Polyelectrolyte complex micelles by self-assembly of polypeptide-based triblock copolymer for doxorubicin delivery

作     者：Jeong Hwan Kim Thiruganesh Ramasamy Tuan Hiep Tran Ju Yeon Choi Hyuk Jun Cho Chul Soon Yong Jong Oh Kim 

作者机构：College of PharmacyYeungnam University214-1Dae-DongGyongsan 712-749South Korea 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2014年第9卷第4期

页      面：191-198页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：This research was supported by the National Research Foundation of Korea(NRF)grant funded by the Ministry of Education Science and Technology(No.2012R1A2A2A02044997 and No.2012R1A1A1039059) 

主　　题：Polyelectrolyte Micelles Drug delivery Poly(L-aspartic acid) Poly(ethylene glycol) 

摘      要：Polyelectrolyte complex micelles were prepared by self-assembly of polypeptide-based triblock copolymer as a new drug carrier for cancer *** triblock copolymer,poly(L-aspartic acid)-b-poly(ethylene glycol)-b-poly(L-aspartic acid)(PLD-b-PEG-b-PLD),spontaneously self-assembled with doxorubicin(DOX)via electrostatic interactions to form spherical micelles with a particle size of 60e80 nm(triblock ionomer complexes micelles,TBIC micelles).These micelles exhibited a high loading capacity of 70%(w/w)at a drug/polymer ratio of 0.5 at pH *** showed pH-responsive release patterns,with higher release at acidic pH than at physiological ***,DOX-loaded TBIC micelles exerted less cytotoxicity than free DOX in the A-549 human lung cancer cell *** microscopy in A-549 cells indicated that DOX-loaded TBIC micelles were transported into lysosomes via *** micelles possessed favorable pharmacokinetic characteristics and showed sustained DOX release in ***,these findings indicate that PLDb-PEG-b-PLD polypeptide micelles are a promising approach for anti-cancer drug delivery.