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Nano Research 2021年第4期14卷 1126-1134页

作者： Razi Ahmad Gautam Virender Nutan Dinesh Singh Govind Gupta udit soni Sameer Sapra Ritu Srivastava Advanced Materials and Devices Metrology Division CSIR-National Physical LaboratoryDr.K.S.Krishnan RoadNew Delhi-110012India Indian Reference Materials Division CSIR-National Physical LaboratoryDr.K.S.Krishnan RoadNew Delhi-110012India Department of Biotechnology TERI School of Advanced studiesNew Delhi 110070India Department ofChemistryy Indian Institute of Technology Delhi New Delhi 110016India Regional Centre of Advanced Technologies and Materials Faculty of SciencePalacky University OlomoucSlechtitelu 2778371 OlomoucCzech Republic

Recently developed lead-free double perovskite nanocrystals(NCs)have been proposed for the possible application in solutionprocessed optoelectronic ***,the optoelectronic applications of double perovskite NCs have been hampered due to the structural and chemical instability in the presence of polar ***,we report a facile strategy for the synthesis and purification of Cs_(2)AgBiBr_(6)double perovskite NCs that remained stable even after washing with polar *** is realized with our efficient colloidal route to synthesize Cs_(2)AgBiBr_(6)NCs that involve stable and strongly coordinated precursor such as silvertrioctyl phosphine complex together with bismuth neodecanoate,which leads to a significantly improved chemical and colloidal *** layer-by-layer solid-state ligand exchange technique,a compact and crack-free thin film of Cs_(2)AgBiBr_(6)NCs were ***,perovskite solar cells consisting of Cs_(2)AgBiBr_(6)as an absorber layer were fabricated and tested.

关键词： double perovskite nanocrystals colloidal and chemical stability thin film solar cells

Comparative measurement of CO_(2),CH_(4)and CO at two traffic interjunctions having inflated vehicular flow in Delhi

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Journal of Environmental Sciences 2024年第7期141卷 314-329页

作者： Komal Daya soni Khem Singh Shankar G.Aggarwal CSIR-National Physical Laboratory Dr.K.S.Krishnan MargNew Delhi 110012India Academy of Scientific&Innovative Research(AcSIR) Ghaziabad 201002India

Vehicular emissions are considered one of the major anthropogenic sources of greenhouse gases and poor air quality in metropolitan *** study aims to see the correlation of CO_(2),CH_(4),and CO through monitoring over a period from December 2020 to October 2021 covering three seasons’winter,summer,and monsoon at two different traffic locations of Delhi having different traffic volumes,road patterns,and traffic *** annual average morning concentration of CO_(2),CH_(4)and CO was found(533±105),(7.3±3.1),(10.7±3.0)ppm at Najafgarh and(480±70),(5.2±1.8),(7.8±2.8)ppm at Rajendra Place,respectively.A relationship between concentration of all three gases and meteorological parameters such as temperature,humidity,wind speed and wind direction has also been investigated using Pearson correlation coefficient and pollution rose diagram.A comparable pattern in concentration was observed for all three gases in spatial(location)and temporal(diurnal)*** concentration trend of CO_(2)in different seasons is winter>summer>monsoon,while in the case of CH_(4)winter=summer>monsoon but not any seasonal trend was noted in CO *** is observed that CO_(2)has a good relation with CO(a tracer for vehicular emission)in terms of diurnal variation,whereas,CH_(4)does not represent a relation with CO and CO_(2)diurnally,suggesting that vehicles are the source of CO_(2)but not much contributing to other greenhouse gases like CH_(4).

关键词： Vehicular emission Greenhouse gases Harmful pollutants Meteorological parameters

C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 279-287页

作者： Hritik Rathod Ritu M.soni Jigna S.Shah Department of Pharmacology Institute of Pharmacy Nirma UniversityAhmedabadGujaratIndia

Objective:To investigate the neuroprotective effect of C-phycocyanin in a mouse model of rotenone-induced Parkinson’s ***:C-phycocyanin(50 mg/kg,i.p.,daily)was administered to rotenone(30 mg/kg,p.o.,daily)treated mice for 28 *** studies(Y-maze,rotarod,round beam walk,and wire-hang tests)were carried out to assess neurobehavioral *** and malondialdehyde were determined in both serum and striatal *** proteins(AKT,AMPK,NF-κB,BDNF,and alpha-synuclein)in the striatum were estimated using *** analyses(hematoxylin and eosin stainning as well as Nissl staining)were carried out to assess structural abnormalities in the ***:C-phycocyanin significantly increased BDNF levels and decreased alpha-synuclein *** also slightly upregulated AMPK and AKT levels without significant difference compared with the rotenone ***,rotenone-induced elevated oxidative stress and structural abnormalities in the striatum were markedly mitigated by ***:C-phycocyanin might have potential neuroprotective effects against Parkinson’s *** studies are warranted to verify its efficacy and to understand the molecular mechanisms behind the neuroprotective effects of C-phycocyanin in Parkinson’s disease.

关键词： Parkinson’s disease C-phycocyanin Alphasynuclein BDNF Oxidative stress Rotenone

Amebic liver abscess: An update

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World Journal of Hepatology 2024年第3期16卷 316-330页

作者： Ramesh Kumar Rishabh Patel Rajeev Nayan Priyadarshi Ruchika Narayan Tanmoy Maji Utpal Anand Jinit R soni Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Department of Radiodiagnosis All India Institute of Medical SciencesPatna 801507India Department of Surgical Gastroenterology All India Institute of Medical SciencesPatna 801507India

Amebic liver abscess(ALA)is still a common problem in the tropical world,where it affects over three-quarters of patients with liver *** is caused by an anaerobic protozoan Entamoeba hystolytica,which primarily colonises the *** is a non-suppurative infection of the liver consisting primarily of dead hepatocytes and cellular *** of the male gender,during their reproductive years,are most prone to ALA,and this appears to be due to a poorly mounted immune response linked to serum testosterone *** is more common in the right lobe of the liver,is strongly associated with alcohol consumption,and can heal without the need for *** majority of ALA patients have an uncomplicated course,a number of complications have been described,including rupture into abdomino-thoracic structures,biliary fistula,vascular thrombosis,bilio-vascular compression,and secondary bacterial *** on clinico-radiological findings,a classification system for ALA has emerged recently,which can assist clinicians in making treatment *** research has revealed the role of venous thrombosis-related ischemia in the severity of *** years have seen the development and refinement of newer molecular diagnostic techniques that can greatly aid in overcoming the diagnostic challenge in endemic area where serology-based tests have limited *** has been the drug of choice for ALA patients for many ***,concerns over the resistance and adverse effects necessitate the creation of new,safe,and potent antiamebic *** the indication of the drainage of uncomplicated ALA has become more clear,high-quality randomised trials are still necessary for robust *** drainage appears to be a viable option for patients with ruptured ALA and diffuse peritonitis,for whom surgery represents a significant risk of *** regard to all of the aforementioned issues,this article intends to present an u

关键词： Amebic liver abscess Amebiasis Ruptured liver abscess Percutaneous drainage Metronidazole

Atherosclerotic plaque classification in carotid ultrasound images using machine learning and explainable deep learning

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Intelligent Medicine 2024年第2期4卷 83-95页

作者： soni Singh Pankaj K.Jain Neeraj Sharma Mausumi Pohit Sudipta Roy School of Vocational Studies and Applied Sciences Gautam Buddha UniversityGreater NoidaUttar PradeshIndia Artificial Intelligence and Data Science Jio Institute Navi MumbaiMaharashtraIndia School of Biomedical Engineering Indian Institute of TechnologyVaranasiUttar PradeshIndia

Objective The incidence of cardiovascular diseases(CVD)is rising rapidly *** forms of CVD,such as stroke and heart attack,are more common among patients with certain *** development is a major factor underlying cardiovascular events,such as heart attack and stroke,and its early detection may prevent such *** imaging of carotid arteries is a useful method for diagnosis of atherosclerotic plaques;however,an automated method to classify atherosclerotic plaques for evaluation of early-stage CVD is ***,we propose an automated method for classification of high-risk atherosclerotic plaque ultrasound *** Five deep learning(DL)models(VGG16,ResNet-50,GoogLeNet,XceptionNet,and SqueezeNet)were used for automated classification and the results compared with those of a machine learning(ML)-based technique,involving extraction of 23 texture features from ultrasound images and classification using a Support Vector Machine *** enhance model interpretability,output gradient-weighted convolutional activation maps(GradCAMs)were generated and overlayed on original *** A series of indices,including accuracy,sensitivity,specificity,F1-score,Cohen-kappa index,and area under the curve values,were calculated to evaluate model *** output images allowed visualization of the most significant ultrasound image *** GoogLeNet model yielded the highest accuracy(98.20%).Conclusion ML models may be also suitable for applications requiring low computational ***,DL models could be more completely automated than ML models.

关键词： Explainable deep learning Carotid artery Classification VGG 16 ResNet-50 GoogLeNet XceptionNet SqueezeNet

Overview of perspectives on cancer,newer therapies,and future directions

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Oncology and Translational Medicine 2024年第3期10卷 105-109页

作者： Rajeev M.Joshi Bhushan Telang Gagan soni Asma Khalife Department of General Surgery T.N.Medical College&B.Y.L.Nair Charitable HospitalMumbaiIndia Department of Surgical Oncology Government Cancer Hospital AurangabadMaharashtraIndia Department of Surgical Disciplines All India Institute of Medical ScienceNew DelhiIndia

Theword“cancer”is associated with terrifying situations,and there is often an aggressive intent to *** about survival and fear of disfigurement cause major turmoil in the minds of patients and *** with multimodal care is the key to achieving satisfactory *** imaging modalities have aided in early detection and derivation of optimal treatment *** radical excision of tumors with neoadjuvant or concurrent chemotherapy/radiotherapy has long been the best management option,we have moved froma radical to a conservative *** advanced disease,the plan should be to provide supportive care and improve quality of *** and counseling play important *** support for correcting cancer cachexia is equally important during tumor *** therapies such as targeted therapy,stem cell therapy,and chemodynamic therapy are all focused on ensuring safe and efficient outcomes;however,the war against cancer continues to oscillate between hope and despair.

关键词： Cancer Modern medicine Preventive oncology Psychology Nutrition

Retrospective study evaluating association of colorectal tumors and hepatitis C virus

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World Journal of Virology 2024年第3期13卷 56-64页

作者： Maya Gogtay Lekha Yadukumar Yuvaraj Singh Mithil Gowda Suresh Aakriti soni Anuroop Yekula Asha Bullappa George M Abraham Department of Hematology and Oncology Internal MedicineUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Internal Medicine The Wright Center for Graduate Medical EducationScrantonPA 18505United States Department of Gastroenterology and Hepatology University of Massachusetts Chan Medical SchoolWorcesterMA 01605United States Department of Internal Medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Internal Medicine St.Vincent HospitalWorcesterMA 01608United States Department of Community Medicine SS Institute of Medical Sciences and Research CentreDavangere 577003KarnatakaIndia

BACKGROUND Chronic hepatitis C virus(HCV)has been associated with hepatic and extrahe-patic *** studies have shown an association between colorectal adenomas and HCV *** To study the prevalence of colorectal adenomas in patients with HCV compared to the general population and to evaluate if it is an independent risk factor for colorectal *** Patients were divided into HCV and non-HCV based on their HCV RNA *** with alcoholic liver disease,hepatitis B infection,and inflammatory bowel disease were *** variables were analyzed using the Mann-Whitney U test,and categorical variables usingχ^(2) with P<0.05 were considered statistically *** significant covariates(independent variables)were matched in both groups by propensity score matching,followed by multivariate regression *** Of the 415 patients screened,109 HCV patients and 97 non-HCV patients with colonoscopy results were included in the *** patients were older,had a smoking history,had less frequent aspirin use,and had a lower body mass index(BMI)(P<0.05).The HCV cohort had a significantly increased number of patients with adenomas(adenoma detection rate of 53.2%vs 34%.P=0.006).We performed a propensity-matched multivariate analysis where HCV infection was significantly associated with colorectal adenoma(OR:2.070,P=0.019).CONCLUSION Our study shows a significantly higher rate of adenomas in HCV patients compared to the general *** studies would help determine if the increase in adenoma detection lowers the risk for colorectal cancer.

关键词： Hepatitis C Colon cancer Adenoma Polyps Colonoscopy

Sedation reversal trends at outpatient ambulatory endoscopic center vs in-hospital ambulatory procedure center using a triage protocol

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World Journal of Gastrointestinal Endoscopy 2024年第7期16卷 413-423页

作者： Saqib Walayat Peter Stadmeyer Azfar Hameed Minahil Sarfaraz Paul Estrada Mark Benson Anurag soni Patrick Pfau Paul Hayes Brittney Kile Toni Cruz Deepak Gopal Department of Gastroenterology University of IllinoisPeoriaIL 61605United States Department of Gastroenterology University of WisconsinMadisonWI 53792United States Department of Internal Medicine Texas Health DentonDentonTX 76201United States Department of Internal Medicine Allama Iqbal Medical CollegeLahore 042Pakistan Department of Gastroenterology Texas Tech University Health Services CenterEl PasoTX 79911United States Department of Gastroenterology and Hepatology University of WisconsinMadisonWI 53705United States Finance Business Partners UW Health University of WisconsinMadisonWI 53792United States UW Health Digestive Health Center Endoscopy University of WisconsinMadisonWI 53792United States Division of Gastroenterology and Hepatology Department of MedicineUniversity of Wisconsin Hospitals and ClinicsMadisonWI 53705United States

BACKGROUND Routine outpatient endoscopy is performed across a variety of outpatient settings.A known risk of performing endoscopy under moderate sedation is the potential for over-sedation,requiring the use of reversal *** needs to be reported on rates of reversal across different outpatient *** academic tertiary care center utilizes a triage tool that directs higher-risk patients to the in-hospital ambulatory procedure center(APC)for their ***,we report data on outpatient sedation reversal rates for endoscopy performed at an inhospital APC vs at a free-standing ambulatory endoscopy digestive health center(AEC-DHC)following risk stratification with a triage *** To observe the effect of risk stratification using a triage tool on patient outcomes,primarily sedation reversal *** We observed all outpatient endoscopy procedures performed at AEC-DHC and APC from April 2013 to September *** were stratified to their respective sites using a triage *** evaluated each procedure for which sedation reversal with flumazenil and naloxone was *** and characteristics recorded include patient age,gender,body mass index(BMI),American Society of Anesthesiologists(ASA)classification,procedure type,and reason for sedation *** There were 97366 endoscopic procedures performed at AEC-DHC and 22494 at the APC during the study *** these,17 patients at AEC-DHC and 9 at the APC underwent sedation reversals(0.017%vs 0.04%;P=0.06).Demographics recorded for those requiring reversal at AEC-DHC vs APC included mean age(53.5±21 vs 60.4±17.42 years;P=0.23),ASA class(1.66±0.48 vs 2.22±0.83;P=0.20),BMI(27.7±6.7 kg/m^(2) vs 23.7±4.03 kg/m^(2);P=0.06),and female gender(64.7%vs 22%;P=0.04).The mean doses of sedative agents and reversal drugs used at AEC-DHC vs APC were midazolam(5.9±1.7 mg vs 8.9±3.5 mg;P=0.01),fentanyl(147.1±49.9μg vs 188.9±74.1μg;P=0.10),flumazenil(0.3±0.18μg vs 0.17±0.17μg;P=0.13)and naloxo

关键词： Ambulatory care Conscious sedation Endoscopy Colonoscopy Risk assessment Risk factors

Promising light converting BaMoO_4:Er^(3+)-Tm^(3+)-Yb^(3+) phosphors for display and optical temperature sensing

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Journal of Rare Earths 2018年第12期36卷 1256-1263页

作者： Abhishek Kumar soni Vineet Kumar Rai Chemistry Division Bhabha Atomic Research Centre Laser and Spectroscopy Laboratory Department of Applied Physics Indian Institute of Technology (Indian School of Mines)

Er-Tm3+-Ybtri-doped BaMoOphosphors were synthesized by co-precipitation technique and characterized by X-ray diffraction analysis, absorption study and field emission scanning electron microscopy analysis. Upconversion as well as downconversion luminescence studies were performed by using near infrared(980 nm) and ultraviolet(380 nm) excitations. Energy level diagram, pump power dependence and colour coordinate study were utilized to describe the multicolor upconversion emission properties. Under single 980 nm diode laser excitation the dual mode sensing behaviour is realized via Stark sublevels and thermally coupled energy levels of the Tm3+ and Erions in the prepared tri-doped phosphors. A comparative fluorescence intensity ratio analysis for integrated emission intensities arising from the Stark sublevels {~1 G4(a)) and ~1 G4(b))} and thermally coupled energy levels {~2 Hand 4 S3/2} of the Tm3+ and Er3+ ions, respectively was carried out in the prepared tri-doped BaMoOphosphors. The maximum sensitivity for thermally coupled energy levels of the Er3+ and Stark sublevels of the Tm3+ ion was reported. The developed phosphors could be useful in the display devices and optical thermo metric applications.

关键词： Phosphor Optical temperature sensing Stark sublevels Thermally coupled energy levels Rare earths

A case study illustrating the use of an integrated approach to treat secondary Anal Fistula Post I&D of Perianal Abscess

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Clinical Research Communications 2024年第1期7卷 11-17页

作者： Sandeep Kumar Upadhyay Sheetal Asutkar Shreya soni Department of Shalya Tantra Mahatma Gandhi Ayurved College Hospital and Research CentreWardha 442001India HOD Shalya Tantra Mahatma Gandhi Ayurved College Hospital and Research CentreWardha 442001India

Background:Anal fistula is a long-term disease characterized by a tubular structure with one end opening in the anorectal canal and the other end opening on the surface of the perineum or perianal skin with chronic pus *** is linked to Bhagandar in Ayurveda,and in Sushruta Samhita,Acharya has mentioned 5 forms of *** boil in the present case was Shukla,sthira *** and firm,with Picchila strava and Kandu resembling the features of Parisraavi *** and objective:The current case was diagnosed as Parisravi bhagandar,which resembles trans-sphincteric or intersphincteric fistula in modern *** Ayurveda,the management of Parisraavi Bhagandar,Shastra,kshara,and Agnikarma is advised and the use of Ksharasutra,which contributes to complete cutting and healing of the track without reoccurrence,similarly Modern surgeon depends on surgery i.e radical excision of the track,ligation with Seton,and use of chemical irritants like urethane,silver nitrates,etc.A cutting seton(tight)gently slices the confined muscle to close the fistula with the least interruption to *** operation is especially advised when a one-stage fistulotomy poses a considerable risk of *** and methods:The method performed here was Core Partial Fistulectomy followed by Ksharasutra application till complete healing of the *** and conclusion:This case study provides the successful management of Parisraavi Bhagandara(high anal,trans-sphincteric fistula in ano)in 61-year-old male patient with an integrated surgical&Ayurvedic management approach.

关键词： Anal fistula Colonoscopy ligation of trans-sphincteric fistula Methylene blue dye perianal abscess Radical excision Sushrut Samhita