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心房颤动对慢性心力衰竭伴左室射血分数≥0．50患者预后的临床研究

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中国危重病急救医学 2008年第4期20卷 200-203页

作者：詹红 tse hung-fat 曹晶茗 LAU Cpu-pak 中山大学第一附属医院广东广州510080 香港大学玛丽医院心脏内科昆明医学院第一附属医院心内科

目的探讨左室射血分数（LVEF）≥0．50的住院慢性心力衰竭（心衰）患者中心房颤动（房颤）的发生和分布类型，及房颤对此类心衰预后的影响。方法调查患者417例次，按LVEF〈0．50与≥0．50分为两组，根据患者入院前是否有房颤病史分为阵... 详细信息

目的探讨左室射血分数（LVEF）≥0．50的住院慢性心力衰竭（心衰）患者中心房颤动（房颤）的发生和分布类型，及房颤对此类心衰预后的影响。方法调查患者417例次，按LVEF〈0．50与≥0．50分为两组，根据患者入院前是否有房颤病史分为阵发性房颤、持续性房颤及入院后新发房颤。随后观察并记录严重恶性事件发生情况及因慢性心衰而再入院次数及每两次住院的间隔时间。结果LVEF〈0．50的慢性心衰更多见于男性，一年内心肌梗死的发病率较LVEF≥0．50者高[15．6％（34／218）比8．0％（16／199），P〈0．01]，且房颤使得患者脑卒中发生率较不伴房颤者明显增高[24．3％（27／111）比8．4％（9／107），P〈0．053，急性冠脉综合征、心血管死亡事件例数及死亡数也高于不伴房颤者；在LVEF≥0．50的慢性心衰患者中新发房颤数量较LVEF〈0．50者明显增多（51比30，P〈0．05），房颤可见伴发在近2／3的患者中，且再入院次数较不伴房颤者增加[（2．78±1．79）次比（2．00±1．35）次，P〈0．013，前两次入院间隔时间亦较不伴房颤者缩短[（117±107）d比（154±130）d，P〈0．053。结论房颤更易发生在LVEF≥0．50的慢性心衰患者，导致更短的再入院间隔，强调治疗和管理这类房颤的重要性。

关键词：左室射血分数心力衰竭慢性心房颤动预后

SPECIAL COMMUNICATION Atrial sensing and pacing with a single pass ventricular lead

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Chinese Medical Journal 1998年第12期 62-67页

作者： hung fat tse and Chu Pak Lau

Abstract The use of single lead for atrial synchronous ventricular (VDD) pacing in patients with high grade atrioventricular (AV) block and normal sinus node function is an acceptable alternative to dual chamber (DDD) pacing. Implantation and follow up procedures are simplified, and cost is usually reduced by more than the cost of an additional atrial lead. With the use of either diagonally arranged dipole or closely spaced ring electrodes, reliable atrial sensing can be achieved using differential atrial amplifier and high atrial sensitivity. Also oversensing is infrequently observed using provocation tests and dynamic recordings, clinical undersensing is unusual and minimized by programming to the highest atrial sensitivity. However, as atrial pacing is not possible, loss of AV synchrony and rate response may occur for unrecognized or progressive sinus node disease and lower rate limit. The development of single lead dual chamber pacing system may overcome this limitation. Recent studies have demonstrated that atrial pacing can be effective either with the use of a special pacing lead configuration or via floating atrial electrode with a novel stimulation method. Overlapping biphasic impulse (OLBI) can reduce atrial pacing threshold. Early clinical experience suggested that this new pacing method can provide effective and reliable atrial pacing with a relatively low incidence of diaphragmatic pacing. Thus the problem of atrial sensing is solved with a single pass lead but further long term evaluation is required to assess the efficacy and feasibility of new instrumentation for single lead dual chamber pacing.

关键词： pacing single pass sensing Atrial and

Long-term clinical outcomes of drug-eluting stents ***-metal stents in Chinese geriatric patients

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Journal of Geriatric Cardiology 2013年第4期10卷 330-335页

作者： Pak-Hei Chan Sha-Sha Liu hung-fat tse Wing-Hing Chow Man-Hong Jim Hee-Hwa HO Chung Wah Siu Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong 102 Pokfulam Rd Hong Kong China Cardiac Medical Unit Grantham Hospital 125 Wong Chuk Hang Rd Aberdeen Hong Kong China

BACKGROUND & OBJECTIVE: Little is known about the relative efficacies of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and bare-metal stents (BMS) in elderly patients。 The objective of this study was to evaluate the clinical outcome for geriatric patients who received either DES or BMS。 METHODS: From January 2002 to October 2005, 199 consecutive Chinese geriatric patients (≥ 75 years old) underwent PCI with coronary DES or BMS implantation at our institution。 We analyzed the major clinical end points that included all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), stent thrombosis, and bleeding complications。 RESULTS: The three-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (6.3%,3.6%,5.4%) compared with the BMS group (16.2%,11.5%,14.9%; P <0.05)。 No significant differences were found in the three-year cumulative rate for target lesion revascularization (6.3% vs4.6%, P =0.61) or stent thrombosis (3.6% vs2.3%, P =0.70)。 Likewise, there were no statistically significant differences in the cumulative rate for intracranial hemorrhage, or major and minor hemorrhage at three years。 CONCLUSIONS: DES-based PCI was associated with a significant reduction in the three-year cumulative rate of all-cause mortality, cardiovascular death, and myocardial infarction compared with BMS, without increased risk of TLR, stent thrombosis, or bleeding complications at three years in this group of Chinese geriatric patients。

关键词： Bare-metal stents Drug-eluting stents Geriatric patients Percutaneous coronary intervention

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澳門地區心房顫動患病率先導計劃研究

镜湖医学 2020年第2期20卷 28-30,23页

作者：陳菡子馮秀華招漫玲 Mario Evora 吳燕儀麥惠芝吳寶群陳少穎謝鴻發澳門鏡湖醫院内科中國澳門仁伯爵醫院心臟科中國香港大學内科學系中國

目的調查澳門地區高血壓病或糖尿病的老年人房顫患病率、初診CHA_(2)DS_(2)-VASc卒中風險評分,以及患者對房顫的認識程度。方法2019年1月~3月,在門診年齡≥65歲,伴有高血壓病或糖尿病患者中,隨機抽樣210例患者(本院75例,仁伯爵醫院135... 详细信息

目的調查澳門地區高血壓病或糖尿病的老年人房顫患病率、初診CHA_(2)DS_(2)-VASc卒中風險評分,以及患者對房顫的認識程度。方法2019年1月~3月,在門診年齡≥65歲,伴有高血壓病或糖尿病患者中,隨機抽樣210例患者(本院75例,仁伯爵醫院135例),採用AliveCor程式初篩可疑房顫患者,後經心電圖檢查確診後行CHA_(2)DS_(2)-VASc評分;並在每例入選患者中進行房顫知識問卷調查。結果所調查210例患者(本院75例,仁伯爵醫院135例),其中男性97例,女性113例,平均年齡(74.16±7.08)歲。採用AliveCor程式初篩可疑房顫5例,後經心電圖檢查確診為房顫患者2例(本院1例,仁伯爵醫院1例)。患病率為0.95%。2例房顫患者性別女性,年齡分別為68歲和84歲。其CHA_(2)DS_(2)-VASc卒中風險評分分別為3和5分。房顫知曉率為66%;房顫導致相關症狀知曉率為5.5%;瞭解關於房顫導致卒中風險增加知曉率為5.5%。結論這是澳門地區首次開展房顫流行病學調查的先導計劃研究,希望後期通過科學的流行病學調查的方法,明確澳門地區人群房顫患病率,尋找適合地區人文地域特點的房顫早期診斷方法和干預模式。

关键词：心房顫動流行病學 CHA_(2)DS_(2)-VASc評分

Glucose Oxidase/Polypyrrole Biosensor Fabricated by Galvanostatic Electropolymerization Accompanied with a Potential Jumping

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稀有金属材料与工程 2006年第A3期35卷 277-281页

作者： Yuh-Ming Uangl hung-Te Chung tse-Chuan Chou Department of Chemical Engineering WuFeng Institute of TechnologyChiayiTaiwan62153China Dpartment of Chemical Engineering National Cheng Kung UniversityTainanTaiwan70101China

A galvanostatic glucose oxidase (GOD_x)/polypyrrole (Ppy) biosensor fabricated through a potential jumping process was *** spite of the instantaneous voltage jumping from 0.95 V to 1.7 V versus Ag/AgCl in the galvanostatic polymerization of pyrrole with commercial GOD_x,this GOD_x enzyme still could be successfully bundled with polypyrrole (Ppy).And,the results also confirmed that this glucose sensor not only possessed of better sensitivity to glucose than that fabricated from potentiometry or mild voltage elevating galvanometry for the similar preparing conditions but also exhibited two-week long-term ***,the kinetic data of Michalis constant (K_m) and Maximum current (I_m) for the optimized sensor were *** discovery this electro-modification process may disclose a novel method for fabricating the other enzyme biosensors.

关键词： conformation conducting galvanostatic dentritic jumping

Multiple ion channel currents and their role in proliferation of human cardiac fibroblasts

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Multiple ion channel currents and their role in proliferatio...

Predictive value of red cell distribution width on left atrial thrombus or left atrial spontaneous echo contrast in patients with non-valvular atrial fibrillation

第七届海峡两岸心血管科学研讨会

作者： hung-fat tse Chu-Pak Lau Departments of 1 Medicine and 2Physiology The University of Hong Kong

Objective:Electrophysiology is well established in cardiac contractile myocytes;however,information for ion channels is poorly understood in human cardiac fibroblasts,though cardiac fibroblasts play a crucial role in maintenance of the extra-cellular matrix in the normal heart,and in myocardial remodeling in the injured and failing *** present study was designed to investigate ion channel expression and function of ion channels in cultured human cardiac ***:Whole-cell patch voltage clamp and RT-PCR approaches were employed to determine ion channel expression,and cell proliferation assay was made to study the potential role of these channels in fibroblast ***:It was found that multiple ion channels were heterogeneously expressed in human cardiac *** include a big conductance calcium-activated potassium channel current(BKCa)in most(88%)human cardiac fibroblasts,a delayed rectifier potassium current(IKDR)and a transient outward potassium current(Ito)that is sensitive to 4-aminopyridine in a small population(15 and 14%,respectively)of cells,an inwardly-rectifying potassium current(IKir)in 24%of cells,and a chloride current(ICl)in 7%of *** addition,two types of voltage-gated sodium currents(INa)with distinct properties are present in most human (61%)cardiac *** is a slowly inactivated current,sensitive to tetrodotoxin(TTX)inhibition (***,IC=7.8 nmol/L),and another was a fast inactivated M).RT-PCR revealed current,relatively resistant to TTX(***,IC=1.8 the molecular identities(mRNAs)of these ion channels in human cardiac fibroblasts,including KCa.1.1(for BKCa),Kv1.5(likely responsible for IKDR),Kv4.2(likely responsible for Ito),Kir2.1(for IKir)and ClC2 and ClC3(likely responsible for ICl).NaV1.2,NaV1.3,NaV1.6,NaV1.7 (for ***),and NaV1.5(for ***),The proliferation assay with MTT and H-thymidine incorporation approaches demonstrated that inhibition of BKCa with paxilline or ICl with DID

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Journal of Geriatric Cardiology 2018年第6期15卷 408-412页

作者： Xian-Zhang ZHAN Wei-Dong LIN Fang-Zhou LIU Yu-Mei XUE Hong-Tao LIAO Xin LI Xian-Hong FANG Hai DENG Jun HUANG Yang-Qiu LI Jo-Jo HAI hung-fat tse Shu-Lin WU Department of Hematology the First Affiliated Hospital Jinan University Guangzhou China Department of Cardiology Atrial Fibrillation Center Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou China Cardiology Division Department of Medicine Queen Mary Hospital the University of Hong Kong Hong Kong China Division of Cardiology Department of Medicine the University of Hong Kong Shenzhen Hospital Shenzhen China

Objective To evaluate the predictive value of red cell distribution width （RDW） on left atrial thrombus （LAT） or left atrial spontane- ous echo contrast （LASEC） in patients with non-valvular atrial fibrillation （AF）. Methods We reviewed 692 patients who were diagnosed as non-valvular AF and underwent transesophageal echocardiography （TEE） in Guangdong Cardiovascular Institute from April 2014 to December 2015. The baseline clinical characteristics, laboratory test of blood routine, electrocardiograph measurements were analyzed. Results Eighty-four patients were examined with LAT/LASEC under TEE. The mean RDW level was significantly higher in LAT/LASEC patients compared with the non-LAT/LASEC patients （13.59% ± 1.07% ws. 14.34% ± 1.34%; P 〈 0.001）. Receiver-operating characteristic curve analysis was performed and indicated the best RDW cut point was 13.16%. Furthermore, multivariate logistic regression analysis indicated that RDW level 〉 13.16% could be an independent risk factor for LAT/LASEC in patients with AF. Conclusion Elevated RDW level is associated with the presence of LAT/LASEC and could be with moderate predictive value for LAT/LASEC in patients with non-valvular AF.

关键词： Atrial fibrillation Left atrial spontaneous echo contrast Left atrial thrombus Red cell distribution width

Nutrient supplemented serum-free medium increases cardiomyogenesis efficiency of human pluripotent stem cells

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World Journal of Stem Cells 2013年第3期5卷 86-97页

作者： Sherwin Ting Marti Lecina Yau-Chi Chan hung fat tse Shaul Reuveny Steve KW Oh Bioprocessing Technology Institute A*STAR (Agency for Science Technology and Research) Cardiology Division Department of Medicine The University of Hong KongQueen Mary Hospital

AIM: To development of an improved p38 MAPK inhibitor-based serum-free medium for embryoid body cardiomyocyte differentiation of human pluripotent stem cells. METHODS: Human embryonic stem cells (hESC) differentiated to cardiomyocytes (CM) using a p38 MAPK inhibitor (SB203580) based serum-free medium (SB media). Nutrient supplements known to increase cell viability were added to SB medium. The ability of these supplements to improve cardiomyogenesis was evaluated by measurements of cell viability, total cell count, and the expression of cardiac markers via flow cytometry. An improved medium containing Soy hydrolysate (HySoy) and bovine serum albumin (BSA) (SupSB media) was developed and tested on 2 additional cell lines (H1 and Siu-hiPSC). Characterization of the cardiomyocytes was done by immunohistochemistry, electrophysiology and quantitative real-time reverse transcriptionpolymerase chain reaction. RESULTS: hESC cell line, HES-3, differentiating in SB medium for 16 d resulted in a cardiomyocyte yield of 0.07 ± 0.03 CM/hESC. A new medium (SupSB media) was developed with the addition of HySoy and BSA to SB medium. This medium resulted in 2.6 fold increase in cardiomyocyte yield (0.21 ± 0.08 CM/hESC). The robustness of SupSB medium was further demonstrated using two additional pluripotent cell lines (H1, hESC and Siu1, hiPSC), showing a 15 and 9 fold increase in cardiomyocyte yield respectively. The age (passage number) of the pluripotent cells did not affect the cardiomyocyte yields. Embryoid body (EB) cardiomyocytes formed in SupSB medium expressed canonical cardiac markers (sarcomeric α-actinin, myosin heavy chain and troponin-T) and demonstrated all three major phenotypes: nodal-, atrial- and ventricular-like. Electrophysiological characteristics (maximum diastolic potentials and action potential durations) of cardiomyocytes derived from SB and SupSB media were similar. CONCLUSION: The nutrient supplementation (HySoy and BSA) leads to increase in cell viability

关键词： Soy hydrolysate Bovine serum albumin Differentiation Cardiomyocyte Human embryonic stem cells Human induced pluripotent stem cells

Impact of Atrial Fibrillation on Preserved Left Ventricular Systolic Function of Congestive Heart Failure Patients

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Impact of Atrial Fibrillation on Preserved Left Ventricular ...