输卵管切除术对输卵管积水患者子宫内膜淋巴细胞群作用的前瞻性评估
A prospective evaluation of the effects of salpingectomy on endometrial lymphocyte clusters in patients with hydrosalpinges作者机构：Department of Pathology Nagoya U niversity Hospital Nagoya Japan Dr.
出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)
年 卷 期：2005年第1卷第1期
页 面：32-32页
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
主 题：输卵管切除术 输卵管积水 子宫内膜 群作用 胚胎植入 淋巴细胞数 中淋巴细胞 附属医院 颗粒酶 免疫组织化学
摘 要：Objective To investigate the effect of hydrosalpinges on embryo impla ntation. Design Prospective study. Setting Private fertility and university hospitals. Pa tient(s) Eighteen patients with unilateral or bilateral hydrosalpinges who under went salpingectomy. Intervention(s) Pre-and posttreatment endometrial biopsies for immunohistochemical evaluation. Main outcome measure(s) Pre-and posttreatme nt lymphocyte populations in endometrial samples, evaluated by immunohistochemic al identification. Result(s) Endometrial samples from pretreatment exhibited sma ll lymphocytic clusters of CD3+, CD8+, CD4+, granzyme B positive, and CD56+. After salpingectomy, the numbers of cluster lesions were significantly decrease d. Conclusion( s) Because a characteristic distribution of lymphocytes in endome trium with hydrosalpinges was found, activation of T/NK (natural killer) lymphoc ytes in endometrium might be involved in the impairment of embryo implantation i n cases of hydrosalpinges.
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