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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung tsun ming lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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Defect engineering in transition-metal(Fe,Co,andNi)-based electrocatalysts for water splitting

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Carbon Energy 2024年第6期6卷 165-199页

作者： Kaili Wu Chaojie Lyu Jiarun Cheng Weifan Ding Jiwen Wu Qian Wang Woon-ming lau Jinlong Zheng Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijingChina School of Chemistry and Chemical Engineering Linyi UniversityLinyiChina Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijingChina Shunde Innovation School University of Science and Technology BeijingFoshanChina

Electrocatalytic water splitting seems to be an efficient strategy to deal with increasingly serious environmental problems and energy crises but still suffers from the lack of stable and efficient *** practical electrocatalysts by introducing defect engineering,such as hybrid structure,surface vacancies,functional modification,and structural distortions,is proven to be a dependable solution for fabricating electrocatalysts with high catalytic activities,robust stability,and good *** review is an overview of some relevant reports about the effects of defect engineering on the electrocatalytic water splitting performance of *** detail,the types of defects,the preparation and characterization methods,and catalytic performances of electrocatalysts are presented,emphasizing the effects of the introduced defects on the electronic structures of electrocatalysts and the optimization of the intermediates'adsorption energy throughout the ***,the existing challenges and personal perspectives of possible strategies for enhancing the catalytic performances of electrocatalysts are *** in-depth understanding of the effects of defect engineering on the catalytic performance of electrocatalysts will light the way to design high-efficiency electrocatalysts for water splitting and other possible applications.

关键词： defect engineering electrocatalytic water splitting element doping interfacial engineering vacancy

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Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes

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National Science Review 2024年第1期11卷 161-173页

作者： Feng Xue Fei Li Ke-ming Zhang Lufeng Ding Yang Wang Xingtao Zhao Fang Xu Danke Zhang mingzhai Sun Pak-ming lau Qingyuan Zhu Pengcheng Zhou Guo-Qiang Bi Department of Precision Machinery and Precision Instruments University of Science and Technology of China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Interdisciplinary Center for Brain Information the Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Faculty of Life and Health Sciences Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences School of Life Sciences University of Science and Technology of China Institute of Semiconductors Chinese Academy of Sciences Department of Modern Life Sciences and Biotecnology Xiongan Institute of Innovation Xiongan New Area Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Suzhou Institute for Advanced Research University of Science and Technology of China Institute of Artiflcial Intelligence Hefei Comprehensive National Science Center

To investigate the circuit-level neural mechanisms of behavior, simultaneous imaging of neuronal activity in multiple cortical and subcortical regions is highly desired. Miniature head-mounted microscopes offer the capability of calcium imaging in freely behaving animals. However, implanting multiple microscopes on a mouse brain remains challenging due to space constraints and the cumbersome weight of the ***, we present TINIscope, a Tightly Integrated Neuronal Imaging microscope optimized for electronic and opto-mechanical design. With its compact and lightweight design of 0.43 g, TINIscope enables unprecedented simultaneous imaging of behavior-relevant activity in up to four brain regions in ***-of-concept experiments with TINIscope recorded over 1000 neurons in four hippocampal subregions and revealed concurrent activity patterns spanning across these regions. Moreover, we explored potential multi-modal experimental designs by integrating additional modules for optogenetics, electrical stimulation or local field potential recordings. Overall, TINIscope represents a timely and indispensable tool for studying the brain-wide interregional coordination that underlies unrestrained behaviors.

关键词： miniature microscope multiple sites calcium imaging multimodal integration hippocampus

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Multifunctional catalytic sites regulation of atomic-scale iridium on orthorhombic-CoSe_(2)for high efficiency dual-functional alkaline hydrogen evolution and organic degradation

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Journal of Energy Chemistry 2024年第5期92卷 271-281页

作者： Jingjing Huang Chenglin Zhong Yanjie Xia Jia Liu Guizhen Li Chao Yang Jiahong Wang Qian Wang Zhenbao Zhang Feng Yan Jianghua Wu Yu Deng Zhenjiang Zhou Xingchen He Paul K.Chu Woon-ming lau Xue-Feng Yu College of Chemistry and Chemical Engineering Linyi UniversityLinyi 276005ShandongChina Shenzhen Engineering Center for the Fabrication of Two-Dimensional Atomic Crystals Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied Sciences and Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093JiangsuChina College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058ZhejiangChina Department of Physics Department of Materials Science and EngineeringDepartment of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina

The earth-abundant and high-performance catalysts are crucial for commercial implementation of hydrogen evolution reaction(HER).Herein,a multifunctional site strategy to construct excellent HER catalysts by incorporating iridium(Ir)ions on the atomic scale into orthorhombic-CoSe2(Ir-CoSe_(2))was *** hydrogen evolution activity in alkaline media such as a low overpotential of 48.7 mV at a current density of 10 mA cm^(-2)and better performance than commercial Pt/C catalysts at high current densities were found in the Ir-CoSe_(2) *** the experiments and theoretical calculations,it was revealed that Ir enabled CoSe_(2)to form multifunctional sites to synergistically catalyze alkaline HER by promoting the adsorption and dissociation of H_(2)O(Ir sites)and optimizing the binding energy for H^(*)on Co *** was noticeable that the electrolytic system comprising the Ir-CoSe_(2)electrode not only produced hydrogen efficiently via HER,but also degraded organic pollutants(Methylene blue).The cell voltage of the dual-function electrolytic system was 1.58 V at the benchmark current density of 50 mA cm^(-2),which was significantly lower than the conventional water splitting *** was indicated that this method was a novel strategy for designing advanced HER electrocatalysts by constructing multifunctional catalytic sites for hydrogen production and organic degradation.

关键词： Orthorhombic-CoSe_(2) Multifunctional sites design Hydrogen evolution reaction Synergistically catalyze Methylene blue oxidation

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Recent progress in cobalt-based compounds as high-performance anode materials for lithium ion batteries

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Rare Metals 2017年第5期36卷 307-320页

作者： Jian Wu Woon-ming lau Dong-Sheng Geng Center for Green Innovation Beijing Key Laboratory for Magneto-Photoelectrical Composite and Interface ScienceSchool of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing 100083China

Despite carbonaceous materials are widely employed as commercial negative electrodes for lithium ion battery, an urge requirement for new electrode materials that meet the needs of high energy density, long cycle life, low cost and safety is still underway. A number of cobalt-based compounds（Co（OH）_2, Co_3O_4, CoN, CoS,CoP, NiCo_2O_4, etc.） have been developed over the past years as promising anode materials for lithium ion batteries（LIBs） due to their high theoretical capacity, rich redox reaction and adequate cyclability. The LIBs performances of the cobalt-based compounds have been significantly improved in recent years, and it is anticipated that these materials will become a tangible reality for practical applications in the near future. However, the different types of cobalt-based compounds will result in diverse electrochemical performance. This review briefly analyzes recent progress in this field, especially highlights the synthetic approaches and the prepared nanostructures of the diverse cobalt-based compounds and their corresponding performances in LIBs, including the storage capacity, rate capability, cycling stability and so on.

关键词： Lithium ion batteries Anode materials Cobalt Conversion reaction

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Cosmic microwave background constraints on the tensor-to-scalar ratio

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Research in Astronomy and Astrophysics 2014年第6期14卷 635-647页

作者： King lau Jia-Yu Tang ming-Chung Chu Department of Physics and Institute of Theoretical Physics The Chinese University of Hong Kong

One of the main goals of modern cosmic microwave background （CMB） missions is to measure the tensor-to-scalar ratio r accurately to constrain inflation models. Due to ignorance about the reionization history Xe （z）, this analysis is usu- ally done by assuming an instantaneous reionization Xe （z） which, however, can bias the best-fit value of r. Moreover, due to the strong mixing of B-mode and E-mode polarizations in cut-sky measurements, multiplying the sky coverage fraction fsky by the full-sky likelihood would not give satisfactory results. In this work, we forecast constraints on r for the Planck mission taking into account the general reionization scenario and cut-sky effects. Our results show that by applying an N-point interpo- lation analysis to the reionization history, the bias induced by the assumption of in- stantaneous reionization is removed and the value of r is constrained within 5% error level, if the true value of r is greater than about 0.1.

关键词： cosmology: cosmic microwave background -- cosmology: cosmologicalparameters -- cosmology: early universe -- gravitational waves

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Recent Advances in Directed Assembly of Nanowires or Nanotubes

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Nano-Micro Letters 2012年第3期4卷 142-153页

作者： Mei Liu Zhizheng Wu Woon ming lau Jun Yang School of Mechatronics Engineering and Automation Shanghai University State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences Green Energy and Green Manufacturing Technology R&D Center Department of Mechanical and Materials Engineering the University of West ern Ontario

Nanowires and nanotubes of diverse material compositions,properties and/or functions have been produced or fabricated through various bottom-up or top-down *** nanowires or nanotubes have also been utilized as potential building blocks for functional *** key for the integration of those nanowire or nanotube based devices is to assemble these one dimensional nanomaterials to specific locations using techniques that are highly controllable and *** such techniques should enable assembly of highly uniform nanowire/nanotube arrays with precise control of density,location,dimension or even material types of nanowires/*** assembly techniques are being developed that can quickly align and assemble large quantities of one type or multiple types of nanowires through parallel processes,including flow-assisted alignment,Langmuir-Blodgett assembly,bubble-blown technique,electric/magnetic-field directed assembly,contact/roll printing,knocking-down,etc..With these assembling techniques,applications of nanowire/nanotube based devices such as flexible electronics and sensors have been *** paper delivers an overall review of directed nanowire/nanotube assembling approaches and analyzes advantages and limitations of each *** future research directions have also been discussed.

关键词： Nanowire Nanotube Assembly Shear force Contact printing Dielectrophoresis Microfluidics Nanosystems Nanodevices

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On the first negative Hecke eigenvalue of an automorphic representation of GL_(2)(A_(Q))

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Science China Mathematics 2021年第11期64卷 2381-2394页

作者： Yuk-Kam lau ming Ho Ng Hengcai Tang Yingnan Wang Department of Mathematics The University of Hong KongHong KongChina Department of Mathematics The Chinese University of Hong KongHong KongChina Institute of Modern Mathematics School of Mathematics and StatisticsHenan UniversityKaifeng 475004China Shenzhen Key Laboratory of Advanced Machine Learning and Applications College of Mathematics and StatisticsShenzhen UniversityShenzhen 518060China

Letπbe a self-dual irreducible cuspidal automorphic representation of GL_(2)(A_(Q))with trivial central *** Hecke eigenvalue λπ(n)is a real multiplicative function in *** show that λπ(n)<0 for some n< 详细信息

关键词： automorphic representation Hecke eigenvalue Maass cusp form sign change

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Synthesis of FeOOH scaly hollow tubes based on Cu_(2)O wire templates toward high-efficiency oxygen evolution reaction

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Rare Metals 2023年第6期42卷 1836-1846页

作者： Yu Zhang Xue-Ai Teng Ze-Qun Ma Rong-ming Wang Woon-ming lau Ai-Xian Shan Beijing Advanced Innovation Center for Materials Genome Engineering and Center for Green Innovation School of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing100083China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Magneto-Photoelectrical Composite and Interface ScienceSchool of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing100083China Shunde Innovation School of University of Science and Technology Beijing Foshan528000China Institute of Materials Science and Devices School of Materials Science and EngineeringSuzhou University of Science and TechnologySuzhou215009China

For catalytic materials,the characteristics of one-dimension and hollowness are the promotion factors for their full presentation of catalytic activity,and through a template-as sis ted method,both above superiorities can be fused ***,we proposed a novel strategy inspired by Pearson's principle with Cu_(2)O wires as templates,and prepared FeOOH hollow tubes,which covered by FeOOH *** applied as oxygen evolution reaction(OER)catalyst,the FeOOH scaly hollow tubes(FeOOH SHTs)showed outstanding catalytic activity with a low overpotential of 245 mV to drive a current density of10 mA·cm^(-2),excellent kinetics manifesting as a low Tafel slope of 46.9 mV·dec^(-1),and robust *** work provides a new synthesis strategy for an ideal OER catalyst,FeOOH,with high inherent activity and enhances the feasibility to broaden the design ideas of transition metalbased catalysts.

关键词： FeOOH scaly hollow tube(SHT) Cu_(2)O wire template One-dimensional(1D)hollow structure Oxygen evolution reaction(OER)

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Cu2O-templated fabrication of Ni(OH)2·0.75H2O hollow tubes for electrocatalytic oxygen evolution reaction

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Progress in Natural Science:Materials International 2022年第5期32卷 554-560页

作者： Yu Zhang Xueai Teng Zequn Ma Rongming Wang Woon-ming lau Aixian Shan Beijing Advanced Innovation Center for Materials Genome Engineering & Center for Green Innovation School of Mathematics and Physics University of Science and Technology Beijing Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Magneto-Photoelectrical Composite and Interface Science School of Mathematics and Physics University of Science and Technology Beijing Institute of Materials Science and Devices School of Materials Science and Engineering Suzhou University of Science and Technology Shunde Innovation School of University of Science and Technology Beijing

Cu2O is an ideal template material for the preparation of transition metal hydroxide/oxyhydroxides with oxygen evolution reaction(OER) enhanced catalytic performance. Here, inspired by Pearson’s principle, Cu2O wires were prepared and used as a sacrificial template to prepare Ni(OH)2·0.75H2O hollow tubes(Ni(OH)2HTs) with highly improved surface roughness. Benefiting from unique structural advantages, the Ni(OH)2HTs showed excellent catalytic activity, rapid kinetics and a long-term stability as the OER catalyst, where an overpotential of only 207mV was required to drive a current density of 10 mA cm-2, an ideal kinetics with a Tafel slope as 79.8 mV dec-1was calculated, and no obvious attenuation in chronoamperometry was discovered after operation for 24 h. This paper provides a novel template-assisted strategy to prepare high-performance transition metal-based OER catalysts possessing hollow and tubular structures.

关键词： Ni(OH) 2 hollow tube Cu 2 O wire Template One-dimensional hollow structure Oxygen evolution reaction

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