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Schisandrin B Inhibits NLRP3 Inflammasome Pathway and Attenuates Early Brain Injury in Rats of Subarachnoid Hemorrhage

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Chinese Journal of Integrative Medicine 2022年第7期28卷 594-602页

作者： CHEN Song DING Yi-hang SHI Song-sheng tu xian-kun Department of Neurosurgery Fujian Medical University Union HospitalNeurosurgery Research Institute of Fujian ProvinceFuzhou 350001China

Objective: To determine whether Schisandrin B(Sch B) attenuates early brain injury(EBI) in rats with subarachnoid hemorrhage(SAH). Methods: Sprague-Dawley rats were divided into sham(sham operation), SAH, SAH+vehicle, and SAH+Sch B groups using a random number table. Rats underwent SAH by endovascular perforation and received Sch B(100 mg/kg) or normal saline after 2 and 12 h of SAH. SAH grading, neurological scores, brain water content, Evan’s blue extravasation, and terminal transferase-mediated dUTP nick end-labeling(tuNEL) staining were carried out 24 h after SAH. Immunofluorescent staining was performed to detect the expressions of ionized calcium binding adapter molecule 1(Iba-1) and myeloperoxidase(MPO) in the rat brain, while the expressions of B-cell lymphoma 2(Bcl-2), Bax, Caspase-3, nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3), apoptosis-associated specklike protein containing the caspase-1 activator domain(ASC), Caspase-1, interleukin(IL)-1β, and IL-18 in the rat brains were detected by Western blot. Results: Compared with the SAH group, Sch B significantly improved the neurological function, reduced brain water content, Evan’s blue content, and apoptotic cells number in the brain of rats(P<0.05 or P<0.01). Moreover, Sch B decreased SAH-induced expressions of Iba-1 and MPO(P<0.01). SAH caused the elevated expressions of Bax, Caspase-3, NLRP3, ASC, Caspase-1, IL-1β, and IL-18 in the rat brain(P<0.01), all of which were inhibited by Sch B(P<0.01). In addition, Sch B increased the Bcl-2 expression(P<0.01). Conclusion: Sch B attenuated SAH-induced EBI, which might be associated with the inhibition of neuroinflammation, neuronal apoptosis, and the NLRP3 inflammatory signaling pathway.

关键词： schisandrin B subarachnoid hemorrhage early brain injury inflammation neuronal apoptosis nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 Chinese medicine

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Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats

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Chinese Journal of Integrative Medicine 2020年第7期26卷 510-518页

作者： ZHANG Hua-bin tu xian-kun SONG Shi-wei LIANG Ri-sheng SHI Song-sheng Department of Neurosurgery Fujian Medical University Union HospitalNeurosurgery Research Institute of Fujian ProvinceFuzhou(350001)China

Objective: To evaluate the effect of baicalin on subarachnoid hemorrhage(SAH) in rats and explore the potential mechanisms. Methods: Sprague-Dawley rats underwent experimental SAH and received treatment with baicalin at 10 or 50 mg/kg after 2 and 12 h of SAH. Neurological scores, brain water content, Evans-blue extravasation, and levels of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD), myeloperoxidase(MPO), and malondialdehyde(MDA) were measured 24 h after SAH. Expression of nuclear factor erythroid-related factor 2(Nrf2), NAD(P)H: quinone oxidoreductase 1(NQO1), matrix metalloproteinase-9(MMP-9), aquaporin 4(AQP4), occludin, and zonulaoccludens-1(ZO-1) were detected in the brain by Western blot. Heme oxygenase-1(HO-1) was detected by quantitative polymerase chain reaction, and tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) were assessed by enzyme-linked immunosorbent assay. Results: Baicalin attenuated EBI 24 h after SAH in rats(P<0.05). Baicalin elevated neurological scores, GSH-Px, SOD, and increased the expression of Nrf2, NQO1, HO-1, occludin, and ZO-1 in SAH rats(P<0.05 or P<0.01). Baicalin reduced MPO, MDA, and the expression of MMP-9, AQP4, TNF-α, and IL-1β(P<0.05 or P<0.01). Conclusion: Baicalin reduced SAH-induced EBI, partially via activation of the Nrf2/HO-1 pathway and inhibition of MMP-9 and AQP4.

关键词： aquaporin 4 baicalin Chinese medicine early brain injury matrix metalloproteinase-9 subarachnoid hemorrhage

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Schisandrin B Protects against Ischemic Brain Damage by Regulating PI3K/AKT Signaling in Rats

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中国结合医学杂志:英文版 2023年第10期29卷 885-894页

作者： HONG Quan-long DING Yi-hang CHEN Jing-yi SHI Song-sheng LIANG Ri-sheng tu xian-kun Department of Neurology The First Hospital of Quanzhou Affiliated to Fujian Medical UniversityQuanzhouFujian Province362000China Department of Neurosurgery Fujian Medical University Union HospitalFuzhou350001China

Objective To explore the effect and mechanism of schisandrin B(Sch B)in the treatment of cerebral ischemia in *** The cerebral ischemia models were induced by middle cerebral artery occlusion(MCAO)and ***-Dawley rats were divided into 6 groups using a random number table,including sham,MCAO,MCAO+Sch B(50 mg/kg),MCAO+Sch B(100 mg/kg),MCAO+Sch B(100 mg/kg)+LY294002,and MCAO+Sch B(100 mg/kg)+wortmannin *** effects of Sch B on pathological indicators,including neurological deficit scores,cerebral infarct volume,and brain edema,were subsequently *** apoptosis was identified by terminal transferase-mediated dUTP nick end-labeling(tuNEL)*** protein expressions involved in apoptosis,inflammation response and oxidative stress were examined by immunofluorescent staining,biochemical analysis and Western blot analysis,*** effect of Sch B on phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)signaling was also *** Sch B treatment decreased neurological deficit scores,cerebral water content,and infarct volume in MCAO rats(PtuNEL staining indicated that Sch B also reduced apoptosis in brain tissues,as well as the Bax/Bcl-2 ratio and caspase-3 expression(P<0.01).Sch B regulated the production of myeloperoxidase,malondialdehyde,nitric oxide and superoxide dismutase,as well as the release of cytokine interleukin(IL)-1βand IL-18,in MCAO rats(P<0.05 or P<0.01).Sch B promoted the phosphorylation of PI3K and *** the PI3K/AKT signaling pathway with LY294002 or wortmannin reduced the protective effect of Sch B against cerebral ischemia(P<0.05 or P<0.01).Conclusions Sch B reduced apoptosis,inflammatory response,and oxidative stress of MCAO rats by modulating the PI3K/AKT *** B had a potential for treating cerebral ischemia.

关键词： cerebral ischemia inflammation neuroprotection PI3K/AKT signaling schisandrin B Chinese medicine

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Quasi-shadowing for Z^(d)-actions

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1563-1580页

作者： Juan PAN xian kun REN Yun Hua ZHOU School of Mathematics and Statistics Chongqing Technology and Business UniversityChongqing 400067P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing 401331P.R.China

A diffeomorphism is non-uniformly partially hyperbolic if it preserves an ergodic measure with at least one zero Lyapunov *** prove that a C^(1)-smooth Z^(d)-action has the quasishadowing property if one of the genera... 详细信息

关键词： Quasi-shadowing Z^(d)-action non-uniformly partially hyperbolic ergodic measure

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Multisensor information fusion:Future of environmental perception in intelligent vehicles

Journal of Intelligent and Connected Vehicles

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Journal of Intelligent and Connected Vehicles 2024年第3期7卷 163-176页

作者： Yongsheng Zhang Chen tu kun Gao Liang Wang CRRC Qishuyan Institute Co. Ltd.Changzhou 213011China School of Information Science and Engineering Southeast UniversityNanjing 211189China Department of Architecture and Civil Engineering Chalmers University of TechnologyGothenburg SE-41296Sweden School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China

As urban transportation increasingly impacts daily life,efficiently utilizing traffic resources and developing public transportation have become crucial for addressing issues such as congestion,frequent accidents,and noise *** rapid advancement of intelligent autonomous driving technologies,particularly environmental perception technologies,offers new directions for solving these *** review discusses the application of multisensor information fusion technology in environmental perception for intelligent vehicles,analyzing the components and performance of various sensors and their specific applications in autonomous *** multisensor information fusion,the accuracy of environmental perception is enhanced,optimizing decision support for autonomous driving systems and thereby improving vehicle safety and driving *** study also discusses the challenges faced by information fusion technology and future development trends,providing references for further research and application in intelligent transportation systems.

关键词： intelligent vehicles environmental perception multisensor information fusion autonomous driving traffic safety

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Different mechanisms underlie similar species-area relationships in two tropical archipelagoes

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Plant Diversity 2024年第2期46卷 238-246页

作者： Shengchun Li Tieyao tu Shaopeng Li xian Yang Yong Zheng Liang-Dong Guo Dianxiang Zhang Lin Jiang Key Laboratory of Plant Resources Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China ECNU-Alberta Joint Lab for Biodiversity Study Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China School of Biological Sciences Georgia Institute of TechnologyAtlantaGA 30332USA Jiangxi Academy of Forestry Nanchang 330032China Institute of Eco-Chongming(IEC) Shanghai 202162China State Key Laboratory of Biocontrol School of EcologySun Yat-sen UniversityGuangzhou 510275China School of Geographical Sciences Fujian Normal UniversityFuzhou 350007China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Despite much research in the field of island biogeography,mechanisms regulating insular diversity remain ***,we aim to explore mechanisms underlying plant species-area relationships in two tropical archipelagoes in the South China *** found positive plant species-area relationships for both coral and continental ***,our results showed that different mechanisms contributed to similar plant species-area relationships between the two *** coral islands,soil nutrients and spatial distance among communities played major roles in shaping plant community structure and species *** contrast,the direct effect of island area,and to a lesser extent,soil nutrients determined plant species richness on continental ***,increasing soil nutrients availability(N,P,K)had opposite effects on plant diversity between the two *** summary,the habitat quality effect and dispersal limitation are important for regulating plant diversity on coral islands,whereas the passive sampling effect,and to a lesser extent,the habitat quality effect are important for regulating plant diversity on continental *** generally,our findings indicate that island plant species-area relationships are outcomes of the interplay of both niche and neutral processes,but the driving mechanisms behind these relationships depends on the type of islands.

关键词： Coral and continental islands Plant diversity Soil nutrients Species-area relationships The sampling effect

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Efficient removal of U(VI) from wastewater by a sponge-like 3D porous architecture with hybrid electrospun nanofibers

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Water Science and Engineering 2024年第2期17卷 150-156页

作者： Lin Hu Lin Chen xian-kun Wu Rui Luo Rong-guan Lv Zheng-hao Fei Feng Yang School of Chemistry and Environmental Engineering Yancheng Teachers UniversityYancheng 224051China Jiangsu Province Engineering Research Center of Agriculural Breeding Pollution Control and Resource Yancheng 224051China Jiangsu Nanda Huaxing Science and Technology of Environmental Protection Co.Ltd. Yancheng 224001China

Removal of uranium(VI)from nuclear wastewater is urgent due to the global nuclear energy *** study synthesized novel sponge-like 3D porous materials for enhanced uranium adsorption by combining electrospinning and fibrous freeze-shaping *** materials possessed an organic-inorganic hybrid architecture based on the electrospun fibers of polyacrylonitrile(PAN)and SiO_(2).As a sup-porting material,the surface of fibrous SiO_(2) could be further functionalized by cyano groups via(3-cyanopropyl)*** the cyano groups were turned into amidoxime(AO)groups to obtain a amidoxime-functionalized sponge(PAO/SiO_(2)-AO)through the subsequent ami-doximation *** proposed sponge exhibited enhanced uranium adsorption performance with a high removal capacity of 367.12 mg/g,a large adsorption coefficient of 4.0×10^(4)mL/g,and a high removal efficiency of 97.59%.The UO_(2)^(2+)adsorption kinetics perfectly conformed to the pseudo-second-order *** sorbent also exhibited an excellent selectivity for UO_(2)^(2+) with other interfering metal ions.2023 Hohai *** and hosting by Elsevier B.V.

关键词： Uranium removal Sponge Amidoximation Organic-inorganic hybrid structure Electrospinning

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Flotation separation of feldspar from quartz using sodium fluosilicate as a selective depressant

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Rare Metals 2024年第3期43卷 1288-1300页

作者： Xin Hu xian-Ping Luo Zi-Shuai Liu Yong-Bing Zhang He-Peng Zhou Zhi-Zhao Yang Xue-kun Tang Faculty of Resource and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou341000China Yichun Lithium New Energy Industry Research Institute Jiangxi University of Science and TechnologyYichun336000China

The physical and chemical properties of feldspar and quartz are highly similar,thus they cannot be easily separated *** this work,the flotation separation of feldspar from quartz using sodium fluosilicate(Na_(2)SiF_(6);SF)as a selective depressant was ***,the influence mechanism of SF on the selective flotation separation of feldspar and quartz was investigated via flotation tests,chemical analysis of flotation solution,Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and contact angle *** results of the flotation tests show that feld spar and quartz without SF treatment have good *** SF treatment,feldspar still has good floatability,whereas quartz has significantly reduced *** solution chemical analysis shows that the functional group plays an important role in depressing the quartz is[SiF_(6)]^(2-).FTIR,XPS and contact angle analysis results show that[SiF_(6)]^(2-)is adsorbed only on the surface of ***,a thin hydrophilic SiOF layer is generated on the surface,which interferes with the adsorption of the collector on the surface of the *** phenomenon leads to a significant reduction in quartz's ***,SF has a good ability to separate feldspar from quartz by flotation.

关键词： Flotation separation Depressants Sodium fluorosilicate Quartz Feldspar

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PI3K/Akt通路在丙泊酚减轻大鼠脑缺血性损伤中的作用

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中国药理学通报 2019年第5期35卷 630-633页

作者：涂献坤杨滨涂德文梁日生石松生福建医科大学附属协和医院神经外科福建省神经外科研究所福建福州350001

目的研究PI3K/Akt信号通路在丙泊酚减轻大鼠缺血性脑损伤中的作用。方法制备大鼠脑缺血模型,随机分为对照组、溶媒组、丙泊酚治疗组和LY294002干预组,丙泊酚腹腔注射给药,LY294002脑室内给药。对大鼠神经功能损伤进行评分,测量大鼠脑梗... 详细信息

目的研究PI3K/Akt信号通路在丙泊酚减轻大鼠缺血性脑损伤中的作用。方法制备大鼠脑缺血模型,随机分为对照组、溶媒组、丙泊酚治疗组和LY294002干预组,丙泊酚腹腔注射给药,LY294002脑室内给药。对大鼠神经功能损伤进行评分,测量大鼠脑梗死体积;分析大鼠缺血性脑水肿程度;检测脑组织髓过氧化物酶(MPO)的含量;Western blot法检测信号通路关键蛋白p-Akt、Akt的表达变化;ELISA法检测血浆TNF-α和IL-1β的分泌。结果丙泊酚能明显减轻大鼠神经功能障碍、脑梗死体积、脑水肿、MPO活性、TNF-α和IL-1β含量,丙泊酚的抗炎作用和神经保护作用被LY294002抑制。丙泊酚上调p-Akt的表达,这种作用也被LY294002抑制。结论 PI3K/Akt信号通路在丙泊酚减轻脑缺血诱导的脑损伤过程中起重要的调节作用。

关键词：脑缺血丙泊酚炎症反应 PI3K/Akt 信号通路 LY294002

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Clinical review and literature analysis of hepatic epithelioid angiomyolipoma in alcoholic cirrhosis: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2382-2388页

作者： Jing-Qiang Guo Jia-Hui Zhou kun Zhang Xin-Liang Lv Chao-Yong tu Department of Hepatobiliary and Pancreatic Surgery Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of Pathology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of General Surgery The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Hepatic epithelioid angiomyolipoma(HEA)has a low incidence and both clinical manifestations and imaging lack ***,it is easy to misdiagnose HEA as other tumors of the liver,especially in the presence of liver diseases such as hepatitis *** article reviewed the diagnosis and treatment of a patient with HEA and alcoholic cirrhosis,and analyzed the literature,in order to improve the understanding of this *** SUMMARY A 67-year-old male patient with a history of alcoholic cirrhosis was admitted due to the discovery of a space-occupying lesion in the *** on the patient’s history,laboratory examinations,and imaging examinations,a malignant liver tumor was considered and laparoscopic partial hepatectomy was *** pathology showed *** outpatient follow-up,the patient showed no sign of *** HEA is difficult to make a definite diagnosis before *** has the poten-tial for malignant *** conditions permit,surgical treatment is recom-mended.

关键词： Hepatic epithelioid angiomyolipoma Alcoholic cirrhosis Magnetic resonance imaging Computed tomography Immunohistochemistry Misdiagnose analysis Case report

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