an. Zn.+ at the ratio of 1:1 was 90.57%, which was sign.fican.ly higher than.that treated with EGCG alon. (30.33%). Electron.spin.reson.n.e (ESR) studies an. determin.tion.of fatty acids showed that the effects of EGCG on.the membran. fluidity of Ln.aP were decreased by Zn.+. EGCG accelerated the accumulation.of zin. in.the mitochon.ria an. cytosol as observed by atomic absorption.spectrometer. Con.lusion. These results show that EGCG in.eracted with cell membran., decreased the membran. fluidity of Ln.aP cells, an. accelerated zin. accumulation.in.the mitochon.ria an. cytosol, which could be the mechan.sm by which EGCG in.ibits proliferation.of Ln.aP cells. In.addition. high con.en.ration. of Zn.+ could atten.ate the action. elicited by EGCG.

关键词： Epigallocatechin.3-gallate (EGCG) Zin. Ln.aP Membran. fluidity

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Molecular pathobiology of scleritis an. its therapeutic implication.

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In.ern.tion.l Journ.l of Ophthalmology(En.lish edition. 2020年第1期13卷 163-175页

作者： undurti n.das Un. Life Scien.es Battle Ground Bio Scien.e Research Cen.re an. Departmen. of Medicin. GVP Medical College and Hospital

Scleritis an. other autoimmun. diseases are characterized by an.imbalan.e in.the levels of pro-in.lammatory an. an.i-in.lammatory molecules with the balan.e tilted more towards the former due to the failure of recogn.tion.of self. The triggerin. of in.lammatory process could be ascribed to the presen.e of cytoplasmic Dn./chromatin.that leads to activation.of cytosolic Dn.-sen.in. c GAS-STIn.(cyclic GMP-AMP syn.hase lin.ed to stimulator of in.erferon.gen.s) pathway an. en.an.ed expression.of n.-κB that results in.an.in.rease in.the production.of pro-in.lammatory bioactive lipids. Bioactive lipids gamma-lin.len.c acid(GLA), dihomoGLA(DGLA), prostaglan.in.E1(PGE1), prostacyclin.PGI2) an. lipoxin.A4, resolvin., protectin. an. maresin. have an.iin.lammatory action., bin. to Dn. to ren.er it n.n.an.igen.c an. are decreased in.autoimmun. diseases. These results suggest that efforts design.d to en.an.e the production.of an.i-in.lammatory bioactive lipids may form a n.w approach to autoimmun. diseases. Local in.ection.or in.usion.of lipoxin., resolvin., protectin. an. maresin. or their precursors such as arachidon.c acid may be exploited in.the preven.ion.an. man.gemen. of autoimmun. diseases in.ludin. scleritis, uveitis an. lupus/rheumatoid arthritis.

关键词： scleritis autoimmun. diseases bioactive lipids in.lammation micron.cleus cytokin.s resolution.of in.lammation

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Relation.hip between.gut an. sepsis:Role of ghrelin

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World Journ.l of Diabetes 2011年第1期2卷 1-7页

作者： undurti n.das Jawaharlal n.hru Techn.logical Un.versity Un. Life Scien.es Shaker Heights

Ghrelin.is a growth hormon. secretagogue producedby the gut,an. is expressed in.the hypothalamusan. other tissues as *** n.t on.y plays an.mportan. role in.the regulation.of appetite,en.rgy balan.e an. glucose homeostasis,but also shows an.ibacterial activity,suppresses pro-in.lammatory cytokin. production.an. restores gut barrier *** an.mals,ghrelin.has shown.sign.fican.ben.ficial action. in.preven.in. mortality from *** the critically ill,corticosteroid in.ufficien.y as a resultof dysfun.tion.of the hypothalamic-pituitary-adren.laxis is kn.wn.to *** is therefore possible that bothgut an. hypothalamus play an.importan. role in.thepathogen.sis of sepsis by virtue of their ability to produce ghrelin.which,in.turn.could be a protective phen.men.n.to suppress *** remain. to beseen.whether ghrelin.an. its an.logues are of ben.fit in.reatin. patien.s with sepsis.

关键词： Ghrelin Sepsis Cytokin.s In.lammation Critically ill In.ulin

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Vagal n.rve stimulation.in.preven.ion.an. man.gemen. of coron.ry heart disease

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World Journ.l of Cardiology 2011年第4期3卷 105-110页

作者： undurti n.das Un. Life Scien.es School of Biotechn.logy Jawaharlal Nehru Technological University Departmen. of Medicin. Krishna Institute of Medical Sciences

Coron.ry heart disease (CHD) that is due to atherosclerosis is associated with low-grade systemic in.lammation. Con.estive cardiac failure an. arrhythmias that are respon.ible for mortality in.CHD can.be suppressed by appropriate vagal stimulation.that is an.i-in.lammatory in.n.ture. Acetylcholin., the prin.ipal vagal n.urotran.mitter, is a poten. an.i-in.lammatory molecule. Polyun.aturated fatty acids (PUFAs) augmen. acetylcholin. release, while acetylcholin. can.en.an.e the formation.of prostacyclin. lipoxin., resolvin., protectin. an. maresin. from PUFAs, which are an.i-in.lammatory an. an.i-arrhythmic molecules. Furthermore, plasma an. tissue levels of PUFAs are low in.those with CHD an. atherosclerosis. Hen.e, vagal n.rve stimulation.is ben.ficial in.the preven.ion.of CHD an. cardiac arrhythmias. Thus, measuremen. of catecholamin.s, acetylcholin., various PUFAs, an. their products lipoxin., resolvin., protectin. an. maresin. in.the plasma an. peripheral leukocytes, an. vagal ton. by heart rate variation.could be useful in.the prediction. preven.ion.an. man.gemen. of CHD an. cardiac arrhythmias.

关键词： Vagal n.rve stimulation Acetylcholin. Coron.ry heart disease Cardiac arrhythmias Heart failure

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Hypothesis:In.en.ive in.ulin.therapy-in.uced mortality is due to excessive seroton.n.autoin.ibition.an. auton.mic dysregulation

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World Journ.l of Diabetes 2010年第4期1卷 101-108页

作者： undurti n.das Jawaharlal n.hru Techn.logical Un.versity Un. Life Scien.es Shaker Heights

Action.to Con.rol Cardiovascular Risk in.Diabetes(ACCORD),The Action.in.Diabetes an. Vascular Disease:Preterax an. Diamicron.Modified Release Con.rolled Evaluation.an. the Veteran. Affairs Diabetes Trial were design.d to study whether older patien.s with type 2 diabetes mellitus could reduce the risk of heart attacks an. stroke an. thereby prolon. their lives by main.ain.n. their blood glucose levels at n.ar-healthy levels but failed to demon.trate the hoped-for ben.f *** the trials failed,though,an. why ACCORD saw sign.fican.ly more deaths due to in.reased rates of cardiovascular even.s in.the in.en.ive therapy arm of the study are n.t *** data have n.w been.con.irmed by the results of the recen.ly con.luded n.CE-SUGAR Study which again.revealed that in.en.ive gluc ose con.rol in.reased mortality amon. adults in.in.en.ive care un.ts.I propose that the n.gative results n.ted in.these trials are due to altered brain.serot o n.n.con.en.ration. an. auton.mic dysregulation.in.addition.to the low-grade systemic in.lammation.decreased en.othelial n.tric oxide an. en.an.ed free radical gen.ration.dimin.shed an.i-oxidan. defen.es an. altered metabol ism of essen.ial fatty acids presen. in.patien.s with type 2 diabetes.

关键词： Type 2 diabetes mellitus Cardiovascular even.s Coron.ry heart disease Stroke Dyslipidemia Essen.ial fatty acids n.tric oxide Free radicals An.ioxidan.s In.ulin

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A defect in.the activities of △~6 an. △~5 desaturases an. pro-resolution.bioactive lipids in.the pathobiology of n.n.alcoholic fatty liver disease

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World Journ.l of Diabetes 2011年第11期2卷 176-188页

作者： undurti n.das Un. Life Scien.es School of Biotechn.logy Jawaharlal Nehru Technological University Bio-Scien.e Research Cen.re Gayatri Vidya Parishad College of Engineering Visakhapatnam-530 048

n.n.alcoholic fatty liver disease (n.FLD) is a low-grade systemic in.lammatory con.ition. sin.e liver an. adipose tissue tumor n.crosis factor-α (Tn.-α) an. Tn. receptor 1 tran.cripts an. serum Tn.-α levels are in.reased an. IL-6-/-mice are less pron. to n.FLD. Fatty liver damage caused by high-fat diets is associated with the gen.ration.of pro-in.lammatory prostaglan.in.E2 (PGE2). A decrease in.the levels of arachidon.c acid (AA), eicosapen.aen.ic acid (EPA) an. docosahexaen.ic acid (DHA) an. the usefuln.ss of EPA an. DHA both in.the preven.ion.an. man.gemen. of n.FLD has been.reported. AA, EPA an. DHA an. their an.i-in.lammatory products lipoxin. (LXs), resolvin. an. protectin. suppress IL-6 an. Tn.-α an. PGE2 production. These results suggest that the activities of △6 an. △5 desaturases are reduced in.n.FLD an. hen.e, the dietary essen.ial fatty acids, lin.leic acid (LA) an. α-lin.len.c acid (ALA) are n.t metabolized to their lon.-chain.products AA, EPA an. DHA, the precursors of an.i-in.lammatory molecules, LXs, resolvin. an. protectin. that could preven. n.FLD. This suggests that an.imbalan.e between.proan. an.i-in.lammatory bioactive lipids con.ribute to n.FLD. Hen.e, it is proposed that plasma an. tissue levels of AA, EPA, DHA an. LXs, resolvin. an. protectin. could be used as predictors an. progn.stic biomarkers of n.FLD. It is suggested that the syn.hesis an. use of more stable an.logues of LXs, resolvin. an. protectin. n.ed to be explored in.the preven.ion.an. man.gemen. of n.FLD.

关键词： Prostaglan.in. Lipids Arachidon.c acid Eicosapen.aen.ic acid n.n.alcoholic fatty liver disease Docosahexaen.ic acid Lipoxin. Resolvin. Protectin. Cytokin.s Free radicals Hyperlipidemia

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EXISTEn.E OF SOLUTIOn.An. APPROXIMATE COn.ROLLABILITY OF A SECOn.-ORDER n.UTRAL STOCHASTIC DIFFEREn.IAL EQUATIOn.WITH STATE DEPEn.En. DELAY

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Acta Mathematica Scien.ia 2016年第5期36卷 1509-1523页

作者： San.ukta das Dwijen.ra PAn.EY n. SUKAVAn.M Departmen. of Mathematics Indian Institution of Technology Roorkee

This paper has two section. which deals with a secon. order stochastic n.utral partial differen.ial equation.with state depen.en. delay. In.the first section.the existen.e an. un.quen.ss of mild solution.is obtain.d by use of measure of n.n.compactn.ss. In.the secon. section.the con.ition. for approximate con.rollability are in.estigated for the distributed secon. order n.utral stochastic differen.ial system with respect to the approximate con.rollability of the correspon.in. lin.ar system in.a Hilbert space. Our method is an.exten.ion.of co-author n. Sukavan.m’s n.vel approach in.[22]. Thereby, we remove the n.ed to assume the in.ertibility of a con.rollability operator used by authors in.[5], which fails to exist in.in.in.te dimen.ion.l spaces if the associated semigroup is compact. Our approach also removes the n.ed to check the in.ertibility of the con.rollability Gramian.operator an. associated limit con.ition.used by the authors in.[20], which are practically difficult to verify an. apply. An.example is provided to illustrate the presen.ed theory.

关键词： approximate con.rollability cosin. family state depen.en. delay n.utral stochastic differen.ial equation measure of n.n.ompactn.ss

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n.cleoside modified mRn.-lipid n.n.particles as a n.w delivery platform for the repair of the in.ured spin.l cord

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n.ural Regen.ration.Research 2025年第8期20卷 2311-2312页

作者： Krisztián.Pajer Tamás Bellák An.al n.grádi Departmen. of An.tomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spin.l cord in.ury an. treatmen. opportun.ties:The adult mammalian.spin.l cord has a very limited capacity for spon.an.ous regen.ration.due to various in.rin.ic molecular an. cellular *** the spin.l cord n.uron. have the capacity to regen.rate their axon.,the expression.of growth in.ibitory factors,lack or suppression.of proper guidan.e cues,an. profoun. in.lammatory respon.es do n.t permit successful regen.ration.Khyeam et al.,2021).

关键词： in.ured capacity modified

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Impacts of PI3K/protein.kin.se B pathway activation.in.reactive astrocytes: from detrimen.al effects to protective fun.tion.

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n.ural Regen.ration.Research 2025年第4期20卷 1031-1041页

作者： Ramón.Pérez-n.ñez María Fern.n.a Gon.ález An. María Avalos Lisette Leyton Cellular Commun.cation.Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advan.ed Cen.er for Chron.c Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile In.tituto de Cien.ias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abun.an. type of glial cell in.the cen.ral n.rvous *** in.ury an. in.lammation.astrocytes become reactive an. un.ergo morphological an. fun.tion.l *** on.their phen.typic classification.as A1 or A2,reactive astrocytes con.ribute to both n.urotoxic an. n.uroprotective respon.es,***,this bin.ry classification.does n.t fully capture the diversity of astrocyte respon.es observed across differen. diseases an. *** an.lysis has revealed that reactive astrocytes have a complex lan.scape of gen. expression.profiles,which emphasizes the heterogen.ous n.ture of their *** actively participate in.regulatin. cen.ral n.rvous system in.lammation.by in.eractin. with microglia an. other cell types,releasin. cytokin.s,an. in.luen.in. the immun. *** phosphoin.sitide 3-kin.se(PI3K)/protein.kin.se B(AKT)sign.lin. pathway is a cen.ral player in.astrocyte reactivity an. impacts various aspects of astrocyte behavior,as eviden.ed by in.silico,in.vitro,an. in.vivo *** astrocytes,in.lammatory cues trigger a cascade of molecular even.s,where n.clear factor-κB serves as a cen.ral mediator of the pro-in.lammatory ***,we review the heterogen.ity of reactive astrocytes an. the molecular mechan.sms un.erlyin. their *** highlight the in.olvemen. of various sign.lin. pathways that regulate astrocyte reactivity,in.ludin. the PI3K/AKT/mammalian.target of rapamycin.mTOR),αvβ3 in.egrin.PI3K/AKT/con.exin.43,an. n.tch/PI3K/AKT *** targetin. the in.ctivation.of the PI3K/AKT cellular sign.lin. pathway to con.rol reactive astrocytes an. preven. cen.ral n.rvous system damage,eviden.e suggests that activatin. this pathway could also yield ben.ficial *** dual fun.tion.of the PI3K/AKT pathway un.erscores its complexity in.astrocyte reactivity an. brain.fun.tion.*** review emphasizes the importan.e of employin. astrocyte-exclusive models to un.erst

关键词： in.lammation in.egrin. n.uroprotective n.urotoxic phosphatidylin.sitol 3-kin.se reactive astrocytes sign.l tran.duction Thy-1(CD90)

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