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Witten's D_4 Integrable Hierarchies Conjecture

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Chinese Annals of Mathematics,Series B 2016年第2期37卷 175-192页

作者： Huijun FAN Amanda FRANCIS tyler jARVIS Evan MERRELL Yongbin RUAN School of Mathematical Sciences Peking University Department of Mathematics Brigham Young University Department of Mathematics University of Michigan Ann Arbor the Yangtz Center of Mathematics at Sichuan University

The authors prove that the total descendant potential functions of the theory of Fan-jarvis-Ruan-Witten for D4 with symmetry group j and for D4T with symmetry group Gmax, respectively, are both tau-functions of the D4 Kac-Wakimoto/Drinfeld-Sokolov hierarchy. This completes the proof, begun in the article by Fan-jarvis-Ruan（2013）, of the Witten Integrable Hierarchies Conjecture for all simple（ADE） singularities.

关键词：可积模型猜想 D4 tau蛋白潜在功能功能层次对称群 ADE

Magnetic anchor guidance for endoscopic submucosal dissection and other endoscopic procedures

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World journal of Gastroenterology 2017年第16期23卷 2883-2890页

作者： Mohamed Mortagy Neal Mehta Mansour A Parsi Seiichiro Abe tyler Stevens john j Vargo Yutaka Saito Amit Bhatt Department of Internal Medicine Homer Stryker MD School of MedicineWestern Michigan UniversityKalamazooMI 49008United States Department of Internal Medicine Medicine InstituteCleveland ClinicClevelandOH 44195United States Department of Gastroenterology and Hepatology Digestive Disease InstituteCleveland ClinicClevelandOH 44195United States Endoscopy Division National Cancer Center HospitalTokyo 104-0045Japan

Endoscopic submucosal dissection(ESD) is a wellestablished, minimally invasive treatment for superficial neoplasms of the gastrointestinal tract. The universal adoption of ESD has been limited by its slow learning curve, long procedure times, and high risk of complications. One technical challenge is the lack of a second hand that can provide traction, as in conventional surgery. Reliable tissue retraction that exposes the submucosal plane of dissection would allow for safer and more efficient dissection. Magnetic anchor guided endoscopic submucosal dissection(MAGESD) has potential benefits compared to other current traction methods. MAG-ESD offers dynamic tissue retraction independent of the endoscope mimicking a surgeon's "second hand". Two types of magnets can be used: electromagnets and permanent magnets. In this article we review the MAG-ESD technology, published work and studies of magnets in ESD. We also review the use of magnetic anchor guidance systems in natural orifice transluminal endoscopic surgery and the idea of magnetic non-contact retraction using surface ferromagentization. We discuss the current limitations, the future potential of MAG-ESD and the developments needed for adoption of this technology.

关键词： Endoscopic submucosal dissection Gastric cancer Magnetic anchor guidance Esophageal cancer Magnets Traction Natural orifice transluminal endoscopic surgery

Designing Hardware for the Boundary Condition Round Robin Challenge

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Sound & Vibration 2018年第1期52卷 9-12页

作者： David E.Soine Richard j.jones julie M.Harvie Troy j.Skousen tyler F.Schoenherr Kansas City National Security Campus* 14520 Botts RoadKansas CityMissouriUSA Sandia National Laboratories P.O.Box 5800-MS 0840AlbuquerqueNM 87185

Qualification of products to their vibration and shock requirements in a laboratory setting consists of two basic *** first is the quantification of the product’s mechanical environment in the *** second is the process of testing the product in the laboratory to ensure it is robust enough to survive the field *** latter part is the subject of the“Boundary Condition for Component Qualification”challenge *** paper describes the challenges in determining the appropriate boundary conditions and input stimulus required to qualify the *** paper also describes the step sand analyses that were taken to design a set of hardware that demonstrates the issue and can be used by round robin challenge participants to investigate the problem.

关键词： field. Boundary Robin

Simulations of a logistic-type model with delays for Chagas disease with insecticide spraying

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International journal of Biomathematics 2017年第3期10卷 41-60页

作者： Nofe Al-Asuoad tyler Pleasant Meir Shillor Hrishikesh Munugala Daniel j. Coffield jr. Anna Maria Spagnuolo Department of Mathematics and Statistics Oakland University Rochester MI 48309 USA Harrison High School MI USA Novi High School Novi MI 48375 USA Mathematics Department University of Michigan-Flint Flint MI 48502 USA

This work studies and numerically simulates a logistic-type model for the dynamics of Chagas disease, which is caused by the parasite T. cruzi and affects millions of humans and domestic mammals throughout rural areas in Central and South America. A basic model for the disease dynamics that includes insecticide spraying was developed in Spagnuolo et al. (2010) [27] and consists of a delay-differential equation for the vectors and three nonlinear ordinary differential equations for the populations of the infected vectors, infected humans and infected domestic mammals. In this work, the vector equation is modified by using a logistic term with zero, one or two delays or time lags. The aim of this study is three-fold: to numerically study the effects of using different numbers of delays on the model behavior; to find if twice yearly insecticide spraying schedules improve vector control; and to study the sensitivity of the system to the delays in the case of two delays, by introducing randomness in the delays. It is found that the vector equation with different number of delays has very different solutions. The “best” day of spraying is the middle of Spring and twice annual sprayings cause only minor improvements in disease control. Finally, the model is found to be insensitive to the values of the delays, when the delays are randomly distributed within rather narrow intervals or ranges centered on the parameter values used in Coffield et al. (2014) [8].

关键词： Chagas disease logistic equation with delays epidemic dynamics nonlinear dynamical system simulations

Are demographics associated with mucoepidermoid or acinic cell carcinoma parotid malignancies in children?

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World journal of Otorhinolaryngology-Head and Neck Surgery 2019年第4期5卷 222-227页

作者： tyler A.janz Eric j.Lentsch Shaun A.Nguyen Clarice S.Clemmens University of Texas Medical Branch GalvestonTX77550USA University of Central Florida College of Medicine OrlandoFL32827USA Medical University of South Carolina CharlestonSC29425USA

Objective:To identify possible associations between patient demographics and parotid cancer histological type in pediatric ***:Pediatric patients(ages:birth-18.0 years)in the Surveillance,Epidemiology,and End Results(SEER)database were included from 1973 to 2014 based on a diagnosis of mucoepidermoid carcinoma or acinic cell carcinoma of the parotid gland using the ICD O-3 codes of C07.9 and 8430 or *** were classified into the following cohorts:justed OR:7.68[95%Cl:2.01-29.44]).When stratified by histological type,58.9%of female pediatric patients≥14 years of age had an acinic cell carcinoma as compared to 37.3%of male pediatric patients≥14 years of age,36.5%of female pediatric patients<14 years of age,and 34.0%of male pediatric patients<14 years of age(P=0.01).Conclusions:Based on this study,pediatric female patients between the ages of 14 and 18 years are the most likely cohort to have acinic cell *** results of this study may assist providers during the work up of a pediatric patient with a suspected parotid malignancy.

关键词： Pediatric parotid cancer Head and neck surgery Pediatric otolaryngology Level of evidence:4

Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study

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World journal of Otorhinolaryngology-Head and Neck Surgery 2019年第1期5卷 34-40页

作者： tyler A.janz David M.Neskey Shaun A.Nguyen Eric j.Lentsch Medical University of South Carolina 135 Rutledge Ave.CharlestonSC.29425USA

Objective:To provide an understanding of the incidence of anaplastic thyroid cancer within the United ***:Patients in the Surveillance,Epidemiology,and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of anaplastic thyroid cancer using ICDO-3 *** were categorized into cohorts based on their year of ***:1527 patients were diagnosed with anaplastic thyroid cancer within the SEER 18 *** age-adjusted incidence rate was 0.2 per 1,000,000 people (95% CI:0.0-0.5) in 1973 and was 1.2 per 1,000,000 people (95% Cl:0.8-1.6) in 2014 (average annual percent change:3.0% [95% CI:2.2%-3.7%]).Patients tended to be of older age (mean age:70.5 [range 15.0-102.0]),of female sex (62.8%),and Caucasian (81.1%).Finally,survival over time remained the same,as median disease specific survival months was 4.00 (95% CI:2.26-5.74) from 1995 to 1999 and 4.00 (95% Cl:3.26-4.74) from 2010 to ***:The incidence rate of anaplastic thyroid cancer has increased from 1973 to ***,median survival in months did not greatly change *** on this increasing incidence,physicians must act appropriately to identify patients with anaplastic thyroid cancer as it possesses a high morbidity and mortality.

关键词： Anaplastic thyroid cancer Thyroid cancer Head and neck Head and neck endocrine surgery Head and neck oncology

Predictors of occult lymph node metastasis in cutaneous head and neck melanoma

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World journal of Otorhinolaryngology-Head and Neck Surgery 2019年第4期5卷 200-206页

作者： jonathan S.Ni tyler A.janz Shaun A.Nguyen Eric j.Lentsch Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharleston SC USA

Objective:To use the Surveillance,Epidemiology,and End Results(SEER)database to verify the findings of a recent National Cancer Database(NCDB)study that identified factors predicting occult nodal involvement in cutaneous head and neck melanoma(CHNM)while identifying additional predictors of occult nodal metastasis and comparing two distinct cancer ***:Cases of CHNM in the SEER database diagnosed between 2004 and 2014 were *** information and oncologic data were *** and multivariate analysis were performed to identify factors associated with pathologic nodal ***:There were 34002 patients with CHNM *** this population,16232 were clinically node-negative,1090 of which were found to be pathologically *** multivariate analysis,factors associated with an increased risk of occult nodal metastasis included increasing depth of invasion(stepwise increase in adjusted odds ratio[OR]),nodular histology(aOR:1.47[95%CI:1.21-1.80]),ulceration(aOR:1.74[95%CI:1.48-2.05]),and mitoses(aOR:1.86[95%CI:1.36-2.54]).Factors associated with a decreased risk of occult nodal metastasis included female sex(aOR:0.80[0.67-0.94])and desmoplastic histology(aOR:0.37[95%CI:0.24-0.59]).Between the SEER database and the NCDB,factors associated with occult nodal involvement were similar except for nodular histology and female sex,which did not demonstrate significance in the ***:Regarding clinically node-negative CHNM,the SEER database and the NCDB have similarities in demographic information but differences in baseline population sizes and tumor characteristics that should be considered when comparing findings between the two databases.

关键词： Head and neck melanoma Lymph node metastasis Occult nodal metastasis Sentinel lymph node biopsy

Pheromone pollution from invasive sea lamprey misguides a native confamilial

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Current Zoology 2021年第3期67卷 333-335页

作者： tyler j.Buchinger Skye D.Fissette Belinda HUERTA Ke Li Nicholas S.johnson Weiming Li Department of Fisheries and Wildlife Michigan State UniversityEast LansingMl 48825USA U.S.Geological Survey Great Lakes Science CenterHammond Bay Biological StationMillersburgMl49759USA

Animals interact with mates in a sensory environment rife with the footprints of human *** chorus over the noise of traffic(Bee and Swanson 2007),glow-worms search for bioluminescent mates against backlight from street lamps(Bird and Parker 2014),and fish attend to conspecific olfactory cues mixed with sewage(Fisher et al.2006).As invasive species proliferate throughout the world,animals also encounter noise in the form of novel heterospecific signals that can interfere with existing communication channels(Groning and Hochkirch 2008).Pheromones,for example,are often species-specific in natural contexts involving sympatric heterospecifics but may become detrimental pollution when animals invade regions inhabited by historically allopatric relatives that previously faced less selection for signal divergence(Gozlan et al.2014).

关键词： Hoc Bee pollution

Comparison of five video-assisted intubation devices by novice and expert laryngoscopists for use in the aeromedical evacuation environment

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Military Medical Research 2017年第2期4卷 61-69页

作者： Matthew C.Wallace SSgt tyler Britton Robbie Meek Sharon Walsh-Hart Col Todd E.Carter Steven j.Lisco University of Cincinnati Medical Center Department of Anesthesiology

Background: The critically ill or injured patient undergoing military medical evacuation may require emergent intubation. Intubation may be life-saving, but it carries *** novice or infrequent laryngoscopist has a distinct disadvantage because experience is critical for the rapid and safe establishment of a secured airway. This challenge is compounded by the austere environment of the back of an aircraft under blackout conditions. This study determined which of five different video-assisted intubation devices(VAIDs) was best suited for in-flight use by U.S. Air Force Critical Care Air Transport Teams by comparing time to successful intubation between novice and expert laryngoscopists under three conditions, Normal Airway Lights on(NAL), Difficult Airway Lights on(DAL) and Difficult Airway Blackout(DAB), using manikins on a standard military transport stanchion and the floor with a minimal amount of setup time and extraneous light ***: A convenience sample size of 40 participants(24 novices and 16 experts) attempted intubation with each of the 5 different video laryngoscopic devices on high-fidelity airway manikins. Time to tracheal intubation and number of optimization maneuvers used were recorded. Kruskal-Wallis testing determined significant differences between the VAIDs in time to intubation for each particular scenario. Devices with significant differences underwent pair-wise comparison testing using rank-sum analysis to further clarify the difference. Device assembly times, startup times and the amount of light emitted were recorded. Perceived ease of use was surveyed. Results: Novices were fastest with the Pentax AWS in all difficult airway scenarios. Experts recorded the shortest median times consistently using 3 of the 5 devices. The AWS was superior overall in 4 of the 6 scenarios tested. Experts and novices subjectively judged the Glide Scope Ranger as easiest to use. The light emitted by all the devices was less than the USAF-issued hea

关键词： simulation difficult airway novice expert military video laryngoscopy light emission