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Mitochondria-targeting multi-metallic ZnCuO nanoparticles and IR780 for efficient photodynamic and photothermal cancer treatments

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Journal of Materials Science & Technology 2021年第27期86卷 139-150页

作者： Hima Bindu Ruttala Thiruganesh Ramasamy Raghu Ram Teja Ruttala tuan hiep tran Jee-Heon Jeong Han-Gon Choi Sae Kwang Ku Chul Soon Yong Jong Oh Kim College of Pharmacy Yeungnam University214-1Dae-dongGyeongsan712-749Republic of Korea Magee-Women’s Research Institute University of PittsburghPittsburghPA15213USA Center for Ultrasound Molecular Imaging and Therapeutics University of Pittsburgh Medical Center(UPMC)PittsburghPA15213USA Sri Vasavi Institute of Pharmaceutical Sciences West GodavariAndhra PradeshIndia Faculty of Pharmacy PHENIKAA UniversityYen NghiaHa DongHanoi12116Viet Nam PHENIKAA Research and Technology Institute(PRATI) A&A Green Phoenix Group JSCNo.167 Hoang NganTrung HoaCau GiayHanoi11313Viet Nam College of Pharmacy Hanyang UniversityAnsan426-791Republic of Korea College of Korean Medicine Daegu Haany UniversityGyeongsan712-715Republic of Korea

Chemo-resistance has pushed cancer treatment to the boundary of *** challenge has encouraged scientists to look for nanotechnological *** this study,we have taken this goal one step further without depending on ***,hybrid metal,polymer,and lipid nanoparticles that formed an IR780-a photosensitizer and Zinc copper oxide incorporated nanoparticle(ZCNP)nanoparticles were utilized in a combined photothermal and photodynamic *** the mediation of triphenylphosphonium(TPP)as a mitochondria-targeting moiety,TPP-conjugated polymer-lipid hybrid nanoparticles containing ZCNP/IR-780 significantly enhanced cellular uptake by cancer cells and selectively targeted the mitochondria,which improved the induction of *** tumor-bearing mice,the nanoparticles were detected predominantly in tumors rather than in the other principle organs,which did not show notable signs of *** in vitro and in vivo results demonstrated a great improvement in photothermal and photodynamic efficacy in combination when compared to either one individually,and a significant inhibition of tumor growth was observed with the combined *** summary,this study describes an effective mitochondria-targeting nanocarrier for the treatment of cancer using combined photothermal and photodynamic therapies.

关键词： Zinc-doped copper Nanoparticles Mitochondria Cancer Photothermal Photodynamic

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Polyelectrolyte complex micelles by self-assembly of polypeptide-based triblock copolymer for doxorubicin delivery

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Asian Journal of Pharmaceutical Sciences 2014年第4期9卷 191-198页

作者： Jeong Hwan Kim Thiruganesh Ramasamy tuan hiep tran Ju Yeon Choi Hyuk Jun Cho Chul Soon Yong Jong Oh Kim College of Pharmacy Yeungnam University214-1Dae-DongGyongsan 712-749South Korea

Polyelectrolyte complex micelles were prepared by self-assembly of polypeptide-based triblock copolymer as a new drug carrier for cancer *** triblock copolymer,poly(L-aspartic acid)-b-poly(ethylene glycol)-b-poly(L-aspartic acid)(PLD-b-PEG-b-PLD),spontaneously self-assembled with doxorubicin(DOX)via electrostatic interactions to form spherical micelles with a particle size of 60e80 nm(triblock ionomer complexes micelles,TBIC micelles).These micelles exhibited a high loading capacity of 70%(w/w)at a drug/polymer ratio of 0.5 at pH *** showed pH-responsive release patterns,with higher release at acidic pH than at physiological ***,DOX-loaded TBIC micelles exerted less cytotoxicity than free DOX in the A-549 human lung cancer cell *** microscopy in A-549 cells indicated that DOX-loaded TBIC micelles were transported into lysosomes via *** micelles possessed favorable pharmacokinetic characteristics and showed sustained DOX release in ***,these findings indicate that PLDb-PEG-b-PLD polypeptide micelles are a promising approach for anti-cancer drug delivery.

关键词： Polyelectrolyte Micelles Drug delivery Poly(L-aspartic acid) Poly(ethylene glycol)

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Gravitationally lensed extended sources: the case of QSO RXJ0911

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Research in Astronomy and Astrophysics 2013年第7期13卷 803-814页

作者： Do Thi Hoai Pham Tuyet Nhung Pham tuan Anh Frederic Boone Pierre Darriulat Pham Ngoc Diep Pham Ngoc Dong Nguyen Van hiep Nguyen Thi Thao VATLY INST179Hoang Quoc VietCau GiayHanoiVietnam IRAP 14avenue Edouard BelinF31400 ToulouseFrance

After a brief reminder of the mechanism of gravitational lensing of ex- tended sources, the particular case of the host galaxy of QSO RXJ0911, a high red-shift （z - 2.8） quadruply imaged quasar, is explored. The non linearity of the problem, together with the proximity of the source to a cusp of the lens inner caustic, has impor-tant consequences on the dependence of the image appearance on the size and shape of the source. Their expected main features and their interpretation in terms of source extension and shape are investigated in a spirit of simplicity and in preparation for the analysis of high sensitivity and spatial resolution images that will soon be within reach with the completion of the Atacama Large Millimeter/submillimeter Array （ALMA）. In particular, the information on source size carded by relative image brightness is dis-cussed. Extension of the results to other types of quadruply imaged quasars is briefly considered.

关键词： gravitational lensing - galaxies: high-redshift

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Brunner’s gland hyperplasia associated with lipomatous pseudohypertrophy of the pancreas presenting with gastrointestinal bleeding:A case report

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World Journal of Clinical Cases 2021年第31期9卷 9670-9679页

作者： Long Cong Nguyen Khanh Truong Vu trang Thi Thuy Vo Chau Ha Trinh Tan Dang Do Ngoc Thi Van Pham Tuyen Van Pham Thanh tuan Nguyen hiep Canh Nguyen Jeong-Sik Byeon Gastroenterology and Hepatology Center Bach Mai HospitalHanoi 10000Viet Nam Department of Gastroenterology School of Medicine and PharmacyVietnam National University HanoiHanoi 10000Viet Nam Radiology Center Bach Mai HospitalHanoi 10000Viet Nam Pathology Center Bach Mai HospitalHanoi 10000Viet Nam Department of Human Pathology Kanazawa University Graduate School of MedicineKanazawa 920-8640Japan Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Brunner’s gland hyperplasia(BGH)is a rare benign lesion of the *** pseudohypertrophy(LiPH)of the pancreas is an extremely rare *** each condition is rare,the probability of purely coincidental coexistence of both conditions is extremely *** SUMMARY We report a 26-year-old man presenting to our hospital with symptoms of recurrent upper gastrointestinal *** gastrointestinal endoscopy showed a huge pedunculated polypoid lesion in the duodenum with bleeding at the base of the *** examination of the duodenal biopsy specimens showed ***,abdominal computed tomography and magnetic resonance imaging revealed marked fat replacement over the entire pancreas,confirmed by histopathological evaluation on percutaneous pancreatic *** on the radiological and histological findings,LiPH of the pancreas and BGH were *** patient refused any surgical ***,he was managed with supportive *** patient’s symptoms improved and there was no further *** This is the first well-documented case showing the coexistence of LiPH of the pancreas and BGH.

关键词： Lipomatous pseudohypertrophy Pancreas Gastrointestinal bleeding Brunner’s gland Case report

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Remote Sensing-Based Accounting of Reservoir’s Water Storage for Water Scarcity Mitigation: A Case Study for Small and Medium Irrigation Dams in Vietnam

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Journal of Geoscience and Environment Protection 2021年第11期9卷 89-97页

作者： Hung X. Dinh Thanh T. Hoang Lan T. Ha tuan V. Nguyen Thanh C. Pham Minh C. Nguyen hiep T. Luong Institute of Water Resources Planning Hanoi Vietnam

Integrated water resources management requires consistent and accurate data on available water storage in reservoirs as well as water stress level. Vietnam is enduring a significant deficit in collecting necessary information to manage its water resources in that manner. While reservoirs are abundant, the majority of them were constructed a long ago and often lack of regular and adequate measurement on storage volume. Furthermore, the condition of water stress is often missing or remains bias leading to certain risks in reservoir operation, e.g. during water scarcity period. This paper presents how remote sensing data can be used to acquire needed information that is fundamental to understand water resources conditions. The results indicated that Sentinel-1 and Moderate Resolution Imaging Spectroradiometer (MODIS) can be applied to determine water surface area and water stress, through vegetation health index (VHI). This information is deemed necessary to improve water resources monitoring and management and hence, ensure long-term drought resilience and water and food security.

关键词： Remote Sensing Water Scarcity Management Reservoir Volume

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