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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 50-50页

作者： Borderie V.m . Touzeau O. Bourcier T. 张少娟 service V Ctr. Hosp. Natl. d'O. 28 ruede Charenton 75012 Paris FranceDr.

Objective: To analyze the outcome of graft central thickness after penetrating keratoplasty. Design: Retrospective observational cohort study. Participants: E ight hundred fifty-six consecutive penetrating keratoplasties (772 patients) pe rformed between 1992 and 2001 were analyzed and 772 were included (1 graft per p atient was included). methods: slit-lamp examination and ultrasound pachymetry. main Outcome measures: slit-lamp findings, intraocular pressure, and graft cen tral thickness were recorded. Results: Patients were observed for an average of 55 months. The 36-and 60-month graft survival estimates were, respectively, 77 .2%and 71.0%. The average graft central thickness in successful transplants wa s 655 μm at 1 week, 558 μm at 1 month, 533 μm at 6 months, 538 μm at 12 mont hs, 558 μm at 24 months, 561 μm at 36 months, and 568 μm at 5 years. At each postoperative time point, the percentage of eyes with decreased, normal, and inc reased graft central thickness was significantly different according to slit-la mp findings. Of the patients with increased graft thickness, 46.2%had a simple outcome (normal intraocular pressure and normal slit-lamp findings), 28.6%expe rienced rejection, 15.8%experienced a graft nonimmunological event, and 9.4%ex perienced increased intraocular pressure. At each postoperative follow-up, subs equent graft survival was significantly lower in patients with increased graft t hickness as compared with patients with normal or decreased graft thickness. Whe n analyzing only patients with simple outcome, the relative risk of graft failur e was 3.3 if graft thickness was increased at 1 month (P usions: In conclusion, graft central thickness assessed by ultrasound pachymetry is a u seful method for observing patients who have undergone penetrating keratoplasty. Evenwhen slit-lamp examination reveals no complications, patients with an incr ease in graft thickness above the upper limit of normal for the postoperative ti me poi

关键词：植片角膜移植超声测厚仪队列研究观察性相对风险免疫反应

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准分子激光原位角膜磨镶术后双眼浆液性黄斑视网膜脱离

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 32-32页

作者： singhvi A. Dutta m. sharma N. 杨秀梅

To report a case of bilateral serous macular detachment following laser in sit u keratomileusis (LAsIK). Observational case report. A 33-year-old man present ed with sudden decrease of vision in both eyes 4 days following uncomplicated LA sIK in both eyes for spherical equivalent of +5.00 diopters sph in the right ey e and +7.00 diopters sph in the left eye. Detailed history with ocular and syst emic examination, fluorescein angiography, and optical coherence tomography were done. Retinal examination had a documentation of retinal pigment epithelium atr ophy in the macular region in both eyes pre-LAsIK. A diagnosis of central serou s chorioretinopathy (CsCR) was made in both eyes, with multifocal alterations in the retinal pigment epithelium and a pocket of serous retinal fluid in the macu lar region confirmed on OCT. Late venous phase of fluorescein angiogram demonstr ated multiple hyperfluorescent foci of leakage, more in the right eye with areas of retinal pigment epithelium staining. Preexisting macular pathology, such as retinal pigment epithelium atrophy could be a new contraindication to LAsIK for hypermetropia with possible development of CsCR, requiring a careful examination of the fundus pre-LAsIK.

关键词：视网膜脱离视网膜色素上皮眼底检查渗漏点详细病史荧光血管造影禁忌证高荧光多灶性观察性

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输卵管切除术对输卵管积水患者子宫内膜淋巴细胞群作用的前瞻性评估

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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 32-32页

作者： Ito C. Ito m. Itakura A. 朱晓明 Department of Pathology Nagoya U niversity Hospital Nagoya Japan Dr.

Objective To investigate the effect of hydrosalpinges on embryo impla ntation. Design Prospective study. setting Private fertility and university hospitals. Pa tient(s) Eighteen patients with unilateral or bilateral hydrosalpinges who under went salpingectomy. Intervention(s) Pre-and posttreatment endometrial biopsies for immunohistochemical evaluation. main outcome measure(s) Pre-and posttreatme nt lymphocyte populations in endometrial samples, evaluated by immunohistochemic al identification. Result(s) Endometrial samples from pretreatment exhibited sma ll lymphocytic clusters of CD3+, CD8+, CD4+, granzyme B positive, and CD56+. After salpingectomy, the numbers of cluster lesions were significantly decrease d. Conclusion( s) Because a characteristic distribution of lymphocytes in endome trium with hydrosalpinges was found, activation of T/NK (natural killer) lymphoc ytes in endometrium might be involved in the impairment of embryo implantation i n cases of hydrosalpinges.

关键词：输卵管切除术输卵管积水子宫内膜群作用胚胎植入淋巴细胞数中淋巴细胞附属医院颗粒酶免疫组织化学

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早产儿和足月儿尿液中的柠檬酸盐

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 21-21页

作者： White m.P. Aladangady N. Rolton H.A. 贺莉 Neonatal unit Homerton University Hospital Bart's London Qu. Mary's Sch. M. Homerton Row London E9 6SR United Kingdom

Objectives: (1) To determine a normal range for urinary citrate for term babi es. (2) To compare urinary citrate measured in ex preterm babies at term with th is normal range. (3) To evaluate whether urinary citrate was related to presence of nephrocalcinosis (NC) and chronic Lung Disease (CLD) in these ex preterm bab ies. study design: urinary citrate was measured in 38 healthy term babies (mean birth weight 3.52 kg, mean gestation 41weeks) at amean postnatal age of 3 days ( 1- 5 days) and in 53 ex preterm babies ( s gestation at birth) at term . These preterm babies were part of a larger study on NC in which two renal ultr asound scans were performed at 1 month and term. Results: The normal range for u rinary citrate in term babies was 0.025- 2.97 (mean 1.03) mmol/l and citrate/cr eatinine ratio 0.0011- 0.852 (mean 0.27). In the ex- preterm urinary citrate w as not significantly different (mean 1.1 vs. 1.03, p=0.7232)- but urine citrate /creatinine ratio was significantly higher (mean 1.27 vs. 0.27, p=0.0005). There was no significant difference in urinary citrate or ratios of citrate/creatinin e and calcium/citrate in the 11 (20.7% ) with NC or in the 17 (32% ) babies wi th CLD. There was no significant relationship found between duration of TPN and urinary citrate measured at term. Conclusion: We have determined a normal range for urinary citrate in healthy term babies in the first week of life. The range was very wide. Ex preterm babies had similar values at term and there was no ass ociation between urinary citrate and NC or CLD.

关键词：柠檬酸盐肾钙质沉着出生后平均胎龄平均出生体重正常值范围肌酐双侧肾脏慢性肺病无显著性差异

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抑郁和帕金森病

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 46-46页

作者： Lemke m.R. Fuchs G. Gemende I. 夏峰 Rhine Clinic Bonn Kaiser Karl Ring 20 53111 Bonn Germany Dr.

Depression occurs in approximately 45%of all patients with Parkinsons disea se (PD), reduces quality of life independent of motor symptoms and seems to be u nderrated and undertreated. Characteristics of symptoms differ from major depres sion. Because of overlapping clinical symptoms, diagnosis is based on subjective ly experienced anhedonia and feeling of emptiness. Available rating scales for m ajor depression may not be adequate to correctly measure severity of depression in PD. Anxiety and depression may manifest as first symptoms of PD many years be fore motor symptoms. serotonergic, noradrenergic and dopaminergic mechanisms pla y key roles in the etiology of depression in PD. Tricyclic and newer, selective antidepressants including serotonin and noradrenaline reuptake inhibitors (ssRI, sNRI) appear to be effective in treating depression in PD. selective reuptake i nhibitors seem to have a favorable side effect profile. Recent controlled studie s show antidepressant effects of pramipexole in bipolar II depression. New dopam ine agonists pramipexole and ropinirole appear to ameliorate depressive symptoms in PD in addition to effects on motor symptoms. There is a lack of appropriate rating scales and controlled studies regarding depression in PD.

关键词：帕金森病严重抑郁症运动症状普拉克索多巴胺能再摄取抑制剂色胺抗抑郁药物激动剂罗匹尼罗

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多囊卵巢综合征患者接受卵母细胞体外成熟及体外受精-胚胎移植治疗后的产科结局

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 17-17页

作者： Chung H.m. Lee D.R. 朱国栋

Objective: To assess the obstetric outcome of pregnancies resulting from in vi tro maturation (IVm) and IVF-ET of immature oocytes retrieved from women with p olycystic ovary syndrome (PCOs). Design: Prospective observational study. settin g: university fertility clinic. Patient(s): One hundred thirty-nine women under going 203 IVm treatment cycles. Intervention(s): Immature oocyte recovery from u nstimulated ovaries. In vitro oocyte maturation and fertilization. Fresh ET and assessment of obstetric outcomes in the pregnant women. main Outcome measure(s): Pregnancy and obstetric outcome. Result(s): Forty-one pregnancies were obtaine d in 187 ETs, resulting in a pregnancy rate of 21.9%. Except for three patients lost to follow-up in these pregnancies, the abortion and live birth rates were 36.8%(14 of 38) and 63.2%(24 of 38), respectively. The mean (±sD) gestationa l age and birth weight at delivery for singletons were 38.4 ±2.0 weeks (range, 33-41.6 weeks) and 3,252 ±.516 g (1,750-4,100 g), respectively. For twins the se were 36.7 ±1.9 weeks (34.6-39 weeks) and 2,361 ±.304 g (1,900-2,990 g), r espectively. Pregnancy complications occurred in five patients (13.2%); these i ncluded preterm labor (n = 3) and placenta previa (n = 2). Two patients (5.3%) had a major congenital anomaly diagnosed by ultrasonography. Conclusion(s): The abortion rate, gestational age and birth weight at delivery, and obstetric compl ications of pregnancies conceived by IVm-ET in women with PCOs were comparable with those of other women with PCOs being treated by conventional IVF-ET. In vi tro maturation followed by IVF-ET seems to be a useful treatment option for wom en with PCOs, thus avoiding the risk of ovarian hyperstimulation syndrome.

关键词：多囊卵巢综合征卵母细胞体外成熟活产率胚胎移植流产率胎儿出生体重妊娠并发症前置胎盘先天性畸形

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双色激光共振增强的气相C6H6分子的光电离谱

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光学学报 1987年第1期 1-10页

作者：范俊颖 G.müLLER J.L.LYmAN W.E.sOHmID K.L.KOmPA 中国科学院上海光学精密机械研究所 max-Planck-Institut für Quantenoptik D-8046 Garching b.münchen FRG Los Alamos National Laboratory New mexico 87545 usA

本文给出了双色激光共振增强的气相苯的光电离谱结果。激发光子首先把分子从基态选择激发到s-1电子单态中一个确定的振动态,然后第二台激光器输出的离化光子把这个激发分子离化。实验证明离子的产额不但与中间电子能级1B2u的振动态有关... 详细信息

本文给出了双色激光共振增强的气相苯的光电离谱结果。激发光子首先把分子从基态选择激发到s-1电子单态中一个确定的振动态,然后第二台激光器输出的离化光子把这个激发分子离化。实验证明离子的产额不但与中间电子能级1B2u的振动态有关,且依赖于离化激光的波长。从所得到的离子谱的结构和强度可以求得离子的电子基态2E1g的振动频率及分子参数,精度较高。自离化里德堡能级对离化截面的贡献非常显著。某些自离化共振峰可以确认为是这些里德堡态的振动能级。

关键词：电子态跃迁 C6H6 激光双色共振增强气相

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乳腺癌真空辅助旋切术后保乳手术的可行性

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中国临床医学 2016年第6期23卷 710-714页

作者：陈宏亮王懋莉张征丁昂复旦大学附属妇产科医院乳腺外科上海200011

目的:探讨超声引导下真空辅助活检(vacuum-assisted biopsy,VAB)切除乳腺癌肿块后保乳手术的可行性与安全性。方法:选择2008年1月至2014年12月VAB肿块切除术后行保乳手术治疗的45例浸润性导管癌(invasive ductal carcinoma,IDC)患者(VAB... 详细信息

目的:探讨超声引导下真空辅助活检(vacuum-assisted biopsy,VAB)切除乳腺癌肿块后保乳手术的可行性与安全性。方法:选择2008年1月至2014年12月VAB肿块切除术后行保乳手术治疗的45例浸润性导管癌(invasive ductal carcinoma,IDC)患者(VAB组)。选取同一时期单发、直径小于2cm、肿块切除活检后行保乳手术的147例IDC患者为对照组。分析并比较两组患者的临床病理特征与预后。结果:VAB组肿块均单发、直径m且不可触及,影像学检查误诊为良性。所有VAB手术只行1次穿刺,穿刺点距离肿块的平均距离为(2.52±0.89)cm。中位切割8次,影像学检查示完全切除,平均手术时间(25.4±7.6)min,术中未发生活动性出血。保乳手术距VAB术平均(4.50±0.92)d;局部扩大切除病灶的各个切缘均阴性;无患者发生肿瘤细胞针道或皮肤穿刺点种植;3例残腔残留少量导管原位癌病灶,但无浸润性癌灶。VAB组与对照组平均年龄、年龄构成、肿块直径、肿瘤组织学分级、脉管侵犯、淋巴结分期、前哨淋巴结阳性率、肿瘤分子分型及辅助治疗、腋窝手术差异均无统计学意义。两组间5年无病生存期(disease-free survival,DFs)和5年总生存期(overall survival,Os)差异均无统计学意义。结论:VAB切除不可触及的较小乳腺癌肿块后续行保乳手术安全可行,值得进一步大样本研究。

关键词：真空辅助活检乳腺癌保乳手术超声引导

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Naturally acidic and metalliferous waters at unmined volcanogenic massive sulfide deposits in the Bonnifield mining district, Alaska Range, east-central Alaska

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Chinese Journal Of Geochemistry 2006年第B8期25卷 232-232页

作者： Robert G. Eppinger Paul H. Briggs Cynthia Dusel-Bacon stuart A. Giles Larry P. Gough Jane m.Hammarstrom Bernard E. Hubbard u.s. Geological survey Central Mineral Resources Team Denver Colorado USA u.s. Geological survey Western Mineral Resources Team Menlo Park California USA u.s. Geological survey Eastern Mineral Resources Team Reston Virginia USA

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微白蛋白尿对预测Ⅱ型糖尿病患者发生冠心病的价值

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Oncology and Translational medicine 1995年第2期12卷 18-18页

作者： m.mattock,D.Barnes,GC Viberti,H.Keen,A.Fitzgerald,D.Burt,B.sandhu,P.G.Jackson,李仁立 u.m.D.s.Guy's and st Thomas Hospitals and Lewisham Hospital London u.K. u.m.D.s.Guy's and st Thomas Hospitals and Lewisham Hospital London u.K. u.m.D.s.Guy's and st Thomas Hospitals and Lewisham Hospital London u.K. u.m.D.s.Guy's and st Thomas Hospitals and Lewisham Hospital London u.K. u.m.D.s.Guy's and st Thomas Hospitals and Lewisham Hospital London u.K. u.m.D.s.Guy's and st Thomas Hospitals and Lewisham Hospital London u.K. u.m.D.s.Guy's and st Thomas Hospitals and Lewisham Hospital London u.K. u.m.D.s.Guy's and st Thomas Hospitals and Lewisham Hospital London u.K. 同济医科大学附属同济医院

微白蛋白尿可预测Ⅱ型糖尿病患者的早期死亡率,这一前瞻性研究目的是观察微白蛋白尿能否预示冠心病的发病率和死亡率。微白蛋白尿是指整夜尿蛋白排泄率为20～200μg/min。冠心病发病率是根据静息心电图和询问有关病史,而冠心病死亡率应... 详细信息

微白蛋白尿可预测Ⅱ型糖尿病患者的早期死亡率,这一前瞻性研究目的是观察微白蛋白尿能否预示冠心病的发病率和死亡率。微白蛋白尿是指整夜尿蛋白排泄率为20～200μg/min。冠心病发病率是根据静息心电图和询问有关病史,而冠心病死亡率应有死亡证明和临床病情记录。1985年～1987年调查了144名欧洲Ⅱ型糖尿病患者,平均年龄56岁,平均随访7.5年。在随访中34名患者死亡,其中65％死于心血管疾病,这些患者中48％有微白蛋白尿,与之相比,尿白蛋白正常者为15％,P<0.001。在存活者多因素回归分析中,微白蛋白尿有意义地

关键词：微白蛋白尿冠心病冠状动脉病 Ⅱ型糖尿病二型糖尿病患者

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