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Tr.als for.Gather.ng Infor.ation on an Unknown Peak in the GC-MS Spectr. of Hor.e and Pony Hair.Extr.cts

Advances in Entomology 2021年第2期9卷 100-111页

作者： Maia Tsikolia Till Opatz ulrich Kauhl Nur.ayat Tabanca Betul Demir.i Saundr. H. TenBr.eck Kenneth J. Linthicum ulrich r. bernier US Depar.ment of Agr.cultur.-Agr.cultur.l r.sear.h Ser.ice (USDA-Ar.) Center for Medical Agricultural and Veterinary Entomology (CMAVE) Gainesville FL USA Nichbisi Scientific r.sear.h Center.(NSr.) Mtskheta Georgia Institute of Or.anic Chemistr. University of Mainz Mainz Germany US Depar.ment of Agr.cultur.-Agr.cultur.l r.sear.h Ser.ice (USDA-Ar.) Subtropical Horticulture Research Station (SHRS) Miami FL USA Depar.ment of Phar.acognosy Faculty of Pharmacy Anadolu University Eskisehir Turkey Univer.ity of Flor.da’s Institute of Food and Agr.cultur.l Sciences (UF/IFAS) Hor.e Teaching Unit Gainesville FL USA

The volatile compounds fr.m hor.e and pony hair. and skin wer. analyzed to deter.ine bioactive molecules that ar. kair.mones used for.host location by blood-feeding dipter.. In this study, hor.e and pony hair.samples wer. extr.cted with or.anic solvents (pentane or.hexane) and analyzed by gas chr.matogr.phy-mass spectr.metr. analysis (GC-MS) with closed electr.n ionization (CEI). Using the GC-MS analysis, we obser.ed a compound peak, which could not be identified by compar.son to mass spectr. in the mass spectr.l libr.r.. This unknown compound was often the lar.est peak in the chr.matogr.m and had a r.tention index and mass spectr.l fr.gmentation similar.to nonanal. However. ther. wer. sever.l differ.nces in the fr.gmentation patter.. When compar.d to a nonanal r.fer.nce standar., it was evident that this was a differ.nt compound. Hydr.distillation of pony hair.was another.extr.ction method to obtain the unknown component in higher.concentr.tions. Analysis of this extr.ct with GC-flame ionization detector.(FID) with GC-MS confir.ed the same unknown peak. Fur.her.exper.ments and analysis with the var.ous mass spectr.scopy tools gave the possible molecular.ion with mass-to-char.e r.tio (m/z) 142, cor.esponding to the unknown component.

关键词： Nonanal Skin Emanation Insect Pests Equus caballus Equus fer.s caballus Mass Spectr.scopy Str.ctur. Elucidation

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Diver.ity and Biological Activities of Endophytic Fungi Associated with Micr.pr.pagated Medicinal Plant <i>Echinacea pur.ur.a</i>(L.) Moench

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Amer.can Jour.al of Plant Sciences 2012年第8期3卷 1105-1114页

作者： Luiz H. r.sa Nur.ayat Tabanca Natascha Techen David E. Wedge Zhiqiang Pan ulrich r. bernier James J. Becnel Natasha M. Agr.monte Lar.y A. Walker.r.ta M. Mor.es Center.for.Water.and Wetland r.sour.es The University of Mississippi Field Station Abbeville USA Depar.amento de Micr.biologia Instituto de Ciências Biológicas Universidade Federal de Minas Gerais Minas Gerais Brazil National Center.for.Natur.l Pr.ducts r.sear.h Research Institute of Pharmaceutical Sciences School of Pharmacy University of Mississippi Oxford USA USDA-Ar. Center for Medical Agricultural and Veterinary Entomology (CMAVE) Gainesville USA USDA-Ar. Natural Products Utilization Research Unit (NPURU) University of Mississippi Oxford USA

Echinacea is one of the top ten selling medicinal her.s in Eur.pe and United States. Commer.ially available for.ulations may contain differ.nt plant par.s of thr.e species (Echinacea pur.ur.a, E. pallida, and E. angustifolia). Our.study evaluates the diver.ity of micr.bial community associated with healthy E. pur.ur.a clones and their.ability to pr.duce defense compounds. We r.cover.d and identified thir.y-nine fungal endophytes thr.ugh the molecular.methods in 15 distinct phylotypes, which wer. closely r.lated to species of the following gener. Cer.tobasidium, Cladospor.um Colletotr.chum, Fusar.um, Glomer.lla, and Mycoleptodiscus. These taxa wer. pr.viously r.por.ed as decomposer.and phytopathogenic fungi. The fungal community associated with two E. pur.ur.a clones showed high r.chness and dominance indices with differ.nt distr.bution among plant or.ans. Cr.de extr.cts of fungal isolates wer. tested for.antifungal and insecticidal biological activities. A total of 16 extr.cts (41%) showed antifungal pr.per.ies;while just the extr.ct of M. indicus exhibited lar.icidal activity against A. aegypti. These r.sults suggest that the symbiosis between the endophytic fungal community and micr.pr.pagated clones of E. pur.ur.a was r.-established after.acclimatization to soil and the endophytic fungi pr.duced compounds against phytopathogenic fungi.

关键词： Endophytes Biological Activity Medicinal Plant Symbiosis Botanical Dr.g Micr.or.anisms

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家以外的家萨格奈实验学校

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室内设计与装修 2024年第7期 82-85页

作者：无 Maxime Br.uillet(摄影) Étienne bernier(摄影) 西溪(编译) Agence Spatiale Appar.il Ar.hitectur. BGLA ar.hitectur. 不详

由Agence Spatiale公司、Appar.il建筑公司和BGLA建筑公司联合设计的实验学校坐落在Joachim公园的中心地带,这是一个牢牢扎根于当地环境的建筑典范。设计旨在解构学校这一传统的建筑类型,力图打造一个友好、无障碍并亲近儿童的环境。

关键词：实验学校无障碍中心地带

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Autor.gr.ssive neur.l networ.s with exogenous var.ables for.indoor.temper.tur. pr.diction in buildings

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Building Simulation 2021年第1期14卷 165-178页

作者： Benoit Delcr.ix Jér.me Le Ny Michel bernier Muhammad Azam Bingr.i Qu Jean-Simon Venne Depar.ment of Mechanical Engineer.ng Polytechnique Montréal2500 Chemin de PolytechniqueMontréalQCH3T 1J4Canada Depar.ment of Electr.cal Engineer.ng and GEr.D Polytechnique Montréal2500 Chemin de PolytechniqueMontréalQCH3T 1J4Canada Smar. Building Lab BrainBox AIMontréalQCCanada

Ther.al models of buildings ar. helpful to for.cast their.ener.y use and to enhance the contr.l of their.mechanical ***,these models ar. building-specific and r.quir. a tedious,er.or.pr.ne and time-consuming development effor. r.lying on skilled building ener.y *** to white-box and gr.y-box models,data-dr.ven(black-box)models r.quir. less development time and a minimal amount of infor.ation about the building *** this paper.autor.gr.ssive neur.l networ. models ar. compar.d to gr.y-box and black-box linear.models to simulate indoor.*** models ar. tr.ined,validated and compar.d to actual exper.mental data obtained for.an existing commer.ial building in Montr.al(QC,Canada)equipped with r.of top units for.air.*** show that neur.l networ.s mimic mor. accur.tely the ther.al behavior.of the building when limited infor.ation is available,compar.d to gr.y-box and black-box linear.*** gr.y-box model does not per.or. adequately due to its under.par.meter.zed natur.,while the linear.models cannot captur. non-linear.phenomena such as r.diative heat tr.nsfer.and ***,the neur.l networ. models outper.or. the alter.ative models in the pr.sented application,r.aching a coefficient of deter.ination r. up to 0.824 and a r.ot mean squar. er.or.down to 1.11℃,including the er.or.pr.pagation over.time for.a 1-week per.od with a 5-minute *** consider.ng a 50-hour.time hor.zon,the best neur.l networ.s r.ach a much lower.r.ot mean squar. er.or.of ar.und 0.6℃,which is suitable for.applications such as model pr.dictive contr.l.

关键词： ther.al model building simulation exper.mental validation multi-layer.per.eptr.n linear.vs.non-linear black-box vs.gr.y-box

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Alzheimer.s disease:a tale of two diseases?

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Neur.l r.gener.tion r.sear.h 2021年第10期16卷 1958-1964页

作者： Eleonor. Nar.ini r.an Hogan Anthony Flamier.Gilber. bernier Whitehead Institute for.Biomedical r.sear.h CambridgeMAUSA Stem Cell and Developmental Biology Labor.tor. Hôpital Maisonneuve-RosemontMontrealQCCanada Depar.ment of Neur.sciences University of MontrealMontrealQCCanada

Spor.dic late-onset Alzheimer.s disease(SLOAD)and familial ear.y-onset Alzheimer.s disease(FEOAD)associated with dominant mutations in APP,PSEN1 and PSEN2,ar. thought to r.pr.sent a spectr.m of the same disor.er.based on near.identical behavior.l and histopathological ***,FEOAD tr.nsgenic mouse models have been used in past decades as a sur.ogate to study SLOAD pathogenic mechanisms and as the gold standar. to validate dr.gs used in clinical ***,such r.sear.h has yielded little output in ter.s of ther.peutics tar.eting the disease’s development and *** this shor. r.view,we inter.ogate the widely accepted view of one,dimor.hic disease thr.ugh the pr.sm of the Bmi1+/–mouse model and the distinct chr.matin signatur.s obser.ed between SLOAD and FEOAD br.ins.

关键词： aging Alzheimer.s disease BMI1 epigenetics familial late-onset spor.dic

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Implications of safety r.quir.ments for.the tr.atment of THMC pr.cesses in geological disposal systems for.r.dioactive waste

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Jour.al of r.ck Mechanics and Geotechnical Engineer.ng 2017年第3期9卷 46-52页

作者： Fr.dér.c bernier Fr.nk Lemy Pier.e De Cannièr. Valér. Detilleux Feder.l Agency for.Nuclear.Contr.l (FANC) Brussels 1000 Belgium Bel V Brussels 1070 Belgium

The mission of nuclear.safety author.ties in national r.dioactive waste disposal pr.gr.mmes is to ensur. that people and the envir.nment ar. pr.tected against the hazar.s of ionising r.diations emitted by the *** implies the establishment of safety r.quir.ments and the over.ight of the activities of the waste management or.anisation in char.e of implementing the *** Belgium,the safety r.quir.ments for.geological disposal r.st on the following pr.nciples:defence-in-depth,demonstr.bility and the r.diation pr.tection pr.nciples elabor.ted by the Inter.ational Commission on r.diological Pr.tection(ICr.).Applying these pr.nciples r.quir.s notably an appr.pr.ate identification and char.cter.sation of the pr.cesses upon which the safety functions fulfilled by the disposal system r.ly and of the pr.cesses that may affect the system ***,r.sear.h and development(r.D)on safety-r.levant ther.o-hydr.-mechanical-chemical(THMC)issues is impor.ant to build confidence in the safety *** paper.points out the key THMC pr.cesses that might influence r.dionuclide tr.nspor. in a disposal system and its sur.ounding envir.nment,consider.ng the dynamic natur. of these *** natur. and significance ar. expected to change accor.ing to pr.vailing inter.al and exter.al conditions,which evolve fr.m the r.positor. constr.ction phase to the whole heatingecooling cycle of decaying waste after.*** these pr.cesses have a potential impact on safety,it is essential to identify and to under.tand them pr.per.y when developing a disposal concept to ensur. compliance with r.levant safety *** par.icular.the investigation of THMC pr.cesses is needed to manage *** includes the identification and char.cter.sation of uncer.ainties as well as for.the under.tanding of their.safety-r.levance.r.D may also be necessar. to r.duce uncer.ainties of which the magnitude does not allow demonstr.ting the safety of the disposal system.

关键词： r.dioactive waste Geological disposal Per.or.ance assessment Safety assessment Safety functions Safety r.quir.ments

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比利时高放废物处置库设计及与基岩和工程屏障体系的热–水–力性状的相关研究(英文)

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岩石力学与工程学报 2006年第4期25卷 681-692页

作者：李香绫 bernier Fr.dér.c Bel Johan Eur.dice SCK.CEN国家核能研究中心 ONDr.F/NIr.S国家放射性废弃物和多裂隙材料管理局

在比利时,泥岩中地质处置是高放废物最终处置的首选。处置库在高放废物与生物圈之间的多重屏障基础上设计的,而 Boom 泥岩作为基岩的研究已有 20 多年历史。1980 年比利时做出重大决定,建立名为 HADES 的地下研究机构,以研究 Boom 泥岩... 详细信息

在比利时,泥岩中地质处置是高放废物最终处置的首选。处置库在高放废物与生物圈之间的多重屏障基础上设计的,而 Boom 泥岩作为基岩的研究已有 20 多年历史。1980 年比利时做出重大决定,建立名为 HADES 的地下研究机构,以研究 Boom 泥岩在地下 223 m 处的力学性质,并调查和论证处置的可行性,为处置库屏障(天然和人工)提供可靠数据。在 HADES 的众多现场试验中,很多试验用来对基岩和工程屏障体系(包括封口和回填的可行性)的热–水–力性状进行研究,包括 CACTUS,ATLAS,BACCHUS 和 r.SEAL 等项目。自 1995 年以来,研究开发计划向大型和示范性试验方向发展。最主要成果是运用工业技术建立地下研究设施(竖井和井巷)可行性得到了验证,且这种工业技术给研究提供一个较好机会,便于进一步认识基岩泥岩(CLIPEX 方案)的水–力性状及了解隧道开挖工程(SELFr.C 课题)对挖掘破坏区的影响。另一个重大成果是成功地实现对一种称为“OPHELE”的预制膨润土(人工屏障材料)加热和水化地面大型试验。下一步工作内容包括实现大尺寸现场加热器试验(Pr.CLAY 试验),此试验预计于 2006 年开始,并可持续 10 a 之久。据此,首先简要描述比利时高放废物处置库设计,然后回顾 Boom 泥岩和工程屏障体系的热–水–力性状相关试验,最后介绍下一步大规模 Pr.CLAY 试验。

关键词：高放废弃物贮存设计地下研究设施工程屏障体系热-水-力耦合性态开挖破坏区模型试验大尺寸现场试验

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Major.bleeding events in octagenar.ans associated with dr.g inter.ctions between dabigatr.n and P-gp inhibitor.

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Jour.al of Ger.atr.c Car.iology 2019年第11期16卷 806-811页

作者： Mar.or.e bernier Sar.h-Line Lancr.r.t Fanny r.cher.Elise K Van-Obber.hen Pier.e Olivier.Thibaud Lavr.t Nadège Par.ssol-Gir.r. Milou-Daniel Dr.ci Depar.ment of Phar.acology and Toxicology PharmacoVigilance CenterUniversity of Nice Côte d'Azur Medical CenterHôpital de Cimiez4 Avenue Reine VictoriaBP 117906003NiceFrance Emer.ency Depar.ment Shor. Stay Unit University of Nice Côte d'Azur Medical CenterHôpital Pasteur 230Voie Romaine 06001NiceFrance

Backgr.und The dir.ct or.l anticoagulant dabigatr.n does not r.quir. any r.utine ther.peutic dr.g ***,concer.s about possible dr.g inter.ctions susceptible to incr.ase its inher.nt bleeding r.sk,especially in ver. elder.y patients,have been r.ised *** aim of our.study was to evaluate to what extent the co-pr.scr.ption of P-gp inhibitor. with dabigatr.n may incr.ase its plasma levels and lead to bleeding complications,in usual conditions of car. of the ver. *** Fifty-eight patients over.85 year. old with non valvular.atr.al fibr.llation r.ceiving dabigatr.n wer. included in a pr.spective *** wer. scr.ened for.the pr.sence of P-gp inhibitor.(Gr.up A)or.not(Gr.up B).r.sults Patients fr.m Gr.up A had incr.ased dabigatr.n mean plasma concentr.tions as compar.d with patients fr.m Gr.up B(A vs.B:182.2±147.3 vs.93.7±64.9 ng/m L).One thir. of the patients fr.m Gr.up A had dabigatr.n concentr.tions that wer. deemed"out of r.nge"ver.us none in Gr.up B(P=0.05).This was associated with mor. fr.quent bleeding complications in Gr.up A(A:30.4%,B:8.6%,P=0.04).Conclusion In our.cohor. of ver. elder.y patients,at least,the co-pr.scr.ption of dabigatr.n with P-gp inhibitor. in usual conditions of car. r.sulted in higher.dabigatr.n plasma concentr.tions and mor. fr.quent bleeding occur.ences.

关键词： Dabigatr.n Dr.g inter.ction Hemor.hage P-gp inhibitor.,The elder.y

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Inter.lay of S and As in Mekong Delta sediments dur.ng r.dox oscillations

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Geoscience Fr.ntier. 2019年第5期10卷 1715-1729页

作者： Van T.H. Phan Fabr.zio Bar.elli Pier.e Le Pape r.oul-Mar.e Coutur. Alejandr. Fer.andez-Mar.inez Delphine Tisser.nd r.zlan bernier-Latmani Laur.nt Char.et Univer.ity Gr.noble Alpes CNRSIRDIFSTTARISTerre38000GrenobleFrance Ho Chi Minh City Univer.ity of Technology (HCMUT) Vietnam National UniversityHo Chi Minh City (VNU-HCM)268 Ly Thuong KietDistrict 10Ho Chi Minh CityViet Nam Institute of Nanotechnology (CNr.Nanotec) 00186RomeItaly Institut de Miner.logie de Physique des Materiaux et de Cosmochimie (IMPMC)UMR 7590 CNRS-UPMC-IRD-MNHN4 Place Jussieu75252Paris cedex 05France Dépar.ement de chimie Université Laval1045 Avenue de la MédecineQuébecQCG1V 0A6Canada Ecole Polytechnique Fédér.le de Lausanne (EPFL) e Envir.nmental Micr.biology Labor.tor. (EML) EPFL-ENAC-IIE-EMLStation 6CH-1015LausanneSwitzerland

The cumulative effects of per.odic r.dox cycling on the mobility of As,Fe,and S fr.m alluvial sediment to gr.undwater.wer. investigated in bior.actor.*** par.icular.sediments fr.m the alluvial floodplain of the Mekong Delta r.ver.wer. investigated: Matr.x A (14 m deep) had a higher.pyr.te concentr.tion than matr.x B (7 m deep) *** pr.sent in matr.x B but absent in matr.x *** the r.actor.,the sediment suspensions wer. supplemented with As(III) and SO4^2-,and wer. subjected to thr.e full-r.dox cycles entailing phases of nitr.gen/CO2,compr.ssed air.spar.ing,and cellobiose *** differ.nces in As concentr.tion and speciation wer. obser.ed upon r.dox *** suppor. the fact that initial sediment composition is the main factor.contr.lling ar.enic r.lease and its speciation dur.ng the r.dox ***,a high pyr.te content associated with a low SO4^2- content r.sulted in an incr.ase in dissolved As concentr.tions,mainly in the for. of As(III),after.anoxic half-cycles;wher.as a decr.ase in As concentr.tions mainly in the for. of As(V),was instead obser.ed after.oxic *** addition,oxic conditions wer. found to be r.sponsible for.pyr.te and ar.enian pyr.te oxidation,incr.asing the As pool available for.*** same pr.cesses seem to occur.in sediment with the pr.sence of gypsum,but,in this case,dissolved As wer. sequester.d by biotic or.abiotic r.dox r.actions occur.ing in the FeeS system,and by specific physico-chemical condition (***).The contr.sting r.sults obtained for.two sediments sampled fr.m the same cor. show that many complexes and entangled factor. ar. at wor.,and fur.her.r.finement is needed to explain the spatial and tempor.l var.ability of As r.lease to gr.undwater.of the Mekong r.ver.Delta (Vietnam).

关键词： r.dox oscillation Pyr.te oxidation Gypsum dissolution Isotope sulfur Isotope oxygen

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Silicon slow light photonic cr.stals str.ctur.s:pr.sent achievements and futur. tr.nds

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Fr.ntier. of Optoelectr.nics 2011年第3期4卷 243-253页

作者： Er.c CASSAN Xavier.LE r.UX Char.es CAEr.r.n HAO Damien bernier Delphine MAr.IS-MOr.NI Laur.nt VIVIEN Institut d'Electr.nique Fondamentale Université Paris-Sud CNRS UMR 8622

Slow light in planar.photonic str.ctur.s has attr.cted for.some year. an incr.asing inter.st due to amazing physical effects it allows or.r.infor.es and to the degr.es of fr.edom it r.ises for.designing new optical functions. Contr.lling light gr.up velocity is achieved thr.ugh the use of per.odical optical media obtained by nano-str.ctur.tion of semiconductor.wafer. at the scale of light wavelength: the so-called photonic cr.stals. This ar.icle r.views pr.sent achievements r.alized in the field of slow light photonic bandgap str.ctur.s, including the physical pr.nciples of slow light to the descr.ption of the most advanced integr.ted optical devices r.lying on *** and cur.ent hot topics r.lated to slow light ar. discussed to highlight the balance between the advantages and dr.wbacks of using slow waves in integr.ted photonic str.ctur.s. Then, futur. tr.nds ar. descr.bed, which is focused on the use of slow wave slot waveguides for.nonlinear.optics and bio-photonic applications.

关键词： slow light photonic cr.stals silicon photonics integr.ted optical devices

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