检索结果-南通市图书馆

Signal Transduction and Targeted Therapy 2020年第1期5卷 1482-1485页

作者： Yi Ching Esther Wan Jiaxian Liu Lina Zhu tze zhen evangeline kang Xiaoxuan Zhu John Lis Toyotaka Ishibashi Charles G.Danko Xin Wang Kui Ming Chan Department of Biomedical Sciences City University of Hong KongHong KongChina Key Laboratory of Biochip Technology Biotech and Health CentreShenzhen Research Institute of City University of Hong KongShenzhenChina Department of Molecular Biology and Genetics Cornell UniversityNew YorkNYUSA Division of Life Science Hong Kong University of Science and TechnologyHong KongChina USA James A Baker Institute for animal health Cornell UniversityNew YorkNYUSA

Dear Editor,Histones are essential proteins in compacting genomic DNA and regulating gene *** studies on histone H3 oncohistones in pediatric brain cancers1,2 and chondroblastoma3,documented the transcriptomic reprogramming through the alterations of histone *** recently reported the identification of a novel cancer associated mutation,the H2BG53-to-D in pancreatic ductal adenocarcinoma(PDAC)*** showed that the H2BG53D mutation weakens the interaction between nucleosomal DNA and histone octamer,subsequently enhances transcription in *** further showed that cells expressing the G53D mutant H2B acquired oncogenic phenotypes in our CRISPRCas9 knock-in ***,the mechanism by which H2BG53D mutation promotes PDAC remains unknown.

关键词： H2B expression adenocarcinoma

Cancer-associated histone mutation H2BG53D disrupts DNA–histone octamer interaction and promotes oncogenic phenotypes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 2230-2233页

作者： Yi Ching Esther Wan Tsz Chui Sophia Leung Dongbo Ding Xulun Sun Jiaxian Liu Lina Zhu tze zhen evangeline kang Du Yang Yuchen Zhang Jitian Zhang Chengmin Qian Michael Shing Yan Huen Qing Li Maggie Zi Ying Chow Zongli zheng Junhong Han Ajay Goel Xin Wang Toyotaka Ishibashi Kui Ming Chan Department of Biomedical Sciences City University of Hong KongHong KongChina Key Laboratory of Biochip Technology Biotech and Health CentreShenzhen Research Institute of City University of Hong KongShenzhenChina Division of Life Science Hong Kong University of Science and TechnologyHong KongChina State Key Laboratory of Protein and Plant Gene Research School of Life Sciences and Peking-Tsinghua Center for Life SciencesPeking UniversityPekingChina School of Biomedical Sciences The University of Hong KongHong KongChina Ming Wai Lau Centre for Reparative Medicine Karolinska InstitutetHong KongChina State Key Laboratory of Biotherapy and Cancer Center West China HospitalWest China Medical SchoolSichuan UniversitySichuanChina Department of Molecular Diagnostics and Experimental Therapeutics Beckman Research Institute at City of Hope Comprehensive Cancer CenterDuarteCAUSA

Dear Editor,Recent studies from us and others have deciphered the clinical relevance of a variety of oncohistones1 in different *** H3K27M and H3K36M mutant histones exert dominant-negative effects on methylation levels of histone H3K27 and H3K36 on wildtype histone protein in pediatric brain cancers2–4 and chondroblastoma,5,6 *** contrast to H3K27M and H3K36M that act in trans to cause global reduction of methylation at the respective residues,the H3G34 mutations,including H3G34V/R and H3G34W/L found in pediatric high-grade glioma and giant cell tumor of the bone,affect the H3K36 methylation in cis and alter the H3K36 methylation on the nucleosome containing the H3G34 mutation(s).

关键词： Cancer clinical pediatric

Large circuit models: opportunities and challenges

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第10期67卷 25-66页

作者： Lei CHEN Yiqi CHEN Zhufei CHU Wenji FANG Tsung-Yi HO Ru HUANG Yu HUANG Sadaf KHAN Min LI Xingquan LI Yu LI Yun LIANG Jinwei LIU Yi LIU Yibo LIN Guojie LUO Hongyang PAN zhengyuan SHI Guangyu SUN Dimitrios TSARAS Runsheng WANG Ziyi WANG Xinming WEI Zhiyao XIE Qiang XU Chenhao XUE Junchi YAN Jun YANG Bei YU Mingxuan YUAN evangeline F.Y.YOUNG Xuan ZENG Haoyi ZHANG Zuodong ZHANG Yuxiang ZHAO Hui-Ling zhen Ziyang zhenG Binwu ZHU Keren ZHU Sunan ZOU Huawei Noah’s Ark Lab School of Integrated Circuits Peking University Faculty of Electrical Engineering and Computer Science Ningbo University Department of Electronic and Computer Engineering Hong Kong University of Science and Technology Department of Computer Science and Engineering The Chinese University of Hong Kong School of Integrated Circuits Southeast University Huawei HiSilicon Peng Cheng Laboratory School of Computer Science Peking University School of Microelectronics State Key Laboratory of Integrated Chips and System Fudan University School of Artificial Intelligence Shanghai Jiao Tong University

Within the electronic design automation(EDA) domain, artificial intelligence(AI)-driven solutions have emerged as formidable tools, yet they typically augment rather than redefine existing methodologies. These solutions often repurpose deep learning models from other domains, such as vision, text, and graph analytics, applying them to circuit design without tailoring to the unique complexities of electronic circuits. Such an “AI4EDA” approach falls short of achieving a holistic design synthesis and understanding,overlooking the intricate interplay of electrical, logical, and physical facets of circuit data. This study argues for a paradigm shift from AI4EDA towards AI-rooted EDA from the ground up, integrating AI at the core of the design process. Pivotal to this vision is the development of a multimodal circuit representation learning technique, poised to provide a comprehensive understanding by harmonizing and extracting insights from varied data sources, such as functional specifications, register-transfer level(RTL) designs, circuit netlists,and physical layouts. We champion the creation of large circuit models(LCMs) that are inherently multimodal, crafted to decode and express the rich semantics and structures of circuit data, thus fostering more resilient, efficient, and inventive design methodologies. Embracing this AI-rooted philosophy, we foresee a trajectory that transcends the current innovation plateau in EDA, igniting a profound “shift-left” in electronic design methodology. The envisioned advancements herald not just an evolution of existing EDA tools but a revolution, giving rise to novel instruments of design-tools that promise to radically enhance design productivity and inaugurate a new epoch where the optimization of circuit performance, power, and area(PPA) is achieved not incrementally, but through leaps that redefine the benchmarks of electronic systems' capabilities.

关键词： AI-rooted EDA large circuit models (LCMs) multimodal circuit representation learning circuit optimization

Immunomodulatory Function of Pien tze Huang in T Cell-Mediated Anti-tumor Activity against B16-F10,MC38 and Hep1-6 Tumor Models

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第4期30卷 348-358页

作者： FU Yu-bing LIU Chen-feng WANG Jin-jia JI Xiao-lin TANG Rong-han LIAO Kun-yu CHEN Ling-yue HONG Ya-zhen FAN Bin-bin WANG Shi-cong LIU Wen-Hsien State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life ScienceXiamen UniversityXiamenFujian Province(361102)China Fujian Pien tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian Province(363000)China

Objective To investigate the anti-tumor effects of Pien tze Huang(PZH)in mouse models of B16–F10 melanoma,MC38 colorectal cancer,Hep1-6 hepatocellular carcinoma and chemically induced hepatocellular carcinoma *** Various tumor models,including B16–F10,MC38 and Hep1-6 tumor hypodermic inoculation models,B16–F10 and Hep1-6 pulmonary metastasis models,Hep1-6 orthotopic implantation model,and chemically induced hepatocellular carcinoma model,were utilized to evaluate the anti-tumor function of *** growth was assessed by measuring tumor size and weight of solid tumors isolated from C57BL/6 *** cell proliferation and death of tumor cells in vitro,as well as T cell activation markers,cytokine production and immune checkpoints analysis,single-cell suspensions were prepared from mouse spleen,lymph nodes,and tumors after PZH *** PZH demonstrated significant therapeutic efficacy in inhibiting tumor growth(P0.05).Nevertheless,PZH exhibited a remarkable ability to enhance T cell activation and the production of interferon gamma,tumor necrosis factor alpha,and interleukin 2 in CD4^(+)T cells in vitro(P<0.01 or P<0.05).Importantly,PZH substantially inhibited T cell exhaustion and boosted cytokine production by tumor-infiltrating CD8^(+)T cells(P<0.01 or P<0.05).Conclusion This study has confirmed a novel immunomodulatory function of PZH in T cell-mediated anti-tumor immunity,indicating that PZH holds promise as a potential therapeutic agent for cancer treatment.

关键词： Pien tze Huang metastasis anti-tumor immunity T cell activation T cell exhaustion immune checkpoints Chinese medicine

Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： zhen Huang Fan-Ying Meng Lin-Zhu Lu Qian-Qian Guo Chang-Jun Lv Nian-Hua Tan Zhe Deng Jun-Yi Chen Zi-Shu Zhang Bo Zou Hong-Ping Long Qing Zhou Sha Tian Si Mei Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

Factors Associated with Quality of Life in Acute Exacerbation of COPD

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

上海第二医科大学学报 2005年第12期25卷 1266-1266页

作者： CAO zhen-ying Tan Wan Cheng Ng tze Pin Department of Geriatrics Ruijin Hospital Shanghai Second Medical University Shanghai 200025 China Department of Medicine National University of Singapore Singapore 119260 Singapore

Objective To measure the QOLin patients with AECOPD and the frequency of potential risk factors, and to evaluate the as-sociation of risk factors with poor QOL in patients with AECOPD. Methods A study sample of 196 patients with moderate to severeCOPD admitted for acute exacerbations to two large general hospitals were studied. The St George QOL (SGQOL) scale, socio-demo-graphic, clinical and patient care characteristics, including depression and spirometry were ascertained in the stable state before dischargeand at one-month post discharge. Results There was a high prevalence of current or ex-heavy smokers, depression and consumption ofpsychotropic drugs, and lowprevalence of care giver support, pulmonary rehabilitation and vaccination. The mean scores for the differentdomains were 55.9 for Symptoms; 65.1 for Activity; 32.9 for Impact; and the mean of overall Total scores was 46.5. Multiple regressionanalysis showed that CMH, male, depression, previous frequent hospital readmissions and poor therapy compliance were independentlyrelated to worse Symptoms Scores. Previous frequent readmissions, depression, severe dyspnea and older age ( >72 years) were relatedto worse Activity Scores of SGQOL. Depression, previous frequent readmissions, severe dyspnea, long COPD duration(≥5years) andsevere smoking were related to worse Impact Scores of SGQOL. Depression, previous frequent readmissions, severe dyspnea and longCOPD duration(≥5years) were independently related to worse Total Scores of SGQOL. Conclusion Poor QOL in patients with COPDexacerbation was associated with disease severity, psychosocial and health care factors which are modifiable.

关键词：呼吸系统疾病生活质量预后病理机制

影响慢性阻塞性肺病急性加重患者生活质量的危险因素

在线全文

学校读者我要写书评

暂无评论

上海第二医科大学学报 2005年第7期25卷 722-726页

作者：曹振英 Tan Wan Cheng Ng tze Pin 上海第二医科大学瑞金医院老年病科上海200025 新加坡国立大学医学院新加坡国立大学医学院新加坡国立大学医学院

目的测定和评价慢性阻塞性肺病(COPD)急性加重患者的生活质量和潜在危险因素的发生率及其影响。方法研究两家大型医院因COPD急性加重入院的196个中重度COPD患者。在患者出院时和出院后1月稳定状态,测量肺功能指标、精神状态及用圣乔治... 详细信息

目的测定和评价慢性阻塞性肺病(COPD)急性加重患者的生活质量和潜在危险因素的发生率及其影响。方法研究两家大型医院因COPD急性加重入院的196个中重度COPD患者。在患者出院时和出院后1月稳定状态,测量肺功能指标、精神状态及用圣乔治呼吸问卷测定生活质量,并收集了患者的临床性状、社会性状和照料因素。结果196例患者中,吸烟、抑郁及嗜用镇痛剂、安眠药相当普遍,而完成肺康复、接种流感病毒疫苗和肺炎球菌疫苗以及看护支持却很少。生活质量的症状域均值为55.9,活动域均值为65,影响域均值为32.9,总体均值为46.5。多变量分析显示慢性黏液高分泌症、男性、抑郁、前1年多次入院和治疗依顺性差与症状域值低下独立显著相关;前1年多次入院、抑郁、严重气促和72岁以上老年与活动域值低下独立显著相关;抑郁、前1年多次入院、严重气促、病程长和重度吸烟与影响域值低下独立显著相关;抑郁、前1年多次入院、严重气促和病程长与总体数值低下独立显著相关(P<0.05)。结论COPD急性加重患者的生活质量低下与COPD严重程度、患者精神抑郁状态及照料这些可改善因素有关。

关键词：慢性阻塞性肺病急性加重生活质量危险因素

基于LC-MS和SPR垂钓技术的安宫牛黄丸质量标志物研究

在线全文

学校读者我要写书评

暂无评论

中国中药杂志 2024年第7期49卷 1848-1864页

作者：袁慧君陈晓毅陈攀振张基荣张荣霜许文徐伟林小红罗志毅漳州片仔癀药业股份有限公司、福建省片仔癀天然医药研发企业重点实验室福建漳州363000 福建中医药大学药学院福建福州350122

阐明中药复方的质量标志物对于了解中药复方的作用机制、质量标准提升使用和中药新药二次开发至关重要。近年来的研究表明,表面等离子体共振(SPR)技术在中药生物质量标志物鉴定领域具有广阔的应用前景。该研究建了一种基于SPR垂钓技术... 详细信息

阐明中药复方的质量标志物对于了解中药复方的作用机制、质量标准提升使用和中药新药二次开发至关重要。近年来的研究表明,表面等离子体共振(SPR)技术在中药生物质量标志物鉴定领域具有广阔的应用前景。该研究建了一种基于SPR垂钓技术来分析安宫牛黄丸的质量标志物。首先,利用UPLC-Q-TOF-MS分析安宫牛黄丸主要化学成分71个,并采用网络药理学对鉴定化学成分预测包括STAT3在内的安宫牛黄丸抗脑卒中的潜在靶点;其次,构建STAT3蛋白芯片,采用SPR垂钓系统对安宫牛黄丸提取物进行垂钓回收,分析鉴定其潜在的活性成分,包括黄连碱、巴马汀、表小檗碱、小檗碱、甲基黄连碱、去亚甲基小檗碱、药根碱、四氢黄连碱、黄芩素、黄芩苷甲酯10种成分;第三,采用SPR筛选和分子对接技术确定10个活性成分对STAT3靶点的亲和动力学参数KD分别为44.7、44、58.1、51.3、39.7、32.1、49.2、69.1、19.7、24.9μmol·L^(-1),分子对接结果良好。首次利用STAT3靶点芯片联合UPLC-Q-TOF-MS有效鉴定安宫牛黄丸化学成分及与STAT3靶点配体成分,提示STAT3可作为安宫牛黄丸构建生物质量评价的潜在质量标志物。

关键词：安宫牛黄丸网络药理学液质联用表面等离子体共振(SPR) STAT3

在线全文

学校读者我要写书评

暂无评论

牙齿釉质表面的简便影迹法

古脊椎动物与古人类 1964年第1期 87-91页

作者：赵资奎毕初珍中国科学院古脊椎动物与古人类研究所

一、引言近来,研究牙齿表面的细微特征,一般都采用金属—火棉胶影迹法(metal-shadowedcollodion raplica method),这种方法,原来是物理学家用来研究金属表面结构的方法之一;它主要是用2%的火棉胶(collodion u.s.P.)均匀地涂在干净的被... 详细信息

一、引言近来,研究牙齿表面的细微特征,一般都采用金属—火棉胶影迹法(metal-shadowedcollodion raplica method),这种方法,原来是物理学家用来研究金属表面结构的方法之一;它主要是用2%的火棉胶(collodion u.s.P.)均匀地涂在干净的被研究的金属表面上,晾干后,就成为一层薄膜。把它剥下,置于载玻片上。然后在高真空室中用金属蒸气(Ag或 Al)在火棉胶膜上涂上一层极薄的金属薄膜。封固后,就可以用普通光学显微镜或电

关键词：牙齿微特征釉柱釉面釉质火棉胶金属表面牙本

长江经济带省际贸易的源汇地效应研究——基于铁路货运视角

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

华东经济管理 2017年第10期31卷 77-83页

作者：刘镇邱志萍江西财经大学江西经济发展与改革研究院江西南昌330013

文章基于2000-2015年长江经济带11省市铁路货运面板数据,将货物发送省份列为源地,货物到达省份列为汇地,借助考虑了省份异质性特征的三维引力模型实证研究长江经济带省际贸易的源地和汇地效应的大小及贸易状态。通过控制实际人均GDP、... 详细信息

文章基于2000-2015年长江经济带11省市铁路货运面板数据,将货物发送省份列为源地,货物到达省份列为汇地,借助考虑了省份异质性特征的三维引力模型实证研究长江经济带省际贸易的源地和汇地效应的大小及贸易状态。通过控制实际人均GDP、地理距离、经济规模相似性、地方保护、地理邻近和国际贸易的替代效应等因素,研究发现:长江经济带源地与汇地效应整体上自东向西均不断增大,且汇地效应远高于源地效应;长江经济带省际贸易表现出明显的产业间贸易,其互动性和协调性不明显,东中西经济板块内的省际贸易仍具备较大的贸易潜力。因此,东部省市应优化出口结构,内陆省市积极吸收东部产出,加强铁路设施建设,推动市场经济法规建设和地方政府简政放权。

关键词：长江经济带省际贸易源地效应汇地效应三维引力模型