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Melanoma therapeutics: a literature review

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The Journal of Biomedical Research 2022年第2期36卷 77-97页

作者： Pavan Kumar Dhanyamraju trupti n.patel Department of Pediatrics and Pharmacology Pennsylvania State University College of MedicineHersheyPA 17033USA School of Biosciences and Technology Vellore Institute of TechnologyVellore CampusVelloreTamil Nadu 632014India

Melanoma is a relentless type of skin cancer which involves myriad signaling pathways which regulate many cellular *** makes melanoma difficult to treat,especially when identified *** present,therapeutics include chemotherapy,surgical resection,biochemotherapy,immunotherapy,photodynamic and targeted *** interventions are usually administered as either a single-drug or in combination,based on tumor location,stage,and patients'overall health ***,treatment efficacy generally decreases as patients develop treatment *** profiling of melanocytes and the discovery of novel molecular factors involved in the pathogenesis of melanoma have helped to identify new therapeutic *** this literature review,we examine several newly approved therapies,and briefly describe several therapies being assessed for *** goal is to provide a comprehensive overview of recent developments and to consider future directions in the field of melanoma.

关键词： cancer melanoma intervention target resistance

Catharanthus roseus:a natural source for the synthesis of silver nanoparticles

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Asian Pacific Journal of Tropical Biomedicine 2011年第4期1卷 270-274页

作者： Mukunthan KS Elumalai EK trupti n.patel V Ramachandra Murty Department of Biotechnology Manipal Institute of TechnologyManipal UniversityManipal- 576104KarnatakaIndia School of BioSciences and Technology VITVellore-632 014TamilnaduIndia P.G.and Research Department of Zoology Voorhees CollegeVellore-632 001TamilnaduIndia

Objective:To develop a simple rapid procedure for bioreduction of silver nanoparticles(AgnPs)using aqueous leaves extracts of Catharanthus roseus(***).Methods:Characterization were determined by using UV-Vis spectrophotometry,scanning electron microscopy(SEM),energy dispersive X-ray and X-ray ***:SEM showed the formation of silver nanoparticles with an average size of 67 nm to 48 nm.X-ray diffraction analysis showed that the particles were crystalline in nature with face centered cubic ***:*** demonstrates strong potential for synthesis of silver nanoparticles by rapid reduction of silver ions(Ag^+ to Ag^0).This study provides evidence for developing large scale commercial production of value-added products for biomedical/nanotechnology-based industries.

关键词： nanoparticles nanotechnology Silver Catharanthus roseus

Eu(Ⅲ) Indirect Probe to Investigate Interaction of DOPA (3,4,Di-Hydroxyphenylalanine) and Dopamine (3,4-Dihydroxy Phenyl Ethyl Amine) Using Electrochemical Methods

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Journal of Rare Earths 2006年第6期24卷 653-658页

作者： Prashant n Bhatt trupti V Pathak Jignasu P Mehta G.Ramchandraiha Department of Chemistry Bhavnagar University Bhavnagar-364002 India Central Salt and Marine Chemical Research Institute Waghavadi RoadBhavnagar-364002India

Eu（ Ⅲ ） can be utilized as an indirect electrochemical probe to investigate the interaction of bio-molecules such as DOPA and Dopamine with Ca（ Ⅱ ） in vitro. The interaction of DOPA and Dopamine with Eu（ Ⅲ ）-Eu（ Ⅱ ） redox pair was investigated by electrochemical techniques. Both the neurotransmitters are structurally related and undergo interaction with Eu （Ⅲ ）. Eu （ Ⅲ ） coordinates with DOPA and Dopamine through five-member chelate tings via carboxylic oxygen and amino nitrogen. The electrode kinetic parameters viz, transfer coefficient （αna）, diffusion coefficient （D）, forward heterogeneous rate constant （ k^0 fh） were evaluated for Eu（ Ⅲ ）-DOPA/Eu（ Ⅲ ）-Dopamine. The results obtained were used to investigate the nature of interaction of Eu （Ⅲ） with muhi-donor biomolecules. The possible mechanism was also proposed.

关键词： electrochemistry of Eu ( Ⅲ ) chrono techniques electrochemistry of Eu ( Ⅲ )-neurotransmitters solutionstudy rare earths

植物来源的磷脂酰胆碱可介导抗肺纤维化小RnA(HJT-sRnA-m7)进入哺乳动物细胞

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中国科学：生命科学 2018年第4期48卷 469-481页

作者：杜涧超梁竹许剑涛赵妍李晓芸张艳丽赵丹丹陈茹萱刘洋 trupti Joshi 常佳慧王志清张延旭朱锦东刘强许东蒋澄宇中国医学科学院&北京协和医学院基础医学院、医学分子生物学国家重点实验室北京100005 中国医学科学院&北京协和医学院、北京协和医院内科北京100730 Department of Computer Science Informatics Instituteand Christopher S.Bond Life Science CenterUniversity of MissouriColumbiaMO65211USA Department of Health Management and Informatics and Office of Medical Research School of MedicineUniversity of MissouriColumbiaMO 65212USA 四川大学华西医院生物治疗国家重点实验室生物治疗协同创新中心成都610000

肺纤维化是慢性进行性疾病,死亡率高,临床上除肺移植之外尚无其他明显有效治疗手段.本研究发现,来源于中药大花红景天(Rhodiola crenulata)的小RnA,HJT-sRnA-m7,可以显著降低纤维化因子的表达,在细胞和动物水平上均可改善纤维化症状.此... 详细信息

肺纤维化是慢性进行性疾病,死亡率高,临床上除肺移植之外尚无其他明显有效治疗手段.本研究发现,来源于中药大花红景天(Rhodiola crenulata)的小RnA,HJT-sRnA-m7,可以显著降低纤维化因子的表达,在细胞和动物水平上均可改善纤维化症状.此外,本研究组在红景天熬制的汤汁中提取鉴定了一百多种脂质,其中大部分脂质也同时存在于中药蒲公英(Taraxacum mongolicum)、穿心莲(Andrographis paniculata)和金银花(lonicera japonica)中.选取其中两种磷脂酰胆碱PC(18:0/18:2)和PC(16:0/18:2),使之与植物小RnA形成脂质体,发现其可促进HJT-s RnA-m7等小RnA进入人肺和胃肠道细胞,降低纤维化靶基因的表达.实验结果揭示了植物来源小RnA通过脂质复合物进入人体的可能途径,为si RnA的临床应用提供了新的口服递送途径.

关键词：磷脂细胞摄取抗纤维化红景天小RnA