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Synthesis and Crystal Structure of Ethyl (2-Amino-4-(2-chlorophenyl)-4H-benzo-[h]-chromene-2-yl) Formate

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Chinese Journal of Structural Chemistry 2004年第3期23卷 278-281页

作者： Wang XIangshan Shi Daqing tu shujiang Yao Changsheng Department of Chemistry Xuzhou Normal UniversityXuzhou 221116China Key Laboratory of Biotechnology on Medical Plant XuzhouJiangsu 221116China

The title compound ethyl (2-amino-4-(2-chlorophenyl)-4H-benzo-[h]-chromene-2-yl) formate (C22H18ClNO3, Mr = 379.82) was synthesized and characterized by X-ray single-crystal diffraction analysis. The crystal belongs to monoclinic, space group C2/c with a = 25.168(4), b = 9.584(1), c = 16.503(3) ? b = 111.14(1), Z = 8, V = 3713(1) 3, Dc = 1.359 g/cm3, m(MoKa) = 0.228 mm-1, F(000) = 1584, R = 0.0565 and wR = 0.1320 for 1749 observed reflections (I > 2s(I)). X-ray analysis reveals that the C(1), C(2), C(3), C(4), C(5) and O(1) atoms form a six-membered ring which adopts a boat conformation. In this ring, the bond distances of C(1)C(2) and C(4)C(5) are 1.356(4) and 1.357(4) ? respectively, indicating they are C=C double bonds. In addition, there exist intra- and intermolecular hydrogen bonds in the crystal structure.

关键词： crystal structure, 4H-benzo-[h]-chromene, synthesis

A Highly Diastereoselective Three-component Domino Reac- tion in Water Yielding Poly-substituted 4,5-Dihydropyrroles

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Chinese Journal of Chemistry 2013年第8期31卷 1039-1044页

作者： Guangjing Tong Haiwei Xu Wei Fan Bo Jiang Shuliang Wang shujiang tu School of Chemistry and Chemical Engineering and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University Xuzhou Jiangsu 211116 China Jiangsu Provincial Xuzhou Pharmaceutical Vocational College Xuzhou Jiangsu 221116 China

An efficient methodology for highly diastereoselective synthesis ofpoly-substituted 4,5-dihydropyrrole deriva- tives from readily available common reactants in water has been developed. During domino processes, the forma- tion of pyrrole skeleton and its C2-hydroxylation and C3-arylamination were readily achieved via metal-free [3 ＋2] heterocyclization in a one-pot operation.

关键词： highly diastereoselective 4,5-dihydropyrroles hydroxylation arylamination domino reactions

Radical-Enabled Bicyclization Cascades of Oxygen-Tethered 1,7-Enynes Leading to Skeletally Diverse Polycyclic Chromen-2-ones

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Chinese Journal of Chemistry 2017年第3期35卷 323-334页

作者： Bo Jiang Jie Li Yuanyuan Pan Wenjuan Hao Guigen Li shujiang tu School of Chemistry and Chemical Engineering Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University Xuzhou Jiangsu 221116 China Department of Chemistry and Biochemistry Texas Tech University Lubbock Texas 79409-1061 United States Institute of Chemistry & BioMedical Sciences Collaborative Innovation Center of Chemistry for Life Sciences Nanjing University Nanjing Jiangsu 210093 China

Catalytic bicyclization cascades of oxygen-tethered 1,7-enynes with simple cycloalkanes or aryl sulfonhydrazides have been established via subsequent multiple C-C bond-forming events from alkynyl/alkenyl functions, delivering a series of densely functionalized tetracyclic chromen-2-ones in a functional-group-compatible manner. In the former, Fe-catalyzed spiro-bicyclization involves radical addition, 6-exo-dig cyclization, H-abstraction and 5-endo-trig cyclization sequences under mild conditions, resulting in new spiro-fused cyclopenta[c]chromen-2-ones via dual α,α-C(sp3)-H abstractions. The latter enables in-situ sulfonylation and desulfonylation of oxygen-tethered 1,7-enynes to realize the construction of multiple C-C bonds, thereby leading to the formation of naphtho[2,3-c]chromen-6-ones.

关键词： bicyclization radical reaction 1 7-enynes fused chromen-2-ones C(sp3)-H functionalization

Multicomponent Domino [4＋1＋1] Carbocyclization Providing an Efficient and Regioselective Strategy to Fluoren-9-ones

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Chinese Journal of Chemistry 2013年第6期31卷 737-744页

作者： Ying Li Haiwei Xu Liping Fu Qingqing Shi Bo Jiang shujiang tu School of Chemistry and Chemical Engineering Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University Xuzhou Jiangsu 221116 China

Concise and efficient three-component domino [4＋ 1 ＋ 1] carbocyclization to highly substituted fluoren-9-one derivatives promoted by K2CO3 has been developed under microwave irradiation conditions. The direct bis-cyanation and aryl amination residing in fluoren-9-one framework were achieved in a one-pot operation. The reaction proceeds at fast rates and can be finished within 30 min, which makes workup convenient to give good to excellent chemical yields.

关键词： fluoren-9-one synthesis multicomponent reactions carbocyclization regioselectivity microwaveheating

KF-Al_2O_3催化下3-芳基-3-(5,5-二甲基-3-羟基-2-环己烯-1-酮-2-基)丙酰胺衍生物的合成

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有机化学 2002年第11期22卷 909-912页

作者：王香善史达清屠树江徐州师范大学化学系徐州221009

芳醛、5 ,5 二甲基 1,3 环己二酮、丙二酸亚异丙酯、芳胺在KF Al2 O3催化下 ,在DMF中反应生成 3 芳基 3 (5 ,5 二甲基 3 羟基 2 环己烯 1 酮 2 基 )丙酰胺衍生物。

关键词： KF-Al2O3 合成 3-芳基-3-(5 5-二甲基-3-羟基-2-环己烯-1-酮-2-基)丙酰胺衍生物催化剂

叔丁基自由基引发的1,2-炔基迁移反应研究

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有机化学 2021年第6期41卷 2408-2416页

作者：张萍张天舒蔡佩君姜波屠树江中国矿业大学化工学院江苏徐州221116 江苏师范大学化学与材料科学学院江苏徐州221116 江苏省徐州医药高等职业学校江苏徐州221116

报道了一类由叔丁基自由基引发的1,2-炔基迁移反应.该反应利用特戊醛在二叔丁基过氧化物(DTBP)介导下能产生叔丁基自由基的特性,将其与1,4-烯炔底物发生自由基加成及炔基迁移过程,合成了一系列α-炔基酮化合物,产率优良,实现了非活化烯... 详细信息

报道了一类由叔丁基自由基引发的1,2-炔基迁移反应.该反应利用特戊醛在二叔丁基过氧化物(DTBP)介导下能产生叔丁基自由基的特性,将其与1,4-烯炔底物发生自由基加成及炔基迁移过程,合成了一系列α-炔基酮化合物,产率优良,实现了非活化烯烃的烷基炔基化.基于实验结果及文献报道,提出了可能的反应机理,涉及叔丁基自由基激发的自由基加成、反"鲍德温"规则的3-exo-dig环化及炔基迁移过程.该反应具有官能团兼容性高、无需金属催化剂及操作简便等优点,为非活化烯烃的双官能团化提供了一种有效的策略.

关键词：炔基迁移 1,4-烯炔双官能团化反鲍德温规则

KF/Al_2O_3催化下4H-色烯衍生物的合成

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有机化学 2002年第12期22卷 1053-1056页

作者：史达清王香善屠树江徐州师范大学化学系徐州221009

水杨醛与氰乙酸酯在KF Al2 O3 催化下反应生成 4H 色烯的衍生物 ,产物的结构通过单晶X射线确证 .

关键词： KF/Al2O3 水杨醛氰乙酸酯 4H-色烯衍生物晶体结构氟化钾氧化铝催化剂催化合成抗癌药物

KF-Al_2O_3催化下3,4-二氢-2H-吡喃[3,2-h]喹啉衍生物的合成

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有机化学 2003年第2期23卷 203-206页

作者：王香善史达清屠树江徐州师范大学化学系徐州221009

芳醛、8 羟基喹啉与丙二腈或氰乙酸乙酯在KF Al2 O3催化下反应生成一系列新的 3,4 二氢 2H 吡喃 [3,2 h]喹啉衍生物。

关键词： KF-Al2O3 3,4-二氢-2H-吡喃[3,2-h]喹淋衍生物 8-羟基喹啉晶体结构氟化钾氧化铝芳醛丙二腈

NHC-Catalyzed Three-Component Domino Reaction of Bromoenals with Oxindoles: Diastereoselective Assembly of Spirooxindole 4H-Pran-2-Ones

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NHC-Catalyzed Three-Component Domino Reaction of Bromoenals ...